Investment Rating - The report provides an "Outperform" rating for multiple companies in the healthcare sector, including BeiGene, JD Health, WuXi Biologics, and others, indicating a positive outlook for these stocks [1]. Core Insights - The macro and industry environment is improving due to the resolution of policy uncertainties, the release of significant clinical data, and a resurgence in global M&A activity, leading to a notable increase in investor sentiment towards innovative drugs for 2026 [4][11]. - In oncology, the PD-1/VEGF dual antibody approach is transitioning from "mechanism validation" to "clinical and industrial resonance," with multiple global Phase III trials underway, expected to catalyze approvals and data releases within the year [5][17]. - The metabolic sector is seeing growth in the cash-pay market for GLP-1 drugs, driven by limited insurance coverage and high out-of-pocket costs, prompting companies to enhance accessibility through direct sales and pricing adjustments [6][25]. - In the autoimmune space, there is a growing concentration risk among major products from multinational corporations (MNCs), with new antibody platforms expected to yield significant data in 2026, potentially leading to new business development opportunities [7]. - The central nervous system (CNS) investment focus remains on advancing Aβ monoclonal antibody treatments, with key data expected to open up early intervention market opportunities [9]. Summary by Sections Oncology - The PD-1/VEGF dual antibody's clinical and industrial certainty is strengthening, with major companies conducting multiple global Phase III trials across high-value indications [17]. - The Pan-RAS precision therapy is entering a realization phase, with key Phase III data expected in 2026 for pancreatic cancer and NSCLC [22]. Metabolic - The cash-pay market for GLP-1 drugs is expanding due to limited insurance coverage, with companies like Eli Lilly and Novo Nordisk adopting different direct-to-consumer strategies to enhance accessibility [25][26]. - Small nucleic acid therapies are expected to upgrade treatment paradigms, showing competitive data in weight loss and safety profiles when combined with GLP-1 [30]. Autoimmune - MNCs are increasingly reliant on a few blockbuster products, with structural opportunities arising from new antibody platforms expected to report data in 2026 [7]. - The trend towards oral formulations in autoimmune diseases is gaining traction, offering advantages in adherence and competitive differentiation [7]. CNS - The focus in CNS remains on Aβ monoclonal antibody treatments, with advancements expected to shift treatment towards earlier intervention populations [9]. - New delivery methods, such as systemic administration of small nucleic acids, are being explored as complementary approaches [9].

格隆汇2月6日丨和黄医药(00013.HK)宣布，公司将于2026年3月5日(星期四)举行董事会会议，以(其中包 括)批准公司及其附属公司截至2025年12月31日止年度的年度业绩，并将其于同日下午7时正(香港时间) 发布。 ...

Core Viewpoint - HUTCHMED will announce its final results for the year ended December 31, 2025, on March 5, 2026, with subsequent webcasts for analysts and investors to discuss the results and conduct Q&A sessions [1][2]. Company Overview - HUTCHMED is an innovative, commercial-stage biopharmaceutical company focused on the discovery, global development, and commercialization of targeted therapies and immunotherapies for cancer and immunological diseases [4]. - The company has successfully marketed its first three medicines in China, with the first also receiving approval in the US, Europe, and Japan [4]. Event Details - The English webcast for discussing the final results will take place on March 5, 2026, at 8:00 am EST, followed by a Chinese (Putonghua) webcast on March 6, 2026, at 8:30 am HKT [2]. - Both webcasts will be available live on the company's website, with a replay accessible shortly after the events [3].

HUTCHMED (China) Limited 和黃醫藥（中國）有限公司 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不對 因本公告全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 （於開曼群島註冊成立的有限公司） （股份代號：13） 董事會會議召開日期及 2025 年全年業績公告 和黃醫藥（中國）有限公司（「本公司」）董事會（「董事會」）謹此宣佈，本公司將於 2026 年 3 月 5 日（星期四） 舉行董事會會議，以（其中包括）批准本公司及其附屬公司截至 2025 年 12 月 31 日止年度之年度業績，並將其於同 日下午 7 時正（香港時間）發佈。 於業績獲批准及發佈後，本公司之管理層將於同日下午 9 時正（香港時間）舉行設有問答環節之英語網上直播簡報 會。本公司亦將於 2026 年 3 月 6 日（星期五）上午 8 時半（香港時間）舉行中文（普通話）網上直播。兩場實時網 上直播均可於本公司網站 www.hutch-med.com/event/ 收看。簡報文稿將於網上直播開始前上載至本公司網站以供 下載。 ...

I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | | 於香港聯交所上市 (註1) | 是 | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 00013 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 1,500,000,000 | USD | | 0.1 | USD | | 150,000,000 | | 增加 / 減少 (-) | | | 0 | | | | USD | | | | 本月底結存 | | | 1,500,000,000 | USD | | 0.1 | USD | | 150,000,000 | 本月底法定/註冊股本總額： USD 150,000,000 第 1 頁 共 10 頁 v 1.2.0 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2026年1月31日 狀態: 新提交 致：香港交 ...

行 业 研 医药生物 2026 年 02 月 01 日 究 靶向 PAM 通路潜在百亿美元市场：和黄医药及 Celcuity 投资要点： 行 业 定 期 报 告 行情回顾：本周（2026 年 1 月 26 日- 2026 年 1 月 30 日）中信医药指数下 跌 3.3%，跑输沪深 300 指数 3.4pct，在中信一级行业分类中排名第 22 位；2026 年初至今中信医药生物板块指数上涨 3.0%，跑赢沪深 300 指数 1.3 pct，在中 信行业分类中排名第 18 位。本周涨幅前五的个股为：凯普生物（+ 26.5%）、 华兰疫苗（+ 12.8%）、德展健康（+ 8.8%）、万泽股份（+ 7.9%）、华康医疗 （+ 6.9%）。 靶向 PAM 通路市场空间大，关注 Celcuity、和黄医药：PAM 通路突 变发生在 38%肿瘤患者中，其中覆盖乳腺癌和前列腺癌两大癌种。靶向 PAM 潜在收入与 CDK4/6 和 AR 疗法相当（80-100 亿美金），由于过往开 发药物的疗效有限，PAM 抑制剂的药物收入在其他靶向治疗类别中占比很 小。Celcuity 开发的 Gedatolisib 是唯一在 PIK3C ...

行 业 研 究 华福证券 医药生物 2026 年 02 月 01 日 靶向 PAM 通路潜在百亿美元市场：和黄医药及 Celcuity 投资要点： 行 业 定 期 报 告 行情回顾：本周（2026 年 1 月 26 日- 2026 年 1 月 30 日）中信医药指数下 跌 3.3%，跑输沪深 300 指数 3.4pct，在中信一级行业分类中排名第 22 位；2026 年初至今中信医药生物板块指数上涨 3.0%，跑赢沪深 300 指数 1.3 pct，在中 信行业分类中排名第 18 位。本周涨幅前五的个股为：凯普生物（+ 26.5%）、 华兰疫苗（+ 12.8%）、德展健康（+ 8.8%）、万泽股份（+ 7.9%）、华康医疗 （+ 6.9%）。 靶向 PAM 通路市场空间大，关注 Celcuity、和黄医药：PAM 通路突 变发生在 38%肿瘤患者中，其中覆盖乳腺癌和前列腺癌两大癌种。靶向 PAM 潜在收入与 CDK4/6 和 AR 疗法相当（80-100 亿美金），由于过往开 发药物的疗效有限，PAM 抑制剂的药物收入在其他靶向治疗类别中占比很 小。Celcuity 开发的 Gedatolisib 是唯一在 ...

www.leadleo.com 2025年中国生物创新药市场跟踪报告： 呋喹替尼8月市场动向 2025 China Biopharmaceutical Innovation Market Tracking Report: Market Trends for Fitinib in August 2025年中国バイオ医薬品イノベーション市場追跡レポート：月時点のフィチニブ市場動向 概览标签：呋喹替尼、结直肠癌、和黄医药 作者：何婉怡 报告提供的任何内容（包括但不限于数据、文字、图表、图像等）均 系头豹研究院独有的高度机密性文件（在报告中另行标明出处者除外 、再造、传播、出版、引用、改编、汇编本报告内容，若有违反上述 约定的行为发生，头豹研究院保留采取法律措施，追究相关人员责任 的权利。头豹研究院开展的所有商业活动均使用"头豹研究院"或"头豹 "的商号、商标，头豹研究院无任何前述名称之外的其他分支机构， 也未授权或聘用其他任何第三方代表头豹研究院开展商业活动。 1 ©2025 LeadLeo ）。 ，任何人不得以任何方式擅自复制 www.leadleo.com 400-072-5588 #6C0000 #7C000 ...

Group 1 - The core viewpoint is that innovative drugs are expected to show significant excess returns in 2025, driven by continuous BD overseas expansion, excellent clinical data, and policy support [1] - The CXO sector is anticipated to experience substantial growth due to the recovery in demand and improved investment environment in the global pharmaceutical industry [1] - The report emphasizes the importance of focusing on new technologies, particularly bispecific antibodies, small nucleic acid drugs, AI healthcare, and brain-computer interface innovations [3] Group 2 - Domestic supply and demand are relatively stable, with national health expenditure showing a year-on-year growth of 4.7% from January to November 2025, marking a positive turnaround after two years of decline [2] - The medical insurance fund's income and expenditure growth rates continue to decline, with total income of 2.63 trillion yuan (+2.9%) and expenditure of 2.11 trillion yuan (+0.5%) from January to November [2] - The report suggests that the commercialization of new drug forms is entering a critical phase, with significant clinical data supporting the application of B-cell depletion therapies in autoimmune diseases [3] Group 3 - Investment recommendations include focusing on innovative overseas expansion and new technology directions, with suggested stocks such as Mindray Medical, WuXi AppTec, and others [4] - The report highlights the potential for explosive growth in the global market for brain-computer interfaces, supported by policy incentives and technological breakthroughs [3]

Core Viewpoint - HCM (HCM.US) shares rose over 5% to $16.12 following the publication of SACHI III trial results in The Lancet, highlighting the potential of savolitinib and osimertinib combination therapy for specific lung cancer patients [1] Group 1: Company Overview - HCM announced the results of the SACHI III trial, which focuses on the combination therapy of savolitinib and osimertinib for treating EGFR mutation-positive locally advanced or metastatic non-small cell lung cancer patients who progressed after first-line EGFR TKI treatment [1] - Savolitinib is a potent and highly selective oral MET TKI co-developed by AstraZeneca and HCM, with AstraZeneca responsible for commercialization [1] - Osimertinib is an irreversible third-generation EGFR TKI [1] Group 2: Research and Approval - The SACHI study data supports the approval of the savolitinib and osimertinib combination therapy, which is expected to be granted in China by June 2025 [1]