恒生港股通创新药指数是ETF跟踪的指数中首批"纯度"达100%的创新药指数，精准汇聚港股创新药领军 企业；中证港股通医药卫生综合指数从港股通范围内选取医药卫生行业中市值较大的50只上市公司作为 样本，覆盖创新药、医疗器械等领域。投资者可通过港股通创新药ETF易方达（159316）、港股通医药 ETF易方达（513200）等跟踪上述指数的产品，精准捕捉医药产业发展机遇。 1月30日，石药集团与阿斯利康达成总额高达185亿美元的合作，首付款12亿美元，创下中国药企对外授 权交易新纪录。2月8日，信达生物与礼来达成88.5亿美元合作，首付3.5亿美元，创新采用"端到端共 研"模式。据统计，2026年以来创新药BD合作的首付款规模，已超越2025年全年最高单季度水平，总交 易金额已达332.8亿美元，产业出海势头迅猛。 同时，龙头公司业绩预告验证了高景气度。信达生物、荣昌生物与君实生物预告2025年营业收入分别约 为110亿元、32.5亿元和25亿元，同比大幅增长45%、89%和32%，强劲的业绩增长为板块提供了坚实的 基本面支撑。 2月10日，港股医药板块全天强势领涨，截至15:15，恒生港股通创新药指数上涨2.7 ...

Core Viewpoint - The Hong Kong innovative drug sector has emerged as the best-performing segment in the market during the first week of trading this year, with several companies rebounding over 10% [1][3]. Group 1: Market Performance and Trends - The primary reasons for the strong performance include a significant rise in global markets, with the US biotech ETF XBI outperforming the market by 25% since Q4 2025, while Hong Kong innovative drugs are beginning to recover the gap [1][3]. - The market's risk appetite has improved, with ongoing interest in AI themes and innovative drugs, leading to new highs in US biotech stocks [1][3]. - Anticipation for the upcoming JPM Healthcare Conference is high, as Chinese innovative drug companies are expected to present data that could facilitate more business development (BD) transactions [1][9]. Group 2: Business Development Opportunities - The innovative drug sector is expected to benefit from a surge in BD transactions, with projections indicating that by 2025, the total value of BD deals involving Chinese innovative drug companies could reach $135.6 billion, with 157 transactions expected [9][11]. - Recent notable BD transactions include a $2 billion licensing deal for a prostate cancer drug and a $1.06 billion deal for an ADC drug, highlighting the growing interest from multinational pharmaceutical companies [9][11]. Group 3: Economic Factors and Valuation - The expectation of US interest rate cuts is rising, with a 40.7% probability of a rate cut in March, which could serve as a catalyst for the innovative drug sector throughout the year [11][12]. - The valuation of the innovative drug sector has adjusted significantly, with current static valuations being much lower compared to September 2025, indicating potential for future growth as the sector continues to attract BD transactions [12][13]. Group 4: Investment Strategy - Given the current market conditions, investing in innovative drugs through ETFs is recommended as a stable approach, particularly with the anticipated increase in BD transactions and the potential for significant returns [15].

Market Performance - The Hong Kong Stock Connect innovative drug ETF managed by E Fund (159316) experienced a strong rebound today, rising by 3.3% with a trading volume increasing to 500 million [1] Core Drivers - Liquidity expectations have improved as the U.S. December non-farm payroll data fell short of expectations, leading to heightened market anticipation for a Federal Reserve interest rate cut, with the CME "FedWatch" indicating a 40.7% probability of a rate cut in March [2] Industry Updates - Research and Development Progress: Innovent Biologics' anti-CTLA-4 monoclonal antibody "Daboshu" has been approved for market launch as the first domestic drug of its kind [2] - Business Development Activity: GSK has entered into a collaboration with AstraZeneca worth over $2 billion, setting a record for domestic clinical-stage small molecule anti-cancer drug collaborations. The total transaction amount for outbound licensing in 2025 is projected to reach $135.655 billion [2]

Group 1 - The global stock market has seen a significant rise, with the Hang Seng Index increasing nearly 3% in the first week of the new year, particularly driven by the innovative drug sector, which is expected to continue its rebound [1][2] - The innovative drug sector was previously affected by liquidity issues and year-end accounting effects, but the current market conditions present an opportunity for investors as the sector has returned to levels seen in June 2025 [1][2] - The recent comments from Trump regarding Venezuelan oil extraction, which could increase oil supply by approximately 30%, are expected to exert downward pressure on inflation and raise the likelihood of interest rate cuts by the Federal Reserve, benefiting the innovative drug sector [1][2] Group 2 - The innovative drug sector is anticipated to remain a key investment theme in 2025, with the Hang Seng Innovative Drug Index having outperformed the Hang Seng Technology Index significantly, showing a 64% increase compared to the latter's 23% [4] - The sector has experienced a remarkable rebound, with a peak increase of over 116%, although it has since retraced to levels seen in June 2025 due to overall market weakness [4][20] - The trend of overseas licensing deals for Chinese innovative drug companies has become a norm, with several high-value transactions occurring, such as a $60 billion deal between 3SBio and Pfizer, indicating strong international interest [6][8][11] Group 3 - The innovative drug sector is benefiting from supportive policies that have shifted focus towards quality, reducing previous concerns about profitability in the domestic market [14][19] - The introduction of measures to stabilize pricing and ensure quality in the procurement process is expected to positively impact innovative drug companies [16][19] - The overall valuation of the innovative drug sector has adjusted downwards, making it more attractive for investment, especially with the anticipated increase in business development (BD) transactions and favorable monetary policy [20][22] Group 4 - The innovative drug sector's performance is expected to be bolstered by a series of upcoming medical conferences, which are typically high points for BD transactions, providing opportunities for early investment [13] - The sector's growth is supported by a multi-faceted payment system that includes insurance and government funding, creating a conducive environment for rapid expansion [19] - Investment in innovative drugs can be effectively achieved through ETFs, such as the E Fund Innovative Drug ETF (159316), which focuses on leading companies in the sector [22][24]

Core Viewpoint - The Hong Kong Stock Connect innovative drug ETF managed by E Fund (159316) has shown a strong rebound, rising over 4.5% in early trading, indicating positive market sentiment towards innovative drug development in China [1] Group 1: Innovative Drug Development - Innovent Biologics' anti-CTLA-4 monoclonal antibody "Daboshu" has been approved as the first domestic drug of its kind, filling a gap in the market [1] - The TROP2 ADC "Dercumab" jointly developed by AstraZeneca and Daiichi Sankyo has been approved for breast cancer indications in China, strengthening the ADC sector [1] Group 2: Business Development (BD) Growth - By December 31, 2025, the total transaction amount for China's innovative drug BD overseas licensing is expected to reach $135.655 billion, with upfront payments of $7 billion and a total of 157 transactions, marking historical highs across various metrics [1] - Recent BD transactions include: - Tongyi Medicine's peptide-conjugated drug CBP-1018 for prostate cancer licensed to MultiValent Biotherapies for $2 billion [1] - Ascletis Pharma's ADC drug SIM0613 licensed to Ipsen for $1.06 billion [1] - GRAIL's pan-KRAS inhibitor entering a Co-Co collaboration with AstraZeneca for over $2 billion, setting a record for clinical-stage small molecule collaborations [1] Group 3: Key Products - E Fund's Hong Kong Stock Connect innovative drug ETF (159316, linked A/C: 024328/024329) [1] - E Fund's Hong Kong Stock Connect pharmaceutical ETF (513200, linked A/C: 018557/018558) [1] - E Fund's Hang Seng Biotechnology ETF (159105) [1]