江蘇中慧元通生物科技股份有限公司 Ab&B Bio-Tech CO., LTD. JS 全球發售 聯席保薦人、整體協調人、聯席全球協調人、聯席賬簿管理人及聯席牽頭經辦人 聯席賬簿管理人兼聯席牽頭經辦人 Ab&B Bio-Tech CO., LTD. JS 江蘇中慧元通生物科技股份有限公司 重要提示 （於中華人民共和國成立的股份有限公司） 股份代號 : 2 6 2 7 重要提示：閣下如對本招股章程的任何內容有任何疑問，應尋求獨立專業意見。 Ab&B Bio-Tech CO., LTD. JS 江蘇中慧元通生物科技股份有限公司 （於中華人民共和國成立的股份有限公司） 全球發售 全球發售項下的發售股份數目 33,442,600股H股（視發售量調整權 行使與否而定） 香港發售股份數目 3,344,400股H股（可予重新分配） 國際發售股份數目 30,098,200股H股（可予重新分配及 視發售量調整權行使與否而定） 最高發售價 每股H股15.50港元，另加1.0%經紀 佣金、0.0027%證監會交易徵費、 0.00565%聯交所交易費及 0.00015%會財局交易徵費（須於申請 時以港元繳足，多繳股款可予退還） 面值 ...

7月30日，北京科兴控股（集团）有限公司（以下简称"科兴集团"）召开"甲型和乙型肝炎防控"媒体沟 通会。 "近年来，科兴一直在产品研发、产业化等领域加大投入，不断扩展针对呼吸道疾病、肠道传染病、外 伤感染、虫媒传播疾病的疫苗和抗体产品矩阵，并同步布局多种联合疫苗开发，预计2030年前将获批上 市9款产品。"会上，科兴集团副总裁李静表示，科兴以创新产品开发为导向构建研发平台，对前沿突破 性产品、平台技术开展广泛的研发布局和持续投入。当前公司的研发管线拥有疫苗和抗体两类20多种在 研产品。 近日，科兴甲型乙型肝炎联合疫苗倍尔来福®取得了药品再注册批准通知书。对此，李静表示，该产品 最早在2005年上市。上市后该产品在全国29省市累计使用超1300万剂，获得广泛欢迎，对我国甲肝、乙 肝防控发挥了重要作用。基于乙肝、甲肝先后纳入国家免疫规划后防控成效显著，甲乙肝联苗此前也完 成了查漏补种的时代使命。 7月24日，据科兴集团官微消息，由集团旗下北京科兴生物制品有限公司自主研发的甲型乙型肝炎联合 疫苗倍尔来福®于2025年7月21日取得药品再注册批准通知书。倍尔来福®是目前国内唯一获批上市的 甲型乙型肝炎联合疫苗。 科兴 ...

Group 1: Control Change and Share Transfer - Wan Kexin Bio acquired a total of 28.46638 million shares from Wang Zhentao, Aokang Group, and Kangyue Qiming, resulting in a voting rights proportion of 29.9893% [2][3] - The controlling shareholder will change from Wang Zhentao to Wan Kexin Bio, which has no actual controller [3] - The control change requires antitrust review and compliance audit by the Shenzhen Stock Exchange, which is currently in progress [3] Group 2: Norovirus Vaccine Development - The company signed an exclusive licensing agreement with HilleVax for the development and commercialization of a six-valent norovirus vaccine outside of China [4] - Domestic clinical trial approval for the six-valent norovirus vaccine has been obtained, with ongoing efforts to expedite both domestic and international market entry [4] Group 3: Rabies Vaccine Market Situation - In 2024, there were 143 reported rabies deaths in China, highlighting the critical demand for post-exposure rabies vaccination [5] - Approximately 40 million people are exposed to rabies annually in China, with a vaccination rate of only 35%, indicating significant room for improvement [5] - Three types of rabies vaccines are approved in China, with Vero cell vaccines dominating the market, followed by human diploid and mouse kidney cell vaccines [5] Group 4: Marketing and Brand Strategy - The company aims to leverage its established product reputation and market channels to enhance brand influence and market competitiveness [6][7] - Plans include adjusting marketing management structures, expanding the marketing team, and enhancing professional training to improve collaborative capabilities [7]

Group 1 - Valiant Biotech-B's dark market saw a maximum increase of 134.28%, reflecting market recognition of its antibody drug development pipeline in oncology and autoimmune diseases [1] - The company has one core product and 13 other candidates, with 6 having successfully entered clinical stages [1] - Long-term value will depend on the commercialization capabilities of new drugs [1] Group 2 - Hengrui Medicine's subsidiary received approval for clinical trials of HRS-1893 tablets, a selective myosin inhibitor aimed at treating heart failure with preserved ejection fraction [2] - The project has accumulated R&D investment of approximately 60.67 million yuan [2] - If clinical trials proceed successfully, it could become the first drug in this unmet clinical need, enhancing the company's competitiveness [2] Group 3 - 3SBio announced the formal effectiveness of a licensing agreement with Pfizer for the global development and commercialization rights of the PD-1/VEGF bispecific antibody SSGJ-707, excluding mainland China [3] - The agreement includes a total option and exercise fee of up to 150 million USD [3] - This partnership allows 3SBio to leverage Pfizer's resources for accelerated project development and commercialization [3] Group 4 - Zhonghui Yuantong updated its prospectus, indicating that its core products have been commercialized, alongside 11 vaccines in development [4] - The company has raised a total of 999.5 million yuan through three rounds of financing from notable investors [4] - The upcoming Hong Kong listing is expected to accelerate R&D and market expansion in the vaccine sector [4] Group 5 - Eddingpharm received approval for the registration and commercialization of multi-dose diquafosol sodium eye drops in China, which contains 3% diquafosol sodium [5] - The product is intended for the treatment of dry eye syndrome [5] - This approval enhances the treatment options for dry eye disease and is expected to contribute to the company's growth in the ophthalmic market [5]

Core Viewpoint - The company Olin Bio (688319.SH) announced a plan for its controlling shareholder, Shanghai Wushan Biotechnology Co., Ltd., to reduce its stake by up to 12.178 million shares, representing no more than 3% of the total share capital, due to funding needs [1][2] Group 1: Shareholder Actions - Shanghai Wushan plans to cash out over 200 million yuan from the share reduction based on the closing price of 22.11 yuan per share on July 23 [2] - The actual controllers of Olin Bio, Fan Shaowen and Fan Fan, along with board member Chen Aimin, have committed not to participate in this reduction [1][2] - The shares to be reduced were acquired before the company's IPO, indicating a long-term holding period [2] Group 2: Financial Performance - Olin Bio's stock price has increased over 100% year-to-date, with market capitalization rising from approximately 4.3 billion yuan to about 9 billion yuan [2] - The company reported a revenue of 87.49 million yuan in Q1, a year-on-year increase of 23.6%, while the net profit attributable to shareholders was a loss of 7.07 million yuan, which has narrowed compared to the previous year [3] - For 2024, the company expects revenue and net profit to grow by 18.69% and 18.24% respectively, with a significant increase in non-recurring net profit projected at 230.01% [3] Group 3: Product Pipeline - Olin Bio's main commercial product is the adsorbed tetanus vaccine, with additional products including Hib combination vaccine and AC combination vaccine already approved for market [3] - The company is conducting a Phase III clinical trial for its recombinant pneumococcal vaccine, with 5,000 out of 6,000 planned participants already enrolled [3] - The company has also received approval for clinical trials of its oral recombinant Helicobacter pylori vaccine and trivalent and quadrivalent influenza virus vaccines [3]

Core Viewpoint - The article discusses the sale of a vaccine company by Wang Zhentao, the founder of Aokang International, highlighting the challenges faced by the vaccine market and the strategic decision to divest from a declining business [1][3][21]. Group 1: Transaction Details - Wang Zhentao and his associates sold their shares in Kanghua Biological to Shanghai Wankexin Biological for a total of 1.85 billion yuan [1]. - The acquisition involves a performance-based agreement requiring a total net profit of no less than 728 million yuan for the years 2025 and 2026, along with a minimum R&D investment of 260 million yuan [5][6]. - If performance targets are not met, Wang Zhentao and Aokang Group must compensate the difference in cash [6]. Group 2: Company Performance - Kanghua Biological's core product, the freeze-dried human rabies vaccine, has seen a significant decline in market performance, with the number of vaccine batches issued dropping over 40% in 2024 [9]. - The company's revenue for 2024 was approximately 1.43 billion yuan, a decrease of 9.23% from the previous year, while net profit fell by 21.71% to around 400 million yuan [10]. - The company’s market capitalization has shrunk to below 10 billion yuan, reflecting a broader decline in performance [10][17]. Group 3: Background of Wang Zhentao - Wang Zhentao, known as the founder of "China's first men's shoe stock," ventured into the vaccine industry with an investment of 800 million yuan, but faced challenges in this new field [2][16]. - His attempts to innovate within the vaccine sector, including the development of new vaccines, have not yielded significant results, leading to the decision to exit the business [11][13]. - Wang's financial situation is under pressure, with high levels of share pledges in both Aokang International and Kanghua Biological, indicating a need for liquidity [21][22]. Group 4: Market Context - The vaccine market has become increasingly competitive, with new technologies and production capabilities leading to a decline in Kanghua Biological's market position [9][23]. - Aokang International has also faced difficulties, with a reported cumulative loss of 683 million yuan over the past three years, contributing to Wang's decision to divest from Kanghua Biological [24][30].

赛诺菲公司同意以高达16亿美元的价格收购英国生物技术公司Vicebio Ltd.，从而获得了实验性疫苗以及 一种能加快疫苗研发进程的技术。赛诺菲首席执行官Paul Hudson正在寻找与赛诺菲现有产品相契合的 创新方案，而Vicebio的实验性疫苗旨在预防多种呼吸系统疾病，包括呼吸道合胞病毒(RSV)，这也是赛 诺菲新疗法Beyfortus所针对的疾病。 ...

智通财经APP获悉，赛诺菲公司(SNY.US)同意以高达 16 亿美元的价格收购英国生物技术公司Vicebio Ltd.，从而获得了实验性疫苗以及一种能加快疫苗研发进程的技术。该公司在周二发布的一份声明中 称，这家法国制药商将预先支付 11.5 亿美元，并承诺在某些关键节点达成协议时支付高达 4.5 亿美元的 额外款项。 赛诺菲首席执行官Paul Hudson正在寻找与赛诺菲现有产品相契合的创新方案，而Vicebio的实验性疫苗 旨在预防多种呼吸系统疾病，包括呼吸道合胞病毒(RSV)，这也是赛诺菲新疗法Beyfortus所针对的疾 病。 赛诺菲还将获得"分子钳"技术，该技术旨在加快开发出完全以液体形式存在的联合疫苗。该Vicebio的技 术能够加快液体组合疫苗的研发进程，这些疫苗可在冰箱温度下保存，从而简化了生产流程和配送环 节，消除了冷冻或冻干的必要。 这笔交易有助于赛诺菲更接近研发出新一代疫苗，这种疫苗能够在一次注射中为人体提供对多种呼吸道 病毒的防护，而且其技术并非是新冠疫苗所用的 mRNA 技术。 此次收购表明，尽管美国卫生部长小罗伯特·肯尼迪对疫苗接种持怀疑态度，但制药企业仍继续在疫苗 研发方面进行 ...

Group 1 - The company announced that its wholly-owned subsidiary, Jinyu Baoling, received clinical trial approval for an African swine fever subunit vaccine from the Ministry of Agriculture and Rural Affairs [1] - The vaccine is jointly developed by the Institute of Biophysics of the Chinese Academy of Sciences and China National Pharmaceutical Group Animal Health Co., Ltd., with Jinyu Baoling as the clinical trial undertaking unit [1] - The total research and development investment for the project is approximately 64 million yuan [1] Group 2 - Due to the complexity of the immune mechanism of the African swine fever virus, there is a risk of failure in the clinical trials [1] - The vaccine must complete clinical trials and obtain registration approval before it can be marketed and sold [1] - The company will monitor subsequent developments and fulfill its information disclosure obligations [1]

Core Viewpoint - The article discusses the internal conflicts within Sinovac Biotech, highlighting the company's significant financial performance and the ongoing power struggle among its shareholders and board members [5][18][21]. Group 1: Company Overview - Sinovac Biotech, known for its COVID-19 vaccine, has reported revenues exceeding 130 billion yuan and a net profit of over 96 billion yuan from 2021 to 2022, resulting in a net profit margin of approximately 73.8% [11][16]. - The company has been suspended from trading for six years due to internal disputes, indicating ongoing governance issues [21]. Group 2: Shareholder Conflict - A recent shareholder meeting in Antigua and Barbuda involved a proposal to remove current board members and elect new candidates nominated by SAIF Partners, reflecting deep divisions among shareholders [18][22]. - The company announced a massive special dividend payment of up to 7.5 billion USD, leaving it with 2.8 billion USD in cash after the distribution [22][23]. Group 3: Historical Context - The founder, Weidong Yin, has a background in public health and has been pivotal in the company's development since its establishment in 2001 [42][62]. - Sinovac's history includes rapid advancements in vaccine development, notably during the SARS outbreak, which laid the groundwork for its later success with COVID-19 vaccines [60][61].