通化东宝药业股份有限公司 控股股东及其他关联方资金占用情况的 专项说明 德皓核字[2025]]00000925 号 北 京 德 皓 国 际 会 计 师 事 务 所 (特 殊 普 通 合 伙 ) Beijing Dehao International Certified Public Accountants (Limited Liability Partnership) 通化东宝药业股份有限公司 控股股东及其他关联方资金占用情况的专项说明 （截止 2024 年 12 月 31 日） 目 录 页 次 第 1 页 一、 控股股东及其他关联方资金占用情况的专项 说明 1-2 二、 通化东宝药业股份有限公司 2024 年度非经营 性资金占用及其他关联资金往来情况汇总表 1 控 股 股 东 及 其 他 关 联 方 德皓核字[2024] 00000925 号关联方资金占用情况的专项说明 东宝 2024 年度财务报表时所复核的会计资料和经审计的财务报表的 相关内容进行了核对，在所有重大方面未发现不一致。除了对通化东 宝实施 2024 年度财务报表审计中所执行的对关联方交易有关的审计 程序外，我们未对汇总表所载资料执行额外的审 ...

证券代码：600867 证券简称：通化东宝 公告编号：2025-041 通化东宝药业股份有限公司 2025年第一次临时股东会决议公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 本次会议是否有否决议案：无 一、 会议召开和出席情况 (一)股东会召开的时间：2025 年 6 月 9 日 (二)股东会召开的地点：公司会议室 (三)出席会议的普通股股东和恢复表决权的优先股股东及其持有股份情况： | 1、出席会议的股东和代理人人数 | 938 | | --- | --- | | 2、出席会议的股东所持有表决权的股份总数（股） | 844,436,653 | | 3、出席会议的股东所持有表决权股份数占公司有表决权股 | | | 份总数的比例（%） | 43.4501 | (四)表决方式是否符合《公司法》及《公司章程》的规定，大会主持情况等。 本次会议由公司董事会召集，公司董事长李佳鸿先生主持会议。会议采用现 场投票和网络投票相结合的表决方式。本次会议的召集、召开符合《公司法》和 《公司章程》的有关规定。 1 (五)公 ...

吉林秉责律师事务所 关于通化东宝药业股份有限公司 二 0 二五年第一次临时股东会的法律意见书 致：通化东宝药业股份有限公司 根据《中华人民共和国证券法》（以下简称"证券法"）、《中华人民共和国 公司法》（以下简称《公司法》）、《上市公司股东会规则》（以下简称《股东会规 则》）和《通化东宝药业股份有限公司章程》（以下简称《公司章程》）的有关规 定，吉林秉责律师事务所（以下简称"本所"）接受了通化东宝药业股份有限公 司（以下简称"公司"）的委托，担任公司 2025 年第一次临时股东会（以下简称 "本次股东会"）特聘专项法律顾问并出具法律意见书。 本法律意见书仅供公司为本次股东会之目的而使用，不得用于其他任何目 的。本所同意公司将本法律意见书作为本次股东会的公告材料，随其他需要公告 的信息一起向公众披露，并依法对本所在其中发表的法律意见承担责任。 为出具本法律意见书，本所指派郭淑芬、商家碧律师出席了公司于 2025 年 6 月 9 日上午 10 时在公司会议室召开的本次股东会，审查了公司提供的与召开 本次股东会有关的文件和资料，并进行了验证。在此基础上，本所按照律师行业 公认的业务标准、道德规范和勤勉尽责的精神发表 ...

Investment Rating - The report maintains an optimistic outlook on the pharmaceutical industry, particularly focusing on the potential growth in the gout medication market and ongoing drug development [11][18]. Core Insights - The pharmaceutical sector is currently undervalued, with public funds showing low allocation to this sector. The report anticipates a recovery driven by macroeconomic factors and significant product launches in the industry by 2025 [11]. - The report emphasizes the importance of innovative drugs, particularly in the gout treatment space, highlighting the shift from quantity to quality in drug development [11][20]. - The report identifies several key companies and products to watch, including innovative drug developers and medical device manufacturers, suggesting a diversified investment approach [11][12][18]. Summary by Sections Market Overview - The report notes that the CITIC pharmaceutical index rose by 1.22%, outperforming the CSI 300 index by 0.34 percentage points, ranking 16th among 30 sectors [8]. - The top-performing stocks in the pharmaceutical sector include Yiming Pharmaceutical and Wanbangde, while the worst performers include Longjin Retreat and Huasen Pharmaceutical [8]. Gout Treatment Market - The report highlights the significant market potential for gout medications, with a projected market size of approximately 1.821 billion yuan in 2024. The report notes that the market for febuxostat is expected to decline due to its inclusion in national procurement [20]. - The report outlines the two main therapeutic approaches for gout: inhibiting uric acid production and promoting uric acid excretion, with key drugs identified for each approach [20][21]. Innovative Drug Development - The report provides an overview of ongoing clinical trials for gout medications, particularly focusing on URAT1 inhibitors, which are currently the most promising targets in drug development [22][35]. - It highlights the progress of SHR4640, a URAT1 inhibitor developed by Hengrui Medicine, which has shown promising results in clinical trials and is expected to be the first domestic URAT1 inhibitor to be approved [26]. Medical Devices and Equipment - The report discusses the recovery of the medical device market, particularly imaging equipment, which is expected to see significant growth due to ongoing procurement processes and government subsidies [42]. - It emphasizes the importance of domestic manufacturers in the medical device sector, particularly in the context of increasing competition and the need for innovation [42][43]. Investment Recommendations - The report suggests focusing on companies with strong pipelines and innovative products, including those in the pharmaceutical and medical device sectors, to capitalize on the anticipated growth in the industry [11][12][41].

康弘药业：化药1类创新药注射用KH617，已初步观察到抗肿瘤的积极疗效信号 吉林敖东：获批新品种力争尽快实现销售，目前没有开展并购创新药公司的计划 5月27日，吉林敖东参与2025年吉林辖区上市公司投资者网上集体接待日。期间管理层介绍，针对注射用盐酸平阳霉 素等重点品种，依托全国价格监测系统维护省级价格体系稳定性，深化与权威专家的临床研究合作，拓展肿瘤辅助治 疗等新适应症，力争实现销售新突破。获批新品种磷酸奥司他韦胶囊、哌柏西利胶囊、甲磺酸仑伐替尼胶囊等，力争 尽快实现销售。 此外，管理层还表示，公司目前没有开展并购创新药公司的计划，公司围绕新产品和大品种二次开发稳步推进各研发 项目。 通化东宝：Q1实现约20万支利拉鲁肽注射液销售，目前研发管线中没有口服胰岛素 5月27日，通化东宝参与2025年吉林辖区上市公司投资者网上集体接待日。交流中管理层披露，2025年一季度，公司 实现约20万支的利拉鲁肽注射液销售数量。鉴于目前的技术难度、成本效益以及市场环境等因素，公司目前研发管线 中没有口服胰岛素产品，但公司将继续关注行业内的技术进展，并根据实际情况适时调整研发策略。 5月26日，康弘药业发布关于子公司收到药物 ...

证券代码：600867 证券简称：通化东宝 公告编号：2025-040 重要内容提示: 通化东宝药业股份有限公司（以下简称"公司"或"本公司"）控股股东东 宝实业集团股份有限公司（以下简称"东宝集团"）及其一致行动人合计持有公 司股份 623,593,436 股，占公司目前股份总额的 31.84%；东宝集团及其一致行 动人持有公司股份累计质押数量（本次解押及再质押后）为 565,939,472 股，占 其及一致行动人所持有公司股份总额的 90.75%，占公司目前股份总额的 28.90%。 其中：东宝集团持有公司股份 601,731,257 股，占公司目前股份总额的 30.72%， 东宝集团持有公司股份累计质押数量（本次解押及再质押后）为 565,939,472 股， 占其所持有公司股份总额的 94.05%，占公司目前股份总额的 28.90%。 2025 年 5 月 29 日,本公司接到东宝集团关于股份解押及再质押相关情况的 告知函,具体情况如下: 一、公司控股股东本次股份质押解除的具体情况 通化东宝药业股份有限公司 关于控股股东股份解押及再质押公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导 ...

Industry Investment Rating - The report rates the pharmaceutical industry as "Leading" [1] Core Insights - The ASCO conference has showcased significant data from several domestic innovative drugs, highlighting opportunities for innovation and performance resonance [1][4] - The report emphasizes the increasing competitiveness and international influence of Chinese pharmaceutical companies, with a record number of original research results presented at ASCO [4][5] - The report suggests a positive outlook for the innovative drug sector, driven by favorable policies and low valuations compared to historical averages [4] Summary by Sections Market Performance - The Hang Seng Index fell by 2.4% during the week, while the Hang Seng Healthcare Index decreased by 1.0%, ranking 7th among 12 industry indices [4][22] - Sub-industry performance varied, with life sciences tools and services up by 3.4%, and biotechnology down by 4.9% [4][22] Company Ratings and Valuations - The report provides a detailed valuation summary for various companies, with most rated as "Buy" and a few as "Neutral" or "Sell" [3][42] - Notable companies with "Buy" ratings include: - AstraZeneca (AZN US) with a target price of 93.30 and a current price of 70.96 [3] - BeiGene (6160 HK) with a target price of 208.80 and a current price of 146.00 [3] - Innovent Biologics (1801 HK) with a target price of 60.00 and a current price of 59.55 [3] ASCO Conference Highlights - The 2025 ASCO conference featured 71 original research results from Chinese pharmaceutical companies, with 11 studies presented as Late Breaking Abstracts [5][6] - Companies like Innovent Biologics and Rongchang Biologics showcased promising clinical data for their innovative therapies [5][6] Investment Recommendations - The report recommends focusing on companies with strong growth potential and clear profitability timelines, such as Rongchang Biologics, Kangfang Biologics, and Innovent Biologics [4] - It also highlights the potential for prescription drug companies like Xiansheng Pharmaceutical and Hansoh Pharmaceutical to expand their valuations due to high growth rates [4] Recent Approvals and Developments - Rongchang Biologics received approval for a new indication for its drug in treating myasthenia gravis [20] - Innovent Biologics published positive results for its dual receptor agonist in a prominent medical journal [20] - BeiGene's clinical research for its drug in small cell lung cancer has shown promising results [20]

通化东宝药业股份有限公司 关于控股股东股份解押及再质押公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示: 证券代码：600867 证券简称：通化东宝 公告编号：2025-039 通化东宝药业股份有限公司（以下简称"公司"或"本公司"）控股股东东 宝实业集团股份有限公司（以下简称"东宝集团"）及其一致行动人合计持有公 司股份 623,593,436 股，占公司目前股份总额的 31.84%；东宝集团及其一致行 动人持有公司股份累计质押数量（本次解押及再质押后）为 557,439,472 股，占 其及一致行动人所持有公司股份总额的 89.39%，占公司目前股份总额的 28.46%。 其中：东宝集团持有公司股份 601,731,257 股，占公司目前股份总额的 30.72%， 东宝集团持有公司股份累计质押数量（本次解押及再质押后）为 557,439,472 股， 占其所持有公司股份总额的 92.64%，占公司目前股份总额的 28.46%。 2025 年 5 月 28 日,本公司接到东宝集团关于股份解押及再质押相关情况 ...

通化东宝药业股份有限公司 2025 年第一次临时股东会会议资料 股票简称：通化东宝 股票代码：600867 二〇二五年六月九日 通化东宝药业股份有限公司 2025 年第一次临时股东会会议资料 目 录 | 2025 | 年第一次临时股东会会议议程 | 3 | | --- | --- | --- | | 议案 | 1：关于协议转让特宝生物部分股份的议案 | 4 | 2 通化东宝药业股份有限公司 2025 年第一次临时股东会会议资料 2025 年第一次临时股东会 会议议程 一、会议时间： 现场会议时间：2025 年 6 月 9 日上午 10 时 网络投票时间：网络投票起止时间：自 2025 年 6 月 9 日 至 2025 年 6 月 9 日 采用上海证券交易所网络投票系统，通过上海证券交易所交易系统进行网络 投 票 时 间 为 股 东 会 召 开 当 日 的 交 易 时 间 段 ， 即 9:15-9:25,9:30-11:30 ， 13:00-15:00；通过互联网投票平台的投票时间为股东会召开当日的 9:15-15:00。 二、会议召开地点：公司会议室 三、会议议程： （一）主持人宣布会议开始 （二）推选股东会 ...

Group 1 - The company is actively expanding its international market presence, particularly in the U.S. insulin market through strategic partnerships and ongoing clinical trials for three types of insulin [1] - The company has achieved sales of approximately 200,000 units of liraglutide injection in Q1 2025, with a strong foundation for annual sales growth due to successful procurement results [2] - The company is focusing on the sales of insulin analog products and expanding its market presence for GLP-1 receptor agonists and SGLT-2 inhibitors to meet diverse patient needs [2] Group 2 - The company has received approvals for insulin products in several developing countries, including Nicaragua and Uzbekistan, and is working on expanding registrations for insulin products in these markets [1] - The company is advancing its clinical trials for new products, including THDBH120 for weight loss, which has completed its Phase II clinical trial [2][3] - The company is not currently developing oral insulin products due to technical challenges but will monitor industry advancements for potential future adjustments in R&D strategy [3] Group 3 - The company’s parent group, Dongbao Group, is working to reduce its share pledge ratio, which is currently high due to long project cycles and financial pressures [3] - The long-term outlook for Dongbao Group is positive, with ongoing projects and products expected to enter a recovery phase, improving operational capabilities [4]