Group 1 - Dize Pharmaceutical (688192.SH) reported its Q1 2025 results, with 57 institutional investors holding a total of 334 million shares, representing 80.01% of the company's total equity [1] - The top ten institutional investors collectively hold 73.98% of Dize Pharmaceutical's shares, with a slight increase of 0.11 percentage points compared to the previous quarter [1] Group 2 - In the public fund sector, 17 funds increased their holdings, accounting for a 0.86% increase, with notable funds including Yongying Medical Innovation Mixed Fund A and Ping An Medical Health Mixed A [2] - Conversely, 13 public funds reduced their holdings, representing a 0.12% decrease, with key funds including Bosera Health Growth and Penghua Innovation Medical Mixed A [2] - Six new public funds disclosed their holdings this period, while 239 funds were not disclosed compared to the previous quarter [2]

Group 1 - The core viewpoint of the articles highlights the significant revenue growth and commercialization progress of DiZhe Pharmaceutical, with a reported revenue of 360 million yuan in 2024, marking a year-on-year increase of 294.24% [1] - The company has successfully launched two commercialized products, which have seen nearly doubled sales revenue, achieving a year-on-year growth of 96% in the first quarter of this year [1] - DiZhe Pharmaceutical has established a competitive product pipeline with seven products, including two that are in global clinical trials and have been approved for marketing in China [1][2] Group 2 - In 2024, the company invested 724 million yuan in R&D, accounting for 201.08% of its revenue, with an additional 210 million yuan spent in the first quarter [2] - The company plans to allocate nearly 1 billion yuan from its recent fundraising to the development of core pipeline drugs, including Shuwotini and DZD8586 [2] - DiZhe Pharmaceutical's innovative drug development is characterized by long cycles and high costs, with potential uncertainties in future sales revenue due to various market factors [3] Group 3 - The company is expected to remain unprofitable in the short term, with cumulative losses likely to increase due to ongoing investments in drug registration and market promotion [3] - Analysts believe that DiZhe Pharmaceutical's focus on oncology and innovative products will drive rapid growth in performance as commercialized products gain market traction [3]

Core Insights - Dize Pharmaceutical achieved significant revenue growth in 2024, with operating income reaching 360 million yuan, a year-on-year increase of 294.24%, while the net profit attributable to shareholders was approximately -846 million yuan, a reduction in losses by 24% [1] - In Q1 2025, the company reported operating income of 160 million yuan, a year-on-year growth of 96.32%, with a net profit of approximately -193 million yuan, also showing a reduction in losses by 14% [1] - The company focuses on innovative therapies for malignant tumors and immune diseases, with a competitive product pipeline that includes two leading products in global clinical trials, both of which have been approved for market entry in China and included in the national medical insurance drug list [1] Financial Performance - The sales expense ratio for Q1 2025 was 77%, a significant decrease from the 124% sales expense ratio for the entire year of 2024, indicating improved operational efficiency and effective cost control [2] - The company raised a total of 1.796 billion yuan through a private placement of A-shares, with nearly 1 billion yuan allocated for the research and development of core pipeline drugs including Shuwotai and Gaoruizhe [3] Strategic Developments - The company has established a dedicated commercialization team focused on lung cancer and hematological tumor products, creating a nationwide sales network to meet the growing market demand driven by medical insurance expansion [1] - The CEO highlighted the expectation of record growth in the first year of medical insurance coverage for the two commercialized products, emphasizing the commitment to maximizing shareholder returns through efficient commercial operations [2] - Shuwotai's new drug application has been accepted by the FDA and is under priority review, with ongoing global multi-center Phase III clinical trials advancing [2]

Core Viewpoint - The company has made significant progress in the commercialization of its innovative drugs, with two products included in the National Medical Insurance Directory, leading to substantial revenue growth and reduced net losses. Financial Performance - In Q1 2025, the company achieved revenue of 160 million yuan, a year-on-year increase of 96.32% compared to Q1 2024 [5] - The company reported a net loss attributable to shareholders of 317.2 million yuan, a decrease from the previous year [5] - For the full year 2024, the company recorded sales revenue of 360 million yuan, a year-on-year increase of 294.24% [13] Product Development and Regulatory Approvals - The company's products, Shuwozhe® and Gaoruizhe®, received approval for inclusion in the National Medical Insurance Directory in November 2024, effective from January 1, 2025 [5] - Shuwozhe®'s New Drug Application (NDA) was accepted by the FDA in January 2025, with priority review status granted for treating specific types of lung cancer [6][14] - The company has made advancements in clinical research, with multiple presentations at major conferences, including the European Lung Cancer Conference and the American Society of Clinical Oncology [6][7] Research and Development - The company invested 724 million yuan in R&D in 2024, a decrease of 10.17% year-on-year, focusing on advancing clinical trials and new product development [38] - The company is developing several innovative drugs targeting various cancers, including DZD8586 and DZD6008, which are in different stages of clinical trials [19][20][21] Market and Industry Context - The global oncology drug market is expected to grow significantly, with projections of reaching 419.8 billion USD by 2030, driven by an increasing patient population and rising healthcare expenditures [27][28] - The company operates in a highly competitive and innovative sector, focusing on first-in-class and best-in-class drug development to meet unmet clinical needs [32][31]

证券代码：688192 证券简称：迪哲医药 公告编号：2025-24 迪哲（江苏）医药股份有限公司 关于续聘会计师事务所的公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 拟续聘的会计师事务所名称：立信会计师事务所（特殊普通合伙）（以下 简称"立信"） 一、拟续聘会计师事务所的基本情况 （一） 机构信息 1. 基本信息 立信由我国会计泰斗潘序伦博士于 1927 年在上海创建，1986 年复办，2010 年 成为全国首家完成改制的特殊普通合伙制会计师事务所，注册地址为上海市，首席 合伙人为朱建弟先生。立信是国际会计网络 BDO 的成员所，长期从事证券服务业 务，新证券法实施前具有证券、期货业务许可证，具有 H 股审计资格，并已向美 国公众公司会计监督委员会（PCAOB）注册登记。 截至 2024 年末，立信拥有合伙人 296 名，注册会计师 2,498 名，从业人员总 数 10,021 名，签署过证券服务业务审计报告的注册会计师 743 名。2024 年业务收 入（经审计）47.48 亿元，其中审计业务收入 ...

迪哲（江苏）医药股份有限公司 关于 2024 年度"提质增效重回报"行动方案的年度评估报告 以及推动 2025 年度"提质增效重回报"行动方案 为贯彻中央经济工作会议、中央金融工作会议精神，践行以投资者为本的理念， 推动上市公司持续优化经营、规范治理和积极回报投资者，迪哲（江苏）医药股份 有限公司（简称"公司"）基于 2024 年度"提质增效重回报"行动方案取得显著成 效的基础上，结合公司战略规划与行业发展趋势，制定了 2025 年度行动方案，旨 在进一步提升经营质量、强化核心竞争力，为股东创造长期价值，助力公司迈向高 质量发展的新征程。 一、2024 年度"提质增效重回报"行动方案的年度评估 公司是一家创新型生物医药企业，专注于恶性肿瘤、免疫性疾病领域创新疗法 的研究、开发和商业化。公司坚持源头创新的研发理念，以推出全球首创药物 （First-in-class）和具有突破性潜力的治疗方法为目标，旨在填补全球未被满足的 临床需求。2024 年，公司围绕"聚焦主业、创新驱动、优化治理、回馈股东"四 大核心目标，取得显著成效： DZD6008 是一款公司自主研发的、全新的、高选择性 EGFR TKI，可完全穿透 ...

证券代码：688192 证券简称：迪哲医药 公告编号：2025-23 迪哲（江苏）医药股份有限公司 2024年度募集资金存放与实际使用情况的专项报告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 根据《上市公司监管指引第2号——上市公司募集资金管理和使用的监管要 求》《上海证券交易所上市公司自律监管指引第1号——规范运作》和《上海证 券交易所科创板股票上市规则》等有关规定，迪哲（江苏）医药股份有限公司 （以下简称"迪哲医药"或"公司"）就2024年度募集资金存放与使用情况专项报 告说明如下： 一、募集资金基本情况 根据中国证券监督管理委员会出具的《关于同意迪哲（江苏）医药股份有 限公司首次公开发行股票注册的批复》（证监许可[2021]3494号）以及上海证 券交易所出具的《关于迪哲（江苏）医药股份有限公司人民币普通股股票科创 板上市交易的通知》（[2021]468号），公司已向社会公众首次公开发行人民币 普通股（A股）40,000,100股（以下简称"本次发行"），每股发行价格为52.58 元，股款以人民币缴足，募集资金总 ...

一、募集资金基本情况 证券代码：688192 证券简称：迪哲医药 公告编号：2025-27 迪哲（江苏）医药股份有限公司 关于使用部分闲置募集资金临时补充流动资金的公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 公司于2025年4月29日召开了第二届董事会第十三次会议、第二届监事会第 十一次会议，审议通过了《关于使用部分闲置募集资金临时补充流动资金的议 案》，根据募集资金投资项目的资金使用计划及项目的建设进度，公司在确保 不影响募集资金投资项目建设进度的前提下，为了提高募集资金使用效率，降 低公司财务成本，董事会同意公司使用部分闲置募集资金临时补充流动资金。 现将相关事项公告如下： 经中国证券监督管理委员会《关于同意迪哲（江苏）医药股份有限公司向 特定对象发行股票注册的批复》（证监许可〔2025〕171号）同意注册，公司向 特定对象发行人民币普通股（A股）41,764,808股，发行价格为人民币43.00元/ 股 ， 募 集 资 金 总 额 为 人 民 币 1,795,886,744.00 元 ， 扣 ...

公司第二届董事会审计委员会由 5 位成员组成，分别为张昕女士、SIMON DAZHONG LU（吕大忠）先生、RODOLPHE PETER ANDRE GREPINET 先生、 王学恭先生、朱冠山先生。其中，张昕女士为审计委员会主任委员，张昕女士、王 学恭先生、朱冠山先生为独立董事。 迪哲（江苏）医药股份有限公司 2024 年 12 月，公司独立董事张昕女士因个人工作原因提请辞去公司第二届董 事会独立董事职务及其在董事会专门委员会中的委员职务。2024 年 12 月，公司完 成独立董事的变更及董事会专门委员会的调整。新独董加入后第二届董事会审计委 员会由 5 位成员组成，分别为安梅霞女士、SIMON DAZHONG LU（吕大忠）先生、 RODOLPHE PETER ANDRE GREPINET 先生、王学恭先生、朱冠山先生。其中， 安梅霞女士为审计委员会主任委员，安梅霞女士、王学恭先生、朱冠山先生为独立 董事。审计委员会的成员资格和构成均符合有关法律法规的规定。 董事会审计委员会 2024 年度履职情况报告 二、董事会审计委员会会议召开情况 根据《上市公司治理准则》《上海证券交易所科创板上市公司自律监管规则 ...

证券代码：688192 证券简称：迪哲医药 公告编号：2025-25 迪哲（江苏）医药股份有限公司 关于调整募集资金投资项目拟投入募集资金金额 的公告 经中国证券监督管理委员会《关于同意迪哲（江苏）医药股份有限公司向 特定对象发行股票注册的批复》（证监许可〔2025〕171号）同意注册，公司向 特定对象发行人民币普通股（A股）41,764,808股，发行价格为人民币43.00元/ 股 ， 募 集 资 金 总 额 为 人 民 币 1,795,886,744.00 元 ， 扣 除 发 行 费 用 人 民 币 22,440,613.47元（不含增值税），公司本次实际募集资金净额为人民币 1,773,446,130.53元。前述募集资金已于2025年4月10日全部到账，并经立信会计 师事务所（特殊普通合伙）审验，并出具了信会师报字[2025]第ZA10727号《验 资报告》。 为规范募集资金管理和使用，保护投资者权益，公司及子公司设立了募集 资金专项账户，对上述募集资金实施专项存储、专款专用，并与保荐机构、募 1 集资金存储银行签署了《募集资金专户存储三方监管协议》《募集资金专户存 储五方监管协议》。 二、募集资金投 ...