荣昌生物迎驱动 1月12日晚间，荣昌生物公告，2026年1月12日，公司与艾伯维集团控股公司（下称"艾伯维"）就RC148签署独家授权许可协议。RC148是荣昌生 物研发的一款新型靶向PD-1/VEGF的双特异性抗体药物。 创新药迎来利好！ 根据荣昌生物公告，1月12日，公司与艾伯维集团控股公司（以下简称"艾伯维"）就RC148——一款新型靶向PD-1/VEGF的双特异性抗体药物签 署独家授权许可协议，本次交易总额最高为56亿美元（折合人民币390亿元），首付款为6.5亿美元。 受此带动，今天创新药成为市场主角。荣昌生物A股20%涨停，港股创新药ETF上涨超3%。A股创新药板块上涨超2.7%。诺思格、普蕊斯、华人 健康等涨幅显著。据券商统计，创新药在一周内落地5个BD（Business Development，指创新药物领域的业务发展活动）。1月12日，二代IO疗法 更是发生三件大事。 根据协议，艾伯维将获得RC148在大中华区以外地区的开发、生产和商业化的独家权利。协议经相关监管批准生效后，荣昌生物将收到6.5亿美 元的首付款，并有资格获得最高达49.5亿美元的开发、监管和商业化里程碑付款，以及在大中华区以 ...

港股创新药，可能又要热闹起来了。 今天，消息面最大的利好，来自荣昌生物（HK09995）。 荣昌生物昨晚公布了重量级利好：艾伯维（纽约证券交易所代码：ABBV）和荣昌生物宣布签署独家授权许可协议，共同开发、生产以及商业化RC148。 更值得注意的是，最近一周，中国创新药可谓"遍地开花"。据券商机构统计，短短几天时间就落地了5个BD项目。合作项目涵盖小分子抑制剂、单抗、双 抗、ADC和RDC等多个领域。除了荣昌生物外，宜联生物B7H3 ADC授权罗氏，获得5.7亿美元首付款及近期里程碑付款；海思科PDE3/4双重抑制剂与美国 AirNexis Therapeutics公司合作，获得1.08亿美元首付款，总包超10亿美元；中晟全肽RDC授权诺华，处于临床前；此外还有赛神医药Aβ抗体授权给诺华， 1.65亿美元预付款，16.65亿美元总包。 现在的问题是：港股创新药的热度到底有多高，能否重新回到去年上半年的"辉煌"？目前，如果要投资港股创新药板块，渠道还是比较丰富的：可以直接在 港交所"下场"买票，也可以通过"港股创新药"相关ETF来投资。去年，港股创新药ETF也是最快实现翻倍的跨境ETF。 不过，自2025年9月 ...

创新药迎来利好！ 有券商统计称，创新药一周内落地5个BD。合作项目涵盖小分子抑制剂、单抗、双抗、ADC和RDC，展现出 中国在各个技术领域的全球领先布局。 根据荣昌生物公告，1月12日，公司与艾伯维集团控股公司（以下简称"艾伯维"）就RC148——一款新型靶向 PD-1/VEGF的双特异性抗体药物签署独家授权许可协议，本次交易总额最高为56亿美元（折合人民币390亿 元），首付款为6.5亿美元。 受此带动，今天创新药成为市场主角。荣昌生物A股20%涨停，港股创新药ETF上涨超3%。A股创新药板块上 涨超2.7%。诺思格、普蕊斯、华人健康等涨幅显著。据券商统计，创新药在一周内落地5个BD（Business Development，指创新药物领域的业务发展活动）。1月12日，二代IO疗法更是发生三件大事。 荣昌生物迎驱动 1月12日晚间，荣昌生物公告，2026年1月12日，公司与艾伯维集团控股公司（下称"艾伯维"）就RC148签署独 家授权许可协议。RC148是荣昌生物研发的一款新型靶向PD-1/VEGF的双特异性抗体药物。 根据协议，艾伯维将获得RC148在大中华区以外地区的开发、生产和商业化的独家权利。协议经 ...

Summary of the Conference Call on China Healthcare Sector Industry Overview - The conference call focused on the **China healthcare sector**, highlighting recent weaknesses and potential opportunities for 2026 [2][5][6]. Core Insights and Arguments - **Current Market Performance**: The Hang Seng Healthcare Index (HSHCI) has declined by **3.1%**, while the Hang Seng Index fell by **1.6%**. The HSHCI has dropped approximately **17%** from its year-to-date high in early October, with some small and mid-cap stocks down around **30%** [2][5]. - **Valuation Outlook**: Despite the current weakness, the fundamentals of the sector remain intact, and valuations are becoming more attractive, suggesting a potential rebound in 2026 [2][5][6]. - **Investment Recommendations**: - **Biotech**: Innovent and Kelun Biotech (rated Overweight) - **Pharma**: Hansoh Pharma and Hengrui-A (rated Overweight) - **CXO**: WuXi Apptec and WuXi XDC (rated Overweight) - Caution is advised regarding Akeso due to unclear updates on HARMONi-2 OS [2][5][6]. Upcoming Events and Legislative Considerations - **NRDL Price Negotiations**: Anticipated results from the National Reimbursement Drug List (NRDL) price negotiations are expected to be neutral to negative, reflecting the current weak sentiment [5][6]. - **Biosecure Act**: The potential passing of the Biosecure Act could be a negative headline event, although it is not expected to significantly impact China CXOs' business [5][6]. - **Medical Conferences**: Upcoming medical conferences in December (e.g., ASH'25 and SABCS'25) are not expected to affect overall sentiment towards the China healthcare sector [5][6]. Emerging Themes for 2026 - Potential interest in new drug modalities such as **siRNA** (small interfering RNA) and **RDC** (radionuclide drug conjugate) is anticipated, along with expectations for global Phase 3 data from out-licensed assets [5][6]. - A healthy out-licensing deal flow is expected in 2026, although it may not surpass the total deal size of 2025 due to several significant deals this year [6]. - The **JPM Global Healthcare Conference** in January 2026 is expected to provide further insights into the prospects for the China healthcare sector, with presentations from over a dozen public and private Chinese companies [6]. Key Companies Discussed - **Akeso** (9926.HK) - **Hansoh Pharma** (3692.HK) - **Hengrui** (600276.SS) - **Innovent Biologics** (1801.HK) - **Kelun Biotech** (6990.HK) - **WuXi AppTec** (603259.SS and 2359.HK) - **WuXi XDC** (2268.HK) [8]. Conclusion - The China healthcare sector is currently facing challenges but presents potential investment opportunities as valuations become more attractive. Key themes and developments in 2026 will be closely monitored, particularly in light of upcoming conferences and legislative changes [2][5][6].

Summary of the Conference Call for Ruizhi Pharmaceutical Company Overview - **Company**: Ruizhi Pharmaceutical - **Industry**: Pharmaceutical and Biotechnology Key Points and Arguments Financial Performance - In Q1 2025, Ruizhi Pharmaceutical reported revenue of **261 million yuan**, a year-on-year increase of **11.37%** [2][4] - The net profit attributable to shareholders was **6.64 million yuan**, marking a return to profitability [2][4] - The company significantly reduced its non-deductible net profit loss to **1.57 million yuan**, a **94%** reduction in losses year-on-year [2][5] - For 2024, the company faced challenges with revenue dropping to **970 million yuan**, a **14.76%** decline, and a net loss of **226 million yuan**, although this was a **75.49%** improvement compared to the previous year [3] Strategic Initiatives - The company is implementing a comprehensive package strategy, providing one-stop solutions from IND to PCC, enhancing service capabilities across the entire chain [2][6] - Focus on high-value orders and investment in new modalities such as ADC, RDC, AOC, and PDC [2][6] - Initiated a partnership with leading companies in the ADC field to launch a new generation XDC conjugate drug R&D technology platform [2][7] Market Development - Emphasis on large clients in the domestic market, targeting traditional markets transitioning to innovation [2][8] - Optimizing the business development (BD) team for deeper engagement in the U.S. market and increasing exposure in emerging European markets [2][8] - Plans to establish new R&D centers on the U.S. East Coast and in the UK [2][8] Equity Incentive Plan - The company approved an equity incentive plan granting **52.61 million shares**, representing **10.57%** of total equity, to **124 core personnel** [2][9] - Performance targets include a **25%** increase in revenue and a return to profitability [2][9] Business Segment Insights - The small molecule drug segment is experiencing sluggish growth, needing significant effort to return to previous peak levels of **400-500 million yuan** [3][11] - The company is seeing rapid growth in high-risk related businesses, with domestic growth particularly boosted by recent large projects [3][11] ADC Business Capabilities - The company has comprehensive capabilities in the ADC sector, including chemistry, conjugation, and antibody development [2][12] - Currently rebuilding ABC CNC production capacity, with plans to initiate operations soon [2][12] Organizational Changes - The BD structure has been reformed to enhance domestic market engagement, which previously accounted for over **80%** of revenue from international orders [2][13] - New strategies include regional divisions and a focus on strategic client resources [2][13] Future Outlook - The management expresses confidence in achieving annual targets, supported by external market recovery and internal optimization [2][10] - The company is optimistic about future growth, especially in the innovative drug sector, as traditional pharmaceutical companies increase their investments [2][16][22] Investment Fund Strategy - Since 2022, the company has participated in investment funds to drive business development, leveraging government-guided funds for early-stage incubation [2][19] Market Recovery - The overseas market is showing signs of recovery, with a notable return of funds to primary markets [2][17] Emerging Market Trends - ADC, peptides, and small nucleotides are identified as high-growth areas, with the company securing multiple projects in these fields [2][18] Additional Important Insights - The company is focused on cost control while investing in platform development, including small nucleic acid drug platforms and ABC development [2][14] - The second quarter shows positive trends, with traditional pharmaceutical companies increasing their investment in innovative drugs [2][15]