香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 SHANGHAI JUNSHI BIOSCIENCES CO., LTD.* 上海君實生物醫藥科技股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1877） 海外監管公告 * 僅供識別之用 证券代码：688180 证券简称：君实生物 公告编号：临 2025-043 上海君实生物医药科技股份有限公司 关于召开 2025 年半年度业绩说明会的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條規則作出。 茲載列上海君實生物醫藥科技股份有限公司在上海證券交易所網站刊發之《上海 君實生物醫藥科技股份有限公司關於召開2025年半年度業績說明會的公告》，僅 供參閱。 承董事會命 上海君實生物醫藥科技股份有限公司 熊俊先生 主席 中國，上海，20 ...

会议召开时间：2025 年 9 月 8 日（星期一）10：00-11：00 会 议 召 开 地 点 ： 上 海 证 券 交 易 所 上 证 路 演 中 心 （ 网 址 ： https://roadshow.sseinfo.com/） 会议召开方式：上证路演中心网络互动 证券代码：688180 证券简称：君实生物 公告编号：临 2025-043 上海君实生物医药科技股份有限公司 关于召开 2025 年半年度业绩说明会的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： （三）会议召开方式：上证路演中心网络互动 投资者可于 2025 年 9 月 1 日（星期一）至 2025 年 9 月 5 日（星期五） 16:00 前登录上证路演中心网站首页点击"提问预征集"栏目或通过上海君实生 物医药科技股份有限公司（以下简称"公司"）邮箱 info@junshipharma.com 进 行提问。公司将在说明会上对投资者普遍关注的问题进行回答。 公司已于 2025 年 8 月 27 日在上海证券交易所网站（www.sse. ...

Market Overview - The biopharmaceutical sector increased by 0.85% on August 29, with Kangchen Pharmaceutical leading the gains [1] - The Shanghai Composite Index closed at 3857.93, up 0.37%, while the Shenzhen Component Index closed at 12696.15, up 0.99% [1] Top Gainers in Biopharmaceutical Sector - Kangchen Pharmaceutical (603590) closed at 56.17, up 10.01% with a trading volume of 67,100 shares and a transaction value of 366 million [1] - Rongchang Biopharmaceutical (688331) closed at 90.88, up 8.35% with a trading volume of 166,100 shares [1] - Sanofi Biopharmaceutical (688336) closed at 52.60, up 8.01% with a trading volume of 89,900 shares [1] - Baipusais (301080) closed at 58.61, up 7.34% with a trading volume of 42,800 shares [1] - Wanzhe Co. (000534) closed at 17.70, up 6.31% with a trading volume of 382,900 shares [1] Top Losers in Biopharmaceutical Sector - Tibet Pharmaceutical (600211) closed at 47.16, down 3.42% with a trading volume of 193,800 shares and a transaction value of 912 million [2] - Wendi Pharmaceutical (688488) closed at 17.36, down 2.36% with a trading volume of 126,200 shares [2] - Chengda Biopharmaceutical (688739) closed at 27.90, down 2.35% with a trading volume of 50,700 shares [2] Capital Flow Analysis - The biopharmaceutical sector experienced a net outflow of 506 million from institutional investors, while retail investors saw a net inflow of 402 million [2] - The top stocks by net inflow from institutional investors included Rongchang Biopharmaceutical with a net inflow of 127 million [3] - Kangchen Pharmaceutical had a net inflow of 68 million from institutional investors, but also saw outflows from retail investors [3]

Investment Rating - The investment rating for the company is "Buy" and is maintained [6]. Core Views - The company reported a significant increase in sales, with a revenue of 1.168 billion yuan in the first half of 2025, representing a year-on-year growth of 49%. The net loss attributable to shareholders decreased to 413 million yuan, down 36% year-on-year [2][4]. - The sales of the core product, Toripalimab (Tuoyi®), accelerated, generating 954 million yuan in domestic sales in the first half of 2025, a 42% increase year-on-year. The product has received approval for two new indications, totaling 12 indications, with 10 included in medical insurance [6]. - The company has established a comprehensive commercialization network for its core products, with Toripalimab approved in 40 countries and regions globally. The production capabilities are supported by facilities in Suzhou and Shanghai [6]. - The research and development pipeline includes over 50 projects across five therapeutic areas, with nearly 30 in clinical stages. Key products such as JS207 (PD-1/VEGF bispecific antibody) and Tifcemalimab (first BTLA monoclonal antibody) are entering critical clinical phases [6]. - Profitability forecasts indicate net losses of 771 million yuan, 307 million yuan, and a profit of 534 million yuan for 2025, 2026, and 2027, respectively, with corresponding EPS of -0.75 yuan, -0.30 yuan, and 0.52 yuan [6].

Company Overview - Junshi Biosciences has seen a stock price increase of 64.11% year-to-date, with a recent decline of 2.20% over the last five trading days, a 17.78% increase over the last 20 days, and a 35.54% increase over the last 60 days [2] - The company specializes in the research and industrialization of monoclonal antibody drugs and other therapeutic protein drugs, as well as providing technical services and technology transfer for monoclonal antibody drug development [2] Financial Performance - For the period from January to June 2025, Junshi Biosciences reported revenue of 1.168 billion yuan, representing a year-on-year growth of 48.64%, while the net profit attributable to shareholders was -413 million yuan, showing a year-on-year improvement of 36.01% [2] Shareholder Information - As of June 30, 2025, the number of shareholders for Junshi Biosciences was 31,200, an increase of 5.88% from the previous period, with an average of 24,543 circulating shares per person, a decrease of 5.56% [2] - The top ten circulating shareholders include notable ETFs, with 华夏上证科创板50成份ETF holding 29.7167 million shares (a decrease of 536,700 shares), and 易方达上证科创板50ETF holding 22.2132 million shares (an increase of 630,000 shares) [3]

Core Viewpoint - CICC has lowered the 2025 profit forecast for Junshi Biosciences (01877) from a loss of 662 million yuan to a loss of 917 million yuan, and introduced a 2026 profit forecast of a loss of 315 million yuan, while maintaining an outperform rating due to positive R&D progress in PD-1/VEGF and DKK1 monoclonal antibodies, raising the target price by 101% to HKD 36.98, indicating a 21.1% upside from the current stock price [1] Group 1 - The company's 1H25 revenue slightly exceeded expectations, with operating income of 1.168 billion yuan, a year-on-year increase of 46%, and a net loss attributable to shareholders of 413 million yuan, a reduction in loss of 232 million yuan year-on-year [2] - The sales revenue of Tuoyi in the domestic market reached 954 million yuan in 1H25, a year-on-year increase of 42%, with 12 approved indications in China and approvals in 40 countries and regions, indicating a gradual realization of global commercialization value [3] Group 2 - The PD-1/VEGF bispecific antibody JS207 is in Phase II clinical trials for various cancers, showing competitive advantages in tumor efficacy due to its unique molecular design [4] - The DKK1 monoclonal antibody has released clinical data for colorectal and gastric cancers at the 2025 AACR and is also in Phase II clinical trials, leading in global R&D progress [4] Group 3 - The company has established an innovative product pipeline covering five major therapeutic areas with over 50 products, advancing nearly 30 clinical studies, with expectations for several products to enter critical registration clinical trials by 2025 [5]

Core Viewpoint - CICC has downgraded Junshi Biosciences' (01877) 2025 profit forecast from a loss of 6.62 billion to a loss of 9.17 billion, while introducing a 2026 profit forecast of a loss of 3.15 billion, citing the need for further funding for R&D pipeline advancement [1] Group 1: Financial Performance - The company's 1H25 revenue reached 1.168 billion, a year-on-year increase of 46%, with a net loss of 413 million, which is a reduction in loss by 232 million compared to the previous year [2] - The revenue slightly exceeded CICC's expectations, while the reduction in loss was in line with expectations [2] Group 2: Product Sales Growth - Sales revenue of Tuoyi in the domestic market for 1H25 was 954 million, reflecting a year-on-year growth of 42% [3] - Tuoyi has received approval for 12 indications in China and is approved in 40 countries and regions, indicating a gradual realization of its global commercialization value [3] - The company anticipates accelerated global sales of Tuoyi as new indications enter the market and are included in insurance coverage [3] Group 3: Pipeline Development - The company is focusing on the potential of its PD-1/VEGF bispecific antibody (JS207) and DKK1 monoclonal antibody, which are in advanced clinical stages [4] - JS207 is currently in Phase II clinical trials for various cancers and is expected to have a competitive advantage due to its unique molecular design and anti-tumor efficacy [4] - DKK1 monoclonal antibody has shown promising clinical data for colorectal and gastric cancers and is also in Phase II clinical trials [4] Group 4: Innovation and Clinical Research - The company has established a pipeline covering five major therapeutic areas with over 50 innovative products, advancing nearly 30 products in clinical research [5] - Upcoming submissions for market approval are expected for products like subcutaneous Teriprizumab and IL-17 monoclonal antibody, with several others anticipated to enter critical registration clinical trials by 2025 [5]

Core Viewpoint - Junshi Biosciences reported a significant increase in revenue for the first half of 2025, but the company has not yet achieved profitability, highlighting the challenges of the biopharmaceutical industry, which is characterized by long R&D cycles, high investment, and substantial risks [1][2]. Financial Performance - In the first half of 2025, Junshi Biosciences achieved approximately 1.168 billion yuan in revenue, a year-on-year increase of 48.64%, with drug sales revenue reaching 1.059 billion yuan, up 49.41% [1][2]. - The net loss attributable to shareholders was approximately 413 million yuan, which represents a narrowing of losses compared to the previous year [1][2]. - The company's R&D expenses were about 706 million yuan, reflecting a year-on-year increase of 29.14%, driven by a focus on competitive and innovative R&D projects [3]. Product Pipeline and Innovation - Junshi Biosciences has expanded its innovation scope beyond monoclonal antibodies to include small molecule drugs, antibody-drug conjugates (ADC), bispecific or multispecific antibodies, fusion proteins, nucleic acid drugs, and vaccines [2]. - The company has a product pipeline covering five major therapeutic areas: malignant tumors, autoimmune diseases, chronic metabolic diseases, neurological diseases, and infectious diseases [2]. - As of the report date, Junshi Biosciences has four commercialized drugs and nearly 30 drug candidates in clinical trials, with over 20 in preclinical development [2]. Cash Flow and Funding - The net cash flow from operating activities showed a reduction in net outflow compared to the previous year, primarily due to increased sales revenue from commercialized drugs and significant technical licensing fees received during the period [2]. - In June 2025, Junshi Biosciences successfully completed a new H-share placement, raising approximately 1.026 billion HKD, with total cash and financial assets amounting to about 3.507 billion yuan at the end of the reporting period [3].

Group 1 - The core viewpoint of the news highlights the recent performance and financial metrics of Junshi Biosciences, including stock price movements and trading volumes [1] - On August 27, Junshi Biosciences experienced a stock decline of 3.96% with a trading volume of 1.039 billion yuan, and a net financing buy of -999.91 million yuan [1] - As of August 27, the total margin balance for Junshi Biosciences was 1.287 billion yuan, with a financing balance of 1.280 billion yuan, representing 3.85% of the circulating market value [1] Group 2 - As of June 30, Junshi Biosciences had 31,200 shareholders, an increase of 5.88% from the previous period, while the average circulating shares per person decreased by 5.56% to 24,543 shares [2] - For the first half of 2025, Junshi Biosciences reported a revenue of 1.168 billion yuan, a year-on-year increase of 48.64%, and a net profit attributable to shareholders of -413 million yuan, an increase of 36.01% year-on-year [2] - Among the top ten circulating shareholders as of June 30, 2025, Huaxia SSE STAR 50 ETF held 29.7167 million shares, a decrease of 536,700 shares, while E Fund SSE STAR 50 ETF increased its holdings by 630,000 shares to 22.2132 million shares [2]

据证券之星公开数据整理，近期君实生物（688180）发布2025年中报。截至本报告期末，公司营业总收 入11.68亿元，同比上升48.64%，归母净利润-4.13亿元，同比上升36.01%。按单季度数据看，第二季度 营业总收入6.68亿元，同比上升64.78%，第二季度归母净利润-1.78亿元，同比上升50.87%。本报告期君 实生物盈利能力上升，毛利率同比增幅9.33%，净利率同比增幅54.44%。 本次财报公布的各项数据指标表现尚佳。其中，毛利率80.06%，同比增9.33%，净利率-39.86%，同比 增54.44%，销售费用、管理费用、财务费用总计7.08亿元，三费占营收比60.6%，同比减28.51%，每股 净资产6.21元，同比减5.56%，每股经营性现金流-0.32元，同比增63.46%，每股收益-0.42元，同比增 35.38% 财务报表中对有大幅变动的财务项目的原因说明如下： 其他应收款变动幅度为-94.58%,原因:本期公司应收保证金减少。 使用权资产变动幅度为77.07%,原因:本期新增租赁。 短期借款变动幅度为38.29%,原因:本期银行借款增加。 其他应付款变动幅度为39.99%,原 ...