Core Viewpoint - Dongning Biotechnology has submitted its IPO application to the Hong Kong Stock Exchange for the third time, aiming to raise funds for global market expansion, strategic acquisitions, R&D enhancement, and operational needs [1] Group 1: Business Overview - Dongning Biotechnology, established in 2005, is the first domestic provider of serum-free culture media in China, ranking third among local cell culture media suppliers by revenue in 2024 [2] - The company operates two main business lines: bioprocess solutions and laboratory products and services, with the majority of revenue coming from bioprocess solutions [2][3] - Revenue from self-owned products accounted for 86.4%, 89.2%, and 84.9% during the reporting periods, indicating a strong focus on proprietary offerings [3] Group 2: Financial Performance - The company reported revenues of 814 million, 843 million, and 658 million yuan for the years 2023, 2024, and the first three quarters of 2025, respectively, but incurred losses of 315 million, 275 million, and a profit of 14.26 million yuan [4] - Despite revenue growth, the company faced significant losses in 2023 and 2024 due to high expenditures, which accounted for approximately 41.82% and 37.35% of revenue in those years [4] - Non-operating factors, including fair value changes of financial assets, significantly impacted performance, with a loss of 311 million yuan in 2023 alone [4] Group 3: Client and Market Dynamics - Revenue from five major clients represented 31.1%, 23.9%, and 32.0% of total revenue during the reporting periods, with WuXi Biologics being the largest single client [5] - WuXi Biologics holds a 19.75% indirect stake in Dongning Biotechnology and also acts as a supplier, highlighting a complex relationship [5] Group 4: Acquisition Strategy - Since 2020, Dongning Biotechnology has acquired multiple companies to expand its business and product offerings, resulting in a goodwill value of 843 million yuan [6] - The company has faced financial pressure due to significant non-controlling interest put options, amounting to 566 million yuan as of November 2025 [7] - The founder, Wang Meng, holds a combined 39.79% stake in the company, indicating strong insider control [7]

高效把握医疗产业创新升级机遇，认准高弹性T+0"利器"——港股通医疗ETF华宝（159137），标的指 数（港股通医疗主题指数）锚定医疗创新，汇聚港股"医疗器械 + AI医疗 + CXO + 创新药"等医药各领 域核心龙头。 A股医疗投资工具关注——全市场规模最大医疗ETF（512170）及其场外联接基金（012323），聚焦医 疗器械和医疗服务两大领域，标的指数中证医疗覆盖12只AI医疗/脑机接口概念股，合计权重超36%。 数据来源于iFinD、沪深港交易所。截至2026.1.20，医疗ETF基金规模260亿元，在全市场医药医疗类 ETF中规模最大（1/73）。 1月21日，国家医保局新政发布，AH医疗器械股应声上涨！A股最大医疗ETF（512170）盘中上探 1.36%，全天频现溢价，显示买盘较强势，昨日超2.7亿元资金提前进场。 港股医疗弹性更高，汇聚医疗龙头的港股通医疗ETF华宝（159137）盘中摸高1.78%，收涨1.06%终结四 连跌。成份股方面，国产手术机器人龙头微创机器人-B暴涨17.3%，微创医疗、先健科技跟涨逾5%，权 重股阿里健康涨3%。 | | | 分时 3-E 1分 5分 15分 ...

Core Viewpoint - Daiwa reports that WuXi Biologics (02269) and WuXi AppTec (02268) plan to make a full acquisition offer for at least 60% of the shares of Easton Biopharma (01875) for a maximum cost of approximately 2.8 billion yuan, with the expectation that Easton Biopharma will maintain its listing status after the acquisition [1] Group 1 - The acquisition is expected to help WuXi AppTec expand its business and gain additional operational production capacity in China [1] - The deal aims to enrich the project portfolio and expand the customer base for WuXi AppTec [1] - This acquisition is anticipated to strengthen WuXi AppTec's leading market position in the ADC contract research and manufacturing organization sector [1] Group 2 - Daiwa currently assigns a "Buy" investment rating to WuXi Biologics [1]

Group 1 - The core viewpoint of the article is that WuXi Biologics (02269) and WuXi AppTec (02268) have announced a comprehensive acquisition offer to acquire at least 60% of the shares of Easton Biopharma (01875) for a maximum price of approximately 2.8 billion yuan [1] - The acquisition is expected to help WuXi AppTec expand its business and gain additional operational production capacity in China, further enriching its project portfolio and expanding its customer base [1] - The acquisition is anticipated to solidify WuXi AppTec's leading market position in the field of ADC contract research and manufacturing organizations [1] Group 2 - Daiwa currently gives a "Buy" investment rating for WuXi Biologics [1]

Summary of Conference Call Records Industry Overview - The conference call primarily discusses the biopharmaceutical industry, focusing on several key companies and their projected performance for 2025 and beyond. The overall sentiment reflects a robust growth trajectory within the sector. Key Companies and Their Projections 1. WuXi AppTec (药明康德) - Expected revenue for 2025 is 454.56 billion CNY, a year-on-year increase of 15.84% - Adjusted net profit is projected to be 149.57 billion CNY, up 41.33%, with total net profit reaching 191.51 billion CNY, a 102.65% increase [2] - The company has 24 GLP-1 drug candidates, with 15 in Phase II and III clinical trials, indicating strong pipeline growth [4] 2. Kanglong Chemical (康龙化成) - Anticipates revenue between 138.72 billion CNY and 142.4 billion CNY, reflecting a growth of 13%-16% - Adjusted net profit is expected to be between 17.68 billion CNY and 18.48 billion CNY, a growth of 10%-15% [2] 3. Sunway Pharma (阳光诺和) - Projected revenue between 1.192 billion CNY and 1.37 billion CNY, a growth of 10.57%-27.15% - Expected net profit between 190 million CNY and 229 million CNY, a growth of 7.69%-29.23% [2] 4. AstraZeneca (阿斯利康) - Focused on cardiovascular, ADC, next-generation IO, and cell therapy TCE areas - Key clinical data readouts expected in 2026, which may impact market dynamics [5] 5. Gilead Sciences (吉利德) - Key projects include Cloud Native Top two ADC, expected to show promising data in TNBC treatment and potential approval in the second half of the year [8] - Anticipates significant changes in the first-line triple-negative breast cancer market due to the SG molecule [8] 6. DZD Pharma (迪哲医药) - DZD6,008 shows significant efficacy in non-small cell lung cancer (NSCLC) with an ORR of 60% and PFS exceeding 10 months [3][16] Clinical Trials and Data Readouts - Multiple companies, including Gilead, AstraZeneca, and others, are set to release important clinical trial data in 2026, which could reshape competitive dynamics in the NSCLC market [16] - AstraZeneca's ADC project 18.2 is expected to have significant clinical data readouts in 2026, with a focus on large-scale Phase III trials [7] Strategic Collaborations and Market Expansion - WuXi Biologics (药明生物) has signed a strategic cooperation memorandum with Qatar Free Zone Authority to expand into the Middle East market [4] - The conference highlighted the increasing participation of Chinese companies in the global pharmaceutical market, particularly in the dual-antibody and ADC sectors [22] Emerging Trends and Innovations - The industry is witnessing a shift towards L2.0 and ADC combinations, which are expected to become the next wave of drug development [17][18] - The importance of speed and mechanism synergy in new drug development was emphasized, indicating that early-stage projects have a higher success rate [18] Conclusion - The biopharmaceutical industry is poised for significant growth, with several companies reporting strong projections and innovative clinical developments. The upcoming clinical data releases in 2026 are anticipated to have a substantial impact on market dynamics and competitive positioning within the sector.

Company Update - The company participated in the 44th J.P. Morgan Healthcare Conference, where CEO Dr. Chen Zhisheng updated on the business status for 2025 and provided an outlook for accelerated growth in 2026 [1] - The number of new projects signed in 2025 reached a historical high of 209, surpassing 151 in 2024, with approximately half of the new projects coming from U.S. clients [1] - By the end of 2025, the total number of projects is expected to increase to 945, including 74 Phase III clinical projects and 25 commercial production projects, laying a solid foundation for sustained long-term commercial revenue growth [1] Industry Insights - The complex molecule sector shows high industry prosperity, with about two-thirds of the new projects in 2025 being bispecific antibodies and ADCs, indicating a sustained increase in global outsourcing demand for complex molecules [1] - The bispecific antibody business performed exceptionally well, with the number of projects increasing to 196, contributing nearly 20% of the group's revenue, and a year-on-year growth rate exceeding 120% [1] - The ADC pipeline also maintained strong expansion, with the number of projects increasing by 30% year-on-year to 252 [1] - The company is expected to benefit from structural upgrades in the industry as proprietary technology platforms like CD3 TCE continue to advance, enhancing technical barriers and customer stickiness [1] Commercialization and Global Strategy - In 2025, the company completed 28 PPQ projects, a year-on-year increase of 75%, with 34 PPQ projects scheduled for 2026 based on existing contracts [2] - The acceleration of PPQ projects is anticipated to gradually translate into increased CMO revenue and profit release as the number of Phase III and commercial projects rises [2] - The Singapore WuXi AppTec production base was completed on schedule in June 2025, and a strategic partnership with Qatar was established by the end of 2025 to enhance global operational resilience [2] Profit Forecast and Valuation - The profit forecast for 2025 remains unchanged, while the adjusted profit expectation for 2026 has been raised by 4.8% to 5.85 billion yuan, with a new forecast for 2027 set at 6.55 billion yuan [2] - The current stock price corresponds to adjusted P/E ratios of 29.7x for 2025, 25.5x for 2026, and 22.2x for 2027, with a target price increase of 25% to 45 HKD, reflecting an upward potential of 12.5% [2]

Core Insights - The article emphasizes the significant advancements and global presence of Chinese companies in the biopharmaceutical sector, particularly at the JPM 2026 conference, showcasing their capabilities in both service and innovation [7][10]. Group 1: Chinese Companies at JPM 2026 - WuXi Biologics reported a substantial increase in its CRDMO business, achieving 209 comprehensive project collaborations by 2025, up from 150 in 2024, with a focus on complex projects like bispecific antibodies and ADCs [7][8]. - Ascentage Pharma highlighted its global innovation pipeline, featuring key products like the third-generation BCR-ABL inhibitor and BCL-2 inhibitor, which are driving growth in hematological oncology [9]. - Approximately 24 Chinese innovative pharmaceutical companies presented their clinical data and R&D progress at the conference, indicating a shift from being followers to systemic innovators in the global market [9][10]. Group 2: Multinational Pharmaceutical Companies - AbbVie projected an 8% revenue growth for 2025, with a 19% increase in sales from growth platforms, emphasizing the potential of its core immunology products [11]. - Sanofi reiterated its commitment to commercializing respiratory and vaccine-related assets while enhancing its pipeline through external collaborations [11]. - Gilead focused on its long-term strategy in virology, aiming for extended dosing forms and broader disease coverage [12]. Group 3: Healthcare Services and Capital Markets - The third day of the conference saw a shift towards discussions on cash flow, asset quality, and operational resilience among healthcare systems, with many reporting progress in cost control and operational integration [13]. - There was a cautious approach to mergers and acquisitions, with executives indicating a preference for manageable, cash-flow-positive targets rather than high-premium, long-cycle assets [13]. Group 4: Overall Conference Signals - The overall tone of the conference shifted towards practicality, focusing on verifiable results and execution capabilities rather than speculative narratives [14].

药明生物(2269.HK)低开3.4%，报38.66港元。消息面上，药明生物公布，其主要股东Biologics Holdings 已与摩根士丹利订立大宗交易协议，配售其持有的1.5亿股公司股份，占已发行股本总额约3.63%，每股 作价38.52港元，较昨日(15日)药明生物收市价40.02港元折让3.75%，涉资约57.78亿港元。 ...

截至本公告日期但于配售完成前，Biologics Holdings持有公司约5.01亿股股份，占公司已发行股本总额 约12.12%。董事长兼非执行董事李革控制Biologics Holdings已发行股本约19.66%及Biologics Holdings股 东大会55.03%的表决权。假设配售将按预期完成，(i)Biologics Holdings持有的公司股权将由公司已发行 股本总额约12.12%减少至8.49%；及(ii)Biologics Holdings将不再为公司主要股东。 格隆汇1月16日丨药明生物(02269.HK)发布公告，2026年1月15日，董事会获公司其中一名主要股东 WuXi Biologics Holdings Limited("Biologics Holdings")知会，其已与摩根士丹利("配售代理")订立大宗交 易协议，据此，配售代理已同意以每股38.52港元的价格向独立于公司且与公司概无关连的各方配售由 Biologics Holdings持有的公司1.5亿股现有股份(相当于截至本公告日期公司已发行股本总额约3.63%)。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 WUXI BIOLOGICS (CAYMAN) INC. 藥明生物技術有限公司* （於開曼群島註冊成立的有限公司） （股份代號：2269） 內幕消息 主要股東配售現有股份 配售現有股份 於 二 零 二 六 年 一 月 十 五 日，本 公 司 董 事（「董 事」）會（「董事會」）獲 本 公 司 其 中 一 名 主 要 股 東（定 義 見 上 市 規 則）WuXi Biologics Holdings Limited（「Biologics Holdings」）知會，其已與摩根士丹利國際股份有限公司（「配售代理」）訂立大宗 交易協議（「大宗交易協議」），據此，配售代理已同意以每股38.52港元的價格 向獨立於本公司且與本公司概無關連的各方配售由Biologics Holdings持有的本 公司150,000,000股現有股份（相當於截至本公告日期本公司已發行股本總額約 3.63%）（「配售」）。 – 1 – ...