北京市中伦（广州）律师事务所 关于广州迈普再生医学科技股份有限公司 北京市中伦（广州）律师事务所 关于广州迈普再生医学科技股份有限公司 2024 年年度股东大会的 法律意见书 二〇二五年五月 法律意见书 致：广州迈普再生医学科技股份有限公司 北京市中伦（广州）律师事务所（以下简称"本所"）接受广州迈普再生医 学科技股份有限公司（以下简称"公司"）委托，指派孙巧芬律师和曾思律师（以 下简称"本所律师"）对公司 2024 年年度股东大会（以下简称"本次股东大会"） 的合法性进行见证并出具法律意见。 本法律意见书根据《中华人民共和国公司法》（以下简称"《公司法》"）、《证 券法》等现行有效的法律、法规、规范性文件以及《广州迈普再生医学科技股份 有限公司章程》（以下简称"《公司章程》"）、《广州迈普再生医学科技股份有限公 司股东大会议事规则》（以下简称"《股东大会议事规则》"）的规定而出具。 2024 年年度股东大会的 - 1 - 法律意见书 本所及本所律师依据《中华人民共和国证券法》（以下简称"《证券法》"）、 《律师事务所从事证券法律业务管理办法》和《律师事务所证券法律业务执业规 则（试行）》等规定及本法律意见书 ...

Group 1: Company Overview - Guangzhou Maipu Regenerative Medicine Technology Co., Ltd. is the only domestic enterprise in the neurosurgery field that simultaneously possesses artificial dura (spinal) membrane patches, craniofacial repair and fixation systems, absorbable regenerated oxidized cellulose, and dura mater medical glue [3] - The company has entered the international medical device market since 2011, covering over 100 countries and regions, with nearly 1.3 million products sold [3] Group 2: Financial Performance - In 2024, the domestic operating revenue reached ¥221,750,385.17, accounting for 79.64%, with a year-on-year growth of 22.63% [3] - The overseas operating revenue was ¥56,691,742.22, accounting for 20.36%, with a year-on-year growth of 13.28% [3] - The total revenue growth for 2024 was 20.61%, driven primarily by the artificial dura (spinal) membrane patches, which generated ¥155,593,757.71, accounting for 55.88% of total revenue, with an 11.46% increase [6] Group 3: Product Advantages - The absorbable dura (spinal) membrane patch "Rui Mo®" is the only product in China developed using bio-additive manufacturing technology combined with synthetic materials, offering a unique three-dimensional biomimetic porous micro-fiber structure [5] - The materials used are biodegradable and have good biocompatibility, providing higher biological safety compared to animal-derived materials [6] - The dura (spinal) membrane products generated sales revenue of ¥155,593,757.71, with an 11.46% increase year-on-year [6] Group 4: Future Development Strategy - The company emphasizes value management and aims to enhance core competitiveness while expanding into other surgical fields [4] - Plans to develop hemostatic and medical glue product lines, continuously launching new products to meet clinical needs [7] - The craniofacial repair products achieved sales revenue of ¥79,896,317.05, with a 31.05% increase year-on-year [10]

Industry Overview - Regenerative medicine (RM) utilizes biological and engineering theories to promote self-repair and regeneration of the body, or to construct new tissues and organs for repairing, regenerating, and replacing damaged tissues and organs [1][4] - The global regenerative medicine market is expanding, with the market size projected to grow from $20.04 billion in 2021 to $35.82 billion in 2024 [1][12] Market Status - Regenerative medicine is considered the "third medical revolution" following drug and surgical treatments, becoming a core component of life science strategies globally [6][12] - The industry includes upstream raw materials and equipment supply, midstream product R&D and production, and downstream application through medical institutions and aesthetic organizations [4][12] Policy and Regulatory Environment - Various countries have implemented policies to promote the development of regenerative medicine, such as the U.S. "21st Century Cures Act" and the EU's regulations on biotechnology [7][9] - In China, policies have been established to support the clinical application of regenerative medicine technologies, including the management of stem cell therapies and the promotion of innovative medical technologies [9][23] Market Competition - The regenerative medicine sector has attracted numerous companies, with major players including Johnson & Johnson, Bard, Geistlich, and domestic firms like Zhenghai Biological, Guanhou Biological, and Maipu Medical [16][18] - The market is characterized by a diverse range of products and applications, with companies focusing on specific therapeutic areas such as cancer treatment, tissue repair, and organ transplantation [18][20] Development Trends - The industry is witnessing technological integration and innovation, with advancements in 3D bioprinting, gene editing, and artificial intelligence enhancing treatment efficacy [22][24] - The dual drive of policy support and capital investment is accelerating the commercialization of regenerative medicine, with increasing coverage of medical insurance for regenerative products [23][24]

年度持续督导跟踪报告 华泰联合证券有限责任公司关于 广州迈普再生医学科技股份有限公司 2024 年度持续督导跟踪报告 | 保荐人名称：华泰联合证券有限责任公司 | 被保荐公司简称：迈普医学 | | --- | --- | | 保荐代表人姓名：胡轶聪 | 联系电话：0755-82492010 | | 保荐代表人姓名：张冠峰 | 联系电话：0755-82492010 | 一、保荐工作概述 | 项 目 | 工作内容 | | --- | --- | | 1、公司信息披露审阅情况 | | | （1）是否及时审阅公司信息披露文件 | 是 | | （2）未及时审阅公司信息披露文件的次数 | 0 次 | | 2、督导公司建立健全并有效执行规章制度的情况 | | | （1）是否督导公司建立健全规章制度（包括但不限 | | | 于防止关联方占用公司资源的制度、募集资金管理 | 是 | | 制度、内控制度、内部审计制度、关联交易制度） | | | （2）公司是否有效执行相关规章制度 | 是 | | 3、募集资金监督情况 | | | （1）查询公司募集资金专户次数 | 0 次，募集资金专户已于 2021 年注销 | | （2）公司募 ...

华泰联合证券有限责任公司 关于广州迈普再生医学科技股份有限公司 2024年度内部控制自我评价报告的核查意见 华泰联合证券有限责任公司（以下简称"华泰联合"）作为广州迈普再生医学科 技股份有限公司（以下简称"迈普医学"、"公司"或"发行人"）首次公开发行股 票并在创业板上市的保荐人，根据《证券发行上市保荐业务管理办法》、《深圳证券 交易所上市公司自律监管指引第 2 号——创业板上市公司规范运作》等文件的要求， 华泰联合对迈普医学 2024 年度内部控制制度等相关事项进行核查，并发表独立意见如 下： 一、内部控制评价范围 公司按照风险导向原则确定纳入评价范围的主要单位、业务和事项以及高风险领 域。 内部控制自我评价报告的核查意见 纳入评价范围的主要单位包括公司及子公司，及其各事业部和职能部门，纳入评 价范围单位资产总额占公司合并财务报表资产总额的 100%，营业收入合计占公司合并 财务报表营业收入总额的 100%。 纳入评价范围的主要业务和事项包括；组织结构、内部审计、资金活动、募集资 金使用和管理、发展战略、人力资源、企业文化建设等；重点关注的高风险领域主要 包括：风险管理机制、采购业务、销售业务、固定资产内部 ...

一、保荐机构及保荐代表人承诺 保荐总结报告书 华泰联合证券有限责任公司 关于广州迈普再生医学科技股份有限公司 首次公开发行股票并在创业板上市 之保荐总结报告书 | 保荐机构名称 | 华泰联合证券有限责任公司 | | --- | --- | | 保荐机构编号 | Z26774000 | 1、保荐总结报告书和证明文件及其相关资料的内容不存在虚假记载、误导 性陈述或重大遗漏，保荐机构及保荐代表人对其真实性、准确性、完整性承担法 律责任。 2、本机构及本人自愿接受中国证券监督管理委员会（以下简称"中国证监 会"）、深圳证券交易所对保荐总结报告书相关事项进行的任何质询和调查。 3、本机构及本人自愿接受中国证监会按照《证券发行上市保荐业务管理办 法》的有关规定采取的监管措施。 二、保荐机构基本情况 | 情况 | 内容 | | | | --- | --- | --- | --- | | 保荐机构名称 | 华泰联合证券有限责任公司 | | | | 注册地址 | 深圳市前海深港合作区南山街道桂湾五路 | 128 号前海深港基金小 | | | 镇 | B7 栋 401 | | | | 主要办公地址 | 广东省深圳市福田区莲花街道 ...

关于举办 2024 年度网上业绩说明会的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完 整，没有虚假记载、误导性陈述或重大遗漏。 广州迈普再生医学科技股份有限公司（以下简称"公司"）已于 2025 年 4 月 25 日在巨潮资讯网上披露了《2024 年年度报告》及《2024 年年度报告摘要》。为便于广大投资者更加全面深入地了解公司经营 业绩、发展战略等情况，公司定于 2025 年 5 月 15 日（星期四） 15:00-16:00 在"价值在线"（www.ir-online.cn）举办 2024 年度 网上业绩说明会，与投资者进行沟通和交流，广泛听取投资者的意见 和建议。 一、说明会召开的时间、地点和方式 会议召开时间：2025 年 5 月 15 日（星期四）15:00-16:00 会议召开地点：价值在线（www.ir-online.cn） 会议召开方式：网络互动方式 二、参加人员 关于举办 2024 年度网上业绩说明会的公告 证券代码：301033 证券简称：迈普医学 公告编号：2025-024 广州迈普再生医学科技股份有限公司 董事、副总经理、财务总监 骆雅红女士 董事、副总经理、董事会秘书 ...

Investment Rating - The report maintains a "Buy" rating for the company, expecting the stock to outperform the benchmark index by over 20% in the next six months [15]. Core Insights - The company has shown a continuous increase in the proportion of new products, indicating the emergence of a second growth curve [3]. - In 2024, the company achieved a revenue of 278 million yuan, a year-on-year increase of 20.61%, and a net profit attributable to the parent company of 79 million yuan, up 92.90% year-on-year [3][4]. - The company’s new products, including artificial dura mater patches and craniofacial repair systems, accounted for 56%, 29%, and 13% of revenue respectively in 2024 [4]. - The company is focusing on expanding its influence in KA hospitals and enhancing its academic system in neurosurgery [6][8]. Financial Performance - The company’s revenue for Q1 2025 was 74 million yuan, reflecting a year-on-year growth of 28.84%, with a net profit of 24 million yuan, up 61.68% [3]. - The projected revenue for 2025-2027 is expected to be 364 million yuan, 489 million yuan, and 657 million yuan, with year-on-year growth rates of 30.7%, 34.3%, and 34.4% respectively [9][11]. - The net profit attributable to the parent company for the same period is forecasted to be 115 million yuan, 166 million yuan, and 237 million yuan, with growth rates of 46.3%, 43.9%, and 42.9% [9][11]. Product Development and Market Strategy - The company’s hemostatic gauze product has expanded its application from neurosurgery to general surgery, significantly broadening its clinical use [5]. - The hard dura mater medical glue received EU MDR certification, which is expected to enhance the company’s revenue share in overseas markets [5]. - The company plans to deepen its market presence domestically while also expanding internationally, aiming to increase brand influence and market penetration [8].

Investment Rating - The investment rating for the company is "Buy" [7][15]. Core Views - The company has shown a continuous increase in the proportion of new products, indicating the emergence of a second growth curve [3][4]. - In 2024, the company achieved a revenue of 278 million yuan, a year-on-year increase of 20.61%, and a net profit attributable to the parent company of 79 million yuan, a year-on-year increase of 92.90% [3][11]. - The company is focusing on expanding its product influence in KA hospitals and aims to enhance its market penetration both domestically and internationally [6][8]. Financial Performance - In Q1 2025, the company reported a revenue of 74 million yuan, a year-on-year increase of 28.84%, and a net profit of 24 million yuan, a year-on-year increase of 61.68% [3][4]. - The sales revenue from the craniofacial repair and fixation system reached approximately 79.9 million yuan in 2024, growing by 31.05% compared to the previous year [4][5]. - The company expects revenues for 2025 to reach 364 million yuan, with a year-on-year growth rate of 30.7%, and net profits to be 115 million yuan, with a growth rate of 46.3% [9][11]. Product Development - The sales revenue from absorbable regenerated oxidized cellulose and dural glue reached approximately 36 million yuan in 2024, marking a growth of 49.89% [5]. - The company has expanded the application range of its hemostatic gauze products and successfully obtained EU registration for its dural glue, which is expected to enhance its revenue share in overseas markets [5][6]. Market Strategy - The company plans to build an academic system around two main themes: standardized management of cerebrospinal fluid leaks and cranial repair practices, to enhance its product solution influence in neurosurgery [8]. - The company aims to optimize costs and improve production efficiency to ensure product quality and maintain market responsiveness [8].

股份质押的公告 证券代码：301033 证券简称：迈普医学 公告编号：2025-023 广州迈普再生医学科技股份有限公司 关于公司实际控制人、控股股东部分股份质押的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假 记载、误导性陈述或重大遗漏。 一、股东股份质押基本情况 广州迈普再生医学科技股份有限公司（以下简称"公司"）近日 接到公司实际控制人、控股股东袁玉宇先生的函告，获悉其所持有的 公司部分股份办理了质押登记手续，具体情况如下： 注：1、上述质押股份不负担重大资产重组等业绩补偿义务； 2、本公告中的无限售条件流通股包括高管锁定股，不存在股份 冻结情形，下同； 3、公司目前总股本为 66,519,431 股（含回购股份）。 股东名 称 是否为控 股股东或 第一大股 东及其一 致行动人 本次质 押数量 （股） 占其所 持股份 比例 （%） 占公司 总股本 比例 （%） 是否 为限 售股 是否 为补 充质 押 质押 起始 日 质押到期 日期 质权人 质押 用途 袁玉宇 是 410,00 0 3.73 0.62 否 否 2025- 04-28 至办理解 除质押日 结束 王羽琳 个人 融资 ...