Policy Developments - The State Council approved the revised draft of the Drug Administration Law Implementation Regulations, emphasizing the importance of timely revisions to drug management laws for ensuring public safety and promoting the healthy development of the pharmaceutical industry [1] Industry Initiatives - Hainan Province aims to develop over six distinctive traditional Chinese medicine health tourism routes by the end of 2028, with a target of cultivating over 1 million mu of medicinal herb planting and breeding areas, and achieving a 15% growth in the overall output value of traditional Chinese medicine [2] Drug and Medical Device Approvals - Xingqi Eye Medicine announced the approval of its atropine sulfate eye drops for children aged 6 to 12, with new product specifications added [1] Capital Market Activities - Sinovac Biotech has repurchased approximately 1.32 million shares, accounting for 0.66% of its total share capital, with a total expenditure of approximately RMB 49.24 million [3] - Dongcheng Pharmaceutical plans to repurchase shares worth between RMB 100 million and RMB 200 million for employee stock ownership plans, with a maximum repurchase price of RMB 18.00 per share [4] - Haizheng Pharmaceutical's major shareholder intends to transfer 6.06% of the company's shares through a public solicitation, pending approval from relevant authorities [5] Strategic Collaborations - Sinopharm Holdings and Betta Pharmaceuticals have signed a strategic cooperation agreement to enhance collaboration and create a new efficient pharmaceutical supply chain ecosystem [6] Personnel Changes - The independent director of Nanxin Pharmaceutical, Shen Yunqiao, has resigned for personal reasons, and will continue to fulfill his duties until a new independent director is elected [7]

Core Viewpoint - The strategic cooperation signing ceremony and project launch meeting between China National Pharmaceutical Group (Sinopharm) and Betta Pharmaceuticals was held, indicating a commitment to deepen collaboration and create a new ecosystem for an efficient pharmaceutical supply chain [1] Group 1 - Sinopharm and Betta Pharmaceuticals aim to enhance cooperation and work together towards a synergistic and efficient pharmaceutical supply chain [1]

Core Viewpoint - The strategic cooperation between China National Pharmaceutical Group (Sinopharm) and Betta Pharmaceuticals represents a strong alliance between an innovative pharmaceutical company and a supply chain giant, aiming to create a new ecosystem for an efficient pharmaceutical supply chain [1] Group 1: Strategic Cooperation - The signing ceremony for the strategic cooperation between Sinopharm and Betta Pharmaceuticals took place at Betta's headquarters [1] - This partnership is seen as a model of complementary strengths between an innovative drug company and a supply chain leader [1] - Both companies aim to deepen their collaboration and create a synergistic and efficient pharmaceutical supply chain ecosystem [1] Group 2: Company Statements - Sinopharm's Vice President, Hu Ligang, expressed satisfaction with the strategic cooperation, emphasizing the integration of internal resources and optimization of service models to support innovative companies like Betta [1] - Betta Pharmaceuticals' Chairman, Ding Lieming, acknowledged the significant support from Sinopharm in Betta's commercialization process, highlighting the importance of this partnership in enhancing collaborative innovation outcomes [1]

Core Insights - The domestic pharmaceutical industry faced unprecedented challenges in 2025 due to policy adjustments, capital withdrawal, and intense competition, leading to a brutal industry reshuffle [2] - The shift in industry dynamics emphasizes clinical value as the core focus, with capital returning to rationality and competition shifting towards hard power [2] Group 1: Company Failures - *ST Changyao faced multiple crises, including a failed restructuring and financial fraud, resulting in a net asset of -643 million yuan and facing dual delisting risks [3] - Simi Biological, an early player in the mRNA field, entered bankruptcy liquidation due to a broken funding chain after raising over 1.3 billion yuan from 2020 to 2023 [5] - Green Valley Pharmaceutical's core product, "Jiuyi Yi," faced production halts due to expired registration and financial difficulties, leading to operational paralysis [6] - *ST Longjin was delisted due to reliance on a single product, with sales dropping significantly after price reductions and failed diversification attempts [7] - Shanghai Jinzhongnuomei, once a rising star, faced bankruptcy liquidation due to funding issues and high R&D costs [8] - Lizhu Group exited the PD-1 market after incurring significant losses, highlighting the challenges of entering saturated markets [9] - Ruike Biological's founder lost control of the company despite nearing commercialization of a core product, reflecting the struggles of innovation-driven firms [10] - Betta Pharmaceuticals faced a trust crisis due to overdue milestone payments, exposing cash flow issues in the innovative drug sector [11] - Keyuan Pharmaceutical's 3.58 billion yuan acquisition plan fell through, missing a critical transformation opportunity amid market changes [13] - Jikai Gene's founder faced legal issues due to an inability to repay 227 million yuan in debt, illustrating the pressures of capital constraints on companies [14]

Core Viewpoint - The A-share pharmaceutical sector in 2025 exhibits structural differentiation, with innovative drugs and CXO sectors thriving due to overseas demand and business development, while traditional Chinese medicine, medical devices, and pharmaceutical commerce face performance pressures [3][20]. Summary by Category Overall Market Performance - The A-share pharmaceutical and biotechnology sector saw an overall increase of 25.64% from January 1 to December 30, 2025, despite a slight decline in revenue and a stabilization in profits, with total revenue of 18,544.52 billion yuan, down 1.42% year-on-year, and net profit of 1,407.32 billion yuan, down 1.65% year-on-year [4][21]. Innovative Drug Sector - The innovative drug sector was a standout performer in 2025, with the chemical pharmaceutical segment rising by 32.58% and the medical services segment by 32.91% [4][21]. - Companies like BeiGene (百济神州) reported significant growth, achieving revenue of 27.595 billion yuan, a 44.2% increase year-on-year, surpassing the total revenue of 27.21 billion yuan for 2024 [4][22]. Business Development (BD) Trends - The business development landscape for innovative drug companies is evolving, with significant partnerships such as the 11.4 billion USD deal between Innovent Biologics and Takeda, and a 12.5 billion USD collaboration between Hengrui Medicine and GlaxoSmithKline [5][22][24]. - The total value of business development transactions reached approximately 94.158 billion USD in the first three quarters of 2025, significantly exceeding the total for 2024 [25]. CXO Sector Performance - The CXO sector, driven by the demand for innovative drug research, achieved a 32.91% increase in 2025, with total revenue of 1,365.72 billion yuan, up 3.63% year-on-year, and net profit of 209.12 billion yuan, up 36.47% year-on-year [10][27]. - Leading companies like WuXi AppTec (药明康德) and Kanglong Chemical (康龙化成) returned to growth, with WuXi AppTec reporting a revenue increase of 18.61% and net profit growth of 84.84% [28][31]. Traditional Chinese Medicine and Medical Devices - The traditional Chinese medicine sector experienced a modest increase of 6.75% in 2025, with total revenue of 2,590.69 billion yuan, down 4.33% year-on-year, and net profit of 294.99 billion yuan, down 1.53% year-on-year [36]. - The medical device sector reported a revenue of 1,792.10 billion yuan, down 2.24% year-on-year, with notable performance differences among sub-sectors, where companies like Mindray Medical (迈瑞医疗) showed strong overseas revenue growth [33][34].

Group 1 - The company holds a 5.45% stake in Hansai Aitai Biopharmaceutical Technology (Wuhan) Co., Ltd [2]

Core Viewpoint - The collaboration between the company and Kangwanda on the VM-001 project is progressing as planned, with updates to be disclosed at significant milestones [1] Group 1 - The company is jointly developing an antibody-oncolytic virus combination therapy (V113+BK-001) with Kangwanda [1] - The company will provide timely announcements regarding any major developments in the project [1]

国浩律师（杭州）事务所 贝达药业 2025 年第二次临时股东大会法律意见书 国浩律师（杭州）事务所 关于 贝达药业股份有限公司 地址：杭州市上城区老复兴路白塔公园 B 区 2 号、15 号国浩律师楼 邮编：310008 Grandall Building, No.2＆No.15, Block B, Baita Park, Old Fuxing Road, Hangzhou, Zhejiang 310008, China 电话/Tel: (+86)(571) 8577 5888 传真/Fax: (+86)(571) 8577 5643 电子邮箱/Mail：grandallhz@grandall.com.cn 网址/Website：http://www.grandall.com.cn 2025 年第二次临时股东大会 二〇二五年十二月 的 法律意见书 国浩律师（杭州）事务所 贝达药业 2025 年第二次临时股东大会法律意见书 国浩律师（杭州）事务所 关于 贝达药业股份有限公司 2025 年第二次临时股东大会的法律意见书 致：贝达药业股份有限公司 国浩律师（杭州）事务所（以下简称本所）接受贝达药业股份有限公司（以 下 ...

贝达药业股份有限公司（以下简称"公司"）第四届董事会任期届满，根据 《中华人民共和国公司法》（以下简称"《公司法》"）、《中华人民共和国证 券法》《深圳证券交易所创业板股票上市规则》《深圳证券交易所上市公司自律 监管指引第 2 号——创业板上市公司规范运作》（以下简称"《规范运作指 引》"）等法律法规、规范性文件及《贝达药业股份有限公司章程》（以下简称 "《公司章程》"）等有关规定，结合公司实际情况，公司已进行董事会换届选 举工作。公司第五届董事会设 12 名董事，其中非独立董事 7 名、独立董事 4 名、 职工代表董事 1 名，职工代表董事由公司职工代表大会选举产生。 贝达药业股份有限公司 关于选举第五届董事会职工代表董事的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 证券代码：300558 证券简称：贝达药业 公告编号：2025-094 一、选举职工代表董事情况 公司于 2025 年 12 月 31 日召开第三届职工代表大会第八次会议，经与会职 工代表选举，同意选举丁师哲先生为公司第五届董事会职工代表董事（简历详见 附件），与公司 2025 年第二 ...

证券代码：300558 证券简称：贝达药业 公告编号：2025-095 贝达药业股份有限公司 2025 年第二次临时股东大会决议公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 特别提示： 1、本次会议没有出现否决议案的情形； 开与表决程序符合《公司法》《深圳证券交易所股票上市规则》《上市公司股东会 规则》等法律法规、规范性文件及《公司章程》的有关规定。 二、议案审议表决情况 本次股东大会以现场投票与网络投票相结合的方式进行表决，与会股东审议 了以下议案并形成如下决议： 2、本次股东大会没有涉及变更前次股东大会决议。 一、会议召开和出席情况 贝达药业股份有限公司（以下简称"公司"）2025 年第二次临时股东大会会 议通知于 2025 年 12 月 16 日以公告形式发出，现场会议于 2025 年 12 月 31 日 （周三）15:00 时在公司会议室召开；通过深圳证券交易所交易系统进行网络投票 的时间为 2025 年 12 月 31 日 9:15-9:25、9:30-11:30、13:00-15:00；通过深圳证券 交易所互联网投票系统投票的具体时间为 2 ...