Market Performance - After a six-day decline, the Hong Kong Stock Connect Innovation Drug ETF (520880) rebounded on January 23, rising over 2% at one point and closing up 1.53% with a trading volume of 348 million yuan [1][7] - Key constituent stocks such as Cloudtop New Drug led the gain with an 8.2% increase, while major stocks like Kangfang Biotech and CSPC Pharmaceutical rose by 3.5% [1][7] Policy Developments - On January 22, the Ministry of Commerce and nine other departments issued a document promoting high-quality development in the pharmaceutical retail industry, encouraging innovative drugs and reference preparations to enter retail pharmacy sales channels [3][9] - This policy is expected to provide a pathway for high-value innovative drugs, such as CAR-T, to fill the insurance coverage gap through commercial insurance directories [3][9] - The insurance industry association estimates that by 2025, the total compensation amount for innovative drugs and devices from commercial health insurance will reach approximately 14.7 billion yuan, with a compound annual growth rate of 70% over four consecutive years [3][9] Industry Insights - At the recent JPM conference, Chinese pharmaceutical companies showcased technological breakthroughs in areas such as ADC, IO dual antibodies, and GLP-1, moving towards global markets through licensing and collaborative development [3][9] - According to CITIC Securities, the Chinese pharmaceutical industry is at the starting point of a global value reassessment, with 2026 being a critical year for validating transformation effectiveness [3][9] Investment Opportunities - The Hong Kong Stock Connect Innovation Drug ETF (520880) is highlighted as a high-elasticity T+0 investment tool, with its index (Hang Seng Hong Kong Stock Connect Innovation Drug Select Index) offering three unique advantages: 1. Purely innovative drugs with 100% purity, covering companies focused on innovative drug R&D [5][11] 2. A significant concentration of leading companies, with the top ten innovative drug leaders accounting for over 73% of the index [5][11] 3. Enhanced risk control through forced de-weighting of less liquid constituent stocks [5][11] Constituent Stocks - The top ten constituent stocks of the Hong Kong Stock Connect Innovation Drug ETF (520880) have a combined weight of 73.41%, showcasing a strong representation of leading companies in the innovative drug sector [6][12] - Notable constituents include: - Kangfang Biotech: 10.49% weight, market cap of 110.9 billion HKD - BeiGene: 10.01% weight, market cap of 312 billion HKD - CSPC Pharmaceutical: 9.97% weight, market cap of 102.1 billion HKD [6][12]

Group 1 - The Hong Kong pharmaceutical sector is experiencing a strong rebound, with the Hong Kong Stock Connect Innovation Drug ETF (159570) rising nearly 2% and achieving a transaction volume exceeding 700 million yuan in a short period [1] - The ETF has seen a cumulative net inflow of over 430 million yuan in the past five days, with its latest scale surpassing 25.1 billion yuan, leading in its category [1] - The majority of the weighted stocks in the ETF's index have shown positive performance, including Kangfang Biopharma and Kelun-Botai, which both rose over 4% [3][4] Group 2 - Kangfang Biopharma announced that its new humanized anti-IL-17A monoclonal antibody, AK111, has received acceptance for a new drug application for treating active ankylosing spondylitis (AS) by the National Medical Products Administration (NMPA) [3] - This new drug is expected to provide a new treatment option for nearly 4 million AS patients in China [3] - The JPMorgan Healthcare Conference highlighted the achievements of Chinese innovative drug companies, with expectations for significant revenue growth and multiple drug approvals in the coming years [5][6] Group 3 - The domestic pharmaceutical industry is witnessing rapid technological advancements and an acceleration in globalization, with significant transactions exceeding 10 billion USD occurring [6][7] - The industry is entering a critical period of validation for innovative drug performance, with many companies expected to launch global registration studies and new product applications [6][7] - A domestic innovative drug company projected a revenue increase of 15.84% for 2025, with a substantial net profit growth of 102.65% [7]

1月23日早盘，港股通创新药板块强势反弹，高弹性港股通创新药ETF（520880）急速冲上2%！成份股 方面，云顶新耀、映恩生物-B领衔涨势，权重股康方生物涨超5%。 消息面，1月22日，商务部联合国家发展改革委、国家医保局等9部门印发《关于促进药品零售行业高质 量发展的意见》，明确提出鼓励创新药、参比制剂等进入零售药店销售渠道，并推动电子处方流转平台 建设，支持实体医疗机构与互联网医院与零售药店对接，优化购药体验。 分析人士指出，该政策旨在强化药品零售端的专业服务功能，提升创新药可及性，尤其为高值创新药 （如CAR-T）通过商保目录补充医保保障缺口提供落地路径。 二级市场资金提前埋伏，此前港股通创新药板块连阴6日，资金频频借道港股通创新药ETF（520880） 逢跌吸筹。数据显示，本周以来，520880累计获超2.3亿元资金净申购，最新份额升至45.38亿份，续创 历史新高！ 一键投资创新药，认准高弹性T+0利器——港股通创新药ETF（520880）及其场外联接基金 （025221），其跟踪的恒生港股通创新药精选指数具备三大独特优势，配置价值突出： 1、纯粹，全面。不含CXO，纯正创新药！全面覆盖创新药研发 ...

Core Viewpoint - The Hong Kong Stock Connect innovative drug sector has experienced a continuous adjustment for six days, with the Hong Kong Stock Connect Innovative Drug ETF (520880) showing a decline of 0.75% and a trading volume of 200 million [1]. Group 1: Market Performance - The innovative drug ETF (520880) is fully invested in innovative drug R&D companies and has recently attracted significant capital inflows, indicating a potential opportunity for investment in innovative drugs [3][12]. - The leading pharmaceutical companies are expected to have promising earnings forecasts for 2025, which could lead to valuation recovery opportunities [3][12]. - The ETF has seen a recent increase in fund size to 2.348 billion, with the number of shares reaching 4.382 billion, both hitting new highs since its listing [4][10]. Group 2: Long-term Outlook - The core logic of the Hong Kong Stock Connect innovative drug sector remains solid, with expectations of a total overseas licensing amount for innovative drugs reaching 135.7 billion in 2025, reflecting global recognition of Chinese pharmaceutical R&D capabilities [3][12]. - The National Medical Products Administration (NMPA) is expected to approve 76 innovative drugs in 2025, leading the world in approvals, and will continue to optimize the review and approval process for innovative drugs [3][12]. - Investment strategies from Zhongtai International and Guosen Securities recommend continued focus on the innovative drug sector for 2026 [3][12]. Group 3: ETF Characteristics - The ETF exclusively covers innovative drug R&D companies, excluding CXO, and has a significant concentration in leading companies, with the top ten innovative drug companies accounting for over 73% of the weight [5][12]. - The ETF employs a strategy to reduce the weight of less liquid component stocks, effectively managing tail risks [6][12]. - The ETF's tracking index has a notable advantage with a high concentration of leading companies, enhancing its investment value [7][12].

Investment Rating - The report maintains a positive investment rating for the pharmaceutical sector [6] Core Insights - The pharmaceutical sector experienced a week-on-week decline of 0.68%, underperforming compared to the ChiNext and CSI 300 indices, ranking 17th among all industries [2][36] - The report emphasizes the importance of innovation, international expansion, and overcoming challenges as key themes for investment in 2026, with a focus on BD 2.0, small nucleic acids, and supply chain opportunities [3][4] - The upcoming adjustment of the National Essential Drug List is seen as critical, aiming to address clinical needs that have evolved since the last update in 2018, particularly in pediatrics, oncology, and rare diseases [5][14] Summary by Sections National Essential Drug List Adjustment Analysis - The current drug list has not been updated since 2018, leading to a disconnect with clinical needs, necessitating a systematic adjustment [14] - The adjustment will focus on filling gaps in disease coverage, particularly in pediatrics, oncology, and rare diseases, while also solidifying the integration of collective procurement and national negotiation outcomes [18][19] - The report identifies potential beneficiaries in traditional Chinese medicine, particularly in areas with previously weak coverage [28] JP Morgan Conference Overview - The 44th JP Morgan Health Conference highlighted strategic developments from major global pharmaceutical companies, showcasing their core pipeline advancements and key clinical milestones for 2026 [33] - Companies like Pfizer, Merck, and Eli Lilly presented their focus on innovative treatments and upcoming clinical trials, indicating a robust pipeline for future growth [34][35] Pharmaceutical Market Review and Hotspot Tracking - The pharmaceutical sector's performance in early 2026 has shown a 7.08% increase, outperforming both the CSI 300 and ChiNext indices [36] - The report notes a shift in market sentiment, with certain innovative sectors like AI healthcare and medical robotics showing strong performance, while traditional sectors faced adjustments [2][3]

数据来源：wind 进一步展望生物科技领域的投资前景。大家已经了解，港股为生物科技公司上市提供了得天独厚的条 件，那么当前为何要投资港股的生物科技公司？这可以从宏观背景层面进行分析。当前美联储正处于降 息周期，大家也清楚，在降息环境下，包括美国在内的境外资金更倾向于流出美股市场，转而寻找具有 成长价值的投资机会，而非停留在美股市场追求低息无风险收益，而港股很可能成为其优先选择。 在美联储新一轮防御式降息周期中，港股资产展现出比以往更优的收益弹性和流动性前景。这对于以港 股生物科技为代表的成长板块的估值修复和业绩增长，具有重要的指引意义。下方列出的时间序列图 表，重点标记了恒生生物科技指数与美联储降息周期时间节点的重要关联。可以看到，2019年7月至 2020年美联储降息期间，恒生生物科技指数就展现出了较好的业绩弹性。而从2024年至2025年年底，乃 至如今迈入2026年，在降息周期的大背景下，恒生生物科技指数很可能展现出更优的收益弹性表现。这 是我们从宏观政策角度分析得出的结论。 回归国内政策层面，未来境内尤其是港股上市的生物科技公司将获得哪些政策支持？我们能看到，行业 政策正全链条支持创新药发展。其中一个 ...

Investment Rating - The report maintains a "Hold" rating for the pharmaceutical sector [6] Core Insights - The pharmaceutical sector experienced a week-on-week decline of 0.68%, underperforming both the ChiNext Index and the CSI 300 Index, ranking 17th among all industries [2][36] - The report emphasizes a positive outlook for innovation, international expansion, and turnaround opportunities in the pharmaceutical industry, with a focus on BD 2.0, small nucleic acids, and supply chain [3][4] Summary by Sections 1. National Essential Drug List Adjustment Analysis - The adjustment of the National Essential Drug List is urgent as the current version has not been updated since 2018, leading to a disconnect with current clinical needs [14] - The new adjustments will focus on three main areas: addressing gaps in disease coverage, solidifying the integration of centralized procurement and national negotiation results, and enhancing the evidence-based standards for traditional Chinese medicine [5][14] - Potential beneficiaries from the adjustments include companies like Panlong Pharmaceutical, Guizhou Sanli, and Yiling Pharmaceutical, particularly in pediatrics, orthopedics, and cardiovascular fields [5][28] 2. JP Morgan Conference Overview - The 44th JP Morgan Health Conference highlighted strategic developments from major global pharmaceutical companies, showcasing their core pipeline progress and key clinical milestones for 2026 [33] - Companies such as Pfizer, Merck, and Eli Lilly presented their focus on advancing clinical trials and launching new products in various therapeutic areas [34][35] 3. Pharmaceutical Market Review and Hotspot Tracking - The pharmaceutical sector's performance from January 12 to January 16 showed a decrease of 0.68%, with a total trading volume of 916.83 billion yuan, accounting for 5.35% of the total market [2][36] - The report notes that the sector has shown a year-to-date increase of 7.08%, outperforming both the CSI 300 and ChiNext indices [36]

责任编辑：卢昱君 香港联交所最新数据显示，1月16日，汇添富基金管理股份有限公司减持三生制药（01530）178.45万 股，每股作价26.4494港元，总金额约为4719.9万港元。减持后最新持股数目约为1.51亿股，最新持股比 例为5.93%。 责任编辑：卢昱君 热点栏目 自选股 数据中心 行情中心 资金流向 模拟交易 客户端 香港联交所最新数据显示，1月16日，汇添富基金管理股份有限公司减持三生制药（01530）178.45万 股，每股作价26.4494港元，总金额约为4719.9万港元。减持后最新持股数目约为1.51亿股，最新持股比 例为5.93%。 热点栏目 自选股 数据中心 行情中心 资金流向 模拟交易 客户端 ...

Group 1 - The top three companies by Hong Kong Stock Connect holding ratios are China Telecom (00728) at 70.91%, Green Power Environmental (01330) at 69.45%, and Tianjin Chuangye Environmental (01065) at 67.62% [1][2] - The largest increases in holding amounts over the last five trading days were seen in Alibaba-W (09988) with an increase of 2.229 billion, SMIC (00981) with an increase of 1.693 billion, and Huahong Semiconductor (01347) with an increase of 1.379 billion [1][2] - The largest decreases in holding amounts over the last five trading days were recorded for China Mobile (00941) with a decrease of 2.613 billion, UBTECH (09880) with a decrease of 787 million, and Kuaishou-W (01024) with a decrease of 739 million [1][3] Group 2 - The latest holding ratio rankings for Hong Kong Stock Connect show that China Telecom holds 9.842 billion shares, Green Power Environmental holds 0.281 billion shares, and Tianjin Chuangye Environmental holds 0.230 billion shares [2] - The top ten companies with the largest increases in holdings over the last five trading days include Tencent Holdings (00700) with an increase of 917 million and China Construction Bank (00939) with an increase of 866 million [2] - The top ten companies with the largest decreases in holdings over the last five trading days also include Alibaba Health (00241) with a decrease of 665 million and China Hongqiao (01378) with a decrease of 647 million [3]

Group 1 - The top three companies with net inflow of southbound funds are SMIC (00981) with 458 million, Sanhua Intelligent Control (02050) with 405 million, and Hua Hong Semiconductor (01347) with 390 million [1] - The top three companies with net outflow of southbound funds are China Mobile (00941) with -601 million, UBTECH (09880) with -516 million, and Sanofi (01530) with -357 million [1] - In terms of net inflow ratio, Haitian Flavoring (03288) leads with 76.61%, followed by Southern Hong Kong Stock Connect (03432) with 62.50%, and CIMC (02039) with 59.57% [1] Group 2 - The top ten companies by net inflow include Tencent Holdings (00700) with 272 million and Alibaba-W (09988) with 263 million [2] - The top ten companies by net outflow include Meituan-W (03690) with -287 million and Bilibili-W (09626) with -242 million [2] - The top three companies with the highest net outflow ratio are Dekang Agriculture (02419) at -50.69%, Sanofi (01530) at -47.05%, and Jianfa International Group (01908) at -45.45% [3]