Lenacapavir(来那帕韦)

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“一年两次” 长效预防药物落地博鳌,加速终结HIV流行
2 1 Shi Ji Jing Ji Bao Dao· 2025-07-29 04:22
Core Insights - The ongoing battle against HIV/AIDS has persisted for over 40 years, with no cure available, making it a significant global public health issue [1] - In China, over 95% of reported HIV cases are transmitted through sexual contact, with a notable increase in the proportion of cases attributed to sexual transmission in recent years [1] - The introduction of Lenacapavir, a long-acting HIV pre-exposure prophylaxis (PrEP) drug, marks a significant advancement in HIV prevention strategies [2][7] Group 1: Current Situation of HIV/AIDS in China - The proportion of HIV cases transmitted through sexual contact reached 97.6% in 2022, with heterosexual transmission accounting for 72.0% and homosexual transmission for 25.6% [1] - The Chinese government has recognized the importance of HIV prevention, emphasizing a strategy that combines prevention and treatment [2][4] - Despite public awareness of HIV transmission routes, many individuals still perceive HIV as a distant issue, leading to a significant number of undiagnosed cases [1] Group 2: Challenges in HIV Prevention - The effectiveness of PrEP is not widely understood, and there is a significant gap in public knowledge regarding its necessity and proper usage [2][3] - Adherence to daily medication regimens for PrEP, such as Truvada, poses challenges, leading to many individuals discontinuing use or never starting [5] - The market for HIV treatment drugs in China has shown substantial growth, with projections indicating a market size of 4.96 billion yuan by 2023, reflecting a compound annual growth rate of 18.6% from 2019 to 2023 [5] Group 3: Innovations in HIV Prevention - Lenacapavir, requiring only two doses per year, represents a significant innovation in HIV prevention, providing a long-lasting protective effect [2][7] - The drug works by directly targeting the HIV capsid protein, effectively blocking critical steps in the virus's replication process [7] - Clinical studies have demonstrated that Lenacapavir maintains over 99.9% efficacy in preventing HIV infection among high-risk populations [7][8]
一年给药两次的艾滋预防药落地博鳌了,但暴露前预防知晓率低问题待解
Di Yi Cai Jing· 2025-07-25 08:52
Core Viewpoint - The introduction of Lenacapavir, a groundbreaking HIV pre-exposure prophylaxis (PrEP) drug requiring only two doses per year, marks a significant advancement in HIV prevention efforts in China, addressing a critical public health issue with over 100,000 new infections annually in the country [1][3]. Group 1: Product Launch and Availability - Gilead China announced the official launch of Lenacapavir in the Boao Lecheng International Medical Tourism Pilot Zone, with approval received on June 30 for use in adults and adolescents weighing at least 35 kg at risk of HIV-1 infection [1]. - Starting July 25, individuals can make appointments for Lenacapavir through designated institutions such as Boao Super Hospital and Boao Yiling Life Care Center [1]. Group 2: Public Health Context - HIV remains a major public health challenge globally, with China projected to account for 7.8% of new HIV infections worldwide in 2024 [1]. - The World Health Organization has set a target to end the AIDS epidemic by 2030, emphasizing the need for comprehensive prevention strategies to cover 95% of those at risk by 2025 [3]. Group 3: Importance of Pre-Exposure Prophylaxis - Experts highlight that transitioning from treatment-centered approaches to proactive prevention strategies is crucial for effectively controlling HIV spread in China [3][4]. - The introduction of Lenacapavir, which has shown nearly 100% efficacy in preventing HIV in various populations, is expected to improve adherence among high-risk individuals due to its less frequent dosing schedule [4]. Group 4: Challenges and Future Directions - Despite the availability of long-acting prevention drugs like Lenacapavir, there is a need for increased awareness and education about pre-exposure prophylaxis to enhance its uptake among at-risk populations [4]. - The ongoing stigma surrounding HIV may hinder individuals from seeking preventive care, necessitating innovative approaches to resource allocation and outreach in healthcare settings [4].
全球同类首创、一年给药两次的HIV预防药物落地海南博鳌乐城使用
news flash· 2025-07-25 05:18
Core Viewpoint - Gilead China has officially launched Lenacapavir, a groundbreaking HIV pre-exposure prophylaxis (PrEP) drug that requires administration only twice a year, in the Boao Lecheng International Medical Tourism Pilot Zone in Hainan [1] Group 1 - Lenacapavir has been approved for use in the United States since June, aimed at reducing the risk of HIV transmission through sexual contact for adults and adolescents weighing at least 35 kilograms [1]