Group 1 - The core viewpoint of the articles highlights a significant surge in the innovative drug sector within the A-share market, particularly on October 31, where several stocks, including Shuyat and Sanofi, hit the 20% daily limit increase [1] - The A-share market experienced fluctuations, with the ChiNext index dropping over 2%, and the total trading volume in the Shanghai and Shenzhen markets reaching 2.32 trillion yuan, a decrease of 103.9 billion yuan compared to the previous trading day [1] - The introduction of the "Commercial Insurance Innovative Drug Directory" mechanism during the national medical insurance negotiations is expected to benefit innovative drugs that are highly innovative and clinically valuable but are not yet included in the basic directory [1] Group 2 - According to Guosen Securities, the Chinese innovative drug industry is showing a long-term positive development trend, particularly evident in the explosive growth of BD transactions in recent years [2] - For most domestic innovative drugs, external licensing is often just the starting point for global development, with the progress of partners overseas and subsequent global clinical data readings enhancing the certainty of commercialization in the global market [2] - The long-term logic of investing in innovative drugs is favored, with a focus on stocks that are showing signs of bottom reversal [2]

Core Viewpoint - The innovation drug sector is experiencing significant market activity, driven by supportive government policies aimed at promoting the development of innovative drugs and medical devices in China [1] Group 1: Market Performance - Companies such as Sanofi, Sihuan Pharmaceutical, and Zai Lab have seen stock price increases of 20% or more, indicating strong investor interest in the innovation drug sector [1] - Other companies like Maiwei Biotech and Deyuan Pharmaceutical have also reported stock price increases exceeding 10% [1] Group 2: Policy Support - The "14th Five-Year Plan" suggests support for the development of innovative drugs and medical devices, with a focus on four key areas: R&D support, commercial health insurance innovation drug catalog, optimization of drug pricing mechanisms, and support for the application of innovative drugs and devices [1] - The Chinese government has reiterated its commitment to supporting the innovation drug sector starting in 2025, indicating a long-term strategy for growth [1] Group 3: Industry Challenges and Solutions - According to CITIC Securities, the current bottlenecks in the domestic innovation drug development are primarily in the payment and application sectors [1] - The development of commercial health insurance is deemed essential, with the establishment of a commercial insurance catalog playing a guiding role in market pricing for innovative drugs [1] - Strategies such as DRG/DIP exclusion payment, accelerated hospital promotion, and diversified payment methods are identified as key measures for the domestic development of innovative drugs [1]

Core Points - The 2025 National Medical Insurance Directory negotiations have officially commenced, highlighting the importance of pharmaceutical innovation and patient access to medications [1] - The atmosphere at the negotiations is characterized by a cautious and low-key approach from pharmaceutical representatives, with an increased emphasis on confidentiality [3][4] - A total of 535 drugs are under review, with 311 outside the directory and 224 within it, alongside 121 high-value drugs reviewed under the commercial insurance innovation drug directory [9][10] Group 1: Negotiation Atmosphere - The entry process for pharmaceutical representatives was notably quieter and more orderly compared to previous years, reflecting a more subdued approach [3][4] - Representatives from both domestic and multinational pharmaceutical companies, including notable names like 恒瑞医药 and 阿斯利康, participated in the negotiations [4][9] Group 2: Key Drug Categories - Antibacterial drugs are expected to be a significant focus in the afternoon session of the negotiations, with specific products like 万古霉素 being highlighted [9][10] - Innovative drugs, including CAR-T products and new lipid-lowering medications, are also under consideration, with 恒瑞医药 presenting multiple products for initial review [10][12] Group 3: Market Insights - The PCSK9 inhibitor 瑞卡西单抗 has gained attention for its long-acting properties, with a market size of 1.32 billion yuan in 2023, representing 7.8% of the national lipid-lowering drug market [10][11] - The long-acting 阿立哌唑微球 from 丽珠集团 is another product of interest, potentially replacing oral formulations and capturing market share if included in the insurance directory [12]

Core Viewpoint - The stock of Haishike experienced a decline of 2.20% on October 29, 2023, with a current price of 50.58 yuan per share, reflecting a total market capitalization of 566.45 billion yuan. Despite a year-to-date increase of 53.37%, the stock has seen a downward trend in recent trading days [1][2]. Financial Performance - For the period from January to September 2025, Haishike reported a revenue of 3.3 billion yuan, representing a year-on-year growth of 19.95%. However, the net profit attributable to shareholders decreased by 22.66% to 295 million yuan [2]. - Cumulatively, Haishike has distributed 3.673 billion yuan in dividends since its A-share listing, with 687 million yuan distributed over the past three years [3]. Shareholder Information - As of September 30, 2025, the number of shareholders increased by 12.87% to 12,900, with an average of 37,342 circulating shares per shareholder, down by 11.40% from the previous period [2]. - The top ten circulating shareholders include various funds, with notable increases in holdings from several institutional investors, such as China Europe Medical Health Mixed A and Hong Kong Central Clearing Limited [3]. Business Overview - Haishike, established on August 26, 2005, and listed on January 17, 2012, specializes in the research, development, production, and sales of chemical pharmaceuticals. The main revenue sources include anesthetic products (39.81%), cooperative product-related income (23.59%), and other therapeutic areas [1]. - The company operates within the pharmaceutical and biotechnology sector, specifically in chemical pharmaceuticals and formulations, and is involved in various concept sectors such as hypertension treatment and innovative drugs [1].

Core Insights - The report highlights concerns regarding the independence of the Federal Reserve, particularly in light of political pressures, which may impact the macroeconomic narrative and the valuation of the US dollar [2] - The report provides a detailed analysis of various companies, focusing on their financial performance and strategic initiatives [3][4][5][6][7][8][10][11][12][17][19][20][22][24][25][26][27][28][30][31] Company Summaries - **Lihigh Food (300973 CH, Buy)**: The company reported revenue of 3.14 billion and net profit of 250 million for the first three quarters of 2025, showing year-on-year growth of 15.7% and 22.0% respectively. Despite pressure on gross margins due to rising palm oil prices, effective cost control has helped maintain profitability [3] - **Red Flag Chain (002697 CH, Accumulate)**: The company achieved revenue of 7.11 billion in the first three quarters of 2025, a year-on-year decrease of 8.5%. The net profit was 383 million, down 1.9% year-on-year. The company is focusing on internal management and cost reduction to improve profitability [4] - **Kanglong Chemical (300759 CH, Buy)**: The company reported revenue of 10.086 billion and adjusted net profit of 1.227 billion for the first three quarters of 2025, reflecting year-on-year growth of 14.4% and 10.8% respectively. The company has raised its revenue growth guidance for 2025 from 10-15% to 12-16% [5] - **Zhou Dasheng (002867 CH, Buy)**: The company reported revenue of 6.772 billion for the first three quarters of 2025, a decline of 37.3% year-on-year, while net profit increased by 3.1%. The growth in net profit is attributed to a higher proportion of high-margin products [6] - **Aimeike (300896 CH, Buy)**: The company reported revenue of 566 million in Q3 2025, down 21.3% year-on-year, with a net profit of 304 million, down 34.6%. The company is focusing on expanding its product pipeline and international market presence [7] - **Leixin Technology (688018 CH, Accumulate)**: The company achieved revenue of 1.912 billion in the first three quarters of 2025, a year-on-year increase of 30.97%. Despite a slight decline in Q3 revenue, the company is expanding its market presence in high-performance SoC [8] - **Zhongke Chuangda (300496 CH, Buy)**: The company reported revenue of 5.148 billion for the first three quarters of 2025, reflecting a year-on-year increase of 39.34%. The growth is driven by the AIOT sector [9] - **Yihua (301029 CH, Buy)**: The company reported revenue of 736 million in Q3 2025, up 17.52% year-on-year, with a net profit of 136 million, up 28.59%. The growth is attributed to the continued demand in lithium battery and automotive sectors [10] - **Huazhi Technology (688281 CH, Buy)**: The company reported revenue of 285 million in Q3 2025, a year-on-year increase of 12.85%. The company is focusing on its leading position in stealth materials [11] - **Chengdu Bank (601838 CH, Buy)**: The bank reported a net profit of 5.0% and revenue growth of 3.0% for the first nine months of 2025, indicating stable performance despite non-interest income fluctuations [12] - **Yun Tianhua (600096 CH, Buy)**: The company reported revenue of 12.6 billion in Q3 2025, a year-on-year decrease of 14%, but net profit increased by 24%. The company benefits from strong export demand for phosphate products [13] - **Funi Co., Ltd. (600483 CH, Buy)**: The company reported revenue of 3.666 billion in Q3 2025, down 4.04% year-on-year, but net profit increased by 11.53%. The company is focusing on its project reserves and renewable energy contributions [14] - **Hongcheng Environment (600461 CH, Buy)**: The company reported revenue of 1.738 billion in Q3 2025, up 2.41% year-on-year, with net profit of 324 million, reflecting stable operational performance [15] - **Op Lighting (603515 CH, Accumulate)**: The company reported revenue of 1.692 billion in Q3 2025, down 0.59% year-on-year, with net profit of 208 million, down 12.22%. The company is expected to recover as the housing market stabilizes [16] Industry Insights - The macroeconomic environment is influenced by political pressures on the Federal Reserve, which may affect market confidence and asset valuations [2] - The food and beverage sector is experiencing mixed performance, with some companies managing to maintain profitability through cost control and strategic initiatives [3][4][5][6] - The healthcare and pharmaceutical sectors are showing resilience, with companies reporting steady revenue growth and improved cash flow [7][8][9] - The technology sector, particularly in AI and IoT, is witnessing significant growth, driven by increased demand for advanced solutions [10][11][12] - The banking sector is showing stable performance, with banks managing to maintain profitability despite fluctuations in non-interest income [13][14] - The energy sector is focusing on renewable energy projects, with companies looking to expand their project reserves and improve operational efficiency [15][16]

公募基金方面，本期较上一期持股增加的公募基金共计21个，主要包括富国医药创新股票A、汇添富创 新医药混合A、工银前沿医疗股票A、汇添富医疗积极成长一年持有混合A、华宝医药生物混合A等，持 股增加占比达0.60%。本期较上一季度持股减少的公募基金共计14个，主要包括汇添富医疗服务灵活配 置混合A、易方达医疗保健行业混合A、富国精准医疗灵活配置混合A、汇添富医药保健混合、工银医 疗保健股票等，持股减少占比达0.75%。本期较上一季度新披露的公募基金共计6个，主要包括惠升医 药健康6个月持有期混合、宝盈优势产业混合A、华泰柏瑞健康生活混合、华宝安元债券A、方正富邦丰 利债券A等。本期较上一季未再披露的公募基金共计240个，主要包括南方中证500ETF、南方医药保健 灵活配置混合A、中欧医疗创新股票A、创新药、中银创新医疗混合A等。 以上内容与数据，与有连云立场无关，不构成投资建议。据此操作，风险自担。 2025年10月29日，海思科(002653.SZ)发布2025年第三季报。截至2025年10月28日，共有42个机构投资 者披露持有海思科A股股份，合计持股量达1.22亿股，占海思科总股本的10.92%。其中，前十 ...

Core Insights - The company reported a revenue of 3.3 billion yuan for the first three quarters, representing a year-on-year growth of 19.95% [1] - The net profit attributable to shareholders decreased by 22.66% to 295 million yuan [1] - The net profit excluding non-recurring gains and losses increased by 44.49% to 311 million yuan [1] Financial Performance - Revenue for the first three quarters: 3.3 billion yuan, up 19.95% year-on-year [1] - Net profit attributable to shareholders: 295 million yuan, down 22.66% year-on-year [1] - Net profit excluding non-recurring items: 311 million yuan, up 44.49% year-on-year [1]

Core Insights - The article highlights the significant changes in the stock positions of various funds managed by the company, particularly in the healthcare sector, indicating a strategic shift towards high-performing stocks [1] Group 1: Fund Performance - The stock position of the China Europe Medical Health fund reached a record high of 94.56% [1] - The China Europe Medical Innovation fund significantly increased its holdings in Kanglong Chemical [1] Group 2: Stock Adjustments - The China Europe Medical Health fund made its first purchase of Haisco and increased its holdings in Kanglong Chemical, Baillie Gifford, Kylin Pharmaceutical, Tigermed, and Xinlitai [1] - The China Europe Medical Innovation fund reduced its positions in several stocks, including 3SBio and Kanyin Biotech [1] - The China Europe Mingrui New Starting Point fund increased its investments in Yangguang Electric, New Yisheng, Zhongji Xuchuang, Tianfu Communication, Hanwha, and Industrial Fulian [1]

Core Viewpoint - Despite strong performance with over 20% gains in two healthcare-themed funds managed by Guo Lan, the funds faced record net redemptions since inception [1][2]. Fund Performance - In Q3 2025, all three funds managed by Guo Lan significantly outperformed their respective benchmarks, with the China Europe Mingrui New Starting Fund achieving nearly 60% gains [2][9]. - The China Europe Healthcare Fund's stock allocation reached a historical high of 94.56% [2][3]. - The China Europe Healthcare Fund experienced a net redemption of 23.42 million shares in Q3, the highest since its inception, despite an increase in net asset value to 32.953 billion yuan [3][4]. Investment Strategy - The China Europe Healthcare Fund made its first investment in Haikang and increased holdings in Kanglong Chemical, Baili Tianheng, Kailai Ying, Tigermed, and Xinlitai [2][4]. - The China Europe Medical Innovation Fund significantly increased its position in Kanglong Chemical, while reducing stakes in several other companies [6][7]. - The China Europe Mingrui New Starting Fund diversified its investments, adding six new stocks, all of which saw price increases exceeding 100% during Q3 [9][10]. Market Outlook - Guo Lan remains optimistic about the investment value in innovative drugs, medical devices, and consumer healthcare, citing ongoing innovation and recovery in consumption as key drivers for the pharmaceutical industry [2][11]. - The report highlights the continued support for innovative drugs and the potential for new growth in the consumer healthcare sector due to demographic changes and policy support [12].

详见公司同日刊登于巨潮资讯网等公司指定信息披露媒体的 《2025 年第三季度报告》。 二、备查文件 海思科医药集团股份有限公司 第五届董事会第三十一次会议决议公告 本公司及董事会全体成员保证信息披露内容的真实、准确、完整， 没有虚假记载、误导性陈述或重大遗漏。 海思科医药集团股份有限公司（以下简称"公司"）第五届董事 会第三十一次会议（以下简称"会议"）于 2025 年 10 月 28 日以通 讯表决方式召开。会议通知于 2025 年 10 月 22 日以专人送达方式发 出。会议应出席董事 5 人，以通讯表决方式出席董事 5 人。会议由公 司董事长王俊民先生召集并主持。本次会议的通知、召开以及参与表 决董事人数均符合有关法律、法规、规则及《公司章程》的有关规定。 全体董事经过审议，以投票表决方式通过了如下决议： 一、审议通过了《2025 年第三季度报告》 表决结果：5 票同意、0 票弃权、0 票反对 本议案已经公司董事会审计委员会审议通过。 证券代码：002653 证券简称：海思科 公告编号：2025-115 经与会董事签字并加盖董事会印章的董事会决议。 特此公告。 海思科医药集团股份有限公司董事会 2025 ...