Core Viewpoint - The rising global obesity rates are leading to increased risks of diseases such as type 2 diabetes and cardiovascular diseases. GLP-1 class weight loss drugs, particularly Semaglutide, are rapidly gaining popularity and transforming the obesity treatment landscape [2][11]. Group 1: Clinical Study Overview - A clinical study published in the New England Journal of Medicine evaluated the efficacy and safety of oral Semaglutide at a dose of 25 mg for weight management in overweight or obese adults without diabetes over a 71-week period [2][3]. - The study involved 307 participants from 22 centers in Canada, Germany, Poland, and the USA, randomly assigned to receive either oral Semaglutide or a placebo [5]. Group 2: Weight Loss Results - By week 64, participants taking oral Semaglutide experienced an average weight loss of 13.6%, compared to 2.2% in the placebo group, resulting in a difference of 11.4 percentage points [7]. - The proportion of participants achieving weight loss of at least 5% was 79.2% in the Semaglutide group versus 31.1% in the placebo group [7]. Group 3: Cardiovascular and Metabolic Improvements - Oral Semaglutide showed significant advantages in various cardiovascular and metabolic risk factors, including reductions in body weight, waist circumference, and improvements in glycemic control [8]. - Among participants with prediabetes, 71.1% in the Semaglutide group normalized their blood sugar levels by week 64 [8]. Group 4: Safety and Adverse Events - Adverse events were reported in 93.1% of the Semaglutide group compared to 85.3% in the placebo group, with gastrointestinal events being the most common [8]. - The incidence of nausea was 46.6% in the Semaglutide group versus 18.6% in the placebo group, while vomiting rates were 30.9% and 5.9%, respectively [8]. Group 5: Conclusion and Future Implications - The study concluded that a daily oral dose of 25 mg Semaglutide is an effective weight management option for overweight or obese adults and may provide a non-injection alternative for GLP-1 based treatments [11]. - This research lays the groundwork for further formulation testing of this significant weight loss medication, potentially leading to more user-friendly oral tablet forms [11].

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Core Viewpoint - Novo Nordisk (NVO.US) shares rose over 2%, reaching $56.78, following the approval of oral semaglutide by European regulators for reducing cardiovascular death, heart attack, and stroke risks [1] Company Developments - Novo Nordisk announced that its oral version of semaglutide has received approval from European regulatory authorities [1] - The company plans to seek FDA approval for a high-dose version of its popular weight loss drug, semaglutide (Wegovy) [1]

Core Insights - Meituan has launched the weight loss drug Masitide injection (brand name: Xin'ermei) on its self-operated pharmacy platform, marking another exclusive online debut of GLP-1 drugs following oral versions of Semaglutide and Tirzepatide [1][3] - Masitide is the world's first approved GCG/GLP-1 dual receptor agonist for weight management, showing a maximum weight loss of 21% over 20 weeks in clinical trials [3] - The global GLP-1 drug market is projected to exceed $60 billion by 2025, with China's market expected to reach $4.5 billion and an annual growth rate of over 28% [3] Company Developments - Meituan has upgraded its transportation equipment to ensure the quality of GLP-1 drugs during delivery, utilizing specialized temperature-controlled transport boxes [1] - The self-operated pharmacy has introduced a "no weight loss, no pay" service and online consultations with top-tier hospital doctors to enhance user experience in weight management [3] Product Features - Masitide's injection device offers improved convenience and safety, featuring a needle-free design and innovative X-section technology for painless injections [3] - The dual-target mechanism of Masitide not only enhances weight loss effects but also significantly reduces visceral fat by up to 80% and improves metabolic issues such as hypertension and hyperglycemia [3]

Group 1 - The newly approved weight loss drug, Marsutide injection, has been launched on Meituan's self-operated pharmacy platform [1] - Alongside the previously launched oral versions, Semaglutide and Tirzepatide, these three drugs will compete on the Meituan platform [1]