Core Points - The Bioeconomy Index (970038) closed at 2277.51 points, down 0.16%, with a trading volume of 18.883 billion yuan and a turnover rate of 1.2% [1] - Among the index constituents, 23 stocks rose while 27 fell, with Iwubio leading the gainers at 6.71% and Meiya Optoelectronics leading the decliners at 3.02% [1] Index Constituents Summary - The top ten constituents of the Bioeconomy Index include: - Mindray Medical (sz300760) with a weight of 13.81%, latest price at 225.09 yuan, and a market cap of 272.908 billion yuan [1] - Changchun High-tech (sz000661) with a weight of 5.41%, latest price at 116.50 yuan, and a market cap of 47.525 billion yuan [1] - Kanglong Chemical (sz300759) with a weight of 4.66%, latest price at 31.97 yuan, and a market cap of 56.849 billion yuan [1] - Other notable constituents include Shishihistory (sz002252), Table Pharmaceutical (sz300347), and Muyuan Foods (sz002714) [1] Capital Flow Analysis - The Bioeconomy Index constituents experienced a net outflow of 871 million yuan from institutional investors, while retail investors saw a net inflow of 544 million yuan [3] - Key capital flows include: - Iwubio (300357) with a net inflow of 52.9277 million yuan from institutional investors [3] - Dabo Medical (002901) with a net inflow of 31.8434 million yuan from institutional investors [3] - Changchun High-tech (000661) with a net inflow of 27.6452 million yuan from institutional investors [3]

Core Viewpoint - Changchun High-tech Industry (Group) Co., Ltd. announced that its subsidiary, Changchun Jinsai Pharmaceutical Co., Ltd., received approval for clinical trials of GenSci098 injection, a novel monoclonal antibody for treating hyperthyroidism and related conditions [1][2]. Group 1 - GenSci098 injection is a humanized anti-thyroid-stimulating hormone receptor (TSHR) monoclonal antibody developed by Jinsai Pharmaceutical, aimed at treating hyperthyroidism by blocking TSHR interactions [1]. - The clinical trial approval is expected to facilitate the development of GenSci098 for patients with diffuse toxic goiter, a common cause of hyperthyroidism [2]. - Successful progress in clinical trials could enhance the company's business structure, optimize product offerings, and strengthen its competitive edge in the strategic field [2].

Core Viewpoint - The approval of clinical trial application for GenSci098 injection by Changchun High-tech Industry Group's subsidiary, GenSci Pharmaceutical, marks a significant step in developing a new treatment for diffuse toxic goiter, addressing unmet medical needs in the field of thyroid disorders [1][3]. Group 1: Drug Information - Product Name: GenSci098 injection, a humanized monoclonal antibody targeting TSH receptor (TSHR) [1]. - Indication: Diffuse toxic goiter (Graves' disease) [1]. - Approval Status: Clinical trial application approved by the National Medical Products Administration [1]. Group 2: Clinical Background - Graves' disease is the most common cause of hyperthyroidism, characterized by excessive thyroid hormone production, significantly impacting patients' quality of life [2]. - Current treatment options include antithyroid drugs, radioactive iodine, and surgery, each with limitations and potential complications [2]. Group 3: Development Impact - The approval of the clinical trial for GenSci098 injection is expected to facilitate further clinical development for patients with diffuse toxic goiter [3]. - The company aims to enhance its product portfolio and strengthen its competitive position in the pharmaceutical market through this development [4].

Group 1: Meituan's Health Initiative - Meituan has launched a "Health Double Eleven" campaign featuring special medical foods and health supplements, responding to a nearly 40% increase in related search volume on its platform [1] - The campaign includes products like Ejiao and bird's nest, along with special medical foods such as Ai Er Shu and Tai Min Shu, and offers significant discount coupons to users [1] - Users purchasing special medical foods can join a community for exclusive nutritionist consultations and additional discounts [1] Group 2: Qingdao Beer Financial Performance - Qingdao Beer reported a third-quarter net profit of 1.37 billion yuan, representing a year-on-year increase of 1.62% [2] - The company's revenue for the third quarter was 8.876 billion yuan, showing a slight decline of 0.17% compared to the previous year [2] Group 3: Changchun High-tech's Clinical Trial Approval - Changchun High-tech's subsidiary, GenSci, received approval for the clinical trial application of GenSci098 injection, which has potential for treating diffuse toxic goiter [3] - This approval is expected to facilitate the clinical development of the product for the target population [3] Group 4: Kingsoft Office Financial Performance - Kingsoft Office reported a third-quarter net profit of 431 million yuan, marking a year-on-year increase of 35.42% [4] - The company's revenue for the third quarter was 1.521 billion yuan, reflecting a growth of 25.33% year-on-year [4] Group 5: Foreign Exchange and Trade Statistics - In the first three quarters, China's foreign exchange receipts and payments reached 11.6 trillion USD, setting a record for the same period [5] - The foreign exchange market transaction volume is projected to grow by 37% in 2024 compared to 2020, with foreign exchange receipts increasing by 64% over the same period [5] Group 6: Three Squirrels Financial Performance - Three Squirrels reported a third-quarter net profit of 22.27 million yuan, which is a significant decline of 56.79% year-on-year [6] - The company's revenue for the third quarter was 2.281 billion yuan, showing an increase of 8.91% compared to the previous year [6] Group 7: Hengrui Medicine Financial Performance - Hengrui Medicine's third-quarter revenue was 7.427 billion yuan, reflecting a year-on-year growth of 12.72% [6] - The net profit for the third quarter was 1.301 billion yuan, which is a 9.53% increase year-on-year [6] Group 8: Anta Sports Retail Performance - Anta Sports reported low single-digit growth in retail sales for its Anta and FILA brands in the third quarter [9] - Other brands under the company achieved a significant retail sales growth of 45-50% year-on-year [9] Group 9: National Airlines Aircraft Purchase - National Airlines announced plans to purchase six A350F cargo aircraft from Airbus, with an option for four additional aircraft [10] - The total value of the aircraft, based on the January 2024 catalog price, is approximately 4.65 billion USD per unit, with potential discounts negotiated [10] Group 10: Investment and Financing Activities - Guoyi Quantum has completed a new round of strategic financing led by Hefei Xingtai Capital, aimed at enhancing its R&D capabilities in quantum computing and related fields [10] - Song Yang has replaced Shao Jingping as the head of JD Retail's marketing center, following Shao's departure for personal reasons [7] Group 11: New Product Launch by Meituan - Meituan's LongCat team has released and open-sourced the LongCat-Video video generation model, achieving state-of-the-art results in video generation tasks [10] - The model aims to enhance capabilities in various applications, including autonomous driving and interactive business scenarios [10] Group 12: Regulatory Changes in Foreign Investment - The China Securities Regulatory Commission has introduced a green channel and simplified processes for foreign institutional investors, including sovereign funds and pension funds [11]

Group 1: Company Performance - Meituan's special medical food activity section launched for Double Eleven, with a nearly 40% week-on-week increase in related search volume [1] - Qingdao Beer reported a third-quarter net profit of 1.37 billion, a year-on-year increase of 1.62%, with revenue of 8.876 billion, a slight decline of 0.17% [2] - Changchun High-tech's subsidiary received approval for clinical trials of GenSci098 injection, which has potential for treating diffuse toxic goiter [3] - Kingsoft Office reported a third-quarter net profit of 431 million, a year-on-year increase of 35.42%, with revenue of 1.521 billion, up 25.33% [4] - Anta Sports reported low single-digit growth in retail sales for Anta and FILA brands in the third quarter, while other brands saw a 45-50% increase [9] - Heng Rui Pharmaceutical reported a third-quarter net profit of 1.301 billion, a year-on-year increase of 9.53%, with revenue of 7.427 billion, up 12.72% [6] - Three Squirrels reported a third-quarter net profit of 22.27 million, a year-on-year decrease of 56.79%, with revenue of 2.281 billion, up 8.91% [5] - Kangtai Biological reported a third-quarter net profit of 11.62 million, a year-on-year decrease of 93.74%, with revenue of 671 million, down 17.74% [8] Group 2: Investment and Financing - Guoyi Quantum received strategic investment from Hefei Xingtai Capital, which will enhance its R&D capabilities in quantum computing and related fields [10] - Song Yang has replaced Shao Jingping as the head of JD Retail Platform Marketing Center due to personal reasons [7] - Song Yan Power completed nearly 300 million Pre-B round financing led by Fanggu Capital, with participation from several other investors [11] Group 3: Market Trends and Economic Indicators - China's foreign exchange revenue and expenditure scale reached 11.6 trillion in the first three quarters, a historical high, with a 37% increase in trading volume compared to 2020 [5] - The China Securities Regulatory Commission has implemented a green channel and simplified processes for foreign investment from sovereign funds, international organizations, and pension charitable funds [12] Group 4: New Products - Meituan LongCat-Video was officially released and open-sourced, achieving state-of-the-art performance in video generation tasks [11]

长春高新(000661)10月27日晚公告，近日，公司的子公司长春金赛药业有限责任公司（简称"金赛药 业"）收到国家药品监督管理局核准签发的《药物临床试验批准通知书》，金赛药业GenSci098注射液的 境内生产药品注册临床试验申请获得批准。 据介绍，GenSci098注射液是金赛药业自主研发的一种人源化抗促甲状腺激素受体（TSHR）拮抗型单克 隆抗体，为治疗用生物制品1类新药。通过特异性与甲状腺或球后组织内TSHR结合，阻断其与自身抗 体结合，进而抑制甲状腺激素的合成和释放、抑制甲状腺细胞的增殖、阻止HA和炎症因子释放，从而 发挥改善甲亢的作用，并同时具有改善突眼的作用。本品临床前数据、在研的甲状腺眼病（TED）的I 期临床研究以及同靶点其他药物的临床数据表明，GenSci098有潜力作为一种治疗弥漫性毒性甲状腺肿 的新型治疗手段。 甲状腺功能亢进症，指甲状腺腺体不适当地持续合成和分泌过多甲状腺激素而引起的内分泌疾病，简称 甲亢。甲亢作为一种临床常见的病理综合征，以代谢亢进和神经、循环、消化等系统兴奋性增高为主要 临床表现，严重影响患者的生活质量与身心健康。弥漫性毒性甲状腺肿即Graves'disease（ ...

Core Viewpoint - Changchun Gaoxin's subsidiary, Changchun Jinsai Pharmaceutical Co., Ltd., has received approval from the National Medical Products Administration for the clinical trial application of GenSci098 injection, which shows potential for treating diffuse toxic goiter [1] Group 1 - The clinical trial approval for GenSci098 injection is a significant step towards its clinical development for the target population suffering from diffuse toxic goiter [1]

获得批准的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 近日，长春高新技术产业（集团）股份有限公司（以下简称"公司"）子公 司——长春金赛药业有限责任公司（以下简称"金赛药业"）收到国家药品监督 管理局核准签发的《药物临床试验批准通知书》，金赛药业 GenSci098 注射液的 境内生产药品注册临床试验申请获得批准，现将相关情况公告如下： 一、药品的基本情况 证券代码：000661 证券简称：长春高新 公告编号：2025-138 长春高新技术产业（集团）股份有限公司 关于子公司 GenSci098 注射液境内生产药品注册临床试验申请 GenSci098 注射液在 2024 年 8 月已获批开展用于甲状腺相关眼病的临床试 验，具体内容详见公司分别于 2024 年 8 月 6 日、2024 年 8 月 27 日在巨潮资讯 网披露的《关于子公司 GenSci098 注射液临床试验申请获得批准的公告》（公告 编号 2024-083）、《关于子公司 GenSci098 注射液获得美国食品药品监督管理局 新药临床试验申请默示许可的公告》（公告编号 2024-093 ...

Core Viewpoint - Changchun High-tech's stock price has shown a mixed performance in recent trading sessions, with a year-to-date increase of 24.07% but a slight decline in the last five and twenty trading days [1] Group 1: Stock Performance - As of October 27, Changchun High-tech's stock price rose by 2.00% to 120.20 CNY per share, with a trading volume of 2.09 billion CNY and a turnover rate of 0.44%, resulting in a total market capitalization of 49.034 billion CNY [1] - Year-to-date, the stock has increased by 24.07%, but it has decreased by 0.76% over the last five trading days and by 4.01% over the last twenty trading days [1] - The stock has appeared on the "Dragon and Tiger List" twice this year, with the most recent instance on September 2, where it recorded a net purchase of 275 million CNY [1] Group 2: Company Overview - Changchun High-tech was established on June 10, 1993, and listed on December 18, 1996. Its main business includes research, production, and sales of biopharmaceuticals and traditional Chinese medicine, along with real estate development and property management [2] - The revenue composition of the company is 92.83% from pharmaceuticals, 6.81% from real estate, and 0.36% from services [2] - As of June 30, the number of shareholders was 109,100, a decrease of 12.78% from the previous period, with an average of 3,662 circulating shares per shareholder, an increase of 14.66% [2] Group 3: Financial Performance - For the first half of 2025, Changchun High-tech reported a revenue of 6.603 billion CNY, a year-on-year decrease of 0.54%, and a net profit attributable to shareholders of 983 million CNY, down 42.85% year-on-year [2] - The company has distributed a total of 4.791 billion CNY in dividends since its A-share listing, with 3.259 billion CNY distributed in the last three years [3] Group 4: Institutional Holdings - As of June 30, 2025, the top ten circulating shareholders included Hong Kong Central Clearing Limited as the third-largest shareholder, holding 8.4381 million shares, a decrease of 3.4502 million shares from the previous period [3] - Other notable shareholders include Huatai-PB CSI 300 ETF and E Fund CSI 300 Pharmaceutical ETF, with varying changes in their holdings [3]

Group 1 - The core point of the article is the performance and changes in the top holdings of the Yinhua CSI Innovation Drug Industry ETF, which reported a net value growth rate of 24.54% over the past year [1] - The fund has added new top holdings including Kanglong Chemical and Baile Tianheng, while increasing its stake in WuXi AppTec by 64.87 million shares, making it the largest holding [1] - The fund has exited from its previous top holdings, including Tigermed and Tonghua Golden Horse [1] Group 2 - The detailed data shows the number of shares held and market value for each of the top holdings, with WuXi AppTec holding 15.52 million shares valued at 1.74 billion and Kanglong Chemical holding 8.56 million shares valued at 306 million [1] - Other significant holdings include Hengrui Medicine, Changchun High-tech, and Kelun Pharmaceutical, with respective increases in shareholding [1] - The report indicates a strategic shift in the fund's portfolio, reflecting a focus on companies with strong growth potential in the pharmaceutical sector [1]