证券代码：688321 证券简称：微芯生物 公告编号：2025-061 深圳微芯生物科技股份有限公司 关于召开 2025 年第三季度业绩说明会的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： https://roadshow.sseinfo.com/） 会议召开方式：上证路演中心网络互动 本次投资者说明会以网络互动形式召开，公司将针对 2025 年第 三季度的经营成果及财务指标的具体情况与投资者进行互动交流和 沟通，在信息披露允许的范围内就投资者普遍关注的问题进行回答。 二、 说明会召开的时间、地点 （一）会议召开时间：2025 年 11 月 3 日（星期一）16:00-17:00 （二） 会议召开地点：上证路演中心 （三） 会议召开方式：上证路演中心网络互动 三、 参加人员 董事长、总经理：XIANPING LU 博士 投资者可于 2025 年 10 月 27 日（星期一）至 10 月 31 日（星期 五）16:00 前登录上证路演中心网站首页点击"提问预征集"栏目或 通过公司邮箱 ir@chipscr ...

Core Viewpoint - The announcement details a change in equity ownership for Shenzhen Micu Biotechnology Co., Ltd., specifically regarding a reduction in shares held by major shareholder Boao Biological Group Co., Ltd. This change does not involve a takeover bid and will not alter the company's controlling shareholder or actual controller [3][4]. Summary by Sections Equity Change Overview - The equity change is a result of Boao Biological executing a previously disclosed share reduction plan, reducing its holdings from 42,919,572 shares (10.52%) to 40,799,072 shares (10.00%), triggering a change in ownership that touches the 5% integer scale [3][4]. Shareholder Information - Boao Biological and its concerted action party, Tianfu Qingyuan Holdings Co., Ltd., are responsible for the accuracy and completeness of the information provided [3][4]. Shareholding Details - The shares involved in this equity change are all unrestricted circulating shares, and Boao Biological's shares are not subject to any rights restrictions, such as pledges or freezes. Tianfu Qingyuan holds 8,214,410 shares, all of which are frozen [3][12]. Compliance and Regulations - The equity change complies with the relevant laws and regulations, including the Securities Law of the People's Republic of China and the Measures for the Administration of the Acquisition of Listed Companies [3][4]. Future Plans - The shareholders do not rule out the possibility of increasing or further reducing their holdings in Micu Biotechnology within the next 12 months, and they will adhere to disclosure obligations as required by law [11][12].

深圳微芯生物科技股份有限公司 简式权益变动报告书 上市公司名称：深圳微芯生物科技股份有限公司 信息披露义务人 1：博奥生物集团有限公司 住所及通讯地址：北京市昌平区生命科学园路 18 号 信息披露义务人 2（信息披露义务人 1 之一致行动人）：天府清源控 股有限公司 住所及通讯地址：北京市海淀区中关村东路 1号院 8号楼(科技大厦)A 座 25 层 股份变动性质：股份减少（通过证券交易所集中竞价交易，信息披露 义务人 1 和信息披露义务人 2 合并持股比例减少至 10%）。 签署日期：2025 年 10 月 16 日 1 股票上市地点：上海证券交易所 股票简称：微芯生物 股票代码：688321 信息披露义务人声明 一、信息披露义务人依据《中华人民共和国证券法》（以下简称"《证券 法》"）、《上市公司收购管理办法》（以下简称"《收购办法》"）、《公 开发行证券的公司信息披露内容与格式准则第 15 号—权益变动报告书》（以下 简称"《准则 15 号》"）及相关的法律、法规及规范性文件编写本报告书。 二、信息披露义务人签署本报告已获得必要的授权和批准，其履行亦不违 反信息披露义务人合伙协议或内部规则中的任何条款，或 ...

证券代码：688321 证券简称：微芯生物 公告编号： 2025-060 5%整数倍刻度的提示性公告 股东博奥生物集团有限公司及其一致行动人天府清源控股有限公司保证向 本公司提供的信息真实、准确、完整，没有虚假记载、误导性陈述或重大遗漏， 并对其内容的真实性、准确性和完整性依法承担法律责任。 本公司董事会及全体董事保证公告内容与信息披露义务人提供的信息一致。 重要内容提示： ●本次权益变动为深圳微芯生物科技股份有限公司（以下简称"公司"） 持股 5%以上股东博奥生物集团有限公司（以下简称"博奥生物"）履行此前披 露的股份减持计划所致，不涉及要约收购，不会导致公司控股股东、实际控制 人发生变化。 ●本次权益变动后，博奥生物及其一致行动人天府清源控股有限公司(以下 简称"清控集团")持有公司股份从 42,919,572 股减少至 40,799,072 股，占公 司总股本的比例由 10.52%减少至 10.00%，股东权益变动触及 5%的整数倍。截 至本公告披露日，减持计划尚未实施完毕。 2025 年 10 月 16 日，公司收到股东博奥生物及其一致行动人清控集团出具 的《深圳微芯生物科技股份有限公司简式权益变动报 ...

Core Points - Microchip Biotech's stock price increased by 2.00% on October 16, reaching 31.06 CNY per share, with a trading volume of 1.22 billion CNY and a total market capitalization of 12.667 billion CNY [1] - The company has seen a year-to-date stock price increase of 67.17%, but has experienced a decline of 2.33% over the last five trading days, 7.26% over the last 20 days, and 10.75% over the last 60 days [1] - As of June 30, the number of shareholders increased by 10.37% to 19,500, while the average number of circulating shares per person decreased by 9.40% to 20,893 shares [2] Financial Performance - For the first half of 2025, Microchip Biotech reported a revenue of 407 million CNY, representing a year-on-year growth of 34.56% [2] - The net profit attributable to the parent company for the same period was 29.5922 million CNY, showing a significant year-on-year increase of 172.16% [2] Company Overview - Microchip Biotech, established on March 21, 2001, and listed on August 12, 2019, is located in the Zhigu Industrial Park, Nanshan District, Shenzhen, Guangdong Province [1] - The company's main business involves providing affordable, urgently needed innovative molecular entity drugs, with 97.80% of its revenue coming from product sales [1] - The company operates in the pharmaceutical and biotechnology sector, specifically in chemical pharmaceuticals and formulations, and is involved in various concept sectors including pharmaceutical e-commerce, monkeypox, innovative drugs, biopharmaceuticals, and anti-cancer drugs [1]

Core Viewpoint - Shenzhen Micron Biotechnology Co., Ltd. plans to issue shares to raise up to 950 million yuan for innovative drug research and development, a new drug manufacturing base, and to supplement working capital, with the Shanghai Stock Exchange issuing an inquiry letter for review [2] Group 1 - The company reported a continuous increase in sales expenses during the reporting period, primarily due to the commercialization of its innovative drug, Siglitazone Sodium, which was approved for market in October 2021 [2] - The increase in sales expenses is attributed to the company's efforts to enhance market recognition and coverage of Siglitazone Sodium through increased marketing activities [2] - Sales expenses mainly consist of employee compensation and marketing promotion costs, with the company implementing internal control systems to regulate marketing activities [2] Group 2 - Micron Biotechnology utilizes both its own sales team and commissioned promotion service providers for marketing activities, focusing on the experience of the service providers' teams [3] - The main promotion service providers are independent and not related to the company, with service fees paid through public bank transactions as per contractual agreements [3] - The company ensures that there are no payments made to related parties, employees, or other stakeholders in its marketing service arrangements [3]

本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 深圳微芯生物科技股份有限公司 关于可转债转股结果暨股份变动的公告 | 证券代码：688321 | 证券简称：微芯生物 | 公告编号： 2025-059 | | --- | --- | --- | | 转债代码：118012 | 转债简称：微芯转债 | | 重要内容提示： ●未转股可转债情况：截至 2025 年 9 月 30 日，"微芯转债"尚 未转股的可转债金额为人民币 499,596,000 元，占"微芯转债"发 行总量的 99.9192%。 一、可转债发行上市概况 经中国证券监督管理委员会"证监许可[2022]1234 号"文同意 注册，公司于 2022 年 7 月 5 日向不特定对象发行可转换公司债券 500.00 万张，每张面值为人民币 100 元，发行总额为人民币 50,000.00 万元（人民币伍亿元整），发行的可转换公司债券的期限 为自发行之日起六年，即自 2022 年 7 月 5 日至 2028 年 7 月 4 日。 经上海证券交易所自律监管决定书〔2022〕 ...

Core Insights - Microchip Biotech has successfully established an integrated technology platform combining "AI-assisted design + chemical genomics," enabling a full process from basic research to clinical transformation [1] - The company has achieved global market approval for two innovative drugs across multiple indications and has seven products in clinical stages [1] Drug Development - The drug Sidalbenamide (Aipushai), the world's first subtype-selective HDAC oral inhibitor, has expanded its indications from peripheral T-cell lymphoma to breast cancer, adult T-cell leukemia, and diffuse large B-cell lymphoma since its approval in 2014, becoming a benchmark in the field of epigenetic therapy [1] - Siglecatin (Shuangluoping), the world's first PPAR pan-agonist, has been approved for the treatment of type 2 diabetes and included in medical insurance, showing significant potential in treating fatty liver disease [1] Clinical Pipeline - The drug Xioroni, a globally patented triple-pathway tumor-targeting inhibitor, has demonstrated good efficacy and safety in treating difficult tumors such as ovarian and pancreatic cancer [1] - Key projects such as CS23546, CS231295, and CS32582 are continuously advancing in the clinical pipeline [1] Future Prospects - The company has a pipeline of candidates with First-in-Class (FIC) and Best-in-Class (BIC) potential, including CS08399 (potential BIC brain-penetrating PRMT5 inhibitor), CS1011 (fibrosis disease inhibitor), CDCS04 (FIC molecule targeting the Alzheimer's-related ApoE4 gene), and CDCS28 (non-incretin weight loss small molecule), which are expected to become core value drivers in the future [1]

Core Viewpoint - Microchip Biotech's stock fell over 5% following the announcement of a patent invalidation decision by the National Intellectual Property Administration, declaring the patent related to its drug, Sidabamine, completely invalid [1][2]. Group 1: Patent Invalidation Impact - The invalidation decision regarding the patent for Sidabamine does not affect the overall patent protection system that the company has established around the drug, which includes multiple patents covering various aspects such as compound, crystal form, key processes, formulations, and indications [2][3]. - The invalidated patent pertains specifically to the indication for peripheral T-cell lymphoma (PTCL), but the company maintains that this does not undermine the validity of other patents protecting Sidabamine [2][3]. Group 2: Drug Approval and Market Position - Sidabamine has received approvals for three indications in China: PTCL in December 2014, breast cancer (BC) in November 2019, and diffuse large B-cell lymphoma (DLBCL) in April 2024, with PTCL and DLBCL being conditionally approved [3]. - The breast cancer indication has not yet been included in the national medical insurance catalog, and the market is competitive with several lower-priced alternatives already listed, resulting in a minor contribution to the company's revenue [3]. Group 3: Financial Performance - For the first half of 2025, Microchip Biotech reported a revenue of 407 million yuan, representing a year-on-year increase of 34.56%, and a net profit attributable to shareholders of 29.59 million yuan, up 172.16% year-on-year [3][4]. - The growth in revenue is attributed to increased sales of Sidabamine and Siglecatin [4].

Group 1 - The A-share market saw a widespread decline in pharmaceutical stocks, with notable drops including Sunflower, Hanyu Pharmaceutical, and Kailaiying, each falling over 3% [1] - The U.S. President announced a new round of high tariffs on various imported products, including a 100% tariff on all brands and patented pharmaceutical products starting October 1 [1] Group 2 - Specific stock performance data shows that ST Complex dropped by 4.98%, with a total market value of 3.886 billion, and a year-to-date decline of 12.94% [2] - Sunflower's market value is 11.1 billion, with a year-to-date increase of 166.98%, despite a recent drop of 3.89% [2] - Hanyu Pharmaceutical's market value stands at 19.8 billion, with a year-to-date increase of 73.62%, and a recent decline of 3.20% [2] - Kailaiying's market value is 39.1 billion, with a year-to-date increase of 44.26%, and a recent drop of 3.01% [2] - Other companies such as Maiwei Bio, Zhaoyan New Drug, and Kanglong Chemical also experienced declines of over 2% [1][2]