Group 1 - The core viewpoint of the news is that Changchun High-tech has experienced fluctuations in stock price and trading volume, with a recent decline of 2.10% on September 22, 2023, and a year-to-date increase of 26.54% [1] - As of June 30, 2023, Changchun High-tech reported a revenue of 6.603 billion yuan, a year-on-year decrease of 0.54%, and a net profit attributable to shareholders of 983 million yuan, down 42.85% year-on-year [2] - The company has a significant focus on the pharmaceutical industry, with 92.83% of its revenue coming from this sector, while real estate and service industries contribute 6.81% and 0.36% respectively [1] Group 2 - Changchun High-tech has distributed a total of 4.791 billion yuan in dividends since its A-share listing, with 3.259 billion yuan distributed in the last three years [3] - The number of shareholders as of June 30, 2023, is 109,100, a decrease of 12.78% from the previous period, while the average number of tradable shares per shareholder increased by 14.66% to 3,662 shares [2] - The company is categorized under the pharmaceutical and biological industry, specifically in the sub-sector of biological products, and is associated with various investment themes such as Northeast revitalization and high dividend stocks [2]

Core Viewpoint - Changchun High-tech is facing significant challenges due to price reductions from centralized procurement of its core products and a lack of new business development, leading to a dramatic decline in net profit by 42.85% in the first half of 2025, marking a potential fall from grace for this once-prominent stock [1][2]. Financial Performance - In the mid-year report of 2025, the company reported revenue of 6.603 billion yuan, a year-on-year decrease of 0.54%, and a net profit attributable to shareholders of 983 million yuan, down 42.85% year-on-year, indicating a continuous decline in both revenue and profit for the first time in 20 years [2][3]. - The second quarter of 2025 showed revenue of 3.605 billion yuan, a slight increase of 4.16% year-on-year, but net profit fell by 48.83% to 463 million yuan, primarily due to rising sales and R&D expenses [2][3]. - Over the past five years, revenue growth has significantly slowed, with figures of 4.963 billion yuan, 5.831 billion yuan, 6.168 billion yuan, 6.639 billion yuan, and 6.603 billion yuan from 2021 to 2025, while net profit has dropped from 1.923 billion yuan in 2021 to 983 million yuan in 2025 [2][3]. Business Structure and Risks - The decline in net profit is largely attributed to the poor performance of its core subsidiary, Jinsai Pharmaceutical, and losses at Baike Biotechnology, highlighting potential risks in the company's business structure and pipeline layout [3][4]. - The company is overly reliant on a few products, making it vulnerable to market changes, increased competition, or quality issues [3][4]. - The shift in the industry from "generic-driven" to "innovation-driven" poses additional challenges for Changchun High-tech, as it faces high R&D costs and long commercialization cycles [4]. Expense Management - The company's mid-year report for 2025 revealed sales expenses of 2.386 billion yuan, up 23.43% year-on-year, and R&D expenses of 1.155 billion yuan, up 30.22%, together accounting for 53.6% of total revenue, significantly squeezing profit margins [5][6]. - The increase in sales expenses is attributed to the promotion of new products and expansion into new medical departments, while the rise in R&D expenses is due to advancements in technology platforms and clinical trials [6][7]. - The high ratio of total expenses to revenue (46.97%) is above the industry average of 35%, indicating structural inefficiencies within the company [7][8]. Future Outlook - The company faces significant challenges in its transformation journey, and how it navigates these business difficulties will be closely monitored [8].

Core Viewpoint - Changchun High-tech is facing significant challenges due to price reductions from centralized procurement of its core product, growth hormone, and a lack of new business opportunities, leading to a dramatic decline in net profit by 42.85% in the mid-2025 report [2][3]. Financial Performance - In the mid-2025 report, the company reported revenue of 6.603 billion yuan, a year-on-year decrease of 0.54%, and net profit attributable to shareholders of 983 million yuan, down 42.85% [3]. - This marks the first occurrence of simultaneous revenue and net profit decline in nearly 20 years for the company [3]. - The second quarter of 2025 showed revenue of 3.605 billion yuan, a slight increase of 4.16% year-on-year, but net profit fell by 48.83% to 463 million yuan, indicating a "revenue without profit" situation due to rising sales and R&D expenses [3]. Business Structure and Risks - The core reason for the "revenue without profit" phenomenon is the decline in net profit from the core subsidiary, Jinsai Pharmaceutical, and losses at Baike Biotechnology [4]. - The company is overly reliant on a single product, which exposes it to risks from market demand changes and increased competition [4]. - The losses at Baike Biotechnology may stem from an unreasonable pipeline layout and poor market prospects for R&D products [4]. Policy and Industry Context - The significant drop in net profit can be attributed to policy impacts and industry cycles, including the expansion of centralized procurement for growth hormone, which saw price reductions exceeding 50% in some regions [5]. - The company’s core product accounts for over 70% of revenue, highlighting its vulnerability due to reliance on a single product [5]. - The domestic innovative pharmaceutical industry is facing challenges transitioning from a "generic-driven" to an "innovation-driven" model, with high R&D costs and long commercialization cycles putting pressure on cash flow [5]. Expense Management - The company reported a significant increase in expenses, with sales expenses reaching 2.386 billion yuan (up 23.43%) and R&D expenses at 1.155 billion yuan (up 30.22%), together accounting for 53.6% of revenue [7]. - The high sales expenses are attributed to market promotion for new products and expansion into new medical departments [7]. - R&D expenses have surged due to the advancement of new technology platforms and clinical trials, with R&D investment reaching 20.21% of revenue, the highest in five years [7]. Comparative Analysis - The company's expense ratio of 46.97% is significantly higher than the industry average of 35%, indicating structural issues in expense management [8]. - The high sales expenses are driven by increased market competition and the need for extensive promotional activities [8]. - In contrast, other companies like Heng Rui Pharmaceutical have managed to reduce their expense ratios through sales team integration and digital marketing strategies, highlighting potential areas for efficiency improvement for Changchun High-tech [9].

Market Performance - The Medical Health Index (980016) closed at 7021.34 points, down 1.08%, with a trading volume of 33.906 billion yuan and a turnover rate of 1.07% [1] - Among the index constituents, 5 stocks rose while 45 stocks fell, with Yirui Technology leading the gainers at 1.82% and Changchun High-tech leading the decliners at 3.91% [1] Key Constituents - The top ten constituents of the Medical Health Index include: - WuXi AppTec (13.58% weight) at 108.75 yuan, up 1.23% with a market cap of 320.976 billion yuan - Hengrui Medicine (10.87% weight) at 69.65 yuan, down 2.03% with a market cap of 462.281 billion yuan - Mindray Medical (8.17% weight) at 235.00 yuan, down 1.18% with a market cap of 284.924 billion yuan - United Imaging Healthcare (4.14% weight) at 147.90 yuan, down 1.40% with a market cap of 121.893 billion yuan - Other notable constituents include Pianzai Shou, Yier Eye Hospital, Kelun Pharmaceutical, Xinhecheng, Fosun Pharma, and Yixiao Aoshi [1] Capital Flow - The Medical Health Index constituents experienced a net outflow of 2.29 billion yuan from institutional investors, while retail investors saw a net inflow of 2.013 billion yuan [3] - Notable capital flows include: - Mindray Medical with a net inflow of 98.789 million yuan from institutional investors and a net outflow of 10.5 million yuan from speculative funds - Changchun High-tech with a net inflow of 67.986 million yuan from institutional investors and a significant net outflow from speculative funds [3]

本报（chinatimes.net.cn）记者张斯文 于娜 北京报道 曾经凭借生长激素独占市场多年的长春高新，如今正面临核心产品集采降价、新业务青黄不接的艰难局 面，2025年中报显示净利润暴跌42.85%，这家老牌白马股或已跌落神坛。 2021年5月是公司股价巅峰时期，长春高新市值曾超过2100亿元，被投资者誉为"东北药茅"。而如今， 其市值仅500亿元，已缩水超过1600亿元。 中期业绩延续颓势 2025年8月30日，公司交出的中报业绩显示：营业收入66.03亿元，同比下滑0.54%；归属于上市公司股 东净利润9.83亿元，同比下降42.85%。延续了去年年报中出现的营收和净利润双双下滑的局面，这也是 公司近20年来首次出现这一情况。 净利润创近五年中报最大降幅的同时，单季度数据进一步反映出公司"增收不增利"特征：公司2025年 Q2营收36.05亿元，同比微增4.16%，但净利润4.63亿元，同比仍下滑48.83%，这一现象主要源于销售费 用与研发投入的双高增长，对利润形成严重侵蚀。 回顾近5年公司中报数据，2021—2025年1—6月，长春高新营收分别为49.63亿元、58.31亿元、61.68亿 元 ...

Market Overview - The biopharmaceutical sector experienced a decline of 1.9% on September 19, with Kanghong Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3820.09, down 0.3%, while the Shenzhen Component Index closed at 13070.86, down 0.04% [1] Stock Performance - Notable gainers included: - Aopumai (688293) with a closing price of 53.41, up 1.71% on a trading volume of 34,700 shares and a turnover of 189 million yuan [1] - Kexing Pharmaceutical (688136) closed at 41.88, up 1.70% with a trading volume of 45,300 shares and a turnover of 189 million yuan [1] - Significant decliners included: - Kanghong Pharmaceutical (002773) which fell 6.09% to a closing price of 37.00, with a trading volume of 94,100 shares and a turnover of 355 million yuan [2] - Changchun High-tech (000661) decreased by 3.91% to 125.22, with a turnover of 1.674 billion yuan [2] Capital Flow - The biopharmaceutical sector saw a net outflow of 999.7 million yuan from institutional investors, while retail investors had a net inflow of 914 million yuan [2] - The table of capital flow indicates that: - Changchun High-tech had a net inflow of 67.986 million yuan from institutional investors [3] - Kanghua Biological (300841) experienced a net inflow of 11.825 million yuan from institutional investors [3]

Investment Rating - The report maintains a "Market Weight" rating for the pharmaceutical and biotechnology industry, indicating that the industry is expected to perform within ±10% of the market index over the next six months [6][29]. Core Insights - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, with a gain of 1.36% from September 5 to September 18, 2025, lagging behind the index by approximately 1.66 percentage points [5][13]. - Most sub-sectors within the industry recorded positive returns during the same period, with the medical research outsourcing and medical equipment sectors leading with increases of 8.17% and 5.83%, respectively, while the chemical preparations sector saw a decline of 0.96% [5][14]. - Approximately 48% of stocks in the industry achieved positive returns, with notable performers including Zhendemedical, which had a weekly increase of 62.30% [15][18]. Summary by Sections 1. Market Review - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, gaining 1.36% from September 5 to September 18, 2025, which is 1.66 percentage points lower than the index [5][13]. - Most sub-sectors recorded positive returns, with medical research outsourcing and medical equipment sectors leading [5][14]. - About 48% of stocks in the industry recorded positive returns, with Zhendemedical showing the highest weekly increase [15][18]. - The overall industry valuation remained stable, with a PE ratio of approximately 56.10 times as of September 18, 2025, which is 4.26 times relative to the Shanghai and Shenzhen 300 index [19][29]. 2. Industry News - The report highlights the upcoming release of the 11th batch of national drug procurement rules, with discussions held on various aspects of the procurement process [6][27]. - The National Health Commission issued a notification regarding the 2025 version of medical quality control indicators, emphasizing the importance of a scientific and standardized quality control system [23][26]. 3. Company Announcements - Changchun High-tech announced a collaboration with Denmark's ALK-Abelló A/S for the development and commercialization of specific immunotherapy products in China [28]. 4. Weekly Industry Outlook - The report suggests maintaining a focus on investment opportunities in innovative drugs and sectors with expected business development catalysts, particularly in medical devices and pharmaceutical commerce [29][30].

Investment Rating - The report maintains a "Market Weight" rating for the pharmaceutical and biotechnology industry, indicating that the industry is expected to perform within ±10% of the market index over the next six months [36]. Core Insights - The SW pharmaceutical and biotechnology industry underperformed the CSI 300 index, with a gain of 1.36% from September 5 to September 18, 2025, lagging behind the index by approximately 1.66 percentage points [11]. - Most sub-sectors within the industry recorded positive returns during the same period, with the medical research outsourcing and medical equipment sectors leading with increases of 8.17% and 5.83%, respectively [12]. - Approximately 48% of stocks in the industry achieved positive returns, while 52% experienced negative returns during the reporting period [13]. - The overall industry valuation remained stable, with a PE (TTM) ratio of about 56.10 times as of September 18, 2025, and a relative PE to the CSI 300 of 4.26 times [17][27]. Summary by Sections Market Review - The SW pharmaceutical and biotechnology industry underperformed the CSI 300 index, with a 1.36% increase compared to the index's performance [11]. - Most sub-sectors recorded positive returns, particularly in medical research outsourcing and medical equipment [12]. - About 48% of stocks in the industry had positive returns, with notable performers and underperformers identified [13]. Industry News - The report highlights the upcoming release of the 11th batch of national drug procurement rules, with discussions on various aspects of the procurement process [25]. - The National Health Commission issued a notification regarding the 2025 version of medical quality control indicators, emphasizing the importance of a scientific and standardized quality control system [21][24]. Company Announcements - Changchun High-tech announced a collaboration with Denmark's ALK-Abelló A/S for the development and commercialization of specific immunotherapy products in China [26]. Industry Outlook - The report suggests focusing on investment opportunities in innovative drugs and sectors with expected business development catalysts, including medical devices and pharmaceutical commerce [27][28]. - Specific companies to watch include Mindray Medical, Yifeng Pharmacy, and Aier Eye Hospital, among others, due to their strong market positions and growth potential [29].

Market Overview - On September 18, the biopharmaceutical sector declined by 0.38%, with Kanghua Biotech leading the drop [1] - The Shanghai Composite Index closed at 3831.66, down 1.15%, while the Shenzhen Component Index closed at 13075.66, down 1.06% [1] Stock Performance - Notable gainers in the biopharmaceutical sector included: - Changchun High-tech: Closed at 130.31, up 5.19% with a trading volume of 233,800 shares and a turnover of 3.024 billion [1] - Zhifei Biological Products: Closed at 22.66, up 4.04% with a trading volume of 925,800 shares and a turnover of 2.12 billion [1] - ST Weiming: Closed at 8.88, up 3.26% with a trading volume of 182,300 shares and a turnover of 162 million [1] - Conversely, Kanghua Biotech experienced a significant decline, closing at 75.88, down 3.46% with a trading volume of 49,100 shares and a turnover of 381 million [2] Capital Flow - The biopharmaceutical sector saw a net inflow of 221 million from institutional investors, while retail investors experienced a net outflow of 340 million [2] - Key stocks with notable capital flows included: - Changchun High-tech: Net inflow of 353 million from institutional investors, with a net outflow of 283 million from retail investors [3] - Zhifei Biological Products: Net inflow of 10 million from institutional investors, with a net outflow of 125 million from retail investors [3] - Anke Bio: Net inflow of 64 million from institutional investors, with a net outflow of 877 million from retail investors [3]

Core Viewpoint - Changchun Gaoxin is actively seeking to overcome performance pressure through a collaboration with ALK for the commercialization of allergy immunotherapy products in China [1][2]. Company Overview - Changchun Gaoxin's subsidiary, Changchun Jinsai Pharmaceutical, has entered into a partnership with ALK to develop and commercialize house dust mite allergy immunotherapy products in China [1]. - The partnership grants Changchun Jinsai exclusive rights to three ALK products in mainland China until December 31, 2039 [1][2]. Financial Performance - In the first half of 2025, Changchun Jinsai achieved a net profit of 1.108 billion yuan [3]. - Changchun Gaoxin's revenue and net profit for 2024 were 13.466 billion yuan and 2.583 billion yuan, respectively, reflecting year-on-year declines of 7.55% and 43.01% [4]. - For the first half of 2025, the company reported revenue of 6.603 billion yuan, a slight decrease of 0.54%, and a net profit of 983 million yuan, down 42.85% year-on-year [4]. Market Potential - China has the highest number of dust mite allergy patients globally, but the market remains underdeveloped with low penetration rates [2]. - The collaboration with ALK is expected to provide new growth opportunities for Changchun Jinsai [5].