截至月份: 2025年7月31日 狀態: 新提交 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 致：香港交易及結算所有限公司 公司名稱: 山東博安生物技術股份有限公司 呈交日期: 2025年8月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06955 | 說明 | H股 | | | | | | | | | 法定/註冊股份數目 | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 574,333,694 | RMB | | 1 RMB | | 574,333,694 | | 增加 / 減少 (-) | | | | | | RMB | | | | 本月底結存 | | | 574,333,694 | RMB | | 1 RMB | | 574,333,694 | 本月底法定/註冊股本總額： RMB 574,333,694 備 ...

Group 1 - The Hang Seng Healthcare Index (HSHCI) has shown a strong increase of 2.14%, with notable gains from stocks such as Livzon Pharmaceutical (up 11.57%) and United Laboratories (up 7.00) [3] - The Hang Seng Healthcare ETF (513060) has risen by 2.02%, with a recent price of 0.66 yuan, and has accumulated an 8.95% increase over the past week, ranking in the top third among comparable funds [3] - The trading activity of the Hang Seng Healthcare ETF is robust, with a turnover rate of 10.09% and a transaction volume of 840 million yuan, indicating active market participation [3] Group 2 - The 11th batch of national drug procurement has officially launched, involving 55 varieties, signaling a positive shift in procurement policies favoring innovative drugs [4] - The procurement policy emphasizes "no procurement for new drugs" and optimizes selection criteria, enhancing protection for innovative drugs and promoting a healthier market ecosystem for generic drugs [4] - The stable operation of the national medical insurance fund, projected to reach total revenue of 34,913.37 billion yuan by the end of 2024, supports the accessibility and market demand for innovative drugs [5] Group 3 - The Hang Seng Healthcare ETF has seen a significant growth in scale, increasing by 221 million yuan over the past two weeks, ranking in the top third among comparable funds [5] - The ETF's financing activities are notable, with a latest financing purchase amount of 160 million yuan and a financing balance of 231 million yuan [5] - The ETF has achieved a net value increase of 30.39% over the past two years, with a maximum monthly return of 28.34% since inception [5] Group 4 - The Hang Seng Healthcare ETF has a Sharpe ratio of 2.22 over the past year, indicating strong risk-adjusted returns [6] - The ETF has the lowest relative drawdown among comparable funds, with a drawdown of 0.52% year-to-date [6] - The ETF's management fee is 0.50%, and its tracking error is 0.060%, the highest tracking precision among comparable funds [6] Group 5 - The top ten weighted stocks in the Hang Seng Healthcare Index account for 60.73% of the index, including companies like BeiGene and WuXi Biologics [7]

智通财经7月22日电，截至发稿，博安生物(06955.HK)涨8.33%、金斯瑞生物科技(01548.HK)涨7.19%、 再鼎医药(09688.HK)涨6.76%、来凯生物-B(02105.HK)涨5.57%。 港股医药股多数走强 博安生物涨超8% ...

（文章来源：证券时报网） 昊天国际建投、国联民生、老铺黄金、博安生物为近一个月首次上榜，昊天国际建投当日港股通成交额 为16.21亿港元，成交净买入1.06亿港元，该股当日收盘下跌32.78%。国联民生当日港股通成交额为 16.87亿港元，成交净买入0.23亿港元，该股当日收盘上涨10.90%。老铺黄金当日港股通成交额为10.15 亿港元，成交净卖出3.65亿港元，该股当日收盘下跌2.67%。博安生物当日港股通成交额为13.84亿港 元，成交净买入0.51亿港元，该股当日收盘上涨22.31%。 7月14日港股通成交活跃股榜单 | 证券 | 证券简称 | 成交金额（亿 | 净买入金额（亿 | 近一个月上榜 | 最新收盘价 | 日涨跌幅 | | --- | --- | --- | --- | --- | --- | --- | | 代码 | | 港元） | 港元） | 次数 | （港元） | （%） | | 00700 | 腾讯控股 | 15.26 | -0.84 | 20 | 500.000 | 0.68 | | 01810 | 小米集团 W | 26.75 | -0.66 | 20 | 57.300 | -0 ...

Core Insights - On July 14, 2025, Guotai Junan International (01788), Legend Holdings (06683), and Alibaba-W (09988) were the top three companies by trading volume in the Southbound Stock Connect, with trading amounts of 39.23 billion, 19.38 billion, and 18.37 billion respectively [1] - In the Shenzhen-Hong Kong Stock Connect, Alibaba-W (09988), Guotai Junan International (01788), and Tencent Holdings (00700) led the trading volume, with amounts of 18.33 billion, 15.70 billion, and 15.26 billion respectively [1] Southbound Stock Connect Top Active Companies - Guotai Junan International (01788) had a trading amount of 39.23 billion with a net buying amount of +18.74 million [2] - Legend Holdings (06683) recorded a trading amount of 19.38 billion with a net buying amount of +53.64 million [2] - Alibaba-W (09988) achieved a trading amount of 18.37 billion with a net buying amount of +223 million [2] - Health Road (02587) had a trading amount of 17.86 billion with a net selling amount of -66.69 million [2] - Other notable companies included Guolian Minsheng (01456) with 16.87 billion and a net buying amount of +23.39 million, and Meituan-W (03690) with 16.20 billion and a net buying amount of +783 million [2] Shenzhen-Hong Kong Stock Connect Top Active Companies - Alibaba-W (09988) led with a trading amount of 18.33 billion and a net buying amount of +636 million [2] - Guotai Junan International (01788) followed with a trading amount of 15.70 billion and a net buying amount of +72.43 million [2] - Tencent Holdings (00700) had a trading amount of 15.26 billion but recorded a net selling amount of -842.80 million [2] - Other significant companies included Xiaomi Group-W (01810) with 12.92 billion and a net selling amount of -1.01 billion, and Meituan-W (03690) with 12.69 billion and a net buying amount of +440 million [2]

Group 1 - The innovative drug sector continues to show strong performance, with significant stock price increases for companies such as Boan Biologics (up 18.68% to HKD 17.66), Hengrui Medicine (up 7.76% to HKD 77.8), and others [1] - The National Healthcare Security Administration has initiated the adjustment application for the 2025 National Basic Medical Insurance, Maternity Insurance, and Work Injury Insurance drug catalog, as well as a new commercial health insurance innovative drug catalog [1] - Recent measures issued by the National Healthcare Security Administration and the National Health Commission aim to support the high-quality development of innovative drugs, indicating a positive outlook for the innovative drug industry and its supply chain [1] Group 2 - The pharmaceutical sector's innovative drugs remain robust, driven by improved biotech investment and supportive domestic policies, which enhance demand expectations for preclinical research [2] - WuXi AppTec's semi-annual performance forecast exceeded expectations, serving as a catalyst for the sector [2] - Investment opportunities in innovative drugs are highlighted, particularly in dual/multi-antibody drugs for various cancers and chronic disease treatments that address unmet clinical needs [2]

Group 1 - The Hong Kong stock market for innovative drugs saw a significant rise in early trading, indicating strong investor interest in the sector [1] - WuXi AppTec (02359.HK) reported a positive earnings forecast, leading to a more than 10% increase in its stock price [1] - WuXi Biologics (02268.HK) experienced a stock price increase of over 7%, reflecting positive market sentiment [1] Group 2 - Other companies in the sector, such as Baoneng Biotech (06955.HK) and Hengrui Medicine (01276.HK), also saw their stock prices rise, indicating a broader trend in the innovative drug market [1]

Core Viewpoint - The recent announcement by President Trump regarding potential high tariffs on copper and pharmaceuticals has led to a decline in Hong Kong's stock market, with the Hang Seng Index falling below 24,000 points, reflecting increased macroeconomic risks and impacting market sentiment [1][4]. Market Performance - The Hang Seng Index closed down 1.06% at 23,892.32 points, with a total trading volume of 233.88 billion HKD. The Hang Seng China Enterprises Index fell 1.28%, while the Hang Seng Tech Index dropped 1.76% [1]. - Major blue-chip stocks experienced significant movements, with Henderson Land Development leading the decline, down 8.64% at 25.9 HKD, while China Biologic Products rose 10.06% to 5.91 HKD [2]. Sector Analysis - The technology sector saw a collective decline, with Alibaba down nearly 4% and Tencent over 1%. The copper sector was negatively impacted by Trump's tariff threats, leading to a drop in copper-related stocks [3][6]. - The innovative drug sector performed well, with Hengrui Medicine surging 15.61% to 69.6 HKD, indicating resilience amid broader market declines [3][4]. Specific Stock Movements - Macau's gaming sector showed strong performance, with Wynn Macau up 6.33% and Melco Resorts up 2.12%, driven by robust gaming revenue growth [4][5]. - Copper stocks faced significant declines, with Luoyang Molybdenum down 4.74% and Jiangxi Copper down 3.46%, reflecting market reactions to tariff announcements [5][6]. Commodity Prices - International gold prices fell below 3,300 USD per ounce, influenced by reduced safe-haven demand amid tariff uncertainties. Analysts expect gold prices to remain volatile within a range of 3,000 to 3,500 USD per ounce [7].

Group 1 - The core viewpoint of the articles highlights the strong performance of the Hong Kong innovative pharmaceutical sector, with significant gains in the Hong Kong Innovative Drug 50 ETF and individual stocks like Boan Biotechnology and Tigermed [1][2] - As of July 8, the top ten constituents of the CSI Hong Kong Stock Connect Innovative Drug Index account for 68% of the total weight, including high-quality A-share companies like Innovent Biologics and CSPC Pharmaceutical Group [2] - The National Medical Products Administration reported that in the first half of the year, 43 innovative drugs and 45 innovative medical devices were approved, representing year-on-year increases of 59% and 87% respectively, indicating a positive trend in the industry [1] Group 2 - The innovative pharmaceutical sector in China is at a new historical starting point, with domestic companies enhancing their competitiveness and expanding overseas, supported by strong policy backing [2] - The net inflow into the Hong Kong Innovative Drug 50 ETF reached 573 million yuan in the last three months and 851 million yuan year-to-date, reflecting investor confidence in the sector [1] - Guotai Junan Securities expresses strong confidence in a reversal in the pharmaceutical sector by 2025, emphasizing investment opportunities in innovative drugs addressing unmet clinical needs and medical devices [1]

Core Viewpoint - The company, Boan Biotech, has achieved significant growth in 2024, with total revenue reaching 730 million yuan, marking a fourfold increase from 2021, and has turned a profit for the first time with an EBITDA of 180 million yuan and a net profit of 73.19 million yuan [1][11]. Group 1: Product Development and Pipeline - Boan Biotech has successfully launched three products and is actively developing multiple innovative biopharmaceuticals, including BA1302, an ADC targeting CD228, which is the first of its kind in China and the second globally to enter clinical trials [1][4]. - BA1302 has received orphan drug designation from the FDA for squamous non-small cell lung cancer (sq-NSCLC) and pancreatic cancer, and is currently undergoing Phase I trials in China, leading the global development of similar drugs [4][5]. - The company is also developing BA1301, another ADC targeting Claudin 18.2, which is currently in Phase I trials in China and has received orphan drug status in the U.S. for gastric and pancreatic cancers [5][7]. Group 2: Market Potential and Competitive Landscape - The market potential for BA1302 is substantial, given the high incidence of non-small cell lung cancer, with 2.48 million cases globally in 2022, and pancreatic cancer, which had approximately 510,000 cases worldwide [4]. - The Claudin 18.2 ADC market is competitive, with over 10 pipelines in clinical stages, including several in Phase III trials, indicating a robust landscape for potential partnerships and business development opportunities [7][8]. Group 3: Financial Strategy and Business Model - Boan Biotech employs a dual strategy of "biosimilars + innovative drugs," which allows for rapid commercialization of biosimilars to fund the development of innovative drugs, achieving profitability in 2024 primarily through biosimilar sales [11][12]. - The company has three biosimilars currently on the market, contributing 690 million yuan in revenue, accounting for 95% of total income, and has several more biosimilars in the pipeline expected to receive approval in the next three years [12][15]. Group 4: Future Outlook - Boan Biotech plans to leverage its PD-1 inhibitors and VEGF inhibitors in combination therapies to enhance the efficacy of existing treatments and increase the value of its pipeline [15][16]. - The company's innovative approach and financial strategy provide a viable model for the transition from biotech to biopharma, showcasing a blend of local focus and international expansion [16].