Core Viewpoint - CICC has downgraded the revenue forecast for Hutchison China MediTech (00013) for 2025 by 12.4% to $594 million, and the net profit forecast for 2026 by 65% to $35 million, while maintaining the 2025 net profit forecast at $366 million due to the timing of equity sale gains. The target price remains at HKD 30, indicating a potential upside of 24.7% from the current stock price [1]. Group 1 - The company's 1H25 performance was below expectations, with revenue of $278 million, down 9% year-on-year, primarily due to lower domestic product sales. The net profit attributable to shareholders was $455 million, mainly due to gains from the sale of non-core business equity. The comprehensive revenue from the oncology immunotherapy business in 1H25 was $144 million, down 15% year-on-year, leading to a downward revision of the full-year revenue guidance from $350-450 million to $270-350 million [2]. Group 2 - The overseas sales of furmonertinib reached $163 million in 1H25, up 25% year-on-year, showing steady growth. The drug has been approved for sale in over 30 countries and regions, expanding insurance reimbursement coverage and increasing market share. However, domestic sales of furmonertinib, savolitinib, and surufatinib declined year-on-year due to sales structure adjustments and changes in the competitive landscape. The company expects improved sales trends in the second half of the year due to new indications for savolitinib and successful overseas sales of furmonertinib [3]. Group 3 - The antibody-drug conjugate (ATTC) candidate HMPL-A251 is expected to enter clinical trials in the second half of 2025, having shown good proof of concept in preclinical models. The company plans to initiate Phase 1 clinical studies in China and the U.S. in 2H25, with two other candidates, HMPL-A580 and HMPL-A830, set to start Phase 1 clinical studies in 2026. Attention is recommended for the clinical validation of this next-generation technology platform [4]. Group 4 - The company anticipates completing the enrollment for savolitinib SAFFRON in 2H25, with data readout expected in 1H26. The SANOVO enrollment is also expected to be completed in 2H25. The application for the re-submission of surufatinib in China is planned for 1H26, and the data for surufatinib in first-line pancreatic ductal adenocarcinoma is expected to be read out in 2H25 [5].

中金发布研报称，考虑到和黄医药(00013)国内产品销售趋势，下调2025年收入预测12.4%至5.94亿美 元，下调2026年归母净利润65%至0.35亿美元。但考虑到出售股权收益的确认节奏，该行基本维持2025 年归母净利润预测3.66亿美元不变。该行维持跑赢行业评级，考虑到公司创新管线进展顺利，基于DCF 模型，维持目标价30港币不变，较当前股价有24.7%的上行空间。 ATTC有望下半年进入临床 根据公司公告，公司抗体靶向偶联药物(ATTC)候选药物HMPL-A251已经在临床前模型中得到了较好的 概念验证，并展示出与化疗联用治疗更早线肿瘤的潜力。公司计划将在2H25启动中国和美国的1期临床 研究，另外两个候选药物HMPL-A580和HMPL-A830将陆续在2026年启动1期临床研究，建议关注该新 一代技术平台的临床验证。 其它研发进展 根据公司公告：公司预计2H25完成赛沃替尼SAFFRON入组，1H26读出数据，2H25完成SANOVO入组; 索乐匹尼布拟于1H26重新递交中国上市申请;索凡替尼将于2H25读出胰腺一线导管腺癌数据。 风险提示：研发失败，竞争格局恶化，审评审批不及预期，费用超预期 ...

Investment Rating - The report maintains a "Buy" rating for the company [1][7][13] Core Insights - The company recently received approval for a new indication of Savolitinib, which will expand its treatment options for lung cancer patients [6] - The ATTC pipeline is set to enter clinical development, with the first candidate expected to begin trials by the end of 2025 [6] - The company's revenue for the first half of 2025 was $278 million, a year-on-year decrease of 9.16%, primarily due to increased competition in the Chinese market [4][5] Financial Performance - The company reported a net profit of $455 million for the first half of 2025, benefiting from the sale of a 45% stake in Shanghai Hutchison Pharmaceuticals, which generated $416 million in after-tax proceeds [4] - The revenue forecast for 2025, 2026, and 2027 is $610 million, $695 million, and $771 million respectively, with expected growth rates of -3.22%, 13.88%, and 11.07% [7][9] - The projected net profit for the same years is $419 million, $113 million, and $136 million, with growth rates of 1,011.38%, -73.01%, and 20.58% respectively [7][9] Product Performance - Domestic sales of Furmonertinib (爱优特®) decreased by 29.51% year-on-year to $43 million due to intensified competition [5] - However, overseas sales of Furmonertinib (FRUZAQLA®) increased by 24.75% year-on-year to $163 million, attributed to market expansion into over 30 countries [5] Market Position - The company’s stock has a market capitalization of HKD 210.7 billion, with a 12-month high of HKD 34.8 and a low of HKD 18.36 [3]

Investment Rating - The report assigns a rating of "Accumulate" to the company, which has been downgraded from a previous rating [1]. Core Views - The company's performance in the first half of 2025 was slightly below expectations, but a turnaround is anticipated in the second half of the year [1]. - The total revenue for H1 2025 was reported at $280 million, reflecting a year-on-year decline of 9.2% [7]. - The company has adjusted its revenue guidance for the full year 2025 to between $270 million and $350 million for its oncology/immunology segment [7]. Financial Summary - Total revenue projections for 2023A, 2024A, 2025E, 2026E, and 2027E are $838 million, $630.2 million, $560 million, $635.91 million, and $711.90 million respectively, with year-on-year changes of 96.52%, -24.80%, -11.14%, 13.55%, and 11.95% [1]. - The net profit attributable to the parent company is forecasted to be $100.78 million, $37.73 million, $413.55 million, $14.50 million, and $62.82 million for the same years, with year-on-year changes of 127.93%, -62.56%, 996.09%, -96.49%, and 333.23% [1]. - The latest diluted EPS is projected to be $0.12, $0.04, $0.47, $0.02, and $0.07 for the years 2023A to 2027E [1]. - The P/E ratios for the years 2023A, 2024A, 2025E, 2026E, and 2027E are 26.55, 70.92, 6.47, 184.55, and 42.60 respectively [1]. Key Catalysts - The report highlights several important catalysts for the company, including the potential participation of the drug "Sewotini" in the national medical insurance negotiations by the end of this year [7]. - The global Phase III study for "Sewotini" is expected to read out data in the first half of 2026, with plans to submit for FDA approval [7]. - The company is also working on new drug candidates through its innovative antibody-drug conjugate (ATTC) platform, with plans to enter clinical development by the end of 2025 [7].

Core Viewpoint - Daiwa has downgraded the revenue forecast for Hutchison China MediTech (00013) for the years 2025 to 2027 by 16% to 29% due to lowered domestic drug sales expectations [1] Revenue Forecast - The new projections for total drug sales are expected to grow by 6%, 21%, and 28% for the years 2025, 2026, and 2027 respectively, compared to previous estimates of 34%, 36%, and 33% [1] - The latest net profit estimates are $433 million, $30 million, and $40 million for the years 2025, 2026, and 2027 respectively [1] Rating and Target Price - Daiwa maintains a "Buy" rating for Hutchison China MediTech, with a target price reduced from HKD 33 to HKD 30 [1] Sales Performance - The company's product sales in the first half of the year decreased by 4% year-on-year to $234 million, primarily due to competitive risks in the domestic market, team restructuring, and industry anti-corruption impacts [1] Drug Development Progress - The progress of Sovleplenib has been delayed, with the company aiming to resubmit its application in the first half of next year [1] - The group plans to advance the development of a new generation Syk inhibitor, with an IND application expected to be submitted in the second quarter of next year [1] Positive Developments - The ATTC platform has achieved breakthroughs, with the first candidate drug HMPL-A251's IND application set to be submitted in early September, and preclinical data to be presented at the EORTC conference [1] - Two additional ATTC drugs are expected to initiate Phase I clinical trials next year [1] Profit Performance - The company reported a net profit of $455 million in the first half of the year, compared to $26 million in the same period last year, mainly due to the sale of part of its non-core joint venture equity, generating $416 million in revenue [1]

Core Viewpoint - Daiwa has downgraded the revenue forecast for Hutchison China MediTech (00013) for the years 2025 to 2027 by 16% to 29% due to lowered domestic drug sales expectations, while maintaining a "Buy" rating and reducing the target price from HKD 33 to HKD 30 [1] Revenue Forecast - The new projections for total drug sales are expected to grow by 6%, 21%, and 28% for the years 2025, 2026, and 2027 respectively, compared to previous estimates of 34%, 36%, and 33% [1] - The latest net profit estimates are projected to be USD 433 million, USD 30 million, and USD 40 million for the years 2025, 2026, and 2027 respectively [1] Sales Performance - In the first half of the year, Hutchison China MediTech's product sales decreased by 4% year-on-year to USD 234 million, primarily due to competitive risks in the domestic market, team restructuring, and industry anti-corruption impacts [1] Product Development - The progress of Sovleplenib has been delayed, with the company aiming to resubmit its application in the first half of next year [1] - The group plans to advance the development of a new generation Syk inhibitor, with an IND application expected to be submitted in the second quarter of next year [1] Positive Developments - The ATTC platform has achieved breakthroughs, with the first candidate drug HMPL-A251's IND application set to be submitted in early September, and preclinical data to be announced at the EORTC conference [1] - Two additional ATTC drugs are expected to initiate Phase I clinical trials next year [1] Financial Performance - The net profit for the first half of this year reached USD 455 million, compared to USD 26 million in the same period last year, primarily due to the sale of part of a non-core joint venture, generating USD 416 million in revenue [1]

Core Viewpoint - The report from CMB International maintains a "Buy" rating for Hutchison China MediTech (00013), highlighting the differentiated ATTC platform while lowering sales forecasts for the company's three major commercial products and adjusting the target price to HKD 37.6 [1] Group 1: Financial Performance - The company's revenue for the first half of the year decreased by 9% year-on-year, with oncology/immunology revenue dropping by 15%, falling short of both the bank's and market expectations [1] - Management has revised the full-year 2025 guidance for oncology/immunology revenue from USD 350 million to USD 450 million down to USD 270 million to USD 350 million [1] - The company significantly narrowed its operating losses in the first half and is expected to achieve operational breakeven starting in the second half of the year [1] Group 2: Product Development - The first candidate drug from the differentiated ATTC platform, HMPL-A251, is expected to initiate Phase I studies for solid tumors in China and the U.S. in the second half of the year [1] - Two additional ATTC molecules are anticipated to enter clinical trials by 2026, presenting potential business development opportunities [1]

Core Viewpoint - The report from CMB International maintains a "Buy" rating for Hutchison China MediTech (00013), highlighting the differentiated ATTC platform while lowering sales forecasts for the company's three major commercial products and adjusting the target price to HKD 37.6 [1] Group 1: Financial Performance - The company's revenue for the first half of the year decreased by 9% year-on-year, with oncology/immunology revenue dropping by 15%, falling short of both the bank's and market expectations [1] - Management has revised the full-year 2025 revenue guidance for oncology/immunology from USD 350 million to USD 450 million down to USD 270 million to USD 350 million [1] - The company has significantly narrowed its operating loss in the first half and is expected to achieve operational breakeven starting in the second half of the year [1] Group 2: Product Development - The first candidate drug HMPL-A251 from the differentiated ATTC platform is expected to initiate Phase I studies for solid tumors in China and the U.S. in the second half of the year [1] - Two additional ATTC molecules are anticipated to enter clinical trials by 2026, presenting potential business development opportunities [1]

Core Viewpoint - The report from CMB International indicates that Hutchison China MediTech's revenue from oncology and immunology products decreased by 15% year-on-year to $144 million, achieving only 36% of the annual forecast due to a decline in domestic sales of core products [1] Group 1: Financial Performance - Revenue from oncology and immunology products fell to $144 million, a 15% decrease compared to the previous year [1] - The company has revised its full-year revenue target for oncology and immunology products from $350 million to $450 million down to $270 million to $350 million [1] Group 2: Management Outlook - Management remains optimistic for the second half of the year, citing the launch of fruquintinib for endometrial cancer and the approval of savolitinib for MET+ EGFRm non-small cell lung cancer as key drivers [1] - The sales team restructuring has been completed, and management noted that sales hit a bottom in the first quarter and began to recover in the second quarter [1] Group 3: Analyst Ratings and Price Target - CMB International maintains a "Buy" rating on the stock despite the underwhelming first-half performance and lowered guidance [1] - The target price has been adjusted from HKD 34.03 to HKD 31.39 [1]

Core Viewpoint - Daiwa's research report indicates that Hutchison China MediTech's product sales in the first half of the year decreased by 4% year-on-year to $234 million, primarily due to competitive risks in the domestic market, team restructuring, and industry anti-corruption impacts [1] Group 1: Sales Performance - The company's product sales for the first half of the year were $234 million, reflecting a 4% year-on-year decline [1] - The decline in sales is attributed to competitive risks, team restructuring, and the impact of industry anti-corruption measures [1] Group 2: Product Development and Pipeline - The progress of Sovleplenib has been delayed, with the company aiming to resubmit its application in the first half of next year [1] - The group plans to advance the development of a new generation Syk inhibitor, with an IND application expected to be submitted in the second quarter of next year [1] - The ATTC platform has achieved breakthroughs, with the first candidate drug HMPL-A251's IND application set to be submitted in early September, and preclinical data to be presented at the EORTC conference [1] - Two additional ATTC drugs are expected to initiate Phase I clinical trials next year [1] Group 3: Financial Forecasts - Based on the downward adjustment of domestic drug sales expectations, the revenue forecasts for 2025 to 2027 have been reduced by 16% to 29% [1] - The revised projections for total drug sales are expected to grow by 6%, 21%, and 28% in 2025, 2026, and 2027 respectively, compared to previous estimates of 34%, 36%, and 33% [1] - The latest net profit estimates are $433 million, $30 million, and $40 million for 2025, 2026, and 2027 respectively [1] Group 4: Rating and Target Price - The company maintains a "Buy" rating, with the target price adjusted from HKD 33 to HKD 30 [1]