The Stock Exchange of Hong Kong Limited and the Securities and Futures Commission take no responsibility for the contents of this Application Proof, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this Application Proof. Application Proof of Simcere Zaiming Pharmaceutical Co., Ltd. 先聲再明醫藥股份有限公司 (A joint stock company with limited liability incorporated in ...

Investment Rating - The investment rating for the company is maintained at "Buy" with a target price of HKD 19.82 [1][5][11] Core Insights - The company has successfully licensed its SIM0613 (LRRC15 ADC) to France's Ipsen for an upfront payment of USD 45 million and a total deal value of USD 1.06 billion, marking the third licensing deal in 2025 and indicating the company's innovative drug pipeline is entering a monetization phase [1][2] - The SIM0613 ADC platform shows significant potential, with advantages demonstrated in preclinical models and no direct competitors in clinical stages, positioning it as a potential first-in-class (FIC) product globally [2][3] - The company is accelerating its global pipeline expansion, with multiple products and technology platforms poised for overseas exploration, including promising candidates in autoimmune and oncology fields [3][4] Financial Projections - The adjusted net profit forecasts for 2025, 2026, and 2027 are projected at RMB 1.18 billion, RMB 1.40 billion, and RMB 1.52 billion respectively, reflecting a compound annual growth rate (CAGR) of 14% from 2025 to 2027 [5][11] - The expected earnings per share (EPS) for the same years are RMB 0.45, RMB 0.54, and RMB 0.59, with a price-to-earnings (PE) ratio projected to be 33.19x for 2026 [5][11][12]

Investment Rating - The report maintains a "Buy" rating for the company, indicating an expected relative price increase of over 15% within the next 6 to 12 months compared to the benchmark index [11]. Core Insights - The company has demonstrated significant growth in its innovative drug business, with total revenue reaching 3.585 billion yuan in the first half of 2025, a year-on-year increase of 15.1%. Innovative drug revenue accounted for 77.4% of total revenue, reflecting a consistent upward trend over the past five years [7]. - The adjusted net profit for the first half of 2025 was 651 million yuan, up 21.1% year-on-year, with a research and development investment rate of 28.7%, an increase of 9 percentage points [7]. - The company has launched 10 innovative drugs and is focusing on three main areas: neuroscience, oncology, and autoimmune diseases, with notable revenue growth in these sectors [7]. Financial Forecast and Valuation - The company is projected to achieve revenues of 7.69 billion yuan, 9.01 billion yuan, and 10.43 billion yuan for the years 2025, 2026, and 2027, respectively, with year-on-year growth rates of 16%, 17%, and 16% [5][8]. - The forecasted net profit for the same years is expected to be 1.193 billion yuan, 1.389 billion yuan, and 1.609 billion yuan, reflecting significant growth of 63% in 2025 and steady growth of 16% in the following years [5][8]. - The report highlights a projected P/E ratio decreasing from 40.5 in 2024 to 18.5 in 2027, indicating an improving valuation as earnings grow [5]. Product Pipeline and Innovation - The company is advancing its innovative product pipeline, with several products in various stages of development, including two products in NDA review and three in Phase III clinical trials [7][8]. - Key products include the unique sublingual stroke treatment and a novel insomnia drug, both of which are expected to capture significant market share due to their differentiated mechanisms and clinical evidence [7]. - The company is also actively pursuing international collaborations and licensing agreements to enhance its technological platform and expand its market reach [7][8].