InnoCare Pharma Limited 諾誠健華醫藥有限公司 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因依賴該等內容而引致的任何損失承擔任何責任。 本公告僅供參考，並不意圖構成或構成收購、購買或認購本公司任何證券之邀請、要約或其 一部分。 – 1 – 一、本期未經審計的業績預告情況 本公告乃由諾誠健華醫藥有限公司（「本公司」，連同其附屬公司統稱「本集團」） 根 據 香 港 聯 合 交 易 所 有 限 公 司 證 券 上 市 規 則（「上市規則」）第13.09(2)條及第 13.10B條及香港法例第571章證券及期貨條例第XIVA部的內幕消息條文（定義見 上市規則）作出。 本公司董事會及全體董事保證，本公告內容不存在任何虛假、誤導性陳述或重 大遺漏，並對其內容的真實性、準確性及完整性承擔責任。 本公告所載的主要財務數據及指標乃根據中國公認會計準則編製的初步數據， 未經本公司核數師審計。 （股份代號：9969） （ 於 開 曼 群 島 註 冊 成 立 的 有 限 公 司 ） 有關20 ...

| A | 股代码：688428 | 股简称：诺诚健华 A | 公告编号：2026-001 | | --- | --- | --- | --- | | 港股代码：09969 | | 港股简称：诺诚健华 | | 诺诚健华医药有限公司 （二）业绩预告情况 （1）经财务部门初步测算，诺诚健华医药有限公司（以下简称"公司"） 预计 2025 年实现营业总收入人民币 23.65 亿元左右，与上年同期相比增长 134% 左右。 （2）公司预计 2025 年度首次实现扭亏为盈。归属于母公司所有者的净利润 为6.33亿元左右，比去年同期归属于母公司所有者的净利润增加10.74亿元左右。 （3）公司预计 2025 年度归属于母公司所有者扣除非经常性损益后的净利润 5.34 亿元左右，比上年同期增加 9.74 亿元左右。 （三）本次业绩预告未经注册会计师审计。 二、 上年同期经营业绩和财务状况 一、 本期业绩预告情况 （一）业绩预告期间 2025 年 1 月 1 日至 2025 年 12 月 31 日。 2025 年年度业绩预告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性 ...

| 代码 | 名称 | 收盘价 | 涨跌幅 | 成交量(手) | 成交额(元) | | | --- | --- | --- | --- | --- | --- | --- | | 300436 | 广生堂 | 105.01 | 14.00% | 21.58万 | | 22.03亿 | | 300765 | 新诺威 | 46.21 | 12.90% | 23.06万 | | 10.27亿 | | 688428 | 诺诚健华 | 20.39 | 2.05% | 6.96万 | | 1.41亿 | | 300401 | 化园生物 | 17.71 | 1.84% | P 29.42万 | | 5.24亿 | | 688192 | 迪哲医药 | 58.96 | 1.78% | 2.60万 | | 1.52亿 | | 002099 | 海翔药业 | 6.35 | 1.28% | 33.69万 | | 2.14亿 | | 688578 | 文力斯 | 101.30 | 1.25% | 4.40万 | | 4.40 乙 | | 300573 | 兴齐眼药 | 72.10 | 1.22% | 8.25万 | | 5.96亿 | ...

1月26日，诺诚健华跌2.02%，成交额1.86亿元。两融数据显示，当日诺诚健华获融资买入额1573.40万 元，融资偿还1308.88万元，融资净买入264.52万元。截至1月26日，诺诚健华融资融券余额合计4.09亿 元。 融资方面，诺诚健华当日融资买入1573.40万元。当前融资余额4.08亿元，占流通市值的7.66%，融资余 额超过近一年90%分位水平，处于高位。 截至9月30日，诺诚健华股东户数1.65万，较上期增加8.66%；人均流通股0股，较上期增加0.00%。2025 年1月-9月，诺诚健华实现营业收入11.15亿元，同比增长59.85%；归母净利润-6441.49万元，同比增长 76.61%。 机构持仓方面，截止2025年9月30日，诺诚健华十大流通股东中，富国精准医疗灵活配置混合A （005176）位居第六大流通股东，持股1215.49万股，相比上期减少42.71万股。万家优选（161903）位 居第七大流通股东，持股1000.00万股，为新进股东。平安医疗健康混合A（003032）位居第八大流通股 东，持股862.66万股，为新进股东。工银前沿医疗股票A（001717）位居第九大流通股东 ...

Core Insights - The report highlights the significant presence of public funds in the stock market, with 2,977 stocks appearing in fund heavy positions as of the end of Q4 last year, indicating a clear trend in institutional investment strategies [1] - A total of 107 stocks have a fund holding ratio exceeding 10%, showcasing the high influence and control of institutional funds over these stocks [1] Group 1: Fund Holdings and Stock Performance - Among the 107 stocks with over 10% fund holdings, 56 saw increased investments in Q4, with notable increases in holdings for ShenGong Co., Tianhua New Energy, and Maiwei Co., with increases of 59,020.96%, 15,808.35%, and 959.13% respectively, indicating strong institutional confidence in their fundamentals [2] - Conversely, 48 stocks experienced reductions in fund holdings, with notable decreases for Nuocheng Jianhua-U, Kaiter Co., and Keda Li, with reductions of 43.91%, 41.04%, and 39.95% respectively [2] - Three new stocks entered the heavy holding category, with Baiao Saitu, Litong Technology, and Xingtou Measurement Control having fund holding ratios of 21.55%, 12.60%, and 10.03% respectively [2] Group 2: Institutional Investment Trends - The phenomenon of institutional clustering remains significant, with over 100 funds holding 42 of the 107 stocks, and 29 stocks held by 50 to 99 funds, indicating a strong consensus among institutional investors [4] - Notably, Ningde Times, despite a holding ratio of 11.63%, has the highest number of fund holders at 2,056, followed by Zhongji Xuchuang, Zijin Mining, and Xinyi with over 1,300 fund holders each [4] - The stocks with high fund holdings are predominantly in the "hard technology" and "innovation" sectors, with 42 from the Sci-Tech Innovation Board, 27 from the Growth Enterprise Market, and 31 from the Shanghai and Shenzhen main boards, reflecting a focus on growth sectors [4] Group 3: Performance Expectations - Among the 107 stocks, 26 have released performance forecasts for 2025, with 18 expecting profit increases, 4 expecting declines, and 2 forecasting losses, indicating a generally positive outlook [5] - The highest expected profit growth is for Baiwei Storage at 473.71%, followed by Changxin Bochuang and Baiao Saitu with expected growths of 378.70% and 303.57% respectively, providing strong support for long-term fund holdings [5] - The concentration of fund holdings in the electronics and biopharmaceutical sectors suggests an increased market expectation for technological innovation and consumer recovery [5]

Group 1 - The core point of the article is that as of January 9, 2026, the number of A-share shareholders for the company is approximately 19,300 [1]

Group 1 - The core viewpoint of the news is that Nocera Biopharma has seen a continuous increase in its stock price, reflecting positive market sentiment and potential investment opportunities [1] - As of January 12, Nocera Biopharma's stock price is 22.58 yuan per share, with a total market capitalization of 39.846 billion yuan and a trading volume of 2.12 billion yuan [1] - The company specializes in the research, production, and commercialization of biopharmaceuticals, focusing on unmet clinical needs in oncology and autoimmune diseases [1] Group 2 - Morgan Stanley's fund holds a significant position in Nocera Biopharma, with the Morgan Stanley Hong Kong-Shanghai Select Mixed A Fund owning 420,000 shares, representing 6.87% of the fund's net value [2] - The fund has generated a floating profit of approximately 69,720 yuan during the four-day stock price increase [2] - The Morgan Stanley Hong Kong-Shanghai Select Mixed A Fund has a total asset size of 67.3812 million yuan and has achieved a year-to-date return of 14.11% [2]

Core Viewpoint - The approval and clinical application of the new generation TRK inhibitor, Zolacotrine (Yinoxin, ICP-723), marks a significant breakthrough in China's broad-spectrum anti-cancer drug development, providing better treatment options for patients with NTRK fusion-positive solid tumors [1][3]. Group 1: Drug Development and Approval - Zolacotrine is the first domestically developed TRK inhibitor approved for clinical use in China, with prescriptions already issued in multiple hospitals [1][3]. - The drug addresses unmet clinical needs for patients with NTRK fusion-positive tumors, which are prevalent in over 26 types of solid tumors [4]. Group 2: Clinical Efficacy - Clinical studies show Zolacotrine has a total response rate (ORR) of 89.1%, with a disease control rate (DCR) of 96.4%, and a 24-month progression-free survival rate (PFS) of 77.4% [5]. - The drug demonstrates a total survival rate (OS) of 90.8%, indicating its potential to provide long-term relief for patients [5]. Group 3: Safety and Administration - Zolacotrine has a low rate of treatment-related adverse events leading to permanent discontinuation, at only 0.4%, enhancing patient compliance [7]. - The once-daily oral administration of Zolacotrine offers convenience for long-term treatment [7]. Group 4: Overcoming Resistance - Zolacotrine effectively overcomes resistance issues associated with first-generation TRK inhibitors, maintaining strong inhibitory activity against common mutations in the TRK kinase domain [9]. Group 5: CNS Penetration - The drug's unique molecular structure allows it to effectively penetrate the blood-brain barrier, achieving a 100% objective response rate in intracranial lesions, thus providing comprehensive protection for patients with brain metastases [10]. Group 6: Company Perspective - The CEO of the company expressed gratitude towards regulatory bodies, clinical experts, and partners for their support in the development and launch of Zolacotrine, emphasizing its role in improving the quality of life for cancer patients [12].

Core Insights - The biopharmaceutical industry is at a significant historical juncture in 2025, marking the end of the "14th Five-Year Plan" and the beginning of the "15th Five-Year Plan," with a focus on balancing technological innovation and commercial rationality, as well as global and local strategies [1][6] - The company, Innovent Biologics, celebrates its 10th anniversary in 2025, achieving significant milestones including a record-breaking collaboration worth over $2 billion with Zenas and achieving profitability two years ahead of schedule [1][6] Company Achievements - Innovent Biologics has successfully launched two innovative drugs, including the first approved CD19 monoclonal antibody for diffuse large B-cell lymphoma (DLBCL) and the first domestically developed TRK inhibitor [7] - The company's core product, Obinutuzumab, has received approval for first-line treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and has been included in the national medical insurance, benefiting more patients [7] Research and Development Progress - The company has made breakthroughs in innovative drug development, with the first BCL2 inhibitor recognized as a breakthrough therapy in China, and multiple clinical trials for various indications are accelerating [8] - The company is advancing its ADC platform with the first ADC drug entering clinical stages, enhancing its competitiveness in solid tumors [8] Future Strategy - Innovent Biologics aims to leverage "Chinese originality" and "global vision" to embark on a new decade of growth, with plans to launch five to six innovative drugs and accelerate globalization efforts [9] - The company is committed to maintaining an entrepreneurial spirit and enhancing its overseas team capabilities to achieve global commercialization of three to four products [9]

Group 1 - The stock price of Nocera Biopharma (688428) closed at 21.65 yuan on January 7, 2026, with an increase of 3.49% and a turnover rate of 3.57% [1] - The trading volume was 95,800 shares, with a total transaction amount of 206 million yuan [1] - On January 7, the net outflow of funds from major investors was 1.24 million yuan, while retail investors saw a net inflow of 1.70 million yuan [2] Group 2 - As of December 31, 2025, the total share capital of Nocera Biopharma remains unchanged at 25 billion ordinary shares, with no change in the number of issued shares [2] - The number of shares listed on the Hong Kong Stock Exchange is 1,496,284,235, which includes 1,493,798,235 issued shares and 2,486,000 treasury shares [1][2] - The number of shares listed on the Sci-Tech Innovation Board is 268,359,717 [1][2] - The company has two equity incentive plans, with 4,531,250 shares remaining to be granted under the 2023 RMB stock incentive plan and 9,645,200 shares under the 2024 RMB stock incentive plan [1]