附件： 孟凡，女，中国国籍，出生于 1984 年 5 月，研究生。曾就职于凯莱英医药 集团（天津）股份有限公司、浙江华海药业有限公司等，在制药行业有十余年工 作经历，尤其在市场拓展和销售方面具备丰富的项目和产品经验。现任公司营销 副总经理。 股票代码：300363 股票简称：博腾股份 公告编号：2025-037号 截至本公告披露日，孟凡女士未持有公司股份，与持有公司 5%以上股份的 股东、实际控制人、其他董事、监事、高级管理人员不存在关联关系；最近 36 个月内孟凡女士未受过中国证监会及其他有关部门的处罚和证券交易所惩戒，不 存在《深圳证券交易所上市公司自律监管指引第 2 号—创业板上市公司规范运 作》第 3.2.3 条所规定的情形，也不属于失信被执行人，符合《公司法》等相关 法律、法规和规定要求的任职条件。 孟凡女士的任职资格符合《中华人民共和国公司法》（以下简称"《公司法》"）、 《深圳证券交易所创业板股票上市规则》《深圳证券交易所上市公司自律监管指 引第 2 号—创业板上市公司规范运作》等法律法规，以及公司《公司章程》等相 关规定。 特此公告。 重庆博腾制药科技股份有限公司董事会 2025 年 7 月 ...

Core Viewpoint - The Chinese innovative drug industry is experiencing a significant moment in the first half of 2025, driven by policy benefits and international breakthroughs, with three companies expected to turn losses into profits [1]. Group 1: Company Performance - Tonghua Dongbao expects to achieve a net profit of approximately 217 million yuan for the first half of 2025, marking a turnaround from losses in the previous year [2]. - The main reason for Tonghua Dongbao's performance improvement is the significant growth in sales of insulin analog products, leading to a substantial increase in domestic sales revenue [4]. - The internationalization strategy has also shown significant results, with noticeable growth in export revenue [5]. Group 2: Other Companies' Performance - Zhaoyan New Drug anticipates a net profit of between 50.32 million and 75.49 million yuan for the first half of 2025, recovering from a loss of 169 million yuan in the same period last year [6]. - The decline in Zhaoyan New Drug's operating income is attributed to intensified competition, which has compressed order profits and exacerbated losses in laboratory services [8]. - The fair value changes of biological assets have offset some business losses, contributing to the overall turnaround [9]. Group 3: BoTeng Co. Performance - BoTeng Co. expects a net profit ranging from 0 to 30 million yuan for the first half of 2025, recovering from a loss of 170 million yuan in the previous year [10]. - The company anticipates achieving revenue of 1.55 billion yuan, representing a year-on-year growth of 15% to 20% [12]. - The improvement in BoTeng Co.'s performance is driven by robust revenue growth, enhanced gross margins, effective cost control, and a reduction in losses from new businesses, along with non-recurring investment income of approximately 18.21 million yuan [13][14]. Group 4: Overall Industry Insights - The performance turnaround of Tonghua Dongbao, Zhaoyan New Drug, and BoTeng Co. reflects the positive progress of different segments within the biopharmaceutical industry in overcoming challenges and seeking growth and profitability restoration [15]. - However, the specific paths and sustainability of these improvements depend on each company's business model and future operating environment [15].

Group 1 - The pharmaceutical sector is showing strong performance, particularly in innovative drugs, generic drugs, and animal vaccines, driven by the recent policy changes from the National Healthcare Security Administration [1] - The 11th batch of drug procurement initiated by the National Healthcare Security Administration excludes innovative drugs from the procurement scope, which is expected to protect the profit margins of innovative drug companies [1] - The CXO and research service sectors have seen significant gains, with companies like WuXi AppTec and Boteng Co. reporting substantial Q2 performance increases, indicating a positive trend in the sector [1] Group 2 - The innovative drug sector is identified as the most clearly defined and growth-oriented sub-industry within the pharmaceutical sector, with a recommendation to actively embrace and allocate resources to this area [2] - The rapid growth of License Out transactions is providing substantial cash flow for innovative drug companies, supporting their core pipelines in overseas markets [2] - There is an expectation for continued domestic market share growth for Chinese innovative drugs due to policy support and improved product capabilities, despite foreign companies holding a significant portion of the market [2]

Summary of Conference Call Records Industry Overview - The global pharmaceutical industry is facing a significant patent cliff, with approximately $180 billion in annual revenue drugs set to lose patent protection between 2027 and 2028, representing nearly 12% of the global market share [3][4][10] - The domestic innovation industry chain is experiencing an increase in orders, particularly among upstream companies such as Baipusais, Bidai Pharmaceutical, and Bai'ao Pharmaceutical [1][5] - The CRO (Contract Research Organization) sector is seeing growth in companies like Zhaoyan New Drug, Yinuosi, and Tigermed, while the CDMO (Contract Development and Manufacturing Organization) sector is highlighted by strong performances from WuXi AppTec, Boteng Co., Tianyu Co., and Pro Pharma [1][5] Key Insights and Arguments - The recovery in the CXO (Contract Research Organization and Contract Development and Manufacturing Organization) sector is driven by increased domestic demand and a resurgence in orders, which is expected to translate into clinical research opportunities within 6 to 12 months [11][12] - The trend of innovation drug out-licensing (BD) is becoming more pronounced, as large pharmaceutical companies seek to diversify their pipelines and manage costs amid pressures from legislation such as the IRA (Inflation Reduction Act) [4][7] - Domestic listed companies have shown an increasing trend in R&D expenses as a percentage of revenue since the second half of last year, indicating a more proactive approach to R&D investment in response to market changes [8][10] Financial Performance and Trends - In the CDMO sector, WuXi AppTec reported a 47% year-on-year increase in orders by the end of last year, while Boteng Co. saw a 30% increase [11][13] - For the first half of 2025, WuXi AppTec's revenue is expected to grow by 21%, with a 44% increase in NON-IFRS net profit, while Boteng Co. is projected to achieve profitability after a turnaround [13] - The structure of R&D expenses in Biotech companies has shifted, with a notable increase in clinical trial costs, reflecting a conservative investment strategy amid market uncertainties [9] Potential Investment Opportunities - Recommended companies in the domestic innovation industry include Yinuosi, Zhaoyan New Drug, and Tigermed, as well as leading CDMO firms like WuXi AppTec and Pro Pharma [16] - The recovery in the domestic innovation industry is expected to create further investment opportunities, particularly as IPOs are being opened up and more companies are preparing to list [14] Additional Considerations - The overall recovery of the innovation industry chain is segmented into phases, with the current transition from phase 1.0 to 2.0 indicating a shift towards increased early-stage project investments by financially robust companies [10] - The competitive landscape of the domestic innovation industry chain should be assessed comprehensively, including comparisons with Indian and other overseas companies to better understand competitive advantages [17]

Investment Rating - The industry investment rating is "Positive" (maintained) [2] Core Insights - The global healthcare industry financing stabilized in H1 2025, with a total financing amount of approximately $28.2 billion, a slight year-on-year decline of 8.6% [6][14] - The average R&D investment of the top 30 global pharmaceutical companies in 2024 was approximately $6.011 billion, reflecting a year-on-year growth of 10.39% [6][16] - In China, the number of new drug IND applications in H1 2025 was approximately 914, showing a year-on-year increase of 2.47% [6][21] Summary by Sections Industry Performance - In the second week of July, the pharmaceutical and biotechnology sector rose by 1.82%, outperforming the CSI 300 index by 1 percentage point [26][30] - The medical R&D outsourcing sector had the highest increase, up 9.29%, while other biopharmaceuticals saw the largest decline, down 1.55% [31][32] Company Performance - WuXi AppTec and Boteng Co. reported H1 2025 earnings that exceeded expectations, with WuXi AppTec projecting revenue of approximately 20.8 billion yuan, a year-on-year increase of 20.64% [7][23] - Boteng Co. expects revenue between 1.55 billion and 1.62 billion yuan, with a year-on-year growth of 15% to 20% [7][24] Recommended Stocks - Recommended stocks in the pharmaceutical and biopharmaceutical sector include: Heng Rui Medicine, East China Medicine, Sanofi, and others [8] - In the CXO sector, recommended stocks include WuXi AppTec, WuXi Biologics, and Boteng Co. [8]

Core Insights - 26 companies listed on the ChiNext board have released their performance forecasts for the first half of the year, with 19 companies expecting profit increases, representing 73.08% of the total [1] - The overall proportion of companies reporting positive forecasts is 80.77%, with 2 companies expecting profits and 1 company forecasting losses [1] Performance Forecast Summary - Among the companies with positive forecasts, 7 are expected to see net profit growth exceeding 100%, while 4 companies anticipate growth between 50% and 100% [1] - Han Yu Pharmaceutical is projected to have the highest net profit growth, with a median increase of 1567.36% [1] - Other notable companies include Chuanjin Nuo and Longyuan Technology, with expected net profit growth of 167.27% and 137.44% respectively [1] Company Performance Highlights - The following companies are highlighted for their significant expected profit increases: - Han Yu Pharmaceutical (Code: 300199) - Expected net profit growth: 1567.36%, Latest closing price: 18.24, Year-to-date change: 41.51%, Industry: Pharmaceutical [1] - Chuanjin Nuo (Code: 300505) - Expected net profit growth: 167.27%, Latest closing price: 19.95, Year-to-date change: 40.94%, Industry: Basic Chemicals [1] - Longyuan Technology (Code: 300105) - Expected net profit growth: 137.44%, Latest closing price: 8.11, Year-to-date change: 7.79%, Industry: Environmental Protection [1] - Other companies with notable growth include Chenguang Biotech, Feirongda, Boteng Co., and Huizhong Co. [1]

Group 1 - The CRO (Contract Research Organization) sector is experiencing a surge in stock prices, with notable increases in companies such as Boteng Co., Ltd. (20% increase), Kailaiying (10% increase), and WuXi AppTec (9.99% increase) [1][2][3] - The Hong Kong CXO concept stocks also saw significant gains, with Kailaiying and WuXi AppTec both rising over 10% [3][4] - WuXi AppTec is projected to achieve approximately RMB 20.8 billion in revenue for the first half of 2025, representing a year-on-year growth of about 20.64%, and an adjusted net profit of approximately RMB 6.315 billion, reflecting a year-on-year increase of about 44.43% [4][5] Group 2 - The growth in performance for WuXi AppTec is attributed to its focus on meeting customer demands, expanding capabilities, and optimizing production processes [5] - The CXO sector is expected to benefit significantly from the current high demand for innovative drugs, with a new upturn in the life sciences and CXO sectors anticipated [5][6] - Analysts predict that the CXO sector will see a recovery in domestic front-end business due to supportive industrial policies and improved investment conditions [6] Group 3 - The current wave of innovation in the pharmaceutical sector is seen as a significant turning point, with a shift from following trends to creating original products, indicating a fundamental change in the industry [7][8] - Large multinational pharmaceutical companies are increasingly purchasing innovative drug patents from China, driven by pressures to lower drug prices and the expiration of patents [8]

Group 1: Innovation Drug Sector - The innovation drug concept is experiencing a resurgence, with Kangchen Pharmaceutical hitting the daily limit up [3] - Other companies in the sector such as Changshan Pharmaceutical and Boteng Co. saw increases exceeding 10% [3] - The overall market sentiment is positive, with the A-share market showing slight gains [1][2] Group 2: Stablecoin Concept - The stablecoin concept is also seeing significant gains, with Guoao Technology reaching a daily limit up of 20% [3] - Other companies like Geer Software and Greenland Holdings also hit their daily limits [3] - The Shanghai Municipal State-owned Assets Supervision and Administration Commission is focusing on the development trends of cryptocurrencies and stablecoins [3] Group 3: Real Estate Sector - The real estate sector is showing strong performance, with companies like Yucheng Development achieving five consecutive limit ups [4] - Policies to stabilize the housing market are being implemented, with over 150 measures introduced to optimize housing provident fund policies [4] - Other real estate companies such as Tianbao Infrastructure and Greenland Holdings also saw significant gains [4] Group 4: Pork Sector - The pork sector is experiencing notable activity, with Zhenghong Technology hitting the daily limit up [5] - Other companies like Dongrui Co. and Muyuan Foods are also among the top gainers in this sector [5]

Group 1 - CRO concept stocks have surged again, with WuXi AppTec (603259) hitting the daily limit, Boten Co. (300363) reaching a 20% limit up, and Medicy exceeding a 10% increase [1] - WuXi AppTec expects its adjusted net profit for the first half of 2025 to be approximately RMB 6.315 billion, representing a year-on-year growth of about 44.43% [1] - Significant dark pool capital is flowing into these stocks, indicating increased investor interest [1]

Core Viewpoint - The innovative drug concept continues to show strong performance, with significant stock price increases for companies such as Boteng Co. and Changshan Pharmaceutical, which rose over 15% [1] Group 1: Stock Performance - Boteng Co. and Changshan Pharmaceutical saw stock increases of over 15% [1] - WuXi AppTec experienced a nearly 9% rise [1] - Other companies like Kylin Pharmaceutical, Guangsheng Pharmaceutical, and Yifang Bio also saw stock increases of over 5% [1] Group 2: Policy Announcement - On July 10, the National Healthcare Security Administration announced the adjustment plan for the 2025 National Basic Medical Insurance, Maternity Insurance, and Work Injury Insurance Drug Catalogs, as well as the Commercial Health Insurance Innovative Drug Catalog [1] - The plan specifies that the adjustments to the basic medical insurance drug catalog and the establishment of the commercial health insurance innovative drug catalog will occur simultaneously in 2025 [1]