Group 1: Market Performance - The U.S. stock market saw all three major indices rise, with the Dow Jones Industrial Average reaching a new historical high, approaching the 50,000 mark, closing at 49,462.08 points, up 0.99% [3] - The Philadelphia Semiconductor Index increased by 2.75%, setting a new historical high, with notable gains in chip stocks such as Microchip Technology up over 11%, Micron Technology up over 10%, and NXP Semiconductors up over 9% [5][6] Group 2: Federal Reserve Insights - Federal Reserve Governor Milan stated that the Fed should lower interest rates by more than 100 basis points this year, as economic data trends may support further rate cuts [5] - Milan noted that core inflation has returned to around the Fed's 2% target, and he expects strong economic growth in the U.S. this year [5] Group 3: Commodity Prices - Silver prices surged again, with COMEX silver futures breaking the $80 per ounce mark, reflecting a rise of approximately 6% [8] - Gold prices also saw a slight increase, with COMEX gold futures surpassing $4,500 per ounce, up over 1% [8]

Market Overview - U.S. stocks experienced an upward trend, with the Dow Jones index increasing by over 500 points on Monday [1] Company Highlights - Altimmune Inc (NASDAQ:ALT) saw a significant increase of 23.6%, reaching $4.34, following the FDA's grant of Breakthrough Therapy Designation for Pemvidutide in MASH [1] - GH Research PLC (NASDAQ:GHRS) surged by 33.8% to $17.72 after the FDA lifted the clinical hold on its Investigational New Drug Application for GH001 [2] - Vicor Corp (NASDAQ:VICR) rose by 20.7% to $141.08 [2] - Critical Metals Corp (NASDAQ:CRML) increased by 19.6% to $9.71 [2] - Kosmos Energy Ltd (NYSE:KOS) gained 19.3% to $1.06 after issuing an operational and financial update [2] - TRON Inc (NASDAQ:TRON) increased by 16.9% to $1.59 [2] - Nuscale Power Corp (NYSE:SMR) rose by 15.7% to $18.88 [2] - Regencell Bioscience Holdings Ltd (NASDAQ:RGC) increased by 15.4% to $23.71 [2] - Rayonier Advanced Materials Inc (NYSE:RYAM) gained 14.1% to $6.68, with the appointment of Scott M. Sutton as President and CEO [2] - Aduro Clean Technologies Inc (NASDAQ:ADUR) rose by 14% to $12.05 [2] - Gyre Therapeutics Inc (NASDAQ:GYRE) increased by 12.7% to $7.67, announcing alignment with China's CDE on conditional approval pathway for hydronidone [2] - Endeavour Silver Corp (NYSE:EXK) gained 12.5% to $10.16 [2] - Allegro MicroSystems Inc (NASDAQ:ALGM) surged by 11.9% to $30.12 [2] - United States Antimony Corp (NYSE:UAMY) rose by 11.7% to $6.69 [2] - Oklo Inc (NYSE:OKLO) gained 11.5% to $86.82 [2] - Figure Technology Solutions Inc (NASDAQ:FIGR) increased by 11.3% to $48.66 [2] - Valero Energy Corp (NYSE:VLO) rose by 9.6% to $181.21 [2] - AeroVironment, Inc. (NASDAQ:AVAV) increased by 8.6% to $278.31 [2] - Coeur Mining Inc (NYSE:CDE) gained 8.5% to $19.05 [2] - Halliburton Co (NYSE:HAL) rose by 7.8% to $31.92, with U.S. energy stocks trading higher amid news of potential investments in Venezuela's oil industry [2] - Kratos Defense & Security Solutions Inc (NASDAQ:KTOS) gained 7.7% to $85.39 [2] - Slb NV (NYSE:SLB) increased by 7.4% to $43.19 [2] - Amkor Technology Inc (NASDAQ:AMKR) rose by 7.3% to $46.05, with Needham analyst Charles Shi maintaining a Buy rating and raising the price target from $37 to $50 [2]

Core Viewpoint - Gyre Therapeutics, Inc. announced that its subsidiary in China, Gyre Pharmaceuticals, has completed a Pre-New Drug Application meeting with the Center for Drug Evaluation regarding Hydronidone, a first-in-class anti-fibrotic therapy for chronic hepatitis B-associated liver fibrosis [1][10]. Group 1: Regulatory Progress - Gyre Pharmaceuticals and the CDE reached a consensus that existing Phase 3 clinical data for Hydronidone support a conditional approval NDA submission for treating chronic hepatitis B-associated liver fibrosis, including early cirrhosis [2][10]. - The CDE indicated that Hydronidone qualifies for inclusion in China's Priority Review and Approval Program for Innovative Drugs, pending formal filing and regulatory review [2][10]. - Hydronidone received Breakthrough Therapy Designation from the NMPA in March 2021, recognizing its potential to address a serious condition with significant unmet medical need [3]. Group 2: Clinical Trial Results - Gyre reported that in its Phase 3 trial, 52.85% of treated patients achieved ≥1-stage fibrosis regression at Week 52, compared to 29.84% in the placebo group (p=0.0002) [4]. - The trial also met a key secondary endpoint by demonstrating improvement in liver inflammation without fibrosis progression and showed a favorable safety profile [4]. Group 3: Future Plans - The company plans to conduct an additional confirmatory Phase 3c trial in China to evaluate liver-related clinical outcomes, supporting the potential conversion from conditional approval to regular approval [5]. - Gyre expects to submit an NDA for conditional approval of Hydronidone in the first half of 2026, subject to final data readiness and regulatory procedures [5][10]. Group 4: Market Opportunity - Chronic hepatitis B-associated liver fibrosis represents a significant unmet medical need in China, with an estimated 60–70 million people infected with hepatitis B virus, and approximately 2.6 million diagnosed with clinically significant liver fibrosis [11].

Core Viewpoint - The gold sector in the US stock market experienced a collective rise in pre-market trading, driven by increased demand for safe-haven assets following the arrest of Venezuelan President Maduro, which led to a surge in gold prices, reaching $4,434 per ounce [1]. Group 1: Stock Performance - New Gold saw a pre-market increase of 5.37% [2] - Coeur Mining rose by 3.42% [2] - Pan American Silver increased by 2.98% [2] - Barrick Mining experienced a rise of 2.56% [2] - Harmony Gold gained 2.20% [2] - Newmont Mining increased by 2.15% [2] - B2Gold rose by 2.00% [2] - Kinross Gold saw an increase of 1.98% [2] - AngloGold Ashanti rose by 1.86% [2] - Gold Fields increased by 1.56% [2]

Core Viewpoint - A senior mining analyst warns against rising investor exuberance in the junior mining sector, particularly regarding silver companies, as prices reach multi-decade highs [1][2]. Group 1: Investor Sentiment and Market Behavior - The analyst expresses concern over the simplistic valuation methods being used by investors in silver companies, indicating a disconnect from fundamental analysis [2][3]. - Many silver stocks are experiencing price increases without sufficient operational success or financial justification, as investor enthusiasm overshadows due diligence [3][4]. - The current market enthusiasm is likened to classic late-cycle behavior, suggesting that optimism may be peaking, with all stocks showing similar valuation trends [6]. Group 2: Performance Metrics - Junior silver miners and ETFs have shown significant performance over the past year, with notable increases in stock prices, such as Coeur Mining Inc. rising by 190.03% and Hecla Mining Co. by 269.28% [7]. - The iShares Silver Trust and Amplify Junior Silver Miners ETF also reported substantial gains of 141.37% and 166.25%, respectively, reflecting the overall bullish trend in the sector [7]. Group 3: Future Outlook - Despite concerns about current valuations, experts predict continued upside for silver prices, with a significant rally expected following a 155% increase in 2025 [8]. - The analyst notes that the recent surge in prices has not yet been fully reflected in the valuations of miners and junior miners, indicating potential for further growth [8].

Core Viewpoint - Precious metal stocks are experiencing a pre-market rise, driven by increasing gold and silver prices, with expectations for strong performance in 2026 due to factors like potential U.S. interest rate cuts and a weakening dollar [1] Group 1: Market Performance - Coeur Mining (CDE.US) rose nearly 4%, Pan American Silver (PAAS.US) increased over 2%, and Barrick Gold (B.US), Newmont Mining (NEM.US), and Harmony Gold (HMY.US) all gained over 1% [1] - Spot gold prices increased by over 1%, reaching a peak of $4,400, while spot silver surged by 3%, reclaiming the $73 mark [1] Group 2: Influencing Factors - The rise in precious metals is attributed to expectations of further U.S. interest rate cuts and a weaker dollar, which may support prices in 2026 [1] - In 2025, precious metals experienced a significant upward trend, with gold prices hitting a series of historical highs due to central bank gold purchases, Federal Reserve easing policies, and a weaker dollar [1] - Geopolitical tensions and trade frictions led by the U.S. have also contributed to increased demand for safe-haven assets [1]

Core Viewpoint - Precious metal stocks showed pre-market gains, with notable increases in companies such as Coeur Mining (CDE.US) and Pan American Silver (PAAS.US), driven by rising gold and silver prices [1] Group 1: Market Performance - Gold prices increased by over 1%, reaching a peak of $4,400 during the day, while silver surged by 3%, surpassing $73 [1] - Major mining companies including Barrick Mining (B.US), Newmont Mining (NEM.US), and Harmony Gold (HMY.US) also experienced gains of over 1% [1] Group 2: Market Influences - The rise in precious metals is attributed to expectations of further interest rate cuts in the U.S. and a weakening dollar, which may lead to strong performance in 2026 [1] - Concerns about broad index rebalancing may exert pressure on prices in the near term [1] Group 3: Historical Context - The year 2025 saw a significant rally in precious metals, with gold prices reaching a series of historical highs due to central bank purchases, Federal Reserve easing policies, and a weaker dollar [1] - Geopolitical tensions and trade frictions led by the U.S. have also contributed to increased demand for safe-haven assets [1]

Core Insights - Coeur Mining, Inc. (CDE) and First Majestic Silver Corp. (AG) are well-positioned to benefit from the strong upcycle in gold and silver markets [1] - Both companies are experiencing favorable industry trends, including rising precious-metal prices driven by inflation hedging, central-bank buying, and geopolitical uncertainty [4] Coeur Mining (CDE) - Coeur Mining focuses on silver and gold production in North America, with key assets in the U.S. and Canada, and has improved margins and cash flow due to higher metal prices and operational optimization [2] - In Q3 2025, Coeur reported record production of 111,364 ounces of gold and 4.8 million ounces of silver, with revenues reaching $555 million, reflecting a 15% increase in silver prices and a 4% increase in gold prices [5][11] - The Las Chispas mine acquisition significantly contributed to Coeur's growth, producing 1.6 million ounces of silver and 16.5 thousand ounces of gold in Q3 2025 [6] - Coeur's flagship assets, Rochester and Palmarejo, are expected to support a total production of 392,500–438,000 ounces of gold and 17.1–19.2 million ounces of silver in 2025 [7] - As of September 2025, Coeur's cash and cash equivalents were approximately $266 million, with a debt-to-capital ratio of 10.5% and free cash flow of about $189 million in Q3 [8] First Majestic Silver Corp. (AG) - First Majestic, primarily focused on silver with growing gold exposure, reported a record production of 3.9 million ounces of silver in Q3 2025, a 96% year-over-year increase [9] - The Los Gatos Silver Mine, acquired in 2025, was a key contributor, producing 2.13 million silver-equivalent ounces during the quarter [10] - Overall, First Majestic produced 7.7 million silver-equivalent ounces in Q3 2025, with significant contributions from San Dimas and other properties [12][13] - At the end of September 2025, First Majestic's cash and cash equivalents were around $575 million, with a debt-to-capital ratio of 6.9% and free cash flow of about $55 million in Q3 [14] Price Performance & Valuation - CDE stock has increased by 104.2% over the past six months, while AG stock has risen by 99.8% [15] - CDE is trading at a forward 12-month sales multiple of 4.38X, compared to AG's 7.68X [16] Earnings Estimates - The Zacks Consensus Estimate for CDE's fiscal 2025 sales implies a year-over-year growth of 96%, with EPS suggesting a 322.22% rise [19] - For AG, the fiscal 2026 sales and EPS estimates imply year-over-year increases of 87% and 279%, respectively [21] Comparative Analysis - CDE is viewed as the stronger overall pick due to its balanced gold-and-silver portfolio, operational execution, and stronger earnings visibility, alongside disciplined cost management and improved balance-sheet profile [23] - CDE holds a Zacks Rank of 1 (Strong Buy), while AG has a Zacks Rank of 3 (Hold) [24]

Group 1 - The core viewpoint of the article highlights a pre-market rebound in gold and silver stocks, with notable increases in share prices for several companies [1] - AngloGold Ashanti (AU.US) saw a rise of over 3%, while Hycroft Mining (HYMC.US) and First Majestic Silver (AG.US) both increased by 3% [1] - Other companies such as Endeavour Silver (EXK.US) and Coeur Mining (CDE.US) experienced a rise of 2.4%, and Newmont Corporation (NEM.US) rose by over 2% [1] Group 2 - In the pre-market, spot gold increased by over 1.2%, reaching $4,385.7 per ounce [1] - Spot silver surpassed $76, with a daily increase of over 5% [1]

Group 1 - Zijin Mining (02899) rose nearly 3% after announcing the completion of the main construction and core equipment installation for the second phase of the Xizang Julong Copper Mine, marking a key step before production [1] - Asia Pacific Satellite (01045) increased over 5.4%, with a cumulative rise of nearly 30% over the past five trading days, as it operates multiple satellites under China Satcom [1] - Zhaoyan New Drug (06127) fell over 6% following an announcement that its actual controller plans to reduce holdings by up to 14.98 million shares, representing 20.0466% of his holdings and 1.99873% of the company's total share capital [1] - Zhongwei New Materials (02579) surged nearly 7% after signing a strategic cooperation framework agreement with Xinwanda for solid-state batteries [1] Group 2 - Dongyue Group (00189) rose nearly 5% as the long-term contract prices for refrigerants were confirmed, with R32 priced at 61,200 yuan/ton (+1,000 yuan) and R410A at 55,100 yuan/ton (+1,900 yuan) [2] - MicroPort Scientific Corporation (02252) increased over 1.2%, reporting that its core products' cumulative order volume exceeded 230 units [2] - Oil stocks saw gains, with CNOOC (00883) up 4.17%, PetroChina (00857) up 2.91%, and Sinopec (00386) up 1.31%, driven by a rise in international crude oil prices due to geopolitical tensions [2] - Baidu Group (09888) rose nearly 7% after announcing a partnership with Uber and Lyft to launch a robotaxi pilot project in the UK by 2026 [2] Group 3 - NIO (09866) rose over 2.4% after announcing that it successfully delivered over 40,000 units of its new ES8 model within 100 days of the official delivery start [3] - Damai Entertainment (01060) increased nearly 5%, with the total box office for the 2025 New Year’s season reaching 5.245 billion yuan as of December 28 [3] Group 4 - Copper mining stocks collectively declined, with Hudbay Minerals (HBM.US) down 4.01%, Taseko Mines (TGB.US) down 3.1%, and Ero Copper (ERO.US) down 1.64%, as international copper futures fell over 4% [5] - Some cryptocurrency-related stocks fell, with IREN Ltd (IREN.US) down 2.21% and Circle (CRCL.US) down 0.94% [5] - NIO (NIO.US) rose 4.71% in the US market, echoing its performance in Hong Kong [6] - The Nasdaq Golden Dragon Index fell nearly 1%, with major Chinese concept stocks declining, including Alibaba (BABA.US) down 2.46% and Xpeng Motors (XPEV.US) down 1.35% [6]