Core Viewpoint - XuanZhu Bio-B (02575) has seen a significant stock price increase of over 234% since its IPO, reflecting strong market interest and confidence in its drug development pipeline [1] Company Overview - XuanZhu Bio-B is a spin-off from the Hong Kong-listed company Sihuan Pharmaceutical (00460), representing a typical "H-share" structure [1] - The company is actively developing over ten drug assets targeting digestive system diseases, tumors, and non-alcoholic steatohepatitis (NASH) [1] Drug Development Pipeline - As of the latest actionable date, XuanZhu Bio-B has three NDA-approved assets, one drug project in the NDA registration stage, one in Phase III clinical trials, four in Phase I clinical trials, and five that have received IND approval [1] - The company is positioned for a commercial explosion by 2025, driven by dual support from its digestive and oncology drug portfolios [1] Commercialization Strategy - The core oncology drugs, Pirlosil and Diroac, are expected to receive approvals, alongside the previously approved proton pump inhibitor, Annelazole Sodium, forming a "three-horse" product matrix for commercialization [1] - This strategy indicates a successful alignment of innovative drug development with commercialization efforts, gaining recognition from both the industry and the market [1]

Core Viewpoint - The Hong Kong Stock Exchange reported that during the week from October 13 to October 19, 9 companies submitted listing applications, 5 companies passed the hearing, 4 companies launched their IPOs, and 2 new stocks were listed [1]. Group 1: Companies Submitted Listing Applications - Hantian Technology (Xiamen) Co., Ltd. is a leader in the global silicon carbide (SiC) epitaxy industry, focusing on the R&D, mass production, and sales of SiC epitaxy chips, with a projected market share of over 30% in 2024 [2]. - Impression Co., Ltd. is a state-owned cultural tourism service enterprise, ranking eighth in China's cultural tourism performance market in 2024, with revenues of approximately 63.04 million yuan in 2022 [3]. - Guangzhou Yujian Noodle Restaurant Co., Ltd. is the fourth largest operator of Chinese noodle restaurants in China, with a market share of 0.5% in 2024 [4]. - Baishan Cloud Holdings Ltd. is the second largest independent edge cloud service provider in China, with a market share of approximately 2.0% in 2024 [5][6]. - Shouchuang Securities Co., Ltd. is a financial service provider with a strong asset management capability, ranking fifth in revenue growth among 42 A-share listed securities companies from 2022 to 2024 [7]. - Chongqing Qianli Technology Co., Ltd. focuses on AI and mobility solutions, with stable growth in automotive products [8]. - Nanjing Qingtian All Tax Information Technology Co., Ltd. is a leading digital service provider for cross-border enterprises, ranking first in the smart tax solution market in China with a market share of 1.7% in 2024 [9]. - Lakala Payment Co., Ltd. is a leading digital payment provider in Asia, with a market share of 9.4% in 2024 [10]. - Sichuan Xin Hehua Traditional Chinese Medicine Co., Ltd. is one of the largest suppliers of traditional Chinese medicine products in China, ranking second in the market with a 0.4% market share in 2024 [12]. Group 2: Companies Passed Hearing - Seres Group Co., Ltd. focuses on the research, manufacturing, and sales of new energy vehicles, achieving revenues of approximately 340.56 billion yuan in 2022 [13]. - Minglue Technology is a leading data intelligence application software company in China, with revenues of approximately 12.69 billion yuan in 2022 [14]. - Pony AI Inc. specializes in autonomous driving services, with a total operational area exceeding 2000 square kilometers [15]. - Ningbo Joyson Electronic Corp. is a global leader in smart automotive technology solutions, ranking second in China and fourth globally in smart cockpit domain control systems [16][17]. - WeRide Inc. is a pioneer in L4 autonomous driving, with operations in over 30 cities across 11 countries [18]. Group 3: Companies Launched IPOs - Yunji Technology launched its IPO with a subscription that was oversubscribed by 5677 times, raising approximately 189.1 billion HKD [19]. - Haixi New Drug's IPO was delayed for regulatory approval, with a price range of 69.88-86.40 HKD per share [20]. - Jushuitan's IPO was set at 30.60 HKD per share, with a total of 681.66 million shares offered [21]. - Guanghetong's IPO was priced between 19.88-21.5 HKD per share, with a total of approximately 135 million shares offered [21]. Group 4: Newly Listed Stocks - Xuan Bamboo Biotechnology was listed on October 15, 2025, with a closing price of 26.30 HKD per share, reflecting a gain of 126.72% [22]. - Yunji was listed on October 16, 2025, with a closing price of 120.5 HKD per share, reflecting a gain of 26.05% [24].

Market Overview - The Hang Seng Index fell by 1.61%, down 415 points, closing at 25,472 points, while the Hang Seng Tech Index dropped by 2.81%. The early trading volume in the Hong Kong market was HKD 153.2 billion [1] Energy Sector - Gas stocks rose, with Zhongyu Energy (03633) increasing by over 10%. This surge is attributed to the early initiation of winter heating in Gansu and other regions due to continuous temperature drops, leading to increased natural gas demand [1] Biotechnology Sector - Newly listed stock Xuan Zhu Bio-B (02575) surged over 13%, reaching a new high, and is up more than 190% from its IPO price. Yimai Sunshine (02522) rose over 4% following the global launch of its medical imaging model product AIR. The performance of medical stocks varied, with Yaojie Ankang-B (02617.HK) up over 21%, Baize Medical (02609) up over 5%, while Kangfang Biotech (09926) fell by 2%. Kangning Jereh Pharma-B (09966) increased by over 13% after announcing a share buyback plan, with market attention on significant data from the ESMO conference [2] Precious Metals Sector - Laopu Gold (06181) rose over 4%, benefiting from increased channel expansion and upgrades, with institutions indicating that rising gold prices favor its high-end brand positioning [3] Hospitality Sector - Wanda Hotel Development (00169) increased by over 10% after completing a sale and announcing a special dividend of HKD 0.462 per share to be paid next month [4] Digital Assets Sector - Delin Holdings (01709) rose over 3% after entering a strategic cooperation agreement with Antalpha to promote business in the digital asset sector [5] Telecommunications Sector - Changfei Optical Fiber and Cable (06869) fell over 6%, having dropped 40% from its September peak due to declining fiber optic prices and shareholder sell-offs. Cryptocurrency-related stocks collectively declined, with Bitcoin experiencing significant volatility and a recent incident in the US stablecoin market. Mi Strategy (02440) fell by 4.36%, and OSL Group (00863) dropped by 3.99% [6] Semiconductor Sector - Chip stocks continued to decline, with SMIC (00981) down over 5% and Huahong (01347) down over 3%, as US export controls accelerate domestic semiconductor replacements [6]

Core Viewpoint - Xuan Zhu Bio-B (02575.HK) has seen a significant increase in stock price, rising over 190% from its IPO price of 11.6 HKD, reaching a new high of 33.96 HKD during trading [2] Summary by Category - **Stock Performance** - The stock price of Xuan Zhu Bio-B increased by over 11%, reaching 32.2 HKD at the time of reporting [2] - The trading volume was reported at 54.043 million HKD [2] - **Market Reaction** - The stock hit a new high of 33.96 HKD during the trading session, marking a significant milestone since its listing [2]

Core Viewpoint - Xuan Zhu Biotech-B (02575) has seen a significant stock price increase, rising over 190% from its IPO price of 11.6 HKD, reaching a new high of 33.96 HKD, indicating strong market interest and confidence in the company's growth potential [1] Company Overview - Xuan Zhu Biotech is a Chinese biopharmaceutical company backed by the Hong Kong-listed company Sihuan Pharmaceutical, with dual research and development systems for small molecule drugs and large molecule biologics [1] - The company has successfully developed four candidate drugs and is actively developing over ten drug assets targeting diseases such as digestive system disorders, tumors, and non-alcoholic fatty liver disease (NASH) [1] Product Pipeline - Currently, Xuan Zhu Biotech has three commercialized products: Annelazole sodium for duodenal ulcers, Pyrotinib for breast cancer, and Dirocitinib for non-small cell lung cancer, with approvals expected in 2023 and 2025 [1] Industry Outlook - Huafu Securities believes that the Chinese innovative drug sector is undergoing a transformation, with a positive outlook for the next 5-10 years driven by overseas business development, continuous data catalysts, and the ramp-up of new product sales [1]

Core Viewpoint - XuanZhu Biotech-B (02575) has seen a significant increase in stock price, rising over 11% and reaching a new high of 33.96 HKD, which is more than 190% above its IPO price of 11.6 HKD [1] Company Overview - XuanZhu Biotech is a Chinese biopharmaceutical company backed by Hong Kong-listed company Sihuan Pharmaceutical, with dual research and development systems for small molecule drugs and large molecule biologics [1] - The company has successfully developed four candidate drugs and is actively developing over ten drug assets targeting diseases such as digestive system disorders, tumors, and non-alcoholic fatty liver disease (NASH) [1] Commercial Products - Currently, XuanZhu Biotech has three commercialized products: Annelazole sodium for duodenal ulcers, Pyrotinib for breast cancer, and Dirocitinib for non-small cell lung cancer, which are expected to be approved in 2023 and 2025 [1] Industry Trends - Huafu Securities believes that the Chinese innovative drug sector is experiencing a transformation driven by quantitative changes leading to qualitative changes, with a positive outlook on the industry trend over the next 5-10 years [1] - Factors such as business development overseas, continuous data catalysts, and the ramp-up of new product sales are expected to drive the rise of innovative drugs [1]

Core Viewpoint - XuanZhu Bio (02575) has seen a significant stock price increase of nearly 150% from its IPO price of HKD 11.6, closing at HKD 28.46 with a trading volume of HKD 56.32 million [1] Company Overview - XuanZhu Bio is an innovation-driven biopharmaceutical company based in China, actively developing over ten drug assets targeting digestive system diseases, tumors, and non-alcoholic fatty liver disease (NASH) [1] - The company has three NDA-approved assets, one drug project in the NDA registration stage, one in Phase III clinical trials, four in Phase I clinical trials, and five that have received IND approval [1] Fund Utilization - The net proceeds from the global offering amount to approximately HKD 701 million, with planned allocations as follows: - About 45% for the research and commercialization of core products (KBP-3571, XZP-3287, and XZP-3621) [1] - Approximately 14% for the research of key products (KM602, KM501, XZP-7797, and XZP-6924) [1] - Around 11% for funding other candidate drugs (including XZB-0004, XZP-5610, XZP-6019, and XZP-6877) [1] - About 20% to enhance commercialization and marketing capabilities, particularly through expanding sales and marketing teams [1] - Approximately 10% for working capital and other general corporate purposes [1]

Core Viewpoint - XuanZhu Bio (02575) has seen a significant stock price increase of over 8%, rising nearly 150% from its IPO price of HKD 11.6, currently trading at HKD 28.46 with a trading volume of HKD 56.32 million [1] Company Overview - XuanZhu Bio is an innovation-driven biopharmaceutical company based in China, actively developing over ten drug assets targeting digestive system diseases, tumors, and non-alcoholic steatohepatitis (NASH) [1] - The company has three drug assets approved for New Drug Application (NDA), one drug project in the NDA registration stage, one in Phase III clinical trials, four in Phase I clinical trials, and five that have received Investigational New Drug (IND) approval [1] Fund Utilization - The net proceeds from the global offering amount to approximately HKD 701 million, with plans to allocate about 45% for the research and commercialization of core products (KBP-3571, XZP-3287, and XZP-3621) [1] - Approximately 14% will be used for the development of key products (KM602, KM501, XZP-7797, and XZP-6924) [1] - About 11% is designated for funding other candidate drugs (XZB-0004, XZP-5610, XZP-6019, and XZP-6877) [1] - Around 20% will enhance commercialization and marketing capabilities, particularly through expanding sales and marketing teams [1] - Approximately 10% is allocated for working capital and other general corporate purposes [1]

Core Viewpoint - XuanZhu Biopharma (02575) has seen a significant stock price increase of over 8%, reaching approximately 28.46 HKD, which is nearly 150% higher than its IPO price of 11.6 HKD [1] Company Overview - XuanZhu Biopharma is an innovation-driven biopharmaceutical company based in China, actively developing over ten drug assets targeting diseases such as digestive system disorders, tumors, and non-alcoholic fatty liver disease (NASH) [1] - The company has three drug assets that have received NDA approval, one drug project in the NDA registration stage, one in Phase III clinical trials, four in Phase I clinical trials, and five that have received IND approval [1] Fund Utilization - The net proceeds from the global offering amount to approximately 701 million HKD, with the following allocation plans: - About 45% will be used for the research and commercialization of core products (KBP-3571, XZP-3287, and XZP-3621) [1] - Approximately 14% will be allocated to the research of key products (KM602, KM501, XZP-7797, and XZP-6924) [1] - Around 11% will be directed towards the development of other candidate drugs (XZB-0004, XZP-5610, XZP-6019, and XZP-6877) [1] - About 20% will enhance commercialization and marketing capabilities, particularly through expanding sales and marketing teams [1] - Approximately 10% will be used for working capital and other general corporate purposes [1]

Core Viewpoint - The successful debut of Xuan Bamboo Biotech (02575.HK) on the Hong Kong Stock Exchange, with a first-day surge of 126.72%, reflects a positive market sentiment towards biotech stocks, particularly those under the 18A listing category [1][8]. Company Overview - Xuan Bamboo Biotech is a subsidiary of Sihuan Pharmaceutical (00460.HK) and has previously attempted to list on the STAR Market without success [1][3]. - The company has three approved products and is actively developing over ten drug assets targeting various diseases, including gastrointestinal disorders, tumors, and non-alcoholic fatty liver disease [3][4]. Financial Performance - Despite the successful listing, Xuan Bamboo Biotech has not yet turned a profit, with revenues of 2.9 million and 30.09 million in 2023 and 2024, respectively, while incurring losses of 300 million and 556 million [6]. - As of the first half of 2025, the company reported revenues of 17.89 million and a loss of 111 million, with cash and cash equivalents dwindling to 8.56 million [6]. Product Pipeline - The core product, KBP-3571, is set to be commercialized starting November 2023, targeting duodenal ulcers and expanding its indications to gastroesophageal reflux disease by the end of 2026 [3][4]. - Other significant products include XZP-3287, a CDK4/6 inhibitor approved for HR+/HER2- advanced breast cancer, and XZP-3621, an ALK-targeted therapy for non-small cell lung cancer [4][5]. Market Sentiment - The recent performance of 18A new stocks, including Xuan Bamboo Biotech, indicates a recovery in investor confidence in the biotech sector, with several stocks experiencing significant first-day gains [1][8]. - The overall market sentiment has improved, leading to higher valuations and expectations for biotech companies [8].