EGFR ADC (SYS6010): a near-term BD catalyst. SYS6010 is currently in global Ph3 development. In China, two pivotal studies are ongoing: a Ph3 trial comparing SYS6010 to chemotherapy in 2L EGFR TKI-resistant NSCLC, and a Ph1b/3 trial evaluating SYS6010 + osimertinib vs osimertinib alone in 1L EGFR-mutant NSCLC, with the Ph3 portion to start by end-2025. The Company is also in discussion with CDE regarding the initiation of SYS6010 in 2L+ EGFR wild-type NSCLC, with additional Ph3 trials in ESCC and HNSCC in p ...

Global Market Dynamics - The report indicates a mixed performance in the A-share market, with active trading in the chip and military sectors, while the Hong Kong market was closed for a holiday, and European markets experienced widespread declines due to trade negotiation concerns [3][9][11] - The U.S. labor market remains stable, with attention on Middle Eastern developments, while international oil prices showed mixed movements, and the dollar index slightly increased [4][27] Economic Indicators - High-frequency data suggests a marginal decline in industrial value-added growth in June, with export growth expected to remain stable compared to May. Infrastructure and manufacturing investments are anticipated to perform well, while real estate sentiment continues to decline [6] - The report highlights that the U.S. Senate passed Trump's tax reform and spending cut bill, and the Eurozone's inflation rate slightly increased to 2% in June [6] Stock Market Insights - The report notes that the U.S. stock market is experiencing a mixed performance, with the Dow Jones rising for four consecutive days, while large tech stocks faced declines. The S&P 500 and Nasdaq both retreated from record highs [9] - In the A-share market, the healthcare sector showed strong performance, while the blockchain concept stocks remained weak. The report emphasizes the rise of innovative drug stocks following supportive measures from health authorities [16][19] Sector Analysis - The report suggests a positive outlook for the U.S. tech sector in the next 6-12 months, driven by fiscal policies and easing trade tensions. Specific sub-sectors such as Robotaxi, Fintech, and AI ASIC are highlighted as areas of focus [8] - The Korean semiconductor and storage industry is noted for strong export performance in June, with expectations for continued robust average selling prices in the second half of 2025 [23] Company-Specific Developments - The report mentions that 和黄医药 (Hutchison China MediTech) is expected to enter a profitable phase with rapid overseas sales growth of its drug 呋喹替尼 (Fruquintinib) and stable domestic sales of 赛沃替尼 (Savolitinib) [14] - 新诺威 (Xinnoway) is highlighted for its promising clinical data on its EGFR ADC product, which shows significant potential for overseas licensing [19]

Core Insights - CSPC reported total revenue of RMB7.0 billion in Q1 2025, with RMB718 million from out-licensing income [1] - Core revenue, excluding out-licensing, reached RMB6.3 billion, reflecting a 1% quarter-over-quarter increase and accounting for 22% of previous FY25 estimates [2] - Core net profit, excluding out-licensing, was RMB868 million, a 58% quarter-over-quarter increase, representing 27% of FY25 estimates [2] Revenue and Profit Trends - Finished drug sales, excluding out-licensing income, declined by 5% quarter-over-quarter and 37% year-over-year, primarily due to a 21% quarter-over-quarter decline in CNS products [2] - Oncology product sales decreased by 7% quarter-over-quarter [2] - Selling expenses fell by 19% quarter-over-quarter to RMB1.7 billion, attributed to the volume-based procurement (VBP) of core products [2] Business Development (BD) Opportunities - CSPC expects three large-scale out-licensing deals in 2025, each with potential deal values exceeding US$5 billion [3] - The company has completed two additional BD agreements in 2025 and anticipates further deals involving key technology platforms [3] - CSPC has invested RMB 5.2 billion in R&D in FY24, supporting a pipeline of 40-50 assets with BD potential [3] Product Development and Clinical Trials - SYS6010, CSPC's leading ADC candidate, is in global Phase 3 development, with pivotal studies ongoing in China and plans for additional trials in the US [4] - SYS6010 demonstrated a median progression-free survival (PFS) of 7.6 months in specific patient populations, indicating promising efficacy [4] - The company plans to initiate two Phase 3 trials in the second half of 2025 for SYS6010 in various NSCLC patient groups [4] Future Outlook - CSPC's BD deals are expected to drive sustainable earnings growth, with projected revenue and net profit growth of 5.8% and 30.4% year-over-year in 2025 [5] - The target price has been revised from HK$5.71 to HK$10.08, reflecting positive growth expectations [5]