Group 1: Market Performance - The Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index rose by 2.51% as of October 31, 2025, with notable increases in individual stocks such as 9.75% for 3SBio, 7.28% for InnoCare Pharma, and 5.51% for Innovent Biologics [3] - The Hong Kong Innovative Drug Selection ETF (520690) increased by 2.75%, reaching a latest price of 0.9 yuan, with a turnover rate of 9.15% and a transaction volume of 48.62 million yuan [3] - Over the past year, the average daily trading volume of the Hong Kong Innovative Drug Selection ETF was 119 million yuan [3] Group 2: Company Developments - Innovent Biologics announced its formal application for a Hong Kong listing on October 30, aiming for a dual listing in both A-share and H-share markets, which is a significant step in its global strategy [3] - The company emphasizes that this listing will support its expansion into overseas markets and strengthen its international business foundation, marking a new phase of "local deepening + global expansion" [3] Group 3: Industry Trends - Small nucleic acid drugs are recognized as the third wave in the pharmaceutical industry, with expectations for the Chinese market to exceed 10 billion yuan by 2030 [4] - The breakthrough of GalNAc technology in 2014 has significantly activated the industry, leading to commercial profitability and advancements in various therapeutic areas [4] - Chinese companies are developing in sync with global trends, expanding from cardiovascular and hepatitis B treatments to areas like weight loss and central nervous system disorders [4] Group 4: Policy and Market Outlook - The 15th Five-Year Plan emphasizes support for innovative drugs and medical devices, focusing on major diseases such as tumors and metabolic diseases, while also promoting new technology platforms like ADCs and nucleic acid drugs [5] - The latest scale of the Hong Kong Innovative Drug Selection ETF reached 523 million yuan, a new high since its inception, with a total share count of 598 million [5] - Recent net inflows into the ETF totaled 21.09 million yuan, with a significant trend of net inflows observed over the past five trading days [5] Group 5: Index Composition - As of October 8, 2025, the top ten weighted stocks in the Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index accounted for 72.15% of the index [6]

截至2025年10月30日 13:37，恒生港股通创新药精选指数下跌2.08%。成分股方面涨跌互现，四环医药 领涨2.74%，映恩生物-B上涨2.68%，MIRXES-B上涨2.29%；信达生物领跌4.79%，药捷安康-B下跌 4.63%，先声药业下跌3.78%。港股创新药精选ETF(520690)下跌2.22%，最新报价0.88元。 流动性方面，港股创新药精选ETF盘中换手18.09%，成交9143.64万元，市场交投活跃。拉长时间看， 截至10月29日，港股创新药精选ETF近1年日均成交1.19亿元。 消息方面，10月30日，2025年国家医保谈判在北京开启。今年国谈在延续医保目录常规调整机制的基础 上，首次正式引入"商保创新药目录"机制。商保创新药目录主要纳入超出保基本定位、暂时无法纳入基 本目录，但创新程度高、临床价值大、患者获益显著的创新药，推荐商业健康保险、医疗互助等多层次 医疗保障体系参考使用。据国家医保局8月28日公告，2025年基本药品目录调整有535个药品通用名通过 形式审查。商保创新药目录有121个药品通用名通过形式审查，其中同时申报基本医保目录和商保创新 药目录的有79个。 10月30 ...

Core Insights - The Hang Seng Healthcare Index has shown a positive trend, with notable increases in constituent stocks such as Kangnate Optical and WuXi AppTec, indicating a robust performance in the healthcare sector [2][8] - The upcoming launch of the Hang Seng Biotechnology Index futures on November 28 is expected to provide hedging and incremental tools for the H-share biotech sector [7] - The 11th round of national centralized procurement (VBP) bidding is scheduled for October 27, introducing uncertainty regarding pricing and product selection [8] Market Performance - As of October 24, 2025, the Hang Seng Healthcare ETF has risen by 0.46%, with a recent price of 0.66 yuan and a 3-month cumulative increase of 2.02% [2][11] - The Hong Kong Stock Connect Innovative Drug Selection Index has increased by 0.19%, with significant gains in stocks like Rongchang Bio and Sanofi [4] - The Medical 50 ETF has also seen a rise of 0.16%, with a recent price of 0.62 yuan and a 3-month cumulative increase of 4.36% [7][13] Liquidity and Trading Activity - The Hang Seng Healthcare ETF recorded a turnover rate of 10.25% with a trading volume of 703 million yuan, indicating active market participation [2][12] - The Hong Kong Innovative Drug Selection ETF had a turnover rate of 12.51% and a trading volume of 61.91 million yuan, reflecting a vibrant trading environment [5] - The Medical 50 ETF had a turnover rate of 0.61% with a trading volume of 1.0073 million yuan, showing lower liquidity compared to the other ETFs [7] Company Performance - Sanofi's Q3 performance was impressive, with a revenue of 1.116 billion yuan, a year-on-year increase of 18.8%, and a net profit of 399 million yuan, up 71.15% [8] - The focus on "outbound + BD" strategies is expected to drive growth in the innovative drug sector, with a concentration of BD events typically occurring in Q4 [9][10] ETF Overview - The Hang Seng Healthcare ETF has a total size of 6.777 billion yuan, ranking in the top third among comparable funds [11] - The Hong Kong Innovative Drug Selection ETF closely tracks the performance of the Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index, focusing on leading innovative drug companies [12] - The Medical 50 ETF tracks the CSI Medical 50 Index, representing the top 50 companies in the pharmaceutical and healthcare sector [13]

Market Performance - The Hang Seng Healthcare Index decreased by 2.74% as of October 14, 2025, with mixed performance among constituent stocks [1] - The Hang Seng Healthcare ETF (513060) fell by 1.74%, with a latest price of 0.68 CNY, but has seen an 18.15% increase over the past three months [1] - The Hong Kong Stock Connect Innovative Drug Selection Index dropped by 3.58%, with the latest price of the corresponding ETF (520690) at 0.94 CNY, reflecting a decline of 2.28% [2] - The CSI Pharmaceutical 50 Index decreased by 1.24%, with the latest price of the Pharmaceutical 50 ETF (159838) at 0.63 CNY, showing an 11.34% increase over the past three months [2] Liquidity and Trading Activity - The Hang Seng Healthcare ETF had a turnover of 12.72% and a trading volume of 884 million CNY, indicating active market participation [1] - The Hong Kong Innovative Drug Selection ETF recorded a turnover of 21.74% with a trading volume of 90.47 million CNY [2] - The Pharmaceutical 50 ETF had a turnover of 1.01% and a trading volume of 1.66 million CNY, with an average daily trading volume of 6.33 million CNY over the past week [3] Regulatory and Market Developments - The National Healthcare Security Administration issued a notice to strengthen the regulation of retail pharmacies, targeting "dual pricing" practices, which may accelerate compliance in the pharmacy sector [3] - Boteng Co., Ltd. expects a revenue growth of 17%-21% year-on-year for the first three quarters, indicating a recovery in the CDMO sector driven by global client pipeline expansion [3] - Four Seasons Pharmaceutical has acquired a stake in Swiss Suisselle SA, gaining exclusive rights to the CELLBOOSTER® product, enhancing its international brand collaboration and product matrix [3] Institutional Insights - The overall signal for the pharmaceutical sector is neutral, with regulatory pressures on retail pharmacies but resilience in CDMO and medical aesthetics sectors [4] - Short-term focus is on the sustainability of performance recovery for companies like Boteng, while mid-term attention is on international collaborations in medical aesthetics and growth in the innovative drug outsourcing industry [4] Fund Flows and Performance - The Hang Seng Healthcare ETF saw a net inflow of 12.05 million CNY, accumulating 177 million CNY over the past 15 trading days [6] - The Hong Kong Innovative Drug Selection ETF reached a record high of 434 million shares, with a net inflow of 2.89 million CNY recently [7] - The CSI Pharmaceutical 50 Index includes major companies like WuXi AppTec and Hengrui Medicine, with the top ten stocks accounting for 59.46% of the index [8]

Core Insights - The healthcare indices in Hong Kong have shown positive performance, with the Hang Seng Healthcare Index rising by 0.67% and the Hang Seng Innovation Drug Selection Index increasing by 0.74% as of September 25, 2025 [3][5] - Notable stock performances include a 6.57% increase in Crystal Technology Holdings and a 6.41% rise in Junshi Biosciences [3][5] - The liquidity of the ETFs tracking these indices is robust, with significant trading volumes and turnover rates [3][5][7] ETF Performance - The Hang Seng Healthcare ETF (513060) has seen a 27.42% increase over the past three months, ranking in the top third among comparable funds [3] - The Hong Kong Innovation Drug Selection ETF (520690) has recorded a 2.63% increase since its inception [5] - The Medical 50 ETF (159838) has increased by 2.19% over the past month, ranking in the top half among comparable funds [7] Company Developments - Heng Rui Medicine has entered an overseas licensing agreement with Glenmark for the drug Rukang Qumai (HER2 ADC), which includes an upfront payment of $18 million and potential milestone payments and sales royalties totaling nearly $1.1 billion, indicating international recognition of its ADC products [7][8] - The National Healthcare Security Administration is actively seeking information on innovative medical consumables such as brain-computer interfaces and surgical robots, aiming to accelerate the coding process for medical insurance and support the commercialization of innovative medical devices [7][8] Market Sentiment - The dual boost from the international licensing agreement and proactive government engagement in innovative technologies is expected to enhance sentiment in the healthcare sector, particularly for companies with technological barriers in ADCs, surgical robots, and brain-computer interfaces [8]

Group 1 - The Hang Seng Hong Kong Stock Connect Innovative Drug Select Index increased by 0.38%, with notable gains from companies such as Hengrui Medicine (+5.42%) and Junshi Biosciences (+3.48%) [2] - The Hong Kong Innovative Drug Select ETF (520690) rose by 0.97%, with a current price of 1.04 yuan, and has accumulated a total increase of 4.15% since its inception [2] - The trading activity for the Hong Kong Innovative Drug Select ETF was robust, with a turnover rate of 35.03% and a transaction volume of 132 million yuan [2] Group 2 - In the first half of 2025, the total amount of overseas licensing for Chinese innovative drugs approached 66 billion USD, nearing the total for the entire year of 2024 [3] - The acceleration of innovative drug research and development is expected due to policy support, which will help companies complete clinical trials faster and bring products to market sooner [3] - The global pharmaceutical transaction volume reached 456 deals, a 32% year-on-year increase, with upfront payments totaling 11.8 billion USD, a 136% increase [4] Group 3 - The top ten weighted stocks in the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index account for 78.87% of the index [5][6] - The recent net inflow of funds into the Hong Kong Innovative Drug Select ETF was 3.076 million yuan, with a total of 14.35 million yuan net inflow over the past five trading days [4]

Market Performance - The Hang Seng Healthcare Index increased by 0.76%, with notable gains from companies such as Baize Medical (+54.41%) and Brainstorm Aurora-B (+34.40%) [3] - The Hang Seng Healthcare ETF (513060) rose by 1.08%, with a recent price of 0.75 yuan, and has accumulated a 4.96% increase over the past two weeks, ranking in the top third among comparable funds [3] - The Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index saw a 0.26% rise, with significant increases from companies like Yaojie Ankang-B (+42.96%) and MIRXES-B (+28.86%) [3] Liquidity and Trading Activity - The Hang Seng Healthcare ETF had a turnover rate of 21.64% and a trading volume of 1.586 billion yuan, indicating active market participation [3] - The Hong Kong Stock Connect Innovative Drug Selection ETF recorded a turnover rate of 27.79% and a trading volume of 105 million yuan, also reflecting a vibrant trading environment [4] Policy and Industry Developments - The State Council reviewed and approved the draft regulations for the management of clinical research and clinical application of biomedical new technologies, emphasizing the dual focus on innovation and safety [5] - The CSCO conference highlighted the rapid rise of China's clinical capabilities, with more Chinese experts becoming principal investigators in global studies, showcasing the international influence of China's innovative drug clinical research [5] Institutional Insights - The combination of supportive policies and international clinical integration is expected to catalyze the full industry chain development of domestic innovative drugs [6] - Companies with global clinical design and MRCT capabilities are likely to capture market share, despite potential review risks from stricter FDA policies [6] Related ETFs - The Hang Seng Healthcare ETF (513060) tracks the Hang Seng Healthcare Index, covering core assets in Hong Kong's healthcare sector [7] - The Hong Kong Stock Connect Innovative Drug Selection ETF (520690) closely follows the Hang Seng Hong Kong Stock Connect Innovative Drug Selection Index, focusing on leading innovative drug companies [8]

Market Performance - The Hang Seng Healthcare Index increased by 2.69% as of September 5, 2025, with notable gains from stocks such as Eucan Vision Bio-B (+13.93%), 3SBio (+11.67%), and CanSino-B (+10.58%) [3] - The Hang Seng Healthcare ETF (513060) rose by 2.36%, closing at 0.74 CNY, and has seen a 5.57% increase over the past week [3] - The Hang Seng Innovation Drug Selection Index surged by 3.33%, with 3SBio and CanSino-B also showing significant increases [5] - The Innovation Drug Selection ETF (520690) increased by 2.61%, reaching 1.06 CNY, and has recorded a 6.60% rise over the past week [5] Liquidity and Trading Activity - The Hang Seng Healthcare ETF had a turnover rate of 25.37% with a trading volume of 1.917 billion CNY, indicating active market participation [3] - The average daily trading volume for the Hang Seng Healthcare ETF over the past week was 3.088 billion CNY, ranking it first among comparable funds [3] - The Innovation Drug Selection ETF had a turnover rate of 34.1% with a trading volume of 124 million CNY, also reflecting active trading [5] - The average daily trading volume for the Innovation Drug Selection ETF over the past week was 237 million CNY [5] New Drug Developments - A new pediatric influenza treatment, the Mavirovir granules, developed by Xiansheng Pharmaceutical and Antikang Bio, has had its market application accepted, targeting children aged 2-11 [6] - The HRS-4729 injection by Heng Rui Pharmaceutical has received clinical trial approval, aiming to be a first-in-class triple receptor agonist for weight loss and liver fat reduction [6][7] Institutional Insights - The introduction of the first domestic pediatric influenza drug is expected to address the seasonal demand for pediatric medications, potentially boosting sentiment in the anti-infection and pediatric channels [7] - The clinical approval of Heng Rui's triple receptor agonist is anticipated to enhance the long-term outlook for local companies in the GLP-1 expansion mechanism, increasing interest in related CRO/CDMO and metabolic pipeline companies [7][8] ETF Overview - The Hang Seng Healthcare ETF has a current size of 7.463 billion CNY, ranking it among the top third of comparable funds [10] - The ETF closely tracks the Hang Seng Healthcare Index, which reflects the performance of healthcare-related securities listed in Hong Kong [10] - The top ten weighted stocks in the Hang Seng Healthcare Index account for 62.87% of the index, including companies like BeiGene and Innovent Biologics [10] - The Innovation Drug Selection Index also has a significant concentration, with its top ten stocks representing 78.87% of the index [10]

Group 1 - The Hong Kong stock market saw all three major indices rise collectively, with gains exceeding 1.1%, indicating a shift from net selling to net buying by southbound funds [1] - The Hang Seng Index rose by 0.63%, surpassing the 25,000-point mark, while the Hang Seng China Enterprises Index and the Hang Seng Tech Index increased by 0.68% and 0.56%, respectively [1] - Biopharmaceutical stocks, which had recently experienced a downturn, rebounded, with companies like Innovent Biologics, WuXi Biologics, and China Biologic Products leading the innovative drug sector [1] Group 2 - The Hong Kong Innovative Drug Selected ETF (520690) saw a peak increase of over 5% during trading, with a transaction volume exceeding 200 million yuan and a turnover rate above 60%, indicating strong buying interest [1] - Most constituent stocks of the ETF experienced gains, with WuXi Biologics rising over 7%, and other companies like CSPC Pharmaceutical, Innovent Biologics, and Green Leaf Pharmaceutical also seeing increases of over 6% [1] - Several innovative drug companies in Hong Kong have recently initiated placement financing, with total fundraising ranging from hundreds of millions to over 2 billion Hong Kong dollars, primarily aimed at research and development, clinical trials, and commercialization [1] Group 3 - A team in China completed the world's first clinical trial using brain-computer interfaces for precise tumor boundary localization during surgery, enhancing surgical quality and preserving healthy brain tissue [2] - The recent wave of placements reflects the capital market's core demand for "funding sustainability" among innovative drug companies, with leading firms consolidating their R&D and internationalization efforts [2] - The integration of brain-computer interfaces and AI is increasing attention on medical AI, improving surgical navigation and operational efficiency in pre- and post-operative processes [2] Group 4 - The Hong Kong Innovative Drug Selected ETF (520690) tracks the Hang Seng Hong Kong Stock Connect Innovative Drug Selected Index, utilizing natural language processing (NLP) to analyze annual reports and patent texts [3] - The ETF systematically excludes CXO (contract research organizations) and "pseudo-innovation" entities, ensuring that all constituent stocks are directly involved in innovative drug R&D and commercialization [3]

Core Insights - The Hang Seng Healthcare Index (HSHCI) has seen a strong increase of 1.86%, with notable gains from stocks such as Ping An Good Doctor (+7.69%) and Lijun Pharmaceutical (+5.95%) [3] - The Hang Seng Innovation Drug Selection Index (HSSCPB) rose by 2.04%, with Lijun Pharmaceutical and King’s Ray Biotechnology also showing significant increases [5] - Heng Rui Medicine reported a 15.88% increase in revenue to 15.761 billion yuan and a 29.67% increase in net profit to 4.450 billion yuan for the first half of 2025 [7] - The company plans to repurchase A-shares worth 1-2 billion yuan to support employee stock ownership plans [7] Market Performance - The Hang Seng Healthcare ETF (513060) increased by 1.13%, with a recent price of 0.72 yuan and a weekly increase of 1.58% [3] - The Hang Seng Innovation Drug Selection ETF (520690) rose by 1.49%, with a recent price of 1.02 yuan and a weekly increase of 0.80% [5] - The trading volume for the Hang Seng Healthcare ETF was 420 million yuan, with a turnover rate of 5.43% [3] Liquidity and Trading Activity - The Hang Seng Innovation Drug Selection ETF had a trading volume of 18.9759 million yuan, with a turnover rate of 4.81% [6] - The average daily trading volume for the Hang Seng Healthcare ETF over the past month was 2.588 billion yuan, ranking first among comparable funds [3] Company Developments - Heng Rui Medicine's Q2 revenue reached 8.556 billion yuan (+12.53%) and net profit was 2.576 billion yuan (+24.88%), marking record highs for the period [7] - The management of China Biopharmaceutical plans to increase their holdings by 1 million shares, signaling confidence in the sector [8] ETF Performance and Valuation - The Hang Seng Healthcare ETF has seen a net value increase of 54.93% over the past two years, ranking 12th out of 91 QDII equity funds [9] - The ETF's latest price-to-earnings ratio (PE-TTM) is 30.35, indicating it is at a historical low compared to the past three years [11] - The Hang Seng Innovation Drug Selection ETF has a PE-TTM of 29.34, also reflecting a low valuation relative to historical performance [13] Key Holdings - The top ten weighted stocks in the Hang Seng Healthcare Index account for 61.65% of the index, including companies like BeiGene and WuXi Biologics [12] - The top ten weighted stocks in the Hang Seng Innovation Drug Selection Index represent 77.56% of the index, highlighting the concentration in leading biotech firms [13]