经营分析 2026年2月3日，公司公告收到与AbbVie关于SIM0500（GPRC5D/BCMA/CD3三抗）的近期里程碑付款 4000万美元。2025年1月，公司与AbbVie就SIM0500签订海外许可选择权协议，公司将收取首付款，以 及最高10.55亿美金的选择性权益付款和里程碑付款以及大中华区以外地区净销售额的分级特许权使用 费。 智通财经APP获悉，国金证券发布研报称，先声药业(02096)创新转型持续加码，多款创新管线陆续出 海，考虑到公司26年首付款、里程碑付款等确认，上调2026年营收和利润预测，维持2025、2027年盈利 预测，预计2025-2027年营业收入分别为76.3/100.3/110.4亿元（原76.3/91.0/110.4亿元），归母净利润 11.5/16.5/16.6亿元（原11.5/13.8/16.6亿元），对应EPS为0.44/0.64/0.64元（原0.44/0.53/0.64元），维 持"买入"评级。 2025年以来至今多管线授权出海，创新转型逐步验证 国金证券主要观点如下： 2025年以来，公司共计4款管线实现对外授权，包括：①SIM0500与AbbVie签订许可 ...

国金证券发布研报称，先声药业(02096)创新转型持续加码，多款创新管线陆续出海，考虑到公司26年 首付款、里程碑付款等确认，上调2026年营收和利润预测，维持2025、2027年盈利预测，预计2025- 2027年营业收入分别为76.3/100.3/110.4亿元(原76.3/91.0/110.4亿元)，归母净利润11.5/16.5/16.6亿元(原 11.5/13.8/16.6亿元)，对应EPS为0.44/0.64/0.64元(原0.44/0.53/0.64元)，维持"买入"评级。 国金证券主要观点如下： 经营分析 ③SIM0613(LRRC15ADC)与Ipsen达成合作，可获得最高达10.6亿美元的总交易付款； 2026年2月3日，公司公告收到与AbbVie关于SIM0500(GPRC5D/BCMA/CD3三抗)的近期里程碑付款4000 万美元。2025年1月，公司与AbbVie就SIM0500签订海外许可选择权协议，公司将收取首付款，以及最 高10.55亿美金的选择性权益付款和里程碑付款以及大中华区以外地区净销售额的分级特许权使用费。 ④SIM0709(TL1A/IL-23双抗)与勃林格殷格翰达成独 ...

Core Insights - The collaboration between Sihuan Pharmaceutical and Boehringer Ingelheim aims to develop the dual-specific antibody SIM0709 for the treatment of inflammatory bowel disease (IBD) [2][3] - The agreement grants Boehringer Ingelheim global rights outside Greater China, with Sihuan Pharmaceutical receiving an upfront payment of €42 million and potential milestone payments up to €1.016 billion [2][4] - The partnership is expected to leverage Sihuan's innovative research capabilities and Boehringer Ingelheim's global development and commercialization strengths to accelerate the development of this innovative therapy [3][4] Company Developments - SIM0709 is developed from Sihuan's multi-antibody technology platform and targets two key pathways involved in IBD, showing superior efficacy in preclinical studies compared to existing therapies [3] - This collaboration marks Sihuan's second overseas licensing project in the autoimmune disease sector and the fifth self-developed innovative drug to be licensed out, with total potential transaction amounts exceeding $4.6 billion [4] - Sihuan has significantly increased its R&D investment, totaling approximately 9 billion RMB over the past five years, with the proportion of revenue from innovative drugs rising from 45% in 2020 to 77% in the first half of 2025 [4] Market Context - Over 3 million people globally are affected by IBD, highlighting a significant unmet clinical need in this therapeutic area [2] - The collaboration is positioned to redefine effective treatment methods and improve the quality of life for patients suffering from IBD [2][3]

The Stock Exchange of Hong Kong Limited and the Securities and Futures Commission take no responsibility for the contents of this Application Proof, make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this Application Proof. Application Proof of Simcere Zaiming Pharmaceutical Co., Ltd. 先聲再明醫藥股份有限公司 (A joint stock company with limited liability incorporated in ...

Investment Rating - The investment rating for the company is maintained at "Buy" with a target price of HKD 19.82 [1][5][11] Core Insights - The company has successfully licensed its SIM0613 (LRRC15 ADC) to France's Ipsen for an upfront payment of USD 45 million and a total deal value of USD 1.06 billion, marking the third licensing deal in 2025 and indicating the company's innovative drug pipeline is entering a monetization phase [1][2] - The SIM0613 ADC platform shows significant potential, with advantages demonstrated in preclinical models and no direct competitors in clinical stages, positioning it as a potential first-in-class (FIC) product globally [2][3] - The company is accelerating its global pipeline expansion, with multiple products and technology platforms poised for overseas exploration, including promising candidates in autoimmune and oncology fields [3][4] Financial Projections - The adjusted net profit forecasts for 2025, 2026, and 2027 are projected at RMB 1.18 billion, RMB 1.40 billion, and RMB 1.52 billion respectively, reflecting a compound annual growth rate (CAGR) of 14% from 2025 to 2027 [5][11] - The expected earnings per share (EPS) for the same years are RMB 0.45, RMB 0.54, and RMB 0.59, with a price-to-earnings (PE) ratio projected to be 33.19x for 2026 [5][11][12]

Market Overview - Recent reactions to China's rare earth measures have led to significant declines in global stock markets, with major Asian markets dropping sharply, particularly in Japan and Taiwan, which fell over 1% [1] - In the U.S., regional banks Zions Bancorp and Western Alliance Bancorp reported losses due to fraudulent commercial mortgage investments, causing their stock prices to plummet by 13% and 11% respectively, triggering widespread panic in the banking sector [1] - The fear index VIX has risen above 25 for the first time in five months, indicating increased market anxiety [1] Commodity Insights - Gold prices have surged past $4,300, with a total market capitalization exceeding $30 trillion, leading to strong performances in gold jewelry stocks such as Chow Tai Fook and Lao Poo Gold, which rose over 5% and 3% respectively [2] - In contrast, oil prices have declined significantly, with WTI crude oil falling to $56.99 per barrel, a drop of 2.3%, attributed to decreased consumption and increased production from OPEC and the U.S. [3] Sector Focus - The logistics sector is being prioritized for cost reduction and efficiency improvements, with a focus on building a modern logistics system that integrates digital infrastructure and supports small and micro enterprises [6] - Companies like Jitu Express and SF Express are highlighted as key players in the logistics market [7] Company Developments - Xiansheng Pharmaceutical Group has completed the first patient dosing in a Phase I clinical trial for its innovative cancer drug SIM0505 in the U.S., which targets advanced solid tumors [8] - The company reported a 15.1% year-on-year revenue growth to 3.585 billion yuan, driven by its innovative drug business, which accounted for 77.4% of total revenue [9] - The company has multiple innovative drugs in the pipeline, with significant potential for future growth, including two new drug applications expected to be submitted within the next 1-2 years [9]

Group 1: Hong Kong Stock Market - Changfei Optical Fiber Cable (06869) fell over 4%, down more than 40% from its September peak due to declining fiber optic prices and shareholder sell-offs [1] - Solar stocks continued to decline, with Fuyao Glass (03606) down over 3%, New Special Energy (01799) down over 5%, Xinyi Solar (00968) down over 5%, and Folaite Glass (06865) down over 4%. Rumors about the establishment of a polysilicon storage platform were found to be untrue, and future installation demand remains to be observed [2] Group 2: US Stock Market - United Airlines (UAL.US) fell 5.63% after reporting third-quarter revenue slightly below market expectations [3] - TSMC (TSM.US) decreased by 1.60%, with Q3 net profit reaching a record high of 452.3 billion New Taiwan dollars [3] - Micron Technology (MU.US) rose 5.52% as Morgan Stanley upgraded its rating from "hold" to "buy" [4] Group 3: Technology and Innovation - Google (GOOGL.US) increased by 0.17% after launching a new video generation model, Veo 3.1, which improved audio output and editing control [4] - Thermo Fisher Scientific (TMO.US) rose 1.69% as it collaborates with OpenAI to enhance drug development speed and success rates [4] Group 4: Other Notable Movements - DoorDash (DASH.US) fell 2.18% after announcing a partnership with Waymo to launch autonomous delivery services [5] - Derin Holdings (01709) rose over 3% after signing a strategic cooperation agreement with Antalpha to promote digital asset business [5] - NIO-SW (09866) increased over 2% after responding to a lawsuit from a Singapore sovereign wealth fund, stating that the allegations have no factual basis [5]

Core Viewpoint - Xiansheng Pharmaceutical (02096) has seen a stock price increase of over 4%, currently trading at HKD 13.42 with a transaction volume of HKD 89.99 million, following the announcement of a clinical trial for its innovative anti-tumor drug SIM0505 [1] Group 1: Clinical Trial Announcement - Xiansheng Pharmaceutical's subsidiary, Xiansheng Zaiming, has completed the first dosing of SIM0505 in a Phase I clinical trial for advanced solid tumor patients in the U.S. [1] - The trial aims to evaluate the safety, tolerability, pharmacokinetics, and efficacy of SIM0505 [1] Group 2: Drug Details - SIM0505 is a novel ADC targeting CDH6 (calcium adhesion protein-6 or K-cadherin), with a higher affinity for tumor antigens compared to similar candidates [1] - The drug utilizes Xiansheng Zaiming's proprietary TOPO I inhibitor as an effective payload, providing strong anti-tumor activity and a high systemic clearance rate, thus expanding the therapeutic window [1] Group 3: Global Expansion - The Phase I dose-escalation study initiated in China has been expanded to the U.S. by NextCure, which has begun enrolling U.S. patients in the mid-dose group [1] - NextCure has obtained exclusive global licensing rights for SIM0505 outside of Greater China [1]

Core Viewpoint - The stock of Sihuan Pharmaceutical (02096) has seen an increase of over 4%, currently trading at 13.42 HKD with a transaction volume of 89.99 million HKD, following the announcement of a significant milestone in its clinical trial for the innovative anti-tumor drug SIM0505 [1] Group 1: Company Developments - Sihuan Pharmaceutical's subsidiary, Sihuan Zaiming, has completed the first dosing of the SIM0505 drug in a Phase I clinical trial for advanced solid tumor patients in the U.S. [1] - The trial aims to evaluate the safety, tolerability, pharmacokinetics, and efficacy of SIM0505 [1] - SIM0505 is a novel ADC targeting CDH6, demonstrating higher affinity for tumor antigens compared to similar candidates [1] Group 2: Drug Characteristics - The drug utilizes Sihuan Zaiming's proprietary TOPO inhibitor as an effective payload, which not only exhibits strong anti-tumor activity but also has a high systemic clearance rate, thereby expanding the therapeutic window [1] - The Phase I dose-escalation study initiated in China has been expanded to include U.S. patients, with the mid-dose group now enrolling participants [1] - NextCure, Inc. has obtained exclusive global rights for SIM0505 outside of Greater China [1]

Core Insights - NextCure, Inc. and Simcere Zaiming have initiated the dosing of the first patient in the U.S. for the Phase 1 trial of SIM0505, an antibody drug conjugate targeting advanced solid tumors [1][3] Company Overview - NextCure is a clinical-stage biopharmaceutical company focused on developing innovative cancer therapies, particularly for patients who do not respond to existing treatments [4] - Simcere Zaiming, a subsidiary of Simcere Pharmaceutical Group, is dedicated to creating groundbreaking therapies for cancer patients globally, with a strong R&D pipeline [5] Product Development - SIM0505 is designed as a novel antibody drug conjugate targeting cadherin-6 (CDH6) and includes a proprietary topoisomerase 1 inhibitor payload, aiming for broad anti-tumor activity and improved therapeutic potential [2] - The ongoing Phase 1 trial has expanded to include U.S. patients, with dose escalation currently progressing in China [2] Clinical Trial Progress - The first patient in the U.S. has been dosed at a mid-tier level where clinical responses have been observed, marking a significant milestone in the global development of SIM0505 [3][7] - The trial aims to accelerate the timeline for proof-of-concept data, expected in the first half of 2026 [7]