股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年10月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 康龍化成（北京）新藥技術股份有限公司 (於中華人民共和國註冊成立的股份有限公司） 呈交日期: 2025年11月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 03759 | 說明 | H股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 301,537,125 | RMB | | 1 RMB | | 301,537,125 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 | | 本月底結存 | | | 301,537,125 | RMB | | 1 RMB | | 301,537,125 | ...

Core Insights - Norges Bank increased its stake in Kanglong Chemical (300759) by 518,200 shares at a price of HKD 25.7617 per share, totaling approximately HKD 13.3497 million [1] - Following this transaction, Norges Bank's total shareholding in Kanglong Chemical is approximately 14.7304 million shares, representing a holding percentage of 5.01% [1]

Core Viewpoint - Norges Bank increased its stake in Kanglong Chemical (03759) by purchasing 518,200 shares at a price of HKD 25.7617 per share, totaling approximately HKD 13.3497 million, bringing its total holdings to about 14.7304 million shares, which represents a 5.01% ownership stake [1] Summary by Category - **Share Purchase Details** - Norges Bank acquired 518,200 shares of Kanglong Chemical at HKD 25.7617 per share [1] - The total investment amounted to approximately HKD 13.3497 million [1] - **Post-Investment Holdings** - Following the purchase, Norges Bank's total shareholding in Kanglong Chemical reached approximately 14.7304 million shares [1] - The updated ownership percentage stands at 5.01% [1]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年10月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 康龍化成（北京）新藥技術股份有限公司 (於中華人民共和國註冊成立的股份有限公司） 呈交日期: 2025年11月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 03759 | 說明 | H股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 301,537,125 | RMB | | 1 RMB | | 301,537,125 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 | | 本月底結存 | | | 301,537,125 | RMB | | 1 RMB | | 301,537,125 | ...

Summary of CRO Industry Conference Call Industry Overview - The CRO (Contract Research Organization) industry is experiencing significant growth, with a 7% increase in revenue and over 40% increase in net profit for 25 CRO companies in the first three quarters of 2025, indicating a recovery in demand and accelerated growth in the industry [1][2][3] - The global and domestic CRO markets saw a remarkable recovery in September, with domestic growth reaching 300%, close to historical highs, reflecting strong market demand [1][5] Key Financial Metrics - In the first three quarters of 2025, the overall revenue growth for the CRO industry was nearly 11%, while profit growth approached 53%, with a 34% increase in non-GAAP profit, driven primarily by order demand [2][8] - The total BD (Business Development) transaction amount globally reached approximately $100 billion, with domestic transactions matching international levels and growing rapidly, indicating increased R&D investment that will benefit CRO order conversion [1][6] Company Performances - WuXi AppTec reported an order backlog of nearly $60 billion, with growth rates accelerating from 37% in the first half to 41% in the third quarter, and raised its full-year revenue guidance to 17-18% [1][10] - Kanglong Chemical achieved a 14% revenue growth and nearly 11% non-GAAP profit growth in the first three quarters, with laboratory services and CMC (Chemistry, Manufacturing, and Controls) segments growing by 15% and 16% respectively [1][10] Investment and Capacity Expansion - The CRO industry is entering an accelerated phase of fixed asset investment, with companies like WuXi AppTec and Kelaiying increasing capital expenditures to enhance future order acquisition and conversion efficiency [1][7] - WuXi AppTec's capital expenditure is expected to increase to $5.5-6 billion for the year, a growth of 30%-50% compared to last year [7] Market Dynamics and Future Outlook - The CRO industry is expected to continue its recovery, with a positive outlook for the next 12-18 months, driven by increased order inquiries and a gradual recovery from previous price wars [9][11] - The overall performance of the CRO industry is anticipated to improve further in 2026, supported by the digestion of historical projects and an increase in demand [9][11] Additional Insights - The CRO industry is benefiting from structural changes in the market, including institutional support, clinical trial approvals, and the growing global influence of China's innovative drug industry [3][11] - Companies are also focusing on enhancing employee retention and productivity, with some firms announcing salary increases to attract talent [7] This summary encapsulates the key points from the CRO industry conference call, highlighting the robust growth, financial performance, and future prospects of the sector.

Investment Rating - The report maintains a positive outlook on the pharmaceutical sector, particularly recommending a focus on innovative drugs and sectors with improving performance such as medical devices and CXO [1][10]. Core Insights - The pharmaceutical sector in Q3 2025 showed signs of recovery with a year-on-year revenue growth of 0.6% in Q3, marking the first positive growth in four quarters [1][10]. - Innovative drugs demonstrated a remarkable revenue growth of 36% in Q3 2025, with a turnaround in net profit from a loss of 500 million to a profit of 1.5 billion [10]. - The CXO sector also showed strong performance with a revenue growth of 10.9% and a net profit increase of 47.7% year-on-year, indicating a trend reversal [10]. Summary by Sections Q3 2025 Performance - The A-share pharmaceutical sector, excluding certain companies, achieved total revenue of 1,806.4 billion with a year-on-year decline of 1.9% and a net profit of 139.2 billion, down 5.1% year-on-year [2][11]. - In Q3 2025, total revenue reached 600.4 billion, reflecting a year-on-year increase of 0.6% but a quarter-on-quarter decrease of 0.4% [2][11]. Profitability and Margins - The gross profit for the pharmaceutical sector in Q3 2025 was 189.1 billion, with a gross margin of 31.5%, slightly down from the previous year [5][8]. - The overall net profit margin for Q3 2025 was 6.8%, showing a slight decline compared to the previous year [8]. Cash Flow - The sector reported a net cash inflow from operating activities of 59.1 billion in Q3 2025, representing a year-on-year growth of 17.9% [7][13]. Subsector Performance - The innovative drug sector's revenue growth of 36% and the CXO sector's revenue growth of 10.9% highlight the strong recovery and growth potential within these subsectors [10][11]. - The report emphasizes the importance of focusing on companies such as 恒瑞医药, 长春高新, and 药明康德, which are expected to perform well in the current market environment [1][10].

Core Insights - The CXO (Contract Research Organization) sector in A-shares has shown strong growth, with 20 out of 29 listed companies reporting year-on-year revenue increases in the first three quarters [1] - The third quarter alone saw 21 companies achieving revenue growth compared to the same period last year, driven by international demand for innovative drugs [1] - The sector is benefiting from both policy support and a surge in demand, which is enhancing new drug development needs and positively impacting the CXO industry [1] Policy Support - The National Healthcare Security Administration and the National Health Commission issued measures on July 1 to support the high-quality development of innovative drugs, outlining 16 policies to enhance the entire chain of support for innovative drug development [1] Demand Growth - Several CXO companies reported robust order backlogs for the first three quarters. For instance, WuXi AppTec reported a backlog of 59.88 billion yuan, a 41.2% increase year-on-year [1] - Kanglong Chemical indicated a more than 13% year-on-year growth in new orders, with acceleration in growth compared to the first half of the year [1] - Yino Science reported a nearly 20% increase in order amounts compared to the end of 2024 [2] - Haoyuan Pharmaceutical noted a 50% year-on-year increase in its small molecule business orders, marking four consecutive quarters of growth [2] Internationalization and Market Trends - The first half of the year saw a significant increase in the internationalization of Chinese innovative drugs, with total external authorization transactions reaching 60 billion USD, accounting for 99% of global related transactions [2] - Morgan Stanley's healthcare research head for Greater China anticipates stable long-term growth in external authorization transactions, with multinational companies likely to be more active in acquiring Chinese innovative drug assets [2] - The CXO industry is transitioning from a "scale dividend" to a "technology premium," with technological iteration and process innovation becoming the core of industry competition [2]

Core Insights - The CXO (Contract Research Organization) sector in A-shares shows strong growth, with 20 out of 29 listed companies reporting year-on-year revenue increases in the first three quarters [1] - In the third quarter alone, 21 companies achieved year-on-year revenue growth, driven by international demand for innovative drugs and a supportive policy environment [2] Industry Overview - The innovative drug industry is experiencing a dual boost from policy support and surging demand, which is activating new drug research and development needs, benefiting the CXO sector [2] - The National Healthcare Security Administration and the National Health Commission issued measures to support high-quality development of innovative drugs, proposing 16 policies to enhance the entire chain of support [2] Company Performance - Several CXO companies reported robust order backlogs for the first three quarters. For instance, WuXi AppTec reported a backlog of 59.88 billion yuan, a 41.2% increase year-on-year [2] - Innosilicon reported a nearly 20% increase in order amounts compared to the end of 2024, while Haoyuan reported a 50% year-on-year increase in its small molecule business orders [3] Market Trends - The first half of the year saw a surge in Chinese innovative drugs going global, with total foreign licensing transactions reaching $60 billion, accounting for 99% of global related transactions [3] - Morgan Stanley's healthcare research head in Greater China anticipates stable long-term growth in foreign licensing transactions for Chinese innovative drugs, with multinational companies likely to be more active in acquiring Chinese assets [3] Future Outlook - The CXO industry is expected to benefit from a combination of demand recovery and structural upgrades, with policies, capital, and technology contributing to a more certain industry development [3] - The industry is transitioning from "scale dividends" to "technology premiums," with technological iteration and process innovation becoming the core of competition [3]

Core Viewpoint - Kanglong Chemical (300759) announced that one of its actual controllers, Mr. Lou Xiaoqiang, has pledged part of his shares, while Ningbo Longtai Kang Investment Management Co., Ltd. has released part of its pledged shares [1] Summary by Relevant Sections - Share Pledge: Mr. Lou Xiaoqiang pledged 2.154 million shares of the company [1] - Share Release: Longtai Kang released 3.75 million shares from pledge [1]

智通财经APP讯，康龙化成(03759)发布公告，近日接到公司实际控制人之一楼小强先生及其一致行动人 宁波龙泰康投资管理有限公司(以下简称"龙泰康")的函告，获悉楼小强先生将其所持有的公司部分股份 进行了质押，龙泰康将其所持有的公司部分股份进行了解除质押。楼小强质押215.4万股公司股份,龙泰 康解除质押375万股公司股份。 ...