Core Insights - Jiangsu Kangyuan Pharmaceutical Co., Ltd. has announced the inclusion of its unique products, including Wenyang Jiedu Granules and Yunu Decoction, in the National Medical Insurance Directory for 2025, along with the first generic version of Sumatriptan and Naproxen Sodium Tablets [1][2] Group 1 - The company has a total of 123 products included in the National Medical Insurance Directory for 2025, with 48 classified as Category A and 75 as Category B [2] - The payment scope for the company's unique product, Ginkgo Biloba Diterpene Glycoside Ammonium Injection, has been slightly adjusted, now allowing payment only for hospital stays [1] - The company has also had its non-exclusive product, Posaconazole Enteric-Coated Tablets, have payment restrictions lifted, and several new products have been approved for inclusion in the 2025 directory [1][2] Group 2 - The addition of new drug varieties to the National Medical Insurance Directory is expected to drive growth in market promotion and sales for the company, enhancing its research and development innovation and brand influence [2] - The impact of these changes on the company's short-term performance is currently difficult to estimate [2]

证券简称：康缘药业 证券代码：600557 公告编号：2025-038 江苏康缘药业股份有限公司 关于公司部分药品纳入《国家医保目录》的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 2025年12月7日，国家医保局、人力资源社会保障部发布了《关于印发<国家 基本医疗保险、生育保险和工伤保险药品目录>以及<商业健康保险创新药品目 录>（2025年）的通知》（医保发〔2025〕33号）。根据该通知，江苏康缘药业 股份有限公司（以下简称"公司"）独家品种温阳解毒颗粒、玉女煎颗粒，国内 首家仿制药品种舒马普坦萘普生钠片首次通过谈判纳入《国家基本医疗保险、生 育保险和工伤保险药品目录（2025年）》（以下简称"《国家医保目录》（2025 年版）"）。具体情况如下： 一、首次纳入国家医保目录品种情况 （一）温阳解毒颗粒 药品名称：温阳解毒颗粒 批准文号：国药准字C20240004 规格：每袋装15g（相当于饮片33.33g） 是否独家品种：是 医保目录药品分类代码：ZA06CA 医保目录药品分类：内科用药.化痰、止咳、平喘剂.清热 ...

Market Overview - The traditional Chinese medicine sector experienced a decline of 0.28% on December 8, with Weikang Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3924.08, up 0.54%, while the Shenzhen Component Index closed at 13329.99, up 1.39% [1] Stock Performance - Notable gainers in the traditional Chinese medicine sector included: - Xinguang Pharmaceutical (300519) with a closing price of 17.34, up 3.96% and a trading volume of 131,800 shares, totaling 229 million yuan [1] - Kanghui Co., Ltd. (603139) closed at 22.35, up 2.48% with a trading volume of 20,300 shares, totaling 45.04 million yuan [1] - Conversely, Weikang Pharmaceutical (300878) saw a significant decline of 8.00%, closing at 22.66 with a trading volume of 110,800 shares, totaling 251 million yuan [2] Capital Flow - The traditional Chinese medicine sector experienced a net outflow of 723 million yuan from institutional investors, while retail investors saw a net inflow of 469 million yuan [2] - The capital flow for specific stocks showed: - Yunnan Baiyao (000538) had a net inflow of 26.56 million yuan from institutional investors, while retail investors had a net outflow of 6,450 yuan [3] - Kang Enbei (600572) reported a net inflow of 21.85 million yuan from institutional investors, with a net outflow of 1.92 million yuan from retail investors [3]

（文章来源：证券日报） 证券日报网讯 12月2日，康缘药业在互动平台回答投资者提问时表示，公司始终高度重视与资本市场的 沟通，接待机构调研是上市公司与资本市场沟通的重要桥梁之一。 ...

Core Insights - The demand for traditional Chinese medicine (TCM) has significantly increased due to the rise in respiratory diseases during the autumn and winter flu season, with multiple pathogens like influenza and respiratory syncytial virus circulating [1] - Companies with reliable evidence-based data and clinically recognized TCM products are expected to benefit in the long term during the flu season [2] Group 1: Market Dynamics - The current flu activity in China is in a rapid upward phase, with sentinel hospitals reporting a continuous increase in flu-like cases [1] - The complexity of respiratory diseases this year, particularly in southern humid regions, has made multi-target, compound TCM more advantageous for managing various symptoms [1] Group 2: Company Performance - Kangyuan Pharmaceutical has seen a surge in demand for its respiratory products, leading to increased production to meet market supply pressures [2] - The company's oral liquid product, Jinzhen Oral Liquid, generated revenue of 1.359 billion yuan in the first three quarters of this year, accounting for 58% of its total revenue [2] Group 3: Product Development - Kangyuan's product line for respiratory and infectious diseases has formed a complete matrix covering prevention and treatment for various symptoms, including products like Hot Toxin Ning Injection and Jinzhen Oral Liquid [2][3] - The Hot Toxin Ning Injection has completed multiple RCT clinical studies, demonstrating its effectiveness in alleviating symptoms caused by viral infections [3] Group 4: Financial Performance - In the first half of 2025, Kangyuan reported revenue of 1.642 billion yuan and a net profit of 142 million yuan, with significant growth in various product categories [4] - The injection revenue reached 506 million yuan, while oral liquid revenue was 279 million yuan, indicating a robust performance across different dosage forms [4][5] Group 5: Strategic Outlook - The simultaneous growth of multiple dosage forms indicates a recovery in the usage of respiratory products during the winter disease season, enhancing the company's market adaptability [5] - Experts believe that TCM's multi-target advantages will continue to provide significant value in managing respiratory diseases in the future [5]

Core Insights - The flu activity in China is rapidly increasing, with the proportion of flu-like cases in southern provinces reaching 6.7% and northern provinces as high as 12%, significantly above previous years' levels [1] - The current flu outbreak is primarily driven by the H3N2 subtype, with a notable increase in demand for antiviral medications such as Oseltamivir and Baloxavir, leading to a surge in sales [1][2] - Domestic pharmaceutical companies, including Notai Bio, Kangyuan Pharmaceutical, and Jindike, are gaining market attention due to their antiviral product offerings and technological advancements [2][4] Industry Trends - The demand for flu medications has led to stock shortages in pharmacies, particularly for original research drugs [2] - Notai Bio has positioned itself competitively in the Oseltamivir market, with multiple drug registration certificates and an organized production line to meet the rising demand [2][3] - The market is transitioning from a dominance of Oseltamivir to a more diversified landscape with both traditional and innovative antiviral drugs being introduced [5] Company Highlights - Notai Bio has achieved significant sales growth for its Oseltamivir capsules, surpassing imported alternatives and establishing a strong online presence [3] - Kangyuan Pharmaceutical's products, such as the anti-viral injection and oral liquid, have shown resilience in sales despite overall revenue declines, indicating a strong growth potential in the flu season [4] - Jindike focuses on flu prevention with its quadrivalent flu vaccine, which has a production capacity of 20 million doses annually and is included in the national immunization program [4][5]

Group 1 - The flu activity in China is rapidly increasing, with sentinel hospitals in southern provinces reporting flu-like cases at 6.7%, up from 5.5% the previous week, and northern provinces reaching 12%, significantly higher than the same period from 2020 to 2023 [1] - The current flu strains include the H3N2 subtype, Victoria lineage, and H1N1, with significant antigenic variation leading to increased susceptibility in the population [1] - The demand for antiviral medications has surged, with sales of Oseltamivir increasing by 237% and Baloxavir by 180%, indicating a doubling of orders for flu-specific medications on platforms like Meituan and JD Health [1][2] Group 2 - Domestic pharmaceutical companies such as Nuotai Bio, Kangyuan Pharmaceutical, and Jindike are accelerating their entry into the flu treatment market, focusing on antiviral products [2] - Nuotai Bio has established itself as a competitive player in the Oseltamivir market, actively organizing production to ensure supply amid rising demand [2][3] - Kangyuan Pharmaceutical's products, including the antiviral injection and oral solution, have seen increased sales, with the oral solution contributing significantly to the company's revenue [4] Group 3 - The market is shifting from a dominance of Oseltamivir to a new phase where traditional and innovative treatments coexist, with new drugs like Marzula and Angladi being approved [5] - Companies with differentiated advantages and stable supply chains are expected to stand out in this competitive landscape, particularly those like Nuotai Bio that are deeply embedded in the global antiviral drug supply chain [5] - The upcoming flu peak is creating new growth opportunities for domestic pharmaceutical companies, driven by the increased demand for flu medications [5]

Core Insights - The avian influenza concept sector experienced a decline of 0.76%, ranking among the top losers in the market, with major stocks like Zhongsheng Pharmaceutical hitting the limit down, while a few stocks like Wens Foodstuff and Weilan Biology saw gains of 1.80% each [1][2] Market Performance - The top-performing concept sectors included Titanium Dioxide with a gain of 4.31%, and Hainan Free Trade Zone with a gain of 3.54%, while the avian influenza sector was among the worst performers [1] - The avian influenza sector saw a net outflow of 784 million yuan, with 18 stocks experiencing net outflows, led by Zhongsheng Pharmaceutical with a net outflow of 684 million yuan [1] Stock Performance - Stocks with significant net outflows included: - Zhongsheng Pharmaceutical: -10.00% with a turnover rate of 18.78% and a net outflow of 683.65 million yuan - Yiling Pharmaceutical: -2.40% with a net outflow of 35.71 million yuan - Lianhuan Pharmaceutical: -1.79% with a net outflow of 25.69 million yuan - Hualan Biological: -6.60% with a net outflow of 18.13 million yuan [1] - Conversely, stocks with net inflows included: - Tiankang Biological: +1.26% with a net inflow of 16.52 million yuan - Shanghai Kaibao: -1.70% with a net inflow of 5.06 million yuan - Jinhai Biological: +0.16% with a net inflow of 3.82 million yuan [2]

Core Viewpoint - The company is committed to research and innovation, with a rich pipeline of products focusing on traditional Chinese medicine and various therapeutic areas [1] Group 1: Research and Development Focus - The company is concentrating on respiratory and infectious diseases, cardiovascular diseases, gynecological diseases, and orthopedic diseases in traditional Chinese medicine [1] - In chemical and biological drugs, the company is actively developing treatments for cardiovascular diseases, metabolic diseases, digestive system diseases, autoimmune diseases, and neurological diseases [1] Group 2: Clinical Trials and Product Pipeline - The innovative biological drug ZX2021 injection for treating obesity or overweight and type 2 diabetes is expected to complete the first patient enrollment in Phase II by June 2025, with plans to enter Phase III clinical trials in Q3 2026 [1] - The innovative biological drug ZX2010 injection for treating type 2 diabetes and obesity is set to complete the first patient enrollment in Phase II by July 2025, also planning to enter Phase III clinical trials in Q3 2026 [1] - The innovative biological drug ZX1305E eye drops for treating neurotrophic keratitis is expected to complete the first patient enrollment in Phase II by June 2025, with plans for Phase III clinical trials in Q3 2026 [1] - The innovative biological drug ZX1305 injection for treating optic nerve injury is currently undergoing Phase IIb clinical trials [1] Group 3: Communication and Disclosure - The company will fulfill its information disclosure obligations regarding clinical trial progress and review results in accordance with relevant laws and regulations, ensuring effective communication with investors [1]

Core Viewpoint - Kangyuan Pharmaceutical (600557.SH) is advancing its innovative drug ZX2010 injection for the treatment of type 2 diabetes and obesity, with key clinical milestones set for 2025 and 2026 [1] Group 1 - The first subject enrollment for the Phase II clinical trial of ZX2010 is expected to be completed by July 2025 [1] - The company has initiated enrollment in three out of four planned dosage groups for the Phase II trial [1] - The company plans to enter Phase III clinical trials in the third quarter of 2026 [1]