每经记者｜许立波 每经编辑｜张海妮 与此形成对比的是，宠物创新药正成为新的增长引擎。mRNA疫苗等前沿技术正在被引入动保领域，推 动行业回归创新驱动的本质。在产业的"水深火热"与"创新突围"之间，中国动保企业正在摸索新的发展 路径。产品同质化导致低价内卷 动保行业也称为兽药行业，从规模看，中国动保产业已发展为一个体量接近700亿元的市场。根据中国 兽药协会披露的数据，2019年至2023年，国内兽药企业销售额从503.95亿元增至696.51亿元，年均复合 增长率达8.4%。不过近年来，受行业竞争加剧影响，市场增速明显放缓，毛利率持续下行，出现增收 不增利的情况。 8月20日至24日，第二十七届亚洲宠物展（以下简称亚宠展）在上海新国际博览中心举行。今年亚宠展 规模约为31万平方米，海内外参展企业2600多家，预计将吸引超51万专业观众和宠物爱好者参观。 亚宠展的热度正是近年来国内动物保健行业高速发展的缩影。伴随着市场规模持续增长，越来越多的玩 家正在被吸引入局，动保行业也不可避免地陷入低价内卷的旋涡。 国海证券在日前发布的研报中指出，动保行业作为养殖产业链的上游，其行业景气度往往跟下游生猪养 殖行业紧密相关。 ...

Group 1 - The World Health Organization warns that the Chikungunya virus is spreading globally, with 119 countries reporting cases and approximately 5.5 million people at risk of infection [1] - In Foshan, Guangdong Province, over 4,000 confirmed cases of Chikungunya have been reported, with Shunde District accounting for 3,627 cases, all of which are mild [1] Group 2 - Domestic animal health mRNA vaccines are entering a clinical boom, with recent approvals for clinical trials of mRNA vaccines for pig diarrhea and cat infectious peritonitis [2] - The rapid approval of mRNA vaccines reflects an accelerating trend in the application of mRNA technology in animal health, although the high development barriers pose risks for investors [2] Group 3 - Huaxi Bio issued a statement addressing false information circulating online, emphasizing the malicious nature of the claims and the background of the individual responsible for the misinformation [3] - The company's swift response highlights its commitment to managing reputation risks, especially in the sensitive beauty and medical aesthetics industry [3] Group 4 - Guangsheng Tang announced the successful enrollment of the first subject in the Phase III clinical trial for its innovative hepatitis B treatment, GST-HG141, marking a significant milestone in its development [4] - GST-HG141 is a novel hepatitis B core protein/capsid regulator and is the first of its kind with global intellectual property rights held by Guangsheng Tang [4]

Core Viewpoint - Tianjin Reap Bio-Tech Co., Ltd. has received clinical trial approval for its mRNA vaccine for porcine epidemic diarrhea virus (RPS1903), marking a significant advancement in the domestic animal vaccine sector [2] Company Summary - The mRNA vaccine is the first of its kind for economic animals in China, indicating that the company has developed a mature veterinary mRNA vaccine research platform, which will help expand its product line and development space [2] - The vaccine demonstrates a 98.7% success rate in immunization during preclinical trials, significantly outperforming traditional vaccines, which have an 85.3% success rate [3] - The mRNA vaccine utilizes advanced delivery technology and can potentially encode multiple pathogen antigens, laying the groundwork for the development of multivalent vaccines [3] Industry Summary - The animal vaccine market in China reached a size of $2.5 billion in 2022, remaining stable compared to 2021, but saw a slight decline to $2.373 billion in 2023, indicating a structural upgrade trend in the industry [3] - The market is expected to exceed $3.8 billion by 2029, with a compound annual growth rate (CAGR) of 6.8%, driven by the commercialization of African swine fever vaccines and increased penetration of pet vaccines [5] - The development of new vaccine technologies, such as mRNA and genetically engineered vaccines, is providing more efficient and safer solutions for animal disease prevention and control [3]

Core Viewpoint - The company has received the first clinical trial approval for an mRNA vaccine for economic animals in China, marking a significant milestone in its veterinary mRNA vaccine development platform [1] Group 1: Company Developments - The company, 瑞普生物, announced that it has obtained a clinical trial approval from the Ministry of Agriculture and Rural Affairs for its mRNA vaccine targeting porcine epidemic diarrhea virus (RPS1903) [1] - This approval signifies that the company possesses a mature research and development platform for veterinary mRNA vaccines, which is expected to broaden its product line and development opportunities [1] Group 2: Industry Context - The approval of the mRNA vaccine is a pioneering step in the domestic market for economic animals, indicating a potential shift in veterinary vaccine development [1] - It is important to note that after obtaining clinical trial approval, the vaccine must complete clinical trials and submit for registration, which involves review and approval by the Ministry of Agriculture and Rural Affairs before it can be marketed [1]

Industry Overview - Vaccines are essential biological products for preventing and controlling infectious diseases, representing a core defense in public health systems [1][5] - The Chinese vaccine industry is experiencing rapid growth, with the market size projected to increase from 306.22 billion yuan in 2015 to 1,762.19 billion yuan in 2024, and expected to exceed 300 billion yuan by 2031 [1][5] Industry Chain - The upstream of the vaccine industry includes raw material supply, such as microcarriers, human serum albumin, and packaging materials [3] - The midstream involves vaccine research and production, with key players including Sinopharm, Sinovac, CanSino, Zhifei, and Watson [3] - The downstream consists of vaccine distribution and consumption, reaching end consumers through health service centers and medical institutions [3] Current Industry Status - As of December 31, 2024, 47 companies in China have received vaccine batch approvals, totaling 543 million doses, with a decrease of 5.6% compared to 2023 [7] - The most approved vaccines in 2024 were influenza and rabies vaccines, each exceeding 80 million doses, accounting for 30% of total approvals [9] Market Competition - The Chinese vaccine market is characterized by a diverse competitive landscape, with local companies like Sinopharm and Zhifei rising against foreign giants like Merck and Pfizer [11] - Zhifei has achieved significant growth in international markets, with a 300% increase in exports of its WHO-precertified 23-valent pneumococcal polysaccharide vaccine [11] - Innovative companies like CanSino and Watson are making breakthroughs in mRNA and recombinant protein vaccines, enhancing their market presence [11][12] Future Trends - Technological innovation is driving the vaccine industry forward, with new platforms like mRNA and gene-engineered vaccines emerging [17] - The adult vaccine market is growing, with a 45% increase in HPV vaccine uptake in 2024, indicating a shift in public health awareness [18] - Chinese vaccine companies are expanding internationally, with over 2.5 billion doses of COVID-19 vaccines supplied abroad, focusing on markets in Africa and Southeast Asia [19]