FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 新提交 公司名稱： 無錫藥明康德新藥開發股份有限公司 呈交日期： 2025年9月30日 (viii) 有關債券、借貸股份、票據或公司債券的信託契約/平邊契據經已製備及簽署，有關詳情已送呈公司註冊處處長存檔（如法律如此規定）。 第一章節註釋： 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 H | | 於香港聯交所上市 | 是 | | | | 證券代號 (如上市) | 02359 | 說明 | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | ...

Core Insights - The medical services sector experienced a rise of 2.89% on September 30, with WuXi AppTec leading the gains [1] - The Shanghai Composite Index closed at 3882.78, up 0.52%, while the Shenzhen Component Index closed at 13526.51, up 0.35% [1] Medical Services Sector Performance - WuXi AppTec (603259) closed at 112.03, with a gain of 6.42% and a trading volume of 707,400 shares, amounting to a transaction value of 7.792 billion [1] - Other notable performers included Haoyuan Pharmaceutical (688131) with a 6.36% increase, Boteng Co., Ltd. (300363) up by 5.31%, and MediSino (688202) rising by 4.85% [1] - The sector saw a net inflow of 1.095 billion in main funds, while retail investors experienced a net outflow of 549 million [2][3] Fund Flow Analysis - WuXi AppTec had a net inflow of 926 million from main funds, but a net outflow of 659 million from speculative funds [3] - Other companies like Kanglong Chemical (300759) and Kailai Ying (002821) also showed significant fund flow dynamics, with varying levels of net inflow and outflow [3] - The overall trend indicates a mixed sentiment among retail and institutional investors within the medical services sector [2][3]

Core Viewpoint - The Hong Kong medical sector is experiencing significant gains, with companies like WuXi AppTec rising over 8%, indicating a strong market interest in AI healthcare and CXO services [1] Group 1: Market Performance - The Hong Kong medical sector saw a collective rise, with notable increases in stocks such as WuXi AppTec, Yaoshi Bang, Crystal Tech Holdings, Zai Lab, and MicroPort, reflecting a bullish sentiment in the market [1] - The Hong Kong Stock Connect medical ETF focusing on AI healthcare and CXO (520510) increased by nearly 3%, while the Hang Seng Medical ETF (159892) focusing on innovative drugs rose over 2% [1] Group 2: Industry Trends - Changjiang Securities reports that an increasing number of Chinese pharmaceutical companies are establishing original innovation capabilities and developing mature R&D technology platforms [1] - Chinese innovative pharmaceutical companies are targeting unmet clinical needs and continuously exploring new targets and mechanisms, leading to the emergence of a batch of innovative drugs with international competitiveness, including FIC (First-in-Class) and BIC (Best-in-Class) potential [1]

从基金十大重仓股角度 数据显示，国海富兰克林基金旗下1只基金重仓药明康德。国富中证A100指数增强(LOF)（164508）二 季度持有股数1.12万股，占基金净值比例为2.28%，位居第十大重仓股。根据测算，今日浮盈赚取约 6.03万元。 9月30日，药明康德涨5.11%，截至发稿，报110.65元/股，成交36.38亿元，换手率1.35%，总市值 3265.84亿元。 资料显示，无锡药明康德新药开发股份有限公司位于上海浦东新区外高桥保税区富特中路288号,香港铜 锣湾希慎道33号利园1期19楼1910室，成立日期2000年12月1日，上市日期2018年5月8日，公司主营业务 涉及小分子化学药的发现、研发及生产全方位、一体化平台服务,以全产业链平台的形式面向全球制药 企业提供各类新药的研发、生产及配套服务。主营业务收入构成为：化学业务78.37%，测试业务 12.93%，生物学业务6.02%，其他(补充)1.90%，其他业务0.79%。 截至发稿，张志强累计任职时间12年197天，现任基金资产总规模4.51亿元，任职期间最佳基金回报 125.94%， 任职期间最差基金回报5.8%。 风险提示：市场有风险，投 ...

9月30日早盘，药明康德AH股齐涨，均涨逾5%。截至10:02，双双涨超5%。 ...

Summary of WuXi AppTec Co Ltd Investor Day Company Overview - **Company**: WuXi AppTec Co Ltd - **Industry**: Contract Development and Manufacturing Organizations (CDMOs) - **Date of Investor Day**: September 29, 2025 - **Location**: Changzhou, Jiangsu province, China Key Points Industry Insights 1. **R&D Pipeline Contribution**: Small molecules and synthetic new modalities are the mainstay of global R&D, contributing 54% of pipeline candidates in 2024 [2] 2. **Innovation from Small Biopharma**: The share of global R&D spending by small biopharma companies increased from 17% in 2015 to 20% in 2024, projected to reach 26% by 2030 [2] 3. **Venture Capital Funding**: Small molecules received 37% of venture capital funding from 2022 to mid-2025, followed by biologics at 26% and cell/gene therapies at 17% [3] 4. **China's Biopharma Ecosystem**: China's early-stage biopharma companies are approximately half of those in the US, indicating a growing innovation ecosystem [4] 5. **Outsourcing Trends**: The global outsourcing rate to Contract Research Organizations (CROs) rose from 35% in 2015 to 52% in 2024, projected to reach 62% by 2030 [4] Company Performance 6. **Molecular Complexity**: WuXi AppTec's contracts showed increased molecular complexity from 2021 to 2025, with a 22% rise in synthetic steps for long-route molecules and a 63% increase in the proportion of molecules weighing over 600 Daltons [4] 7. **Customer Utilization**: Approximately one-third of active customers in oncology, infectious disease, immunology, metabolic disease, and neuroscience utilize WuXi's discovery services [4] 8. **FDA Approvals**: WuXi produced 20% of novel small molecule drugs approved by the US FDA from 2024 to mid-2025, totaling 8 out of 40 approved drugs [4] Market Position 9. **GLP-1 Contracts**: WuXi currently holds 23 GLP-1 contracts, translating to a 24% market share of pipeline drugs by number [5] 10. **Licensing and M&A Activity**: Of 213 licensing and M&A deals for synthetic drugs globally from 2024 to mid-2025, 62 (or 29%) involved WuXi's customers [5] Financial Metrics 11. **Stock Rating**: The stock is rated as Overweight with a price target of HK$106.00, showing a slight downside from the current price of HK$107.60 [7] 12. **Market Capitalization**: The current market cap is approximately RMB 296.437 billion [7] 13. **Revenue Growth**: Projected revenue growth from RMB 39.241 billion in 2024 to RMB 58.491 billion by 2027 [7] 14. **Earnings Per Share (EPS)**: Expected EPS growth from RMB 3.23 in 2024 to RMB 5.87 in 2027 [7] Risks and Opportunities 15. **Upside Risks**: Potential inflection of Fed rates could lead to increased biotech funding, along with favorable government policies and margin expansion [41] 16. **Downside Risks**: Risks include talent turnover, margin pressure from US business, global competition, and geopolitical risks [41] Conclusion WuXi AppTec is positioned strongly within the CDMO sector, with significant contributions to the global R&D landscape and a robust pipeline of contracts. The company is navigating a competitive environment while capitalizing on growth opportunities in the biopharma space.

Core Viewpoint - WuXi AppTec's stock price has shown significant growth this year, with a year-to-date increase of 101.41%, indicating strong market performance and investor interest [1][2]. Financial Performance - For the first half of 2025, WuXi AppTec reported revenue of 20.799 billion yuan, a year-on-year increase of 20.64%, and a net profit attributable to shareholders of 8.561 billion yuan, which represents a remarkable growth of 101.92% [2]. - The company has distributed a total of 14.06 billion yuan in dividends since its A-share listing, with 10.406 billion yuan distributed over the past three years [3]. Stock Market Activity - As of September 30, WuXi AppTec's stock price was 107.47 yuan per share, with a market capitalization of 317.198 billion yuan. The stock experienced a net inflow of 12.9546 million yuan from major funds [1]. - The trading volume on September 30 was 544 million yuan, with a turnover rate of 0.21% [1]. Shareholder Information - As of June 30, 2025, WuXi AppTec had 235,500 shareholders, with the average circulating shares per person remaining at zero [2]. - The second-largest circulating shareholder is Hong Kong Central Clearing Limited, holding 302 million shares, an increase of 56.0239 million shares from the previous period [3].

Core Viewpoint - Bank of America Securities has raised its revenue forecasts for WuXi AppTec (02359) for 2026 and 2027 by 0.2% and 0.3% respectively, citing better-than-expected prospects in its biological and chemical businesses [1] Group 1: Financial Projections - The earnings per share forecast has been increased by 0.4% and 0.8% due to enhanced project values and improved production efficiency [1] - The target price for WuXi AppTec has been raised from HKD 123 to HKD 130.7, maintaining a "Buy" rating [1] Group 2: Market Position and Performance - Since 2021, WuXi AppTec has maintained a 33% market share in the oncology drug development sector among active clients, which includes drug discovery and preclinical stage clients [1] - Revenue from non-oncology in vivo pharmacology business has grown by 42% in the first half of this year [1] - Despite intensified price competition in the industry, the value of new preclinical orders has increased by 14.5% year-on-year [1] - WuXi's chemical business has served approximately 2,550 clients as of the first half of the year, with management expecting revenue growth to exceed 20% for the year [1]

Core Viewpoint - Bank of America Securities has raised its revenue forecasts for WuXi AppTec (02359) for 2026 and 2027 by 0.2% and 0.3% respectively, citing better-than-expected prospects in its biological and chemical businesses [1] Group 1: Financial Projections - The gross margin forecast has been increased due to enhanced project values and improved production efficiency, leading to an upward revision of earnings per share by 0.4% and 0.8% [1] - The target price for WuXi AppTec has been raised from HKD 123 to HKD 130.7, with a reiterated "Buy" rating [1] Group 2: Market Position and Performance - Since 2021, WuXi AppTec has maintained a 33% market share in the oncology drug development sector among active clients, which includes drug discovery and preclinical stage clients [1] - Revenue from non-oncology in vivo pharmacology business grew by 42% in the first half of this year [1] - Despite intensified price competition in the industry, the value of new preclinical orders still increased by 14.5% year-on-year [1] - As of the first half of the year, WuXi AppTec's chemical business served approximately 2,550 clients, with management expecting revenue growth to exceed 20% for the year [1]

Core Insights - WuXi AppTec held an investor day event, highlighting the strong momentum in its TIDES business, rapid capacity expansion, and a rich pipeline [1] - Early-stage research shows signs of further recovery, which is expected to drive growth in early-stage business revenue, accounting for approximately one-third of total company revenue [1] - Enhanced operational efficiency supports the company's resilient profitability amid macro uncertainties and global capacity expansion, with adjusted gross margin and net profit margin reaching historical highs of 44.5% and 30.4% respectively in 1H25 [1] - Management expresses confidence in maintaining resilient profitability, leading to a slight upward adjustment of the target price to RMB 118.79 to reflect positive signals from global early-stage research demand [1] - The rating remains "Buy" [1]