百诚医药（301096）公告，预计2025年1月1日至2025年6月30日，归属于上市公司股东的净利润为0万 元–600万元，同比下降95.53%-100.00%。上年同期净利润为1.34亿元。扣除非经常性损益后的净利润为 亏损900万元–1500万元，上年同期为1.23亿元。公司预计非经常性损益对净利润的影响金额约为1500万 元，主要为政府补助收入。 ...

[Hangzhou Baicheng Pharmaceutical Technology Co., Ltd. 2025 Semi-Annual Performance Forecast](index=1&type=section&id=Hangzhou%20Baicheng%20Pharmaceutical%20Technology%20Co.%2C%20Ltd.%202025%20Semi-Annual%20Performance%20Forecast) [Core Performance Forecast Data](index=1&type=section&id=I.%20Current%20Period%20Performance%20Forecast) The company anticipates a substantial year-over-year decline in its 2025 first-half performance, with net profit attributable to shareholders projected to be between 0 and 6 million yuan Performance Forecast Summary | Item | Current Reporting Period (Jan 1 - Jun 30, 2025) | Prior Period | | :--- | :--- | :--- | | **Net Profit Attributable to Shareholders of Listed Company** | Profit: 0 Million Yuan – 6 Million Yuan | Profit: 134.2105 Million Yuan | | | Year-over-Year Decrease: 95.53% - 100.00% | | | **Net Profit After Non-Recurring Items** | Loss: 9 Million Yuan – 15 Million Yuan | Profit: 123.1989 Million Yuan | | | Year-over-Year Decrease: 107.31% - 112.18% | | [Communication with Accounting Firm](index=1&type=section&id=II.%20Communication%20with%20Accounting%20Firm) The company has pre-communicated with its accounting firm regarding the performance forecast, confirming no major discrepancies, though the forecast remains unaudited - The financial data in this performance forecast is unaudited by the accounting firm, but the company has pre-communicated with the accounting firm on related matters, and there are no significant discrepancies between the parties[5](index=5&type=chunk) [Analysis of Performance Changes](index=2&type=section&id=III.%20Explanation%20of%20Performance%20Changes) The company attributes performance changes to increased Q2 revenue from R&D commercialization and strict cost control, alongside significant government subsidies - In the second quarter of 2025, the company intensified the commercialization of its independent R&D achievements, leading to a sequential increase in revenue and achieving a turnaround from loss to profit in the first half compared to 2024 through strict cost and expense control[6](index=6&type=chunk) - During the reporting period, the estimated impact of non-recurring gains and losses on net profit is approximately **15 million yuan**, primarily from government subsidies recognized in current profit or loss[6](index=6&type=chunk) [Risk Warning and Other Explanations](index=2&type=section&id=IV.%20Other%20Related%20Explanations) The company states this performance forecast is preliminary, with final data in the 2025 semi-annual report, advising investors to exercise caution - This performance forecast represents preliminary data from the company's finance department; the final financial data will be subject to the company's 2025 semi-annual report, and investors are advised to be aware of investment risks[7](index=7&type=chunk)

Group 1 - The CRO sector experienced a slight increase of 0.66% with a total capital inflow of 84.32 million [1] - A total of 27 stocks within the sector saw gains, while 11 stocks experienced declines [1] - The top declining stocks included Yaokang Bio (-3.64%), Zhaoyan New Drug (-2.68%), and Meidi West (-2.04%) [1] Group 2 - Notable stocks with significant capital inflow included Baicheng Pharmaceutical with a price of 48.06 and a rise of 6.05% [1] - Other stocks with positive performance included Heyuan Bio (+4.39%) and Jinkai Biotechnology (+2.76%) [1] - The stock with the highest capital outflow was Yao Stone Technology, which saw a decrease of 8.88% [1]

Core Viewpoint - The hair medical concept sector has shown a positive performance with a 1.77% increase, ranking 7th among various concept sectors, driven by significant gains in stocks like Xiaofang Pharmaceutical, Baicheng Pharmaceutical, and Jiuzhitang [1] Group 1: Sector Performance - The hair medical concept sector experienced a 1.77% increase, with 17 stocks rising, including Xiaofang Pharmaceutical (up 6.65%), Baicheng Pharmaceutical (up 6.05%), and Jiuzhitang (up 6.00%) [1] - The sector attracted a net inflow of 114 million yuan from main funds, with Jiuzhitang leading the inflow at 74.56 million yuan [1] Group 2: Fund Inflow Ratios - Baicheng Pharmaceutical, Aoyang Health, and Yisheng Pharmaceutical had the highest net inflow ratios at 10.73%, 7.21%, and 6.37% respectively [2] - Jiuzhitang recorded a net inflow of 74.56 million yuan with a turnover rate of 27.18% [2] - Other notable stocks include Langzi Co. (up 5.16% with a net inflow of 20.14 million yuan) and Aoyang Health (up 1.03% with a net inflow of 10.81 million yuan) [2]

Group 1 - The core viewpoint of the article highlights that Hongshang Asset has conducted research on Baicheng Pharmaceutical, focusing on its dual development strategy of innovative and generic drug research [1] - Baicheng Pharmaceutical is actively seeking new business growth points and has a wide range of innovative drug research projects in critical medical fields such as oncology, autoimmune diseases, neuropsychiatric disorders, and respiratory diseases [1] - The company is advancing several key projects, including the small molecule innovative drug BIOS-0635 for tumor treatment and multiple large molecule innovative drugs, with a strong emphasis on developing a drug targeting the KT6 site for solid tumors [1] Group 2 - Baicheng Pharmaceutical has established multiple mature organoid models for evaluating the efficacy of anti-tumor drugs, personalized precision medicine, and drug toxicity prediction [1] - The company has a new drug research platform that encompasses several key technology platforms, with a team of over 200 people, of which more than 80% hold master's or doctoral degrees [1] - The market potential for the 0618 target, which addresses osteosarcoma (OS) and neuropathic pain, is significant, especially given the large number of OS patients [1] Group 3 - Hongshang Asset was founded in October 2013, in collaboration with Sequoia Capital, and is recognized as a prominent private equity fund company in China [2] - The company focuses on absolute return goals in equity investment strategies, driven by fundamental research capabilities [2] - The investment research team at Hongshang Asset includes experienced professionals from large fund companies and award-winning analysts, ensuring robust management and industry influence [2]

Group 1: Innovation Drug Development - The company is actively pursuing new business growth points through dual development of innovative and generic drugs, focusing on self-initiated innovative drug projects in key medical fields such as oncology, autoimmune diseases, and respiratory diseases [1] - The small molecule innovative drug R&D center has two approved cases, with several ongoing projects including BIOS-0629, BIOS-0623, BIOS-0632, and BIOS-0635, the latter being a key project targeting tumors [1][2] - The global market for targeted cancer drugs is over 60%, with immunotherapy accounting for 23.4% of the market, indicating a growing demand for innovative treatments [2] Group 2: Organoid Technology - Organoids have been recognized as a significant technology since 2013, with multiple mature organoid models developed by the company for drug efficacy evaluation and personalized medicine [3] - The company has established a service platform for organoids, focusing on drug screening, efficacy evaluation, and safety assessment, enhancing the precision and efficiency of drug development [4] Group 3: Market Potential of Drug 0618 - Drug 0618 targets the H3 receptor and addresses two indications: daytime sleepiness in OSA patients, with approximately 2.1 billion OSA patients in China, and neuropathic pain affecting around 90 million people [6] - The market expectations for the competing drug Pitolisant are significant, with projected sales of $582 million in 2023 and $710 million in 2024 [6] Group 4: New Drug R&D Platform and Team - The company’s new drug development encompasses various stages from compound discovery to clinical trials, focusing on both fast follow-on and first-in-class products [7] - The R&D team consists of over 200 members, with more than 80% holding advanced degrees, emphasizing the importance of talent in the industry [8] - The company collaborates with universities and research institutions to attract top talent, ensuring a strong foundation for innovative drug development [8]

Summary of Baicheng Pharmaceutical Conference Call Company Overview - Baicheng Pharmaceutical has been transitioning to innovative drug development since 2018, responding to changes in centralized procurement policies and the MH system [2][4] - The company has received two IND approvals for innovative drugs and 11 clinical approvals for improved new drugs [2] Core Business and R&D Focus - The company has three main R&D platforms: small molecule innovative drug development, large molecule innovative drug development, and innovative drug discovery and evaluation [6] - Key products include: - Small molecule drug 0,618 targeting neuropathic pain and OSA (Obstructive Sleep Apnea) daytime sleepiness, with significant market potential [2][14] - Antitumor drug XPO1 target 0,629 showing superior efficacy in mouse trials compared to positive controls [2][15] - Other ongoing projects include 0,623 for itching and pain, 0,632 for neuropathic pain, and 0,635 for tumors [6][18] Business Development (BD) Strategy - Baicheng Pharmaceutical is actively expanding its BD market, targeting global markets including Africa, Southeast Asia, Japan, Korea, and Europe, and has obtained EU CEP certification [2][7] - The company aims to make BD a key focus for 2025, seeking to finalize projects through business collaborations [2][9] Financial Performance and Future Outlook - In Q1 2025, the company continued to experience a pessimistic trend with losses exceeding 20 million yuan, but hopes for gradual improvement throughout the year [3] - The company plans to maintain an annual investment of approximately 20% in innovative R&D [5][19] Market Trends and Regulatory Environment - The domestic and international BD markets are thriving, with increasing quality and quantity of Chinese innovative drugs [7][12] - Recent government policies are supportive of innovative drug development, providing unprecedented opportunities [12] Potential Products and Market Prospects - The 0,618 project is expected to enter Phase II clinical trials in July 2025, with significant market potential due to the high prevalence of OSA [14] - The company has a broad layout in oncology, enteritis, allergy, and itching drugs, with promising market prospects [13] Long-term Vision - The actual controller and chairman of Baicheng Pharmaceutical expresses confidence in the company's long-term development and plans to increase shareholding [10][20] - The company aims to embrace the capital market for stable long-term growth and value creation [10] Class Organoid Technology - Baicheng Pharmaceutical is investing in organoid technology, which is seen as a future trend for drug development, potentially replacing animal testing [11] Conclusion - Baicheng Pharmaceutical is in a transitional phase from generic to innovative drug development, with a strong focus on R&D and strategic partnerships to enhance its market position and product pipeline [20]

Group 1 - The CRO concept stocks experienced a partial surge, with Lingkang Pharmaceutical (603669) hitting the daily limit up [1] - Baicheng Pharmaceutical (301096), Kangpeng Technology, Zhaoyan New Drug (603127), and Kailaiying (002821) also saw increases [1]

Group 1: Company Overview and Investment Activities - The company is Hangzhou Baicheng Pharmaceutical Technology Co., Ltd., with stock code 301096 and abbreviation Baicheng Pharmaceutical [1] - The investor relations activities include online meetings and strategy sessions held from June 9 to June 20, 2025 [2] - Key participants include the Chairman and General Manager, Lou Jinfang, and the Financial Director and Board Secretary, Cheng Dandan [2] Group 2: Drug Development Progress - The company has multiple new drug pipelines, with 2 IND approvals for Class 1 new drugs targeting areas such as the nervous system and oncology [3] - The global market for central nervous system drugs exceeded $500 billion in 2023, with China's market at approximately ¥173.4 billion, indicating significant growth potential [3] - The central nervous system drug market in China is projected to grow from about ¥40 billion in 2025 to ¥200 billion by 2030 [3] Group 3: Specific Drug Projects - BIOS-0623 is a novel pain relief drug with advantages such as rapid onset and lower effective doses, showing superior efficacy compared to pregabalin [4] - BIOS-0632 is a strong AAK1 kinase inhibitor that demonstrates faster onset and better efficacy in diabetic neuropathic pain models compared to existing treatments [4] - BIOS-0629, a potential Best-in-Class second-generation XPO1 inhibitor, shows significant anti-tumor efficacy in various cancer models [5][6] Group 4: Market Trends and Opportunities - The global market for anti-tumor drugs reached $235.7 billion in 2023, with China's market at approximately ¥280 billion, driven by increasing cancer incidence [5] - The autoimmune disease drug market is expected to grow from $113.7 billion in 2018 to $176.7 billion by 2030, with a CAGR of 3.7% globally and over 20% in China [6][7] Group 5: Improved Drug Development - The company has over 20 projects in the improved drug category, with 11 receiving clinical approval, indicating a robust pipeline [10] - The market for improved drugs in China is expected to reach ¥560 billion by 2025, suggesting a favorable investment return [11][12] Group 6: Subsidiary Development - The subsidiary, Saimer Pharmaceutical, aims to become a global supplier of raw materials and formulations, with a production area of over 260 acres and 16.3 million square meters of GMP-compliant facilities [13][14] - Saimer has successfully registered 435 projects and has 49 products approved, showcasing its strong production capabilities [14] Group 7: CRO Business Status - The CRO/CDMO industry is experiencing a downturn due to cautious investment and increased competition, leading to a decline in orders [15][16] - Recent regulatory changes are expected to positively impact the CRO/CDMO sector, potentially restoring investment enthusiasm [16][17] Group 8: International Expansion Plans - The company is accelerating its internationalization efforts, establishing partnerships to enhance global resource connectivity [19] - Saimer has obtained the EU CEP certificate for minoxidil, marking a significant step in international business expansion [19]

Core Viewpoint - The announcement by Baicheng Pharmaceutical regarding the lifting of restrictions on 39,600,000 shares, which constitutes 36.25% of the company's total share capital, is significant as it will allow these shares to be traded starting June 20, 2025 [1]. Share Structure Summary - The total share capital before the IPO was 81,125,000 shares, which increased to 108,166,667 shares post-IPO. The shares without trading restrictions account for 23.95% of the total post-IPO shares, while those with restrictions account for 76.05% [1]. - The shareholders applying for the lifting of restrictions include Shao Chunneng, Lou Jinfang, You Minwei, and three investment partnerships, with Shao Chunneng and Lou Jinfang being the controlling shareholders [1][2]. Financial Performance Summary - Baicheng Pharmaceutical's IPO raised a total of 2.153 billion yuan, with a net amount of 1.863 billion yuan after deducting issuance costs. The actual net fundraising exceeded the initial plan by 1.213 billion yuan [5]. - For Q1 2025, the company reported a revenue of 129 million yuan, a decrease of 40.32% year-on-year, and a net loss attributable to shareholders of 26.2 million yuan, down 152.59% year-on-year [5][6]. - In 2024, the company achieved a revenue of 802 million yuan, a decline of 21.18% compared to 2023, with a net loss of 52.7 million yuan, representing a 119.39% decrease year-on-year [7].