Earnings Report - Eli Lilly is set to release its Q1 earnings results on May 1, with expected earnings of $3.46 per share, an increase from $2.58 per share year-over-year [1] - The company projects quarterly revenue of $12.72 billion, up from $8.77 billion in the same period last year [1] Clinical Trial Results - On April 17, Eli Lilly reported positive Phase 3 results from the ACHIEVE-1 trial of orforglipron for adults with type 2 diabetes [2] - Following the announcement, Eli Lilly shares rose by 1.6%, closing at $898.95 [2] Analyst Ratings - HSBC downgraded Eli Lilly from Buy to Reduce, lowering the price target from $1,150 to $700 [8] - Guggenheim maintained a Buy rating but reduced the price target from $973 to $928 [8] - Morgan Stanley kept an Overweight rating, cutting the price target from $1,146 to $1,124 [8] - Goldman Sachs upgraded the stock from Neutral to Buy, lowering the price target from $892 to $888 [8] - Wells Fargo maintained an Overweight rating and increased the price target from $970 to $1,100 [8]

Eli Lilly And Co LLY will be reporting its first-quarter earnings on Thursday. Wall Street expects $3.05 in EPS and $12.67 billion in revenues as the company reports before market hours.The stock is up 14.35% over the past year, 14.79% YTD.Let’s examine the charts for Eli Lilly stock and how it currently compares to Wall Street estimates.Read Also: $1000 Invested In This Stock 20 Years Ago Would Be Worth This Much TodayLLY Stock Chart Strongly Bullish Ahead Of Q1 EarningsChart created using Benzinga ProEli ...

Group 1: Company Overview - Eli Lilly is the most valuable healthcare company globally, with a market cap of approximately $800 billion, and is considered a promising long-term investment due to its dominance in the GLP-1 drug market [1] - The company experienced a 32% increase in sales last year, driven by the popularity of its GLP-1 drugs, Zepbound and Mounjaro, which generated a combined $16.5 billion in sales [2][6] Group 2: Legal and Market Challenges - Eli Lilly is suing compounding pharmacies that have been offering knock-off versions of its GLP-1 drugs, which could divert sales and negatively impact the brand's perception if patients experience side effects from these unapproved products [3][4] Group 3: Future Growth Catalysts - Eli Lilly is developing a daily weight loss pill, orforglipron, which could significantly change the industry landscape, as current GLP-1 treatments are injectables [5] - Positive results from a late-stage trial of orforglipron indicate potential for weight loss and blood sugar reduction, boosting investor confidence [6] - The company plans to release data from nine studies related to orforglipron's performance throughout the year, with the final results expected in October [7] - Approval for orforglipron could occur next year, and strong trial results may lead to significant stock price increases [8] Group 4: Investment Considerations - Despite trading at over 70 times its trailing earnings, Eli Lilly is viewed as a potentially strong buy due to anticipated growth, especially if the weight loss and diabetes pill receives approval [9]

Group 1 - Recent developments have been unfavorable for Novo Nordisk A/S, particularly as competitor Eli Lilly has gained a significant advantage in the obesity and adjacent markets [2] - The Growth Stock Forum focuses on identifying attractive risk/reward situations in growth stocks, particularly in the biotech sector, and maintains a model portfolio of 15-20 stocks [2] Group 2 - The article emphasizes the importance of tracking portfolio and watchlist stocks closely to identify potential investment opportunities [2] - The Growth Stock Forum also provides a top picks list of up to 10 stocks expected to perform well in the current calendar year, along with trading ideas for short-term and medium-term moves [2]

Financial Data and Key Metrics Changes - The company reported a strong cash position of $243 million as of December 2024, providing a cash runway into 2027 [42] Business Line Data and Key Metrics Changes - FHD-909 is highlighted as a highly selective oral inhibitor of SMARCA2, with multibillion-dollar potential, particularly targeting SMARCA4 mutated non-small cell lung cancer [5][6] - The collaboration with Eli Lilly, initiated in December 2021, is noted as one of the largest deals for preclinical programs in the industry, with significant upfront payment and downstream participation for the company [7] Market Data and Key Metrics Changes - SMARCA4 mutations are found in approximately 5% of all human cancers, with non-small cell lung cancer showing about 10% prevalence of these mutations [11] - The median overall survival for patients with SMARCA4 mutations in metastatic non-small cell lung cancer is reported at 8 months, compared to 15 months for wild-type counterparts [12] Company Strategy and Development Direction - The company aims to develop FHD-909 as a standard frontline therapy for patients with non-small cell lung cancer harboring SMARCA4 mutations, addressing a significant unmet medical need [28][29] - The strategy includes defining the potential added benefit of FHD-909 in combination with leading therapies such as pembrolizumab and platinum-based combinations [19][20] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the potential of FHD-909 to change the treatment landscape for patients with SMARCA4 mutations, emphasizing the urgent need for novel agents in this area [29] - The company is focused on advancing its proprietary pipeline programs, including selective CBP and EP300 degraders, which are expected to enhance its position in oncology [31][32] Other Important Information - The company is currently enrolling patients in the monotherapy dose-finding portion of the FHD-909 study, with plans for combination studies in anticipation of successful dose escalation [29] - The proprietary pipeline includes three additional programs that are advancing toward the clinic, showcasing the company's commitment to innovative cancer therapies [31] Q&A Session Summary Question: Can you enrich the backfill cohorts for specific characteristics? - Yes, the company can select specific doses and backfill those levels with specific indications and SMARCA4 alterations [45] Question: How will trial progress be communicated? - The company intends to align with Eli Lilly on clinical data disclosure, aiming to communicate results at the end of dose escalation [46] Question: Are SMARCA4 alterations detectable through standard panels? - Yes, SMARCA4 alterations can be detected using conventional FDA-approved NGS panels and immunohistochemistry [61] Question: What is the therapeutic index for FHD-909? - The dosing holidays at the higher dose were due to accumulation in rodents, not a lack of tolerability, indicating a favorable therapeutic window [62] Question: What is the potential for the ARED1B degrader program? - The company is excited about the selective degradation of ARED1B and is waiting for a complete story before disclosing further updates [74] Question: Will there be partnerships for the proprietary pipeline? - The company is not in a rush to partner but anticipates that strategic partnerships will be beneficial as they progress their proprietary pipeline [76]

Group 1 - Goldman Sachs analysts predict that oral GLP-1 weight loss drugs will become a significant product cycle in the biopharmaceutical sector, capturing 24% and 32% of the weight loss drug market by 2030 and 2035, respectively, with market sizes reaching $22.3 billion and $38.1 billion [1] - Pfizer's danuglipron has been removed from the weight loss drug market model, with previous sales forecasts of $1.2 billion and $1.9 billion for 2030 and 2035, respectively [1] - The market share forecast for Eli Lilly's orforglipron has been increased, with adjusted risk-adjusted sales predictions of $1 billion in 2026, $17.2 billion in 2030, and $24.5 billion in 2035 [1] Group 2 - Goldman Sachs maintains its sales forecast for Novo Nordisk's oral semaglutide at $5.3 billion, noting that despite Eli Lilly's expected market advantage, there remains market space for oral semaglutide 25mg due to low likelihood of generic entry and extended price protection until orforglipron's patent expiration [2] - The obesity market is being segmented by BMI and treatment type (oral vs. injectable), with oral medications likely to attract more patients; approximately 50% of patients may prefer oral medications despite lower efficacy compared to injectables [2] - The expected average net price for the first oral drugs (Eli Lilly's orforglipron and Novo Nordisk's oral semaglutide 25mg) is around $650, projected to decrease to $457 and $308 by 2030 and 2035, respectively, approaching the pricing of injectable drugs [2]

Core Points - CEOs from major companies including Nvidia, Johnson & Johnson, Eli Lilly, General Electric, and SoftBank will visit the White House [1] - President Trump will highlight the investment plans these companies announced within his first 100 days in office [1] - The event will include representatives from defense, technology, healthcare, and consumer goods industries, as well as investment funds [1] - Products from the participating companies will be showcased at the White House [1]

智通财经4月29日电，英伟达、礼来等公司的首席执行官周三将造访白宫。 ...

Group 1 - Eli Lilly and Company has experienced favorable conditions in the obesity and adjacent markets over the last couple of quarters [2] - The main competitor in this space is Novo Nordisk A/S, indicating a competitive landscape [2] Group 2 - The article emphasizes the importance of tracking portfolio and watchlist stocks closely to identify attractive risk/reward situations [2]

Industry Overview - The first-quarter earnings season for the drug and biotech sector is underway, with major companies like Pfizer, Eli Lilly, Amgen, Biogen, and Regeneron set to announce results [1] - Johnson & Johnson and Merck have reported results, both exceeding first-quarter estimates for earnings and sales, while Sanofi had mixed results, beating earnings estimates but missing sales [1] Earnings Trends - As of April 23, 15% of companies in the Medical sector, representing 33.8% of the sector's market capitalization, reported quarterly earnings, with 77.8% surpassing estimates for both earnings and revenues [3] - Year-over-year earnings increased by 4.7%, and revenues rose by 9.4% [3] - Overall, first-quarter earnings for the Medical sector are expected to increase by 35%, while sales are projected to rise by 7.8% compared to the previous year [3] Company Performance Pfizer (PFE) - Pfizer has consistently exceeded earnings expectations in the last four quarters, with an average earnings surprise of 44.16% [5] - The Zacks Consensus Estimate for first-quarter sales and earnings is $13.88 billion and 64 cents per share, respectively [6] - Non-COVID operational revenues are driving growth, supported by products like Vyndaqel, Padcev, and Eliquis, despite a decline in sales of COVID products [7] Eli Lilly (LLY) - Eli Lilly has had mixed performance, exceeding earnings expectations in three of the last four quarters, with an average earnings surprise of 8.47% [8] - The Zacks Consensus Estimate for sales and earnings is $12.62 billion and $3.52 per share, respectively [8] - Growth is expected to be driven by demand for FDA-approved tirzepatide medicines, although sales of Mounjaro and Zepbound were below expectations [9][10] Amgen (AMGN) - Amgen has shown strong performance, beating earnings estimates in each of the last four quarters, with an average earnings surprise of 5.23% [11] - The Zacks Consensus Estimate for first-quarter sales and earnings is $7.96 billion and $4.15 per share, respectively [11] - Product sales are expected to be driven by strong volume growth, although prices may decline due to higher rebates [12] Biogen (BIIB) - Biogen has consistently beaten earnings estimates in the last four quarters, with an average earnings surprise of 11.80% [13] - The Zacks Consensus Estimate for sales and earnings is $2.23 billion and $3.52 per share, respectively [13] - Lower sales of multiple sclerosis drugs are likely to be offset by revenues from new drugs [14] Regeneron (REGN) - Regeneron has had mixed results, surpassing earnings expectations in three of the last four quarters, with an average earnings surprise of 3.23% [16] - The Zacks Consensus Estimate for first-quarter sales and earnings is $3.28 billion and $8.43 per share, respectively [17] - Sales of Eylea are expected to have declined due to competition, but sales of Eylea HD and Dupixent are likely to have surged [18][19]