Core Viewpoint - The approval of SYH2085 by the National Medical Products Administration of China marks a significant advancement for the company in the development of innovative antiviral treatments for influenza [1] Group 1: Product Development - SYH2085 is a novel oral small molecule candidate drug developed by the company, designed to inhibit the RNA polymerase acidic protein (PA) endonuclease activity of influenza viruses [1] - The clinical indication approved is for the treatment of uncomplicated influenza A and B in adults and adolescents aged 12 and older [1] Group 2: Clinical Research and Efficacy - Preclinical studies have demonstrated that SYH2085 exhibits clear, broad-spectrum, and excellent inhibitory effects against both influenza A and B viruses [1] - The drug has shown effectiveness in reducing viral load and flu-like symptoms in animal models, along with favorable pharmacokinetic properties and safety [1] Group 3: Market Potential - The approval of SYH2085 is expected to enhance the company's product pipeline in the field of anti-infective treatments, indicating high clinical development value [1]

Core Viewpoint - The approval of SYH2085 by the National Medical Products Administration of China marks a significant advancement for the company in the development of innovative antiviral treatments for influenza [1] Group 1: Product Development - SYH2085 is a novel oral small molecule candidate drug developed by the company, designed to inhibit the RNA polymerase acidic protein (PA) endonuclease activity of influenza viruses [1] - The clinical indication approved is for the treatment of uncomplicated influenza A and B in adults and adolescents aged 12 and older [1] - Preclinical studies have demonstrated that SYH2085 exhibits clear, broad-spectrum, and excellent inhibitory effects against both influenza A and B viruses, effectively reducing viral load and flu-like symptoms in animal models [1] Group 2: Clinical and Market Potential - The drug shows promising pharmacokinetic properties and safety, indicating a high clinical development value [1] - The introduction of SYH2085 is expected to enhance the company's product pipeline in the field of anti-infective treatments [1]

Group 1 - The company announced a leadership change effective December 19, 2025, with Mr. Zhang Cuilong stepping down as Vice Chairman, CEO, and authorized representative due to job relocation, but will remain an executive director [1] - Dr. Cai Lei has been appointed as Vice Chairman, Executive Director, CEO, and authorized representative [1] - Mr. Wei Qingjie has been appointed as Vice Chairman, Executive Director, and Chief Operating Officer [1]

Core Viewpoint - The announcement from the company indicates significant changes in its leadership structure, effective December 19, 2025, which may impact its strategic direction and operational management [1] Group 1: Leadership Changes - Zhang Cuilong will no longer serve as Vice Chairman, CEO, and authorized representative due to job relocation but will remain an executive director [1] - Cai Lei has been appointed as Vice Chairman, Executive Director, CEO, and authorized representative [1] - Wei Qingjie has been appointed as Vice Chairman, Executive Director, and Chief Operating Officer [1]

智通财经APP讯，石药集团(01093)发布公告，自2025年12月19日起生效：张翠龙先生因工作调动而不再 担任董事会副主席、公司首席执行官及根据香港联合交易所有限公司证券上市规则第3.05条项下公司授 权代表，但将继续担任公司执行董事;蔡磊博士获委任为副主席、公司执行董事、首席执行官及授权代 表;魏青杰先生获委任为副主席、公司执行董事及首席运营官。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準 確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產 生或因倚賴該等內容而引致之任何損失承擔任何責任。 CSPC PHARMACEUTICAL GROUP LIMITED 石 藥 集 團 有 限 公 司 （股份代號：1093） （於香港註冊成立之有限公司） 自願公告 SYH2085片在中國獲臨床試驗批准 石 藥 集 團 有 限 公 司（「 本 公 司 」， 連 同 其 附 屬 公 司 統 稱「 本 集 團 」）董 事 會（「 董 事 會 」）欣 然 宣 布 ， 本 集 團 開 發 的 SYH2085 片（「 該 產 品 」）已 獲 得 中 華 人 民 共 和 國 國 家 藥 品 監 督 管 理 局 批 准，可在中國開展臨床試驗。 該 產 品 為 本 集 團 自主 研 發 的 化 學 1 類創 新 藥 ， 是 一 款 可 抑 制 流 感 病 毒的 RNA 聚 合 酶 酸 性 蛋 白(PA)核酸內切酶活性的新型口服小分子候選藥物。本次獲批的臨床適應症為用於治療成 人及12歲以上青少年單純性甲型和乙型流感。臨床 ...

蔡東晨先生 （ 主席 ） 蔡磊博士 （ 副主席及首席執行官 ） 魏青杰先生 （ 副主席及首席運營官 ） 張翠龍先生 王振國先生 王懷玉先生 李春雷博士 姚兵博士 蔡鑫先生 陳衛平先生 屈志勇先生 獨立非執行董事： 王波先生 CHEN Chuan先生 CSPC PHARMACEUTICAL GROUP LIMITED 石 藥 集 團 有 限 公 司 （股份代號：1093） （於香港註冊成立之有限公司） 董事名單與其角色和職能 石藥集團有限公司董事會（「董事會」）成員載列如下： 執行董事： M 有關董事委員會的成員 香港，2025年12月19日 王宏廣教授 歐振國先生 羅卓堅先生 李泉女士 下表提供董事會成員在董事委員會中所擔任的職位： | 董事委員會 | | | | | --- | --- | --- | --- | | 董事 | 審核委員會 | 提名委員會 | 薪酬委員會 | | 蔡東晨先生 | | C | | | 王波先生 | M | M | M | | CHEN Chuan先生 | M | M | M | | 歐振國先生 | C | | C | | 李泉女士 | | M | | 附註： C 有關董事委員會 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準 確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產 生或因倚賴該等內容而引致之任何損失承擔任何責任。 CSPC PHARMACEUTICAL GROUP LIMITED 石 藥 集 團 有 限 公 司 (1) 委任執行董事； (2) 更換副主席、首席執行官及授權代表； 及 (3) 委任首席運營官 （股份代號：1093） （於香港註冊成立之有限公司） 石 藥 集 團 有 限 公 司（「 本 公 司 」， 連 同 其 附 屬 公 司 統 稱「 本 集 團 」）董 事 會（「 董 事 會 」）謹 此 宣 佈，自2025年12月19日起生效： (3) 魏青杰先生（「魏先生」）獲委任為副主席、本公司執行董事及首席運營官。 張先生已確認，彼與董事會並無意見分歧，且並不知悉任何有關其退任副主席及首席執行 官而需本公司股東關注事項。 董事會藉此機會對張先生在擔任副主席、首席執行官及授權代表之任期內作出之貢獻及領 導致以衷心謝意。 – 1 – (1) 張翠龍先生（「張先生」）因工作調動而不 再擔任董事會副主席（「副主席」 ...

Group 1: Policy and Regulatory Developments - The National Healthcare Security Administration and the Ministry of Human Resources and Social Security announced the "National Basic Medical Insurance, Maternity Insurance, and Work Injury Insurance Drug Catalog (2025)" and the "Commercial Health Insurance Innovative Drug Catalog (2025)", effective from January 1, 2026, nationwide [1] - The medical insurance catalog adds 114 new drugs, including 50 innovative first-class drugs, with an overall success rate of 88%, a 12 percentage point increase from 2024 [1] - The first version of the commercial health insurance innovative drug catalog includes 19 drugs, marking a significant breakthrough in the "medical insurance + commercial insurance" multi-layered medical security system [1] Group 2: Market Trends and Investment Opportunities - The Chinese innovative drug sector is experiencing active out-licensing (BD) transactions, with a total transaction amount exceeding $92 billion and 103 deals completed in the first three quarters of 2025, indicating strong international recognition of Chinese R&D achievements [2] - The innovative drug R&D is entering a harvest period, with pipeline values gradually being realized, supported by overseas payment capabilities and a shift towards hard-core technology-driven growth [2] - Emerging technologies such as small nucleic acids, in vivo CAR-T, and AI drug development platforms are expected to see a clinical value explosion, while the CXO industry remains robust, benefiting from new tracks like ADC, peptides, and CGT [2] Group 3: ETF Performance and Market Sentiment - As of December 18, 2025, the Hong Kong innovative drug ETF (513120) has seen a strong increase of 10.56% over the past six months, with significant contributions from major stocks like WuXi Biologics and 3SBio [3] - The latest scale of the Hong Kong innovative drug ETF reached 24.322 billion yuan, making it the largest in the Hong Kong market for pharmaceutical ETFs, with a net inflow of 327 million yuan over the past five trading days [3] - The innovative drug ETF (515120) also experienced a rise, with major stocks like Zai Lab and WuXi AppTec contributing to the gains, indicating a positive market sentiment towards innovative drug investments [4]

Group 1: Pharmaceutical Sector - The innovation drug sector is expected to be the main focus, with particular attention on small nucleic acid technology and its accelerated development by 2026 [1][2] - The pharmaceutical industry is driven by supply creating demand, with significant trends observed from 2018 to 2024, including breakthroughs in PD-1, ADC technology, and new generation immunotherapy [2] - Key companies to watch in the pharmaceutical sector include Heng Rui Medicine, Hansoh Pharmaceutical, China National Pharmaceutical Group, and others involved in small nucleic acid and weight loss drug development [2] Group 2: CXO and Upstream Life Sciences - The CXO sector is expected to see continued improvement in fundamentals and valuation recovery, with a focus on companies like WuXi AppTec and Kanglong Chemical [3] - Upstream life sciences are benefiting from improved domestic research conditions, with companies like BGI Genomics and Bidu Pharmaceutical showing positive performance trends [3] - The raw material drug sector is entering a bottom price range, with companies that have quality clients and orders likely to see improved profit margins [3] Group 3: Medical Devices - The medical device sector is anticipated to benefit from improved hospital demand and inventory optimization, with a potential turning point in 2026 [4] - High-value consumables are expected to gain from collective procurement, enhancing domestic production capabilities [4] - Key players in the medical device sector include Mindray Medical, United Imaging Healthcare, and others [4] Group 4: Healthcare Consumption - The healthcare service sector is under pressure in 2025, but a mild recovery is expected in 2026, particularly in essential medical services and products [5] - Traditional Chinese medicine is projected to stabilize and grow, with a focus on OTC and prescription drug innovations [5] - The pharmacy sector is experiencing increased concentration due to regulatory changes, with companies like Yifeng Pharmacy and Dazhong Pharmacy showing improved performance [5]