Group 1: Sac-TMT in NSCLC Treatment - Sac-TMT has established a new benchmark for treating EGFR mutation-resistant NSCLC, showing significant improvements in PFS and OS compared to platinum-based chemotherapy in the III phase OptiTROP-Lung04 study, with median PFS of 8.3 months vs. 4.2 months (HR=0.49) and median OS of NR vs. 17.4 months (HR=0.60) [1] - The treatment demonstrated consistent OS and PFS benefits across all predefined key subgroups, including a notable OS HR of 0.59 in patients previously treated with third-generation EGFR therapies [1] - The application for market approval for this indication was granted in October, and Sac-TMT showed lower incidences of oral mucositis, ocular toxicity, and interstitial lung disease compared to competitor Dato-DXd, although it had a higher incidence of hematological toxicity [1] Group 2: ADC Product Matrix in Breast Cancer - Sac-TMT has also made significant progress in treating second-line and above HR+/HER2- breast cancer, with its market application recently accepted by CDE, while HER2 ADC, Dato-DXd, was approved for 2L+ HER2-positive breast cancer [2] - In the OptiTROP-Breast02 study, Sac-TMT achieved statistically significant PFS improvement with a median of 8.3 months vs. 4.1 months (HR 0.35) and preliminary OS HR of 0.33, showing benefits across all predefined subgroups [2] - The KL166-III-06 study indicated that Dato-DXd significantly outperformed T-DM1, extending median PFS to 11.1 months vs. 4.4 months (HR 0.39) [2] Group 3: Revenue Forecast and Target Price Adjustment - Based on regulatory approval progress, the company has a more optimistic outlook for sales of Sac-TMT and Dato-DXd, raising revenue forecasts for 2025-2027 by 0-5% and adjusting peak sales estimates to 6.4 billion and 1.1 billion RMB respectively [3] - The DCF target price has increased to 549 HKD, maintaining a buy rating, reflecting confidence in the global value of the ADC product matrix driven by clinical data [3]

Group 1: Baidu (BIDU US) - The report anticipates that advertising revenue will bottom out in the second half of the year, with a reassessment of the value of cloud services and autonomous driving [1] - Revenue forecasts for Baidu's core business have been adjusted downwards by approximately 2-3% for 2025-27, with operating profit estimates lowered by 5-13% [1] - The target price has been adjusted to $147, reflecting a 23.4% potential upside, based on a sum-of-the-parts (SOTP) valuation approach [1] Group 2: Innovent Biologics (1801 HK) - Innovent Biologics has announced a global strategic collaboration with Takeda Pharmaceutical, involving two late-stage candidates, IBI363 and IBI343, and an early-stage project, IBI3001 [2][3] - The total transaction value could reach up to $11.4 billion, including an upfront payment of $1.2 billion and potential milestone payments of up to $10.2 billion [2][3] - The collaboration is expected to maximize the long-term commercialization prospects of the two products globally, particularly in the gastrointestinal and digestive tract oncology fields [3] Group 3: Kintor Pharmaceutical (6990 HK) - Kintor's ADC product, Sac-TMT, has shown significant improvements in progression-free survival (PFS) and overall survival (OS) in a Phase III study presented at the ESMO 2025 conference [7][8] - The median PFS was reported at 8.3 months compared to 4.2 months for the control group, with a hazard ratio (HR) of 0.49, indicating a statistically significant improvement [7] - The target price has been raised to HKD 549, reflecting a positive outlook based on the recent clinical data [8] Group 4: Pop Mart (9992 HK) - Pop Mart has demonstrated strong sales growth, with Q3 2025 revenue expected to increase by 245-250% year-on-year, accelerating from a 204% increase in the first half of the year [9][10] - The domestic market revenue is projected to grow by 185-190%, while overseas markets are expected to see a remarkable growth rate of 365-370% [9] - The target price has been raised to HKD 401.60, indicating a potential upside of 60.4%, supported by the company's strong growth momentum and upcoming product launches [10]

Investment Rating - The report assigns a "Buy" rating to the company, Kolun Biotechnology (6990 HK), with a target price of HKD 549.00, indicating a potential upside of 16.6% from the current closing price of HKD 471.00 [6][13]. Core Insights - The report highlights the significant clinical advancements of the company's ADC products, particularly Sac-TMT, which has set a new benchmark for treating EGFR mutation-resistant NSCLC. The results from the Phase III OptiTROP-Lung04 study showed a median progression-free survival (PFS) of 8.3 months compared to 4.2 months for the control group, with a hazard ratio (HR) of 0.49 [2]. - The report also notes that the application for market approval for Sac-TMT was granted in October, further enhancing the company's growth prospects [2]. - The financial forecasts for the company have been adjusted upwards, with revenue projections for 2025-2027 increased by 0-5%, leading to a peak sales forecast of RMB 64 billion for Sac-TMT and RMB 11 billion for another product [7]. Financial Performance - The company is projected to generate revenues of RMB 2,050 million in 2025, with a gross profit of RMB 1,322 million, maintaining a gross margin of 64.5% [7][14]. - The net profit for 2026 is expected to turn positive at RMB 50 million, with a significant increase to RMB 751 million by 2027 [7][14]. - The company's market capitalization is approximately HKD 76.66 billion, with a year-to-date stock price increase of 188.43% [4]. Valuation Model - The DCF valuation model estimates the equity value of the company at approximately RMB 116.38 billion, translating to a per-share value of HKD 549.00 [8]. - The model incorporates a perpetual growth rate of 3% and a weighted average cost of capital (WACC) of 9.4% [8]. Stock Performance - The stock has shown a strong performance over the past year, with a significant increase compared to the Hang Seng Index [3]. - The 52-week high for the stock is HKD 577.50, while the low is HKD 154.00, indicating substantial volatility and growth potential [4]. Clinical Data Highlights - The report emphasizes the clinical efficacy of Sac-TMT in treating NSCLC and HR+/HER2- breast cancer, with significant improvements in PFS and overall survival (OS) rates compared to existing therapies [2][6]. - The company is well-positioned to capitalize on the growing ADC market, supported by robust clinical data and regulatory approvals [7].

Group 1 - The core viewpoint of the reports indicates an optimistic outlook on the sales of Sac-TMT and Bodo-Tuzumab, leading to an upward revision of revenue forecasts for 2025-2027 by 0-5% and an increase in peak sales projections to 6.4 billion and 1.1 billion RMB respectively [1] - The DCF target price for Keren Biotechnology-B (06990) has been raised to 549 HKD, maintaining a "Buy" rating due to the significant global value driven by clinical data for the ADC product matrix [1] Group 2 - Sac-TMT has established a new benchmark for treating EGFR mutation-resistant NSCLC, with the III phase OptiTROP-Lung04 study showing significant improvements in PFS and OS compared to the control group, with median PFS of 8.3 vs. 4.2 months and median OS not reached vs. 17.4 months [2] - The application for marketing authorization for Sac-TMT in this indication was approved in October, and it has shown lower incidence rates of oral mucositis, ocular toxicity, and interstitial pneumonia compared to competitor Dato-DXd [2] - In the ADC product matrix for breast cancer, Sac-TMT's application for second-line and above HR+/HER2- breast cancer has been accepted, and Bodo-Tuzumab has been approved for 2L+ HER2-positive breast cancer, with both III phase study results presented at the ESMO conference [3] - The OptiTROP-Breast02 study demonstrated statistical superiority in PFS for Sac-TMT with a median of 8.3 vs. 4.1 months, and the KL166-III-06 study showed Bodo-Tuzumab significantly extended median PFS compared to T-DM1 [3]

Core Viewpoint - The report from CMB International indicates an optimistic outlook for the sales of Sac-TMT and Bodo-Tuzumab based on regulatory approval progress, leading to an upward revision of revenue forecasts for 2025-2027 by 0-5% and an increase in peak sales projections to RMB 6.4 billion and RMB 1.1 billion respectively. The DCF target price has risen to HKD 549, maintaining a "Buy" rating for Kelun-Botai Biopharmaceuticals (06990), driven by the significant global value of the ADC product matrix supported by clinical data [1]. Group 1 - Sac-TMT sets a new benchmark for EGFR mutation-resistant NSCLC treatment: The results of the Phase III OptiTROP-Lung04 study presented at the ESMO conference show that the Sac-TMT treatment group achieved statistically and clinically significant improvements in PFS and OS compared to the control group, with median PFS of 8.3 vs. 4.2 months (HR=0.49, 95% CI: 0.39-0.62, p<0.0001) and median OS of NR vs. 17.4 months (HR=0.60, 95% CI: 0.44-0.82, two-tailed p=0.001) [2]. - The application for marketing authorization for this indication was approved in October, and Sac-TMT shows lower incidence rates of oral mucositis, ocular toxicity, and interstitial lung disease compared to competitor Dato-DXd, although it has a higher incidence of hematological toxicity [2]. Group 2 - The ADC product matrix has also made significant progress in breast cancer: The marketing application for Sac-TMT for second-line and above HR+/HER2- breast cancer has recently been accepted by the CDE, and Bodo-Tuzumab was approved for the first time in October for 2L+ HER2-positive breast cancer. The results of their respective Phase III studies were also presented at the ESMO conference [3]. - In the OptiTROP-Breast02 study, Sac-TMT achieved statistically significant PFS improvement (median 8.3 vs. 4.1 months, HR 0.35, p<0.0001), with preliminary OS HR of 0.33 observed across all predefined subgroups [3]. - In the KL166-III-06 study, Bodo-Tuzumab outperformed T-DM1, significantly extending median PFS (11.1 vs. 4.4 months, HR 0.39, p<0.0001) [3].