Group 1: Core Insights - Xinda Biopharma announced a global strategic collaboration with Takeda Pharmaceutical, with a total deal value of up to $11.4 billion, including an upfront payment of $1.2 billion [1][3][4] - The collaboration aims to accelerate the global development and commercialization of Xinda's next-generation immuno-oncology and antibody-drug conjugate therapies, covering three products: IBI363, IBI343, and IBI3001 [3][4] - Xinda will receive a total of up to $10.2 billion in potential development and sales milestone payments, in addition to sales revenue sharing for the candidates outside Greater China [3][4] Group 2: Market Impact - Following the announcement, the innovative drug ETF (589720) surged, reflecting a 20% increase in a single day, indicating strong market sentiment towards the collaboration [1][6] - The innovative drug sector has seen significant growth, with contract values exceeding $100 billion in the first nine months of the year, marking a 170% year-on-year increase [5] - The sector is expected to continue benefiting from favorable macroeconomic conditions, including potential interest rate cuts, which are seen as supportive for innovation-driven companies [5][7] Group 3: Future Outlook - The innovative drug industry is poised for substantial growth driven by international expansion, policy support, and the strengthening of R&D capabilities among Chinese companies [7] - Investors are encouraged to focus on the innovative drug ETF (589720), which tracks a representative index of high-growth biotech companies, as it has outperformed the Hang Seng Hong Kong Stock Connect Innovative Drug Index since the "924 market" [6][7] - The upcoming ESMO conference is expected to showcase a significant number of Chinese research projects, further highlighting the robust development of the innovative drug sector [5][7]

Group 1 - The stock of Innovent Biologics (01801.HK) opened nearly 10% higher on October 22, reaching a price of 95.5 HKD [1] - As of the time of reporting, the stock had increased by 9.9%, with a trading volume of 182 million HKD [1]

Core Viewpoint - The strategic collaboration between Innovent Biologics and Takeda Pharmaceutical aims to accelerate the development of Innovent's next-generation IO and ADC therapies, with significant financial implications for Innovent [1][2] Group 1: Collaboration Details - Innovent Biologics announced a global strategic partnership with Takeda Pharmaceutical on October 22, focusing on the development of IBI363, IBI343, and IBI3001 [1] - The collaboration includes joint development of IBI363, with Takeda leading commercialization efforts in the U.S. and Innovent granting Takeda commercialization rights outside Greater China and the U.S. for IBI363 and IBI343 [1] Group 2: Financial Aspects - Innovent will receive an upfront payment of $1.2 billion, which includes a $100 million strategic equity investment, with total deal value potentially reaching $11.4 billion [2] - Takeda's investment will involve purchasing approximately 6.91 million shares of Innovent at a price of HKD 112.56 per share, representing a 29.53% premium over the previous closing price [2] - The funding allocation includes 80% for global pipeline clinical and preclinical projects and 20% for general corporate purposes [2]

（文章来源：每日经济新闻） 海通国际此前表示，近期多起BD密集落地，有望催化创新药行情。如10月16日普瑞金宣布与Kite达成 1.2亿美元首付款、总计最高可达15.2亿美元里程碑付款交易；维立志博宣布与Dianthus达成2000万美元 首付款、总金额最高可达10亿美元交易；10月17日翰森制药、奥赛康也分别宣布与罗氏、Visara达成交 易。 恒生医药ETF（159892）重仓股信达生物在港交所公告，其与武田制药达成全球战略合作，旨在加速推 进信达生物新一代IO及ADC疗法开发。本次合作包括两款后期在研疗法IBI363及IBI343，以及一款早期 研发项目IBI3001的选择权。 信达生物将获得12亿美元的首付款，包括以认购事项方式获得的1亿美元的战略股权投资。信达生物另 外有权获得合计最高可达102亿美元的潜在里程碑付款，本次合作交易总金额最高可达114亿美元。此 外，信达生物还将获得每个候选药物在大中华区以外的潜在销售分成。在美国市场，双方就IBI363将采 用利润损失共担模式。 ...

Core Viewpoint - Xinda Biopharmaceutical has entered into a global strategic collaboration with Takeda Pharmaceutical to accelerate the development of its next-generation IO and ADC therapies, with a total deal value potentially reaching $11.4 billion [1] Group 1: Collaboration Details - The collaboration includes two late-stage therapies, IBI363 and IBI343, and an early-stage project, IBI3001 [1] - Xinda Biopharmaceutical and Takeda will jointly develop IBI363 globally, with Takeda leading the development efforts in the U.S. [1] - Xinda grants Takeda commercialization rights for IBI363 outside of Greater China and the U.S., while Takeda receives exclusive rights for IBI343 outside of Greater China [1] Group 2: Financial Aspects - Xinda will receive an upfront payment of $1.2 billion, which includes a strategic equity investment of $100 million [1] - The company is eligible for up to $10.2 billion in potential milestone payments, making the total deal value potentially reach $11.4 billion [1] - Xinda will also receive a share of potential sales for each candidate drug outside of Greater China, with a profit-sharing model for IBI363 in the U.S. [1]

Core Insights - The company has entered into a global strategic collaboration with Takeda Pharmaceuticals to accelerate the development of its next-generation IO and ADC therapies, aiming to expand its global market value [1][3] Group 1: Collaboration Details - The collaboration includes two late-stage therapies, IBI363 (PD-1/IL-2α-bias) and IBI343 (CLDN18.2 ADC), as well as an early-stage project, IBI3001 (EGFR/B7H3 ADC) [1] - The company will jointly develop IBI363 with Takeda and will commercialize it in the U.S., while Takeda will lead the development under a collaborative governance structure [1][3] - Takeda has been granted exclusive rights for IBI343 outside Greater China, and an exclusive option for IBI3001 outside Greater China [1] Group 2: Financial Aspects - The company will receive an upfront payment of $1.2 billion, including a strategic equity investment of $100 million at a 20% premium to the weighted average closing price of the shares over the 30 trading days prior to the agreement [2][4] - The total potential milestone payments could reach up to $10.2 billion, making the total transaction value up to $11.4 billion [2] - The net proceeds from the share issuance will be allocated 80% to R&D for various clinical and preclinical projects and 20% for general corporate purposes [3] Group 3: Strategic Importance - The collaboration is viewed as a significant step towards the company's long-term development and aligns with its mission to become a leading global biopharmaceutical enterprise [3] - The partnership combines the company's expertise in IO and ADC fields with Takeda's extensive experience in global oncology drug development and commercialization [3] - This collaboration is expected to enhance the company's global footprint and establish capabilities in R&D and commercialization in key international markets, maximizing sustainable long-term value [3]

Core Insights - Company enters a global strategic partnership with Takeda Pharmaceuticals to accelerate the development of next-generation IO and ADC therapies, expanding global market value [1] - The collaboration includes late-stage therapies IBI363 (PD-1/IL-2) and IBI343 (CLDN18.2ADC), as well as an early-stage project IBI3001 (EGFR/B7H3 ADC) [1] Group 1 - The partnership allows for joint development of IBI363 (PD-1/IL-2) globally, with Takeda leading the commercialization efforts in the U.S. [1] - Company grants Takeda commercialization rights for IBI363 outside Greater China and the U.S. [1] - Takeda receives exclusive rights for IBI343 (CLDN18.2ADC) outside Greater China and an exclusive option for IBI3001 (EGFR/B7H3 ADC) outside Greater China [1] Group 2 - Company will receive an upfront payment of $1.2 billion, including a strategic equity investment of $100 million at a 20% premium to the weighted average closing price over the previous 30 trading days [2] - Potential milestone payments could total up to $10.2 billion, making the total transaction value up to $11.4 billion [2] - Company will also receive a share of potential sales for each candidate drug outside Greater China, with a profit-sharing model for IBI363 in the U.S. [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 本公告僅供參考之用，並不構成收購、購買或認購本公司任何證券之邀請或要約。 信達生物制藥 本公告由本公司根據香港聯合交易所有限公司證券上市規則第13.09條及第13.28 條以及香港法例第571章證券及期貨條例第XIVA部作出。 與武田製藥達成全球戰略合作，加速本公司新一代IO及ADC療法推向全 球市場 董事會欣然宣佈，於2025年10月22日（香港時間），信達生物與武田製藥（透過 武田製藥全資附屬公司Takeda Pharmaceuticals International AG）達成全球戰略 合作，旨在加速推進信達生物新一代IO及ADC療法開發，拓展全球市場價值。 本次合作包括兩款後期在研療法IBI363 (PD-1/IL-2α-bias)及IBI343 (CLDN18.2 ADC)，以及一款早期研發項目IBI3001 (EGFR/B7H3 ADC)的選擇權。 根據合作，信達生物與武田製藥將在全球範圍內 ...

Summary of Innovent Biologics Conference Call Company Overview - **Company**: Innovent Biologics - **Industry**: Biotechnology - **Focus**: Development and commercialization of innovative therapies, particularly in oncology and metabolic diseases Key Takeaways 1. Product Differentiation and Market Positioning - **Mazdutide**: Launched for obesity in July and recently approved for diabetes, it is positioned as a differentiated GLP-1 dual agonist targeting both GLP-1 and GIP pathways, significantly reducing liver fat, which is crucial for Chinese patients with high hepatic fat despite lower BMI [2][18] - **Pricing Strategy**: The 4mg and 6mg doses are priced approximately 30% below tirzepatide and 30% above semaglutide, aiming to balance affordability with premium positioning [2][18] 2. Market Potential and Commercialization Strategy - **Addressable Market**: There are approximately 300 million overweight and 160 million obese adults in China, presenting a significant market opportunity [3][20] - **Multi-Channel Distribution**: Innovent is utilizing a broad distribution strategy that includes public hospitals, private hospitals, retail pharmacies, and online platforms, with non-hospital channels expected to drive incremental growth [3][18] 3. Financial Projections - **Revenue Targets**: Innovent aims for Mazdutide to contribute at least 25% of its RMB 20 billion revenue target by 2027, with an expected RMB 1 billion in the first 12 months [2][21] - **Financial Forecasts**: Projected revenues for FY 2024, 2025, 2026, and 2027 are RMB 9.42 billion, RMB 12.62 billion, RMB 15.46 billion, and RMB 20.03 billion respectively, with net profits expected to turn positive by 2025 [6] 4. Competitive Landscape - **Increasing Competition**: The GLP-1 market in China is becoming more competitive with generics and multinational entrants. Innovent's strategy focuses on brand equity and differentiated mechanisms to maintain market share [5][19] - **Regulatory Environment**: Inclusion in the National Reimbursement Drug List (NRDL) is critical for diabetes treatments, while obesity and specialty indications may rely on cash-pay models and emerging commercial insurance [5][27] 5. Pipeline and Future Developments - **Oncology and Autoimmune Pipeline**: Innovent is advancing a broad pipeline including next-generation immuno-oncology therapies and autoimmune treatments, with key assets like IBI363 and L23 progressing toward pivotal trials [4][28] - **Oral GLP-1 Development**: An oral GLP-1 candidate is in early-stage development, with FDA IND clearance expected and enrollment in China anticipated in the second half of 2025 [4][24] 6. Sustainability and Corporate Governance - **Sustainability Goals**: Innovent has set targets to reduce water and energy consumption and greenhouse gas emissions by 5% and 10% respectively by 2030, aiming for zero waste landfill by 2030 [17] 7. Investment Recommendation - **Rating**: Innovent is rated as a "Buy" with a price target of HK$105.00, reflecting a potential upside of 13% from the current price [7][31] 8. Risks and Challenges - **Market Risks**: Potential risks include fierce competition, pipeline delays, and regulatory challenges that could impact the achievement of financial targets [31][15] Conclusion Innovent Biologics is positioned strongly within the biotechnology sector, particularly with its innovative product Mazdutide. The company is leveraging a multi-channel commercialization strategy to tap into a vast market while navigating competitive dynamics and regulatory landscapes. The robust pipeline and sustainability initiatives further enhance its investment appeal, although risks remain that could affect future performance.

Core Viewpoint - Zhongyou Securities initiates coverage on Innovent Biologics (01801.HK) with a "Buy" rating, highlighting the company's leading position in the domestic oncology drug sector and its diverse pipeline that is expected to drive high growth in performance [1] Company Analysis - Innovent Biologics is recognized for its comprehensive pipeline layout in the oncology drug market, which is anticipated to support sustained high growth in revenue [1] - The company is projected to achieve net profits attributable to shareholders of 980 million, 1.58 billion, and 3.25 billion yuan for the years 2025, 2026, and 2027 respectively [1] - Corresponding price-to-earnings (PE) ratios are expected to be 162, 100, and 49 for the same years [1]