诺诚健华(09969)涨超4%，截至发稿，涨4.1%，报18.01港元，成交额5971万港元。 消息面上，近日，诺诚健华披露2025上半年中期业绩报告。中信建投（601066）指出，公司2025H1实 现营业收入7.3亿元，同比增长74.3%，主要归功于核心产品奥布替尼的持续放量以及公司与Prolium达 成授权许可获得的首付款。核心产品奥布替尼销售额6.37亿元，同比增长52.8%。归母净利润亏损收窄 至-0.82亿元，同比减亏67.4%，主要源于营业收入的增加以及成本效率进一步提升。截至2025H1，现金 及金融资产达76.8亿元，为后续研发及商业化提供充足保障。 该行续指，诺诚健华正在持续强化其药物发现平台，聚焦B细胞与T细胞信号通路，致力于开发自身免 疫性疾病领域的全球前沿靶点，构建具有差异化优势的自身免疫管线，目标是为存在大量未满足需求的 疾病领域提供"first-in-class"或"best-in-class"疗法。这些创新药物在全球市场具备广阔的应用前景。加速 推进多项自免III期注册临床试验，打造第二增长曲线：奥布替尼联合ICP-248治疗1L CLL/SLL-FDT的III 期临床试验完成 ...

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index increased by 0.39% during the reporting period, ranking 26th among 31 primary industries, underperforming the CSI 300 index which rose by 7.01% [4][14] - The industry shows resilience despite a slight decline in overall revenue and net profit for A-share pharmaceutical companies in the first half of the year, with stable gross profit margins [6] - The CXO sector has returned to high prosperity with significant growth in performance, while the chemical preparation sector shows a mixed performance [6] - The report highlights the approval of several innovative drugs, including Novartis' "Acrux" for IgA nephropathy and the first oral HER2 inhibitor "Zongertinib" by Boehringer Ingelheim [5][41] Industry Review - The pharmaceutical and biotechnology industry PE (TTM, excluding negative values) is at 31.41x, slightly down from 31.38x in the previous period, indicating a valuation below the average [20] - The top three sub-industries by PE are vaccines (56.18x), hospitals (42.24x), and medical devices (40.66x), while pharmaceutical circulation has the lowest valuation at 14.06x [20] - In the reporting period, 29 listed companies in the pharmaceutical and biotechnology sector experienced a net reduction in shareholder holdings amounting to 1 billion CNY [4] Important Industry News - The CDE released a draft guideline for single-arm clinical trials to support the regular approval of anti-tumor drugs [25] - Novartis' IgA nephropathy drug "Acrux" received NMPA approval, marking it as the first of its kind in China [28] - The approval of the new generation ALK inhibitor "Dirocitinib" by Xuan Bamboo Biotech for treating ALK-positive non-small cell lung cancer [36] - The approval of the ADC "Datopotamab deruxtecan" for treating HR-positive, HER2-negative breast cancer [39] Investment Recommendations - The report suggests focusing on investment opportunities in the chemical preparation sector, particularly innovative drugs, and the CXO sector due to their clear long-term growth logic [6]

FF301 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 諾誠健華醫藥有限公司（於開曼群島註冊成立的有限公司） 呈交日期: 2025年9月2日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09969 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 25,000,000,000 | USD | | 0.000002 | USD | | 50,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 25,000,000,000 | USD | | 0.000002 | USD ...

FF301 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09969 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 25,000,000,000 | USD | | 0.000002 | USD | | 50,000 | | 增加 / 減少 (-) | | | | | | | USD | | | | 本月底結存 | | | 25,000,000,000 | USD | | 0.000002 | USD | | 50,000 | 本月底法定/註冊股本總額： USD 50,000 第 1 頁 共 10 頁 v 1.1.1 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 新提交 致：香港 ...

在针对NTRK融合基因阳性的晚期实体瘤患者的注册临床试验中，佐来曲替尼展示了卓越的有效性和安 全性，同时可以克服第一代TRK抑制剂的耐药性。 据了解，佐来曲替尼是诺诚健华自主研发的泛TRK抑制剂。佐来曲替尼治疗携带NTRK融合基因的晚期 实体瘤成人和青少年(12周岁≤年龄<18周岁)患者的新药上市申请(NDA)已在中国获受理并纳入优先审 评，佐来曲替尼针对儿童患者(2周岁≤年龄<12周岁)的注册临床试验正在进行中，目标于2025年下半年 提交新药上市申请(NDA)。 诺诚健华联合创始人、董事长兼CEO崔霁松表示："NTRK基因融合在儿童肿瘤中非常常见。佐来曲替 尼纳入'星光计划'是对诺诚健华创新能力的高度认可，我们将加速推进其临床开发，为儿童患者带来更 优治疗方案。" "星光计划"是药审中心为了落实国家药监局"提前介入、一企一策、全程指导、研审联动"的要求，在儿 童药物研发领域开展的一项试点工作，旨在通过申请人填写提交《儿童抗肿瘤药物研发实施框架》的方 式，与药审中心及早进行沟通，获得其抗肿瘤药物在儿童人群研究过程中技术问题的相应指导，并在研 发过程中，与药审中心保持紧密沟通，最终提高儿童抗肿瘤药物的研发效率 ...

Core Viewpoint - Nocare Biopharma's stock has experienced fluctuations, with a year-to-date increase of 127.44% but a recent decline over the past five and twenty trading days [1] Group 1: Company Overview - Nocare Biopharma, established on November 3, 2015, and listed on September 21, 2022, is based in Beijing and focuses on the research, production, and commercialization of biopharmaceuticals [2] - The company specializes in areas with unmet clinical needs, particularly in oncology and autoimmune diseases, with a product pipeline that includes ICP-022, ICP-B04, ICP-490, ICP-192, and ICP-723 [2] - Revenue composition as of June 30 includes 87.67% from drug sales, 12.04% from technology licensing, and 0.15% each from testing and R&D services [2] Group 2: Financial Performance - For the first half of 2025, Nocare Biopharma reported revenue of 731 million yuan, a year-on-year increase of 74.26%, while the net profit attributable to shareholders was -30.09 million yuan, reflecting an 88.51% year-on-year growth [2] Group 3: Shareholder Information - As of June 30, 2025, the number of shareholders increased by 13.80% to 15,200, with an average of 0 circulating shares per shareholder [2] - The top ten circulating shareholders include various mutual funds, with notable changes in holdings, such as an increase in shares held by China Europe Medical Health Mixed A and new entries like E Fund Healthcare Industry Mixed A [3]

Core Viewpoint - The article highlights the significant style drift observed in the public fund "Baoying Modern Service Industry Mixed Fund," which has deviated from its stated investment theme, focusing heavily on the pharmaceutical and technology sectors instead of modern services [1][10]. Fund Performance and Holdings - As of the end of Q2 2025, the fund's top ten holdings are predominantly in the pharmaceutical and technology sectors, with a notable concentration in stocks like Kelun-Bio and Tencent Holdings, indicating a high industry concentration [1][2]. - The fund has shown high volatility and elasticity, achieving a return of 64.73% since the beginning of 2025 and 73.28% over the past year, ranking well among peers. However, it has experienced declines in previous years, with losses of 11.91% in 2021, 9.32% in 2022, and 3.7% in 2024, indicating issues with performance sustainability [2][9]. Managerial Strategy and Style Drift - The style drift has been evident since the current fund manager, Yao Yi, took over in January 2023, with the first quarterly report showing a complete focus on healthcare stocks, which accounted for over 50% of the net value [5][7]. - Despite achieving a total return of 46.78% and an annualized return of 15.85% under Yao Yi's management, the strategy has not aligned with the fund's original service-oriented theme, raising concerns about the appropriateness of the investment approach [7][9]. Regulatory and Market Implications - The fund's deviation from its contractual investment behavior raises compliance issues and may lead to unexpected risks for investors due to misinterpretation of the fund's theme [9][10]. - The fund's total size is 295 million yuan, with institutional investors holding 20.29%, indicating some level of external oversight, but individual investors remain the primary stakeholders [9].

Investment Rating - The investment rating for the company is "Buy" [1] Core Views - The commercialization value of Oubatinib is being realized, and the pipeline of innovative drugs is steadily advancing [4] - In the first half of 2025, the company achieved operating revenue of 731 million yuan, a year-on-year increase of 74.26%, while the net profit attributable to shareholders was -30.09 million yuan [8] - Oubatinib's sales in the hematological oncology indications are rapidly increasing, with significant growth potential in sales expected [8] - The company has multiple innovative drugs in development, with a rich product pipeline and several catalysts expected in the next 1-3 years [8] Financial Summary - The company’s total share capital is 1.765 billion shares, with a total market value of 53.592 billion yuan [2] - The projected operating revenues for 2025 to 2027 are 1.51 billion yuan, 1.914 billion yuan, and 2.452 billion yuan, with year-on-year growth rates of 49.6%, 26.7%, and 28.2% respectively [9] - The projected net profit attributable to shareholders for the same period is -259 million yuan, -241 million yuan, and -251 million yuan [9] - The current price-to-earnings ratio (PE) is -256.56, with projected PE ratios for 2025, 2026, and 2027 being -207.3, -222.0, and -213.9 respectively [2][9]

Group 1 - The chemical pharmaceutical sector increased by 2.53% on August 25, with Shutaishen leading the gains [1] - The Shanghai Composite Index closed at 3883.56, up 1.51%, while the Shenzhen Component Index closed at 12441.07, up 2.26% [1] - Notable gainers in the chemical pharmaceutical sector included: - Buzoushen (300204) with a closing price of 61.00, up 16.17% and a trading volume of 445,500 shares [1] - Haichen Pharmaceutical (300584) with a closing price of 58.95, up 13.61% and a trading volume of 217,200 shares [1] - Changshan Pharmaceutical (300255) with a closing price of 53.25, up 12.84% and a trading volume of 683,900 shares [1] Group 2 - The chemical pharmaceutical sector experienced a net outflow of 426 million yuan from institutional investors, while retail investors saw a net inflow of 509 million yuan [2] - The top stocks by net inflow from retail investors included: - Anglikang (002940) with a net inflow of 163 million yuan, representing 22.87% of its trading volume [3] - Haichen Pharmaceutical (300584) with a net inflow of 132 million yuan, representing 10.90% of its trading volume [3] - Lingkang Pharmaceutical (603669) with a net inflow of 64.68 million yuan, representing 37.53% of its trading volume [3]

Group 1 - The core viewpoint of the report is that Nuo Cheng Jian Hua (688428.SH) is given a "buy" rating due to several positive developments in its product pipeline and market approvals [1] - The approval of Obinutuzumab for 1LCLL/SLL indications in China is expected to drive rapid market growth [1] - Tafasitamab has received NMPA approval, indicating potential for commercial growth [1] - The company has initiated two registration clinical studies for ICP-248, indicating a global acceleration in its development strategy [1] - Nuo Cheng Jian Hua continues to explore multiple indications in the autoimmune field, with several innovative oral therapies progressing in development [1] - The company has submitted an NDA for ICP-732 in China and received priority review, while its first ADC candidate, ICP-B794, has been granted IND approval domestically [1] Group 2 - The A-share market has seen trading volumes exceed 2 trillion yuan for eight consecutive days, indicating strong market activity [2] - Major brokerage firms are actively recruiting for autumn positions, highlighting a demand for talent in the industry [2]