Core Viewpoint - The announcement by Guangshengtang regarding its innovative hepatitis B drugs aligns with national policies aimed at achieving "clinical cure" for hepatitis B, receiving substantial support from the government [1][2]. Group 1: Project Overview - Guangshengtang's subsidiary, Fujian Guangsheng Zhonglin Biotechnology Co., has been included in a national major science and technology project focused on the clinical cure of chronic hepatitis B [1][2]. - The project, led by Southern Medical University, aims to explore and establish a clinically applicable hepatitis B cure and improve cure rates by 2028 [2]. Group 2: Market Demand and Public Health Significance - As of 2022, there are approximately 79.74 million HBV infected individuals in China, with chronic hepatitis B patients numbering between 20 to 30 million, highlighting a significant unmet clinical need [3]. - The national action plan for hepatitis virus prevention and control sets ambitious targets for diagnosis and treatment rates by 2030, emphasizing the urgency for innovative treatment solutions [3]. Group 3: Drug Development and Clinical Trials - The two innovative drugs, GST-HG131 and GST-HG141, are central to Guangshengtang's strategy and have shown strong competitive potential internationally [4][5]. - GST-HG131 is the first oral hepatitis B surface antigen inhibitor to complete Phase II clinical trials, demonstrating significant reductions in HBsAg levels [4]. - GST-HG141, a novel core protein regulator, has shown promising results in reducing HBV pgRNA levels, indicating potential for addressing the challenges of treatment discontinuation [5]. Group 4: Strategic Implications for Guangshengtang - Participation in the national project will provide Guangshengtang with expert guidance and collaboration opportunities, reinforcing its leading position in hepatitis B treatment [6]. - Successful outcomes from the project could influence industry standards and contribute to the development of clinical guidelines for chronic hepatitis B treatment in China [6].

格隆汇1月5日丨广生堂(300436.SZ)公布，公司创新药控股子公司福建广生中霖生物科技有限公司（简 称"广生中霖"）参与申报的新发突发与重大传染病防控国家科技重大专项"慢性乙型肝炎临床治愈联合 治疗新方案研究"项目已获得国家卫生健康委医药卫生科技发展研究中心下发的立项完成通知。广生中 霖作为课题参与单位参与该乙肝治愈专项项目课题一、课题三，负责课题的研究工作，且在研乙肝创新 药GST-HG131、GST-HG141及联合用药将作为项目课题研究用药。 ...

Core Viewpoint - Guangshengtang (300436.SZ) announced that its subsidiary, Guangsheng Zhonglin, has received a project approval notification for a national science and technology major project focused on the prevention and control of emerging infectious diseases, specifically for the research of new combined treatment plans for chronic hepatitis B clinical cure [1] Group 1 - The project aims to explore new combined treatment plans to improve the clinical cure rate of hepatitis B [1] - Guangsheng Zhonglin is responsible for research tasks one and three, utilizing the innovative hepatitis B drugs GST-HG131, GST-HG141, and combination therapies as research medications [1] - This project affirms the company's technological innovation capabilities and research and development strength in the field of hepatitis B treatment, highlighting its core competitiveness in related areas [1]

证券代码：300436 证券简称：广生堂 公告编号：2026001 项目编号：2025ZD01905900 福建广生堂药业股份有限公司 关于创新药子公司参与新发突发与重大传染病防控 国家科技重大专项的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、 完整，没有虚假记载、误导性陈述或重大遗漏。 一、基本情况 福建广生堂药业股份有限公司（以下简称"公司"）创新药控股子公司福建 广生中霖生物科技有限公司（以下简称"广生中霖"）参与申报的新发突发与重 大传染病防控国家科技重大专项"慢性乙型肝炎临床治愈联合治疗新方案研究" 项目已获得国家卫生健康委医药卫生科技发展研究中心下发的立项完成通知。广 生中霖作为课题参与单位参与该乙肝治愈专项项目课题一、课题三，负责课题的 研究工作，且在研乙肝创新药 GST-HG131、GST-HG141 及联合用药将作为项目课 题研究用药。 （一）项目基本情况 项目名称：慢性乙型肝炎临床治愈联合治疗新方案研究 项目牵头承担单位：南方医科大学南方医院 项目执行年限：2025 年 12 月-2028 年 11 月 项目目标方向，旨在探索获得可推广应用的乙肝临床治愈方案并提高临床治 愈率 ...

广生堂公告称，其创新药控股子公司广生中霖参与申报的"慢性乙型肝炎临床治愈联合治疗新方案研 究"国家科技重大专项已立项。该项目执行期为2025年12月至2028年11月，广生中霖参与课题一和课题 三，负责研究工作，在研乙肝创新药GST - HG131、GST - HG141及联合用药为研究用药。这是对公司 技术和研发实力的肯定，若成果达预期，将积极影响公司乙肝创新药发展，但项目实施存在进度和结果 不及预期等风险。 ...

数据显示，中欧基金旗下1只基金位居广生堂十大流通股东。中欧医疗健康混合A（003095）三季度减 持113.65万股，持有股数70.81万股，占流通股的比例为0.52%。根据测算，今日浮盈赚取约317.96万 元。 1月5日，广生堂涨5.04%，截至发稿，报93.64元/股，成交2.59亿元，换手率2.07%，总市值149.14亿 元。 资料显示，福建广生堂药业股份有限公司位于福建省福州市闽侯县福州高新区乌龙江中大道7号海西高 新技术产业园创新园二期16号楼，成立日期2001年6月28日，上市日期2015年4月22日，公司主营业务涉 及核苷类抗乙肝病毒药物的研发、生产与销售。主营业务收入构成为：肝胆疾病药物98.54%，其他(补 充)1.46%。 从广生堂十大流通股东角度 赵磊累计任职时间186天，现任基金资产总规模329.54亿元，任职期间最佳基金回报1.48%， 任职期间 最差基金回报-2.51%。 风险提示：市场有风险，投资需谨慎。本文为AI大模型自动发布，任何在本文出现的信息（包括但不 限于个股、评论、预测、图表、指标、理论、任何形式的表述等）均只作为参考，不构成个人投资建 议。 责任编辑：小浪快报 ...

Group 1 - The core viewpoint of the news is that Guangshentang's stock has shown significant volatility, with a year-to-date increase of 173.77%, but recent trends indicate a decline over the past 20 and 60 days [1] - As of December 24, Guangshentang's stock price was 89.44 yuan per share, with a market capitalization of 14.245 billion yuan [1] - The company has seen a net inflow of main funds amounting to 471,200 yuan, with significant buying activity from large orders [1] Group 2 - As of September 30, the number of shareholders for Guangshentang increased by 125.95% to 45,800, while the average number of circulating shares per person decreased by 55.74% to 2,985 shares [2] - For the period from January to September 2025, Guangshentang reported an operating income of 316 million yuan, a year-on-year decrease of 3.21%, and a net profit attributable to shareholders of -112 million yuan, down 57.96% year-on-year [2] - Since its A-share listing, Guangshentang has distributed a total of 84.6485 million yuan in dividends, with no dividends paid in the last three years [3]

Market Performance - The chemical pharmaceutical sector increased by 1.95% on December 19, with XinNuoWei leading the gains [1] - The Shanghai Composite Index closed at 3890.45, up 0.36%, while the Shenzhen Component Index closed at 13140.22, up 0.66% [1] Top Gainers in Chemical Pharmaceutical Sector - XinNuoWei (300765) closed at 34.69, up 11.44%, with a trading volume of 311,700 shares and a transaction value of 1.069 billion [1] - KangYi Pharmaceutical (300086) closed at 11.02, up 11.43%, with a trading volume of 965,500 shares and a transaction value of 1.018 billion [1] - MuNanHai Pharmaceutical (000566) closed at 7.24, up 10.03%, with a trading volume of 1,325,900 shares and a transaction value of 914 million [1] Market Capital Flow - The chemical pharmaceutical sector saw a net inflow of 68.1822 million from institutional investors, while retail investors contributed a net inflow of 31.3 million [2] - The sector experienced a net outflow of 381 million from speculative funds [2] Individual Stock Capital Flow - ST Renfu (600079) had a net inflow of 92.7508 million from institutional investors, while it faced a net outflow of 26.4283 million from speculative funds [3] - GuangShengTang (300436) recorded a net inflow of 49.2520 million from institutional investors, with a net outflow of 17.4322 million from speculative funds [3] - KangZhi Pharmaceutical (300086) had a net inflow of 28.1873 million from institutional investors, while it faced a net outflow of 3.1280 million from retail investors [3]

12月19日，广生堂涨5.02%，截至发稿，报90.63元/股，成交2.48亿元，换手率2.05%，总市值144.34亿 元。 责任编辑：小浪快报 同泰大健康主题混合A（011002）成立日期2021年4月8日，最新规模1375.12万。今年以来收益11.87%， 同类排名5281/8098；近一年收益6.25%，同类排名6196/8067；成立以来亏损54.1%。 同泰大健康主题混合A（011002）基金经理为马毅、麦健沛。 截至发稿，马毅累计任职时间11年278天，现任基金资产总规模27.18亿元，任职期间最佳基金回报 42.13%， 任职期间最差基金回报-5.55%。 麦健沛累计任职时间222天，现任基金资产总规模2.31亿元，任职期间最佳基金回报20.94%， 任职期间 最差基金回报-5.55%。 风险提示：市场有风险，投资需谨慎。本文为AI大模型自动发布，任何在本文出现的信息（包括但不 限于个股、评论、预测、图表、指标、理论、任何形式的表述等）均只作为参考，不构成个人投资建 议。 资料显示，福建广生堂药业股份有限公司位于福建省福州市闽侯县福州高新区乌龙江中大道7号海西高 新技术产业园创新园二期16号 ...

广生堂（300436.SZ）12月3日在投资者互动平台表示，尊敬的投资者，您好！GST-HG141的III期临床试 验是一项48周治疗的随机双盲研究，是公司创新药研发管线的重点项目，正按计划全力推进。为确保数 据的完整性，公司目前暂未安排该试验中期揭盲分析计划。公司将持续高效推进试验进程并及时披露创 新药重大进展，感谢您的关注和支持！ （记者 曾健辉） 每经AI快讯，有投资者在投资者互动平台提问：请问广生堂141三期临床会不会出中期数据？如果会的 话大概在什么时候出？ ...