Investment Rating - The industry investment rating is "Positive," indicating an expected overall return exceeding the CSI 300 Index by more than 5% over the next six months [9]. Core Insights - The pharmaceutical sector experienced a decline of 0.96% on March 7, 2025, underperforming the CSI 300 Index by 0.65 percentage points, ranking 22nd among 31 sub-industries [4]. - The approval of ARS's Neffy (1 mg epinephrine nasal spray) by the FDA marks a significant innovation in the delivery method for treating type I allergic reactions in children aged 4 and above, representing the first major advancement in 35 years for this patient group [5][9]. - Notable stock performances included Aosaikang (+9.99%), Yipinhong (+9.77%), and Rejing Biology (+8.84%) on the gainers' list, while Aopumai (-6.26%), Puri Eye (-5.97%), and BGI (-4.86%) led the decliners [4]. Summary by Sections Market Performance - As of March 7, 2025, the pharmaceutical sector's performance was -0.96%, with sub-sectors like in vitro diagnostics (-0.43%) and blood products (-0.72%) performing better, while hospitals (-2.11%) and medical devices (-1.67%) lagged [4]. Industry News - The FDA's approval of Neffy is a pivotal development for the treatment of severe allergic reactions in children, highlighting the ongoing innovation in the pharmaceutical industry [5]. - Companies such as Jingxin Pharmaceutical announced an increase in their share repurchase plan, raising the total amount from a minimum of 200 million RMB to 350 million RMB [5]. - Nouvegen and BGI have entered a strategic cooperation agreement to leverage their respective expertise in reproductive genetics, tumor prevention, chronic disease management, and infection control [5]. Company News - Heng Rui Pharmaceutical received approval for clinical trials of several new drugs, indicating ongoing research and development efforts [6]. - Kanglong Chemical reported the completion of a share reduction plan, with a total of 10,666,716 shares reduced, representing 0.60% of the company's total share capital [6].

关于持股 5%以上股东减持计划实施完成的公告 公司持股 5%以上股东深圳市信中康成投资合伙企业（有限合伙）及其一致行 动人深圳市信中龙成投资合伙企业（有限合伙）保证向本公司提供的信息内容真 实、准确、完整，没有虚假记载、误导性陈述或重大遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 康龙化成（北京）新药技术股份有限公司（以下简称"公司"）于 2024 年 12 月 26 日在巨潮资讯网（www.cninfo.com.cn）披露了《关于持股 5%以上股东 减持股份的预披露公告》（公告编号：2024-079）。公司持股 5%以上股东深圳 市信中康成投资合伙企业（有限合伙）（以下简称"信中康成"）计划自上述减 持公告披露之日起 15 个交易日（2025 年 1 月 20 日）后的 2 个月内以集中竞价 交易或大宗交易等深圳证券交易所认可的合法方式减持公司股份不超过 10,666,716 股（占当时公司总股本的 0.60%）。 证券代码：300759 证券简称：康龙化成 公告编号：2025-007 康龙化成（北京）新药技术股份有限公司 注 1：公司此时间段总股本为 1,777,786,00 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年2月28日 狀態: 新提交 本月底法定/註冊股本總額： RMB 1,778,195,525 FF301 第 1 頁 共 10 頁 v 1.1.1 致：香港交易及結算所有限公司 公司名稱: 康龍化成（北京）新藥技術股份有限公司 (於中華人民共和國註冊成立的股份有限公司） 呈交日期: 2025年3月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 03759 | 說明 | H股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 301,537,125 | RMB | | 1 RMB | | 301,537,125 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 | | ...

Investment Rating - The investment rating for the industry is maintained at "Buy" [3] Core Insights - The report highlights a recovery process for the CXO sector, driven by a rebound in global healthcare investment and the potential of AI in drug development [6][9][10] - The FDA has granted priority review status to a potential "first-in-class" small molecule for cancer treatment, indicating significant advancements in the pharmaceutical pipeline [3][43] Market Performance Review - The Shanghai Composite Index closed at 3379.11, up 0.97%, while the Shenzhen 300 Index rose by 1.00% [1] - The pharmaceutical industry index increased by 0.96%, ranking 8th among 31 primary industry indices [1] - Weekly performance of various segments within the pharmaceutical industry showed mixed results, with traditional Chinese medicine down by 2.30% and medical services up by 6.87% [1] CXO Recovery Process - Global healthcare investment is showing signs of recovery, with 2024 global pharmaceutical investment amounting to $57.747 billion, a slight decline of 1% year-on-year, significantly narrowing from a 34% drop in 2023 [7][22] - Domestic investment in the pharmaceutical sector for 2024 is projected at 517.97 billion yuan, also reflecting a narrowing decline [7][22] - The failure of the 2024 Biodefense Act to pass is expected to alleviate valuation pressures on CXO companies [8][28] AI Empowerment in Drug Development - The rise of artificial intelligence is transforming drug development, addressing challenges such as long development cycles and high costs [9][29] - Companies that achieve breakthroughs in AI applications within the CXO sector are likely to gain competitive advantages in future drug development [9][29] Industry News - The RuiPath pathology model, developed by Huawei and Ruijin Hospital, aims to enhance diagnostic accuracy and efficiency in pathology [2][43] - Chimerix's dordaviprone has received FDA priority review, marking a significant milestone for potential cancer therapies [3][43]

证券代码：300759 证券简称：康龙化成 公告编号：2025-006 康龙化成（北京）新药技术股份有限公司 关于持股 5%以上股东权益变动触及 1%的公告 公司持股 5%以上股东深圳市信中康成投资合伙企业（有限合伙）及其一致行 动人深圳市信中龙成投资合伙企业（有限合伙）保证向本公司提供的信息内容真 实、准确、完整，没有虚假记载、误导性陈述或重大遗漏。 本公司及董事会全体成员保证公告内容与信息披露义务人提供的信息一致。 康龙化成（北京）新药技术股份有限公司（以下简称"公司"）于近日收到 公司持股 5%以上股东深圳市信中康成投资合伙企业（有限合伙）（以下简称"信 中康成"）及其一致行动人深圳市信中龙成投资合伙企业（有限合伙）（以下简称 "信中龙成"）出具的《股份减持进展告知函》，获悉信中康成和信中龙成因减持 导致权益变动触及 1%。现将有关情况公告如下： | 1. 基本情况 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 信息披露义务人（一） | | 深圳市信中康成投资合伙企业（有限合伙） | | | | | | | 住所 ...

以下文章来源于阿基米德Biotech ，作者阿基米德君 阿基米德Biotech . 生物医药第三方独立观察，客观中立，深入浅出，松弛愉悦，写作纯为兴趣，不接广告 一个伟大的开端。 作者 | 阿基米德君 来源 | 阿基米德Biotech （ID：ArchimedesBiotech） 这个冬天太长了。在遥远的2021年夏天，所有人都不会想到医药下行周期会超过3年半，以致于最有耐心的坚守者也濒临崩溃。 参考率先见底的CDMO，当所有负面因素都充分入价后，任何细微的边际改善都将带来巨大弹性。从底部挣扎起来，药明康德反弹约 60% 药明生物反弹约110%，药明合联一度逼近历史新高。 不要指望惊天大逆转，但细微的边际改善是可期待的，这已经足矣。 2024Q4，全部公募基金对医药板块的持仓比例为8.58%，环比下降1.08pct，已超过2022Q3全部基金持仓的低点位（9.37%）， 下降至历史最低位置，意味着任何细微的增量资金都将带来弹性。 寒冰融化。在支付端，单一支付体系即将破局，多元化支付体系将在年内初步建立，而且在用药群众对药效日益关切的推动下，集 采、医保谈判有望转向控费与质控的平衡；在融资端，未盈利生物科技企业 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 03759 | 說明 | H股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 301,537,125 | RMB | | 1 RMB | | 301,537,125 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 | | 本月底結存 | | | 301,537,125 | RMB | | 1 RMB | | 301,537,125 | | 2. 股份分類 | 普通股 | A 股份類別 | | | 於香港聯交所上市 (註1) | 否 | | | | --- | --- | --- | --- | --- | --- | --- | --- | ...

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 康龍化成（北京）新藥技術股份有限公司 (於中華人民共和國註冊成立的股份有限公司） 備註： 在上述第A(1)和第A(2)部分中提到的24,459股A股和385,057股A股的發行數目需經中國證券存管機構最終確認。如有需要調整那些數目，公司會作出更新。 FF305 第 2 頁 共 6 頁 v 1.3.0 FF305 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 A | | 於香港聯交所上市 | 否 | | | 證券代號 (如上市) | | 說明 | A 股 (深圳證券 ...

Investment Rating - The report maintains an "Accumulate" investment rating for the company, indicating a projected relative increase of 5% to 15% compared to the CSI 300 index over the next six months [9][13]. Core Views - The company, established in 2004, specializes in drug research, development, and production services, providing integrated services across four main business segments: laboratory services, CMC services (small molecule CDMO), clinical research services, and large molecule and cell and gene therapy services [7][9]. - The company forecasts a revenue of 12 billion to 12.346 billion yuan for 2024, representing a year-on-year growth of 4% to 7%. The net profit is expected to be between 1.729 billion and 1.857 billion yuan, reflecting an 8% to 16% increase [9]. - The earnings per share (EPS) for 2024 is projected to be between 0.98 and 1.05 yuan, with corresponding price-to-earnings (P/E) ratios of 25.24, 22.52, and 19.00 for the years 2024, 2025, and 2026 respectively [9][10]. Financial Summary - Revenue and profit forecasts for the company are as follows: - 2022A: Revenue of 10,266 million yuan, net profit of 1,375 million yuan - 2023A: Revenue of 11,538 million yuan, net profit of 1,601 million yuan - 2024E: Revenue of 12,190 million yuan, net profit of 1,751 million yuan - 2025E: Revenue of 13,980 million yuan, net profit of 1,962 million yuan - 2026E: Revenue of 16,302 million yuan, net profit of 2,325 million yuan [8][10]. - The company’s gross margin is reported at 33.87%, with a diluted return on equity (ROE) of 10.62% and a debt-to-asset ratio of 40.49% [2][9].

1、本次归属股票数量及归属人数：本次归属限制性股票的激励对象共计 20 名，归属限制性股票数量合计 24,459 股，占公司目前总股本的 0.0014%； 证券代码：300759 证券简称：康龙化成 公告编号：2025-004 康龙化成(北京)新药技术股份有限公司 关于 2021 年 A 股限制性股票激励计划 第三个归属期归属结果暨股份上市的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 重要内容提示： 2、本次限制性股票归属上市流通时间为 2025 年 2 月 5 日。 康龙化成（北京）新药技术股份有限公司（以下简称"公司"或"本公司"）于 2024 年 8 月 27 日召开的第三届董事会第九次会议、第三届监事会第八次会议， 审议通过了《关于 2021 年 A 股限制性股票激励计划第三个归属期归属条件成就 但股票暂不上市的议案》。近日公司办理了 2021 年 A 股限制性股票激励计划（以 下简称"本次激励计划"）第三个归属期归属股份的登记工作，现将有关事项说 明如下： 一、本次激励计划实施情况概要 （一）本次激励计划简述 1、授予限制性股票的股票来源及 ...