香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不 對因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 HUTCHMED (China) Limited 和黃醫藥（中國）有限公司 （於開曼群島註冊成立的有限公司） （股份代號：13） | 摘要標題 | 報告人/ 主要作者 | 報告詳情 | | --- | --- | --- | | 研究者發起的研究 | | | | 索凡替尼、度伐利尤單抗聯合化療用於一線治療廣泛期小細胞肺癌的療效及 | 張卉/ 胡瑛，北京胸科 | P3.13.22 | | 安全性 | 醫院，中國北京 | 海報展示 Poster: Small Cell Lung | | Efficacy and Safety of Surufatinib, Durvalumab in Combined with | | Cancer and Neuroendocrine | | Chemotherapy as First-line Treatment of Extensive-stage Small-cell ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 和黃醫藥（中國）有限公司 呈交日期: 2025年9月1日 II. 已發行股份及/或庫存股份變動 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | 是 | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 00013 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 1,500,000,000 | USD | | 0.1 USD | | | 150,000,000 | | 增加 / 減少 (-) | | | 0 | | | USD | | | | | 本月底結存 | | | 1,500,000,000 | USD | | 0.1 USD | | | 1 ...

Core Viewpoint - The announcement from Hutchison China MediTech Limited (HutchMed) regarding the temporary suspension of its CEO due to health reasons and the appointment of the CFO as acting CEO [1] Company Summary - HutchMed's board has acknowledged that the CEO, Su Weiguo, will pause his duties for health reasons [1] - The board has appointed Zheng Zefeng, the executive director and CFO, to serve as the acting CEO effective immediately [1]

中新网上海8月26日电 (记者 郑莹莹)2024年度上海市科学技术奖26日在沪揭晓，和黄医药以"中国一类 新药呋喹替尼的自主研发与产业化"项目摘得科技进步奖一等奖。 呋喹替尼是中国首个从药物发现到临床开发均在中国本土自主完成的肿瘤药物，也是上海首个在欧美市 场和日本市场均获批的原创新药。 "产品要经历全球化考验，就要全链条按国际标准去做。"和黄医药执行副总裁崔昳昤近日在受访时说。 她在受访时讲起当时的出海选择：造船出海还是借船出海？崔昳昤透露，其实和黄医药最初是想造船出 海的，甚至在美国设立了商业化团队，但后来发现这远远不够，鉴于企业体量以及时间成本等考量，于 是决定借船出海。 "不仅是资金等投入，更重要的是时间。因为很多创新药产品出来后是在跟时间赛跑，哪个产品先上 市，哪个产品成功商业化的机会越大。"她说。 2023年1月，和黄医药与武田签订呋喹替尼在中国以外地区的相关许可协议，提速医药创新的"全球化之 路"。2023年11月，呋喹替尼在美国获批进入当地医药市场。 "2024年在美国上市的首个完整年，呋喹替尼的海外市场销售额达2.9亿美元。""截至2024年年底，呋喹 替尼已经在中国、美国、欧盟、日本等市场 ...

Group 1 - The 2024 Shanghai Science and Technology Awards announced a total of 206 awarded projects, with 49% of the 686 participating units being enterprises, including 93 private companies [1] - Nearly half of the high-level awarded projects are related to integrated circuits, biomedicine, and artificial intelligence [1] - The first prize for scientific progress was awarded to "The Independent Research and Industrialization of a Class 1 New Drug, Fuqunatin," developed by Hutchison China MediTech Ltd. [1] Group 2 - Hutchison China MediTech's team created a three-in-one innovation system for targeted therapy of metastatic colorectal cancer, leading to the development of Fuqunatin, which has been approved in over 30 countries [3] - Fuqunatin has achieved over 8 billion yuan in overseas technology licensing and is projected to exceed 2.9 billion yuan in global sales in 2024 [3] - The drug significantly improves patient outcomes, extending overall survival by 2.7 months and reducing the risk of death by 35% [3][4] Group 3 - The company implemented a randomized controlled dose optimization clinical scheme, which was nine years ahead of similar guidelines from the FDA [4] - The team explored both continuous and intermittent dosing methods, ultimately establishing a dose that is effective for both Chinese and global patients [5] - The company emphasizes the importance of talent, technology, and international vision for the successful globalization of innovative drugs [5]

Group 1 - The Shanghai Science and Technology Awards 2024 recognized a total of 206 awards, including various categories such as the Shanghai Science and Technology Progress Award and the Shanghai International Science and Technology Cooperation Award [1] - Among the award recipients, 1,171 individuals under the age of 45 accounted for 65% of the total, indicating a growing recognition of young scientists in Shanghai's innovation landscape [2] - The number of enterprises involved in award-winning projects reached 336, representing 49% of all completion units, with a notable increase in participation from private enterprises [3] Group 2 - The focus on technology transfer and industrial application is emphasized, with 34 projects directly mentioning "application," making up 54% of high-level award-winning results [4] - The Shanghai government is actively promoting the construction of an international technology innovation center, supporting both state-owned and private enterprises in innovation and development [5] - The success of young scientists and enterprises is seen as a vital source of innovation for Shanghai's technological ecosystem [6]

HUTCHMED (China) Limited 和黃醫藥（中國）有限公司 （於開曼群島註冊成立的有限公司） （股份代號：13） 董事名單及其角色與職能 和黃醫藥(中國)有限公司董事會由 9 名董事組成，載列如下： 主席兼非執行董事 施熙德女士 楊凌女士 獨立非執行董事 莫樹錦教授 （高級兼首席獨立非執行董事） Dr Renu BHATIA（言思雅醫生） Dr Chaohong HU（胡朝紅博士） 黃德偉先生 下表提供董事會成員在委員會中之職務。 | 董事委員會 | 審核委員會 | 提名委員會 | 薪酬委員會 | 可持續發展 | 技術委員會 | | --- | --- | --- | --- | --- | --- | | 董事 | | | | 委員會 | | | 艾樂德 | - | M | - | - | M | | 蘇慰國 | - | - | - | - | M | | 鄭澤鋒 | - | - | - | M | - | | 施熙德 | - | - | M | C | - | | 楊凌 | - | - | - | - | - | | 莫樹錦 | - | C | - | M | C | | 言思雅 | M ...

Core Viewpoint - The management change at Hutchison China MediTech (HCM) reflects a strategic shift from a research-driven model to a dual focus on research and commercialization, aiming to enhance the market realization of its pipeline value [5] Financial Performance - HCM reported total revenue of $277.7 million for the first half of 2023, down from $305.7 million in the same period last year [2] - The net profit attributable to HCM for the first half of 2023 was $455 million, a significant increase from $25.8 million in the previous year [2] Product Performance - Total sales of oncology products amounted to $234 million, a decline of 4% year-on-year [3] - Overseas sales of the main product, fruquintinib, reached $163 million, up 25% year-on-year, while domestic sales fell by 29% to $43 million [3] - Other oncology products, such as surufatinib and savolitinib, experienced significant declines in sales, with surufatinib down 50% and savolitinib down 41% [3] - The overall revenue from the oncology immunotherapy business decreased by 14.9% [3] Strategic Transition - HCM is at a "triple turning point," focusing on expanding market share and indications for core products, enhancing pipeline value, and implementing international strategies [4] - The management change is seen as a necessary step to support the transition from a domestic leader to an international biopharmaceutical company [5] Future Outlook - HCM plans to initiate Phase I clinical trials for new candidates in late 2025, with additional candidates expected to enter trials in 2026 [5] - The company aims to achieve a performance turning point by the second half of 2025, contingent on the approval of fruquintinib in more overseas markets and the advancement of new indications for savolitinib [5]

Group 1 - The company announced that its executive director, Su Weiguo, will suspend his role as CEO due to health reasons [1] - The board has appointed Zheng Zefeng, the company's executive director and CFO, as the acting CEO effective immediately [1] - Zheng will oversee the company's ongoing operations and management during the transition period to ensure continuity in leadership and decision-making [1]

Core Viewpoint - The company announced that its CEO, Su Weiguo, will temporarily suspend his duties due to health reasons, and CFO Zheng Zefeng has been appointed as the acting CEO to ensure continuity in leadership and decision-making [1] Group 1 - The board of directors has acknowledged the temporary suspension of the CEO's duties due to health issues [1] - Zheng Zefeng, who is currently the executive director and CFO, will take on the role of acting CEO effective immediately [1] - During this transitional period, Zheng will oversee the company's daily operations and management [1]