Core Viewpoint - The company expects a reduction in net loss and adjusted net loss for the fiscal year ending December 31, 2025, primarily due to the commercialization of Zewokaiolun Injection and the acceptance of the NDA for Shurukiaolun Injection by the NMPA [1] Financial Performance - The net loss for the reporting period is projected to be no more than approximately RMB 120 million, compared to approximately RMB 798 million for the fiscal year ending December 31, 2024 [1] - The adjusted net loss, which excludes share-based compensation, is expected to be no more than approximately RMB 95 million, compared to approximately RMB 789 million for the fiscal year ending December 31, 2024 [1] Contributing Factors - The reduction in losses is attributed to several factors, including: - Increased commercialization revenue from Zewokaiolun Injection in mainland China [1] - Impact of foreign exchange fluctuations [1] - Significant reduction in R&D expenses for both Zewokaiolun Injection and Shurukiaolun Injection [1]

Core Viewpoint - The company Kintor Pharmaceutical (02171) anticipates a reduction in net loss and adjusted net loss for the fiscal year ending December 31, 2025, primarily due to the commercialization of its drug Zeworkiobulin and the acceptance of the new drug application for Shurikiobulin by the National Medical Products Administration (NMPA) [1] Financial Performance - The expected net loss for the reporting period is projected to be no more than approximately RMB 120 million, compared to approximately RMB 798 million for the fiscal year ending December 31, 2024 [1] - The adjusted net loss, which excludes share-based compensation, is expected to be no more than approximately RMB 95 million, compared to approximately RMB 789 million for the fiscal year ending December 31, 2024 [1] Factors Influencing Loss Reduction - The reduction in losses is attributed to several factors, including: - Increased commercialization revenue from Zeworkiobulin in mainland China [1] - Impact of foreign exchange fluctuations [1] - Significant reduction in research and development expenses for both Zeworkiobulin and Shurikiobulin [1]

Core Viewpoint - Kintor Pharmaceutical Co., Ltd. (02171.HK) expects a reduction in net loss and adjusted net loss for the fiscal year ending December 31, 2025, primarily due to the commercialization of its drug, Zeworkiobulin Injection, and the acceptance of the New Drug Application (NDA) for Shurikiobulin Injection by the National Medical Products Administration (NMPA) [1]. Financial Summary - The net loss for the fiscal year 2025 is projected to be no more than approximately RMB 120 million, a significant decrease from approximately RMB 798 million for the fiscal year ending December 31, 2024 [1]. - The adjusted net loss, which excludes share-based compensation, is expected to be no more than approximately RMB 95 million, down from approximately RMB 789 million for the fiscal year ending December 31, 2024 [1]. Contributing Factors - The reduction in losses is attributed to several factors, including: - Increased commercialization revenue from Zeworkiobulin Injection in mainland China [1]. - Impact of foreign exchange fluctuations [1]. - Significant reduction in research and development expenses for both Zeworkiobulin Injection and Shurikiobulin Injection [1].

CARsgen Therapeutics Holdings Limited 科濟藥業控股有限公司 （於開曼群島註冊成立的有限公司） （股份代號：2171） 香港交易及結算所有限公司、香港聯合交易所有限公司及香港中央結算有限公司對本公告的內 容概不負責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任 何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 詳情介紹如下：(a)與截至2024年12月31日止年度的約人民幣798百萬元相比，報 告期間的淨虧損不超過約人民幣120百萬元；及(b)與截至2024年12月31日止年度 的約人民幣789百萬元相比，報告期間的經調整淨虧損（指不包括以股份為基礎的 薪酬（「經調整項目」）的淨虧損，為一項非國際財務報告準則計量標準（定義見下 文））不超過約人民幣95百萬元。 有關虧損減少主要由於以下各項的綜合影響：(i)澤沃基奧侖賽注射液在中國內地 的商業化收益增加；(ii)外匯波動的影響；及(iii)澤沃基奧侖賽注射液及舒瑞基奧 侖賽注射液的研發開支大幅減少。 1 董事會希望強調，「經調整淨虧損」在國際財務報告準則(IFRSs)中沒有定義，本集 ...

Core Viewpoint - CAR-T cell therapy, despite existing development bottlenecks, has shown excellent results and significant potential in tumor treatment, making it one of the fastest-growing segments in innovative drugs globally [1] Group 1: Industry Development and Challenges - CAR-T technology has demonstrated breakthrough therapeutic effects in hematological malignancies, but its industrialization faces challenges due to the small market size and high treatment costs associated with these indications [2] - Over 90% of new cancer cases globally in 2023 are expected to be solid tumors, indicating a vast potential market for CAR-T therapies if the technology can overcome the treatment bottlenecks for solid tumors [2] - Since 2020, more CAR-T solid tumor therapy projects have entered clinical research, with over 50% of the pipeline focusing on this area, making it a key competitive advantage for many Chinese innovative drug companies [2] Group 2: Company Strategy and Product Pipeline - The company has developed a pipeline that includes 4 autologous CAR-T and 6 universal CAR-T products, covering hematological malignancies, solid tumors, and autoimmune diseases [2] - The new drug application for CT041 (Shurike Aolun Sai Injection) has been accepted by the National Medical Products Administration of China, making it the first CAR-T cell product globally to enter the new drug application stage for solid tumors [2][3] Group 3: Cost and Accessibility - The high cost of CAR-T therapies, typically priced in the millions, poses a significant barrier to patient accessibility, necessitating solutions for affordability [5] - Universal CAR-T therapies, which can be produced in batches for multiple patients, have the potential to significantly reduce costs, with estimates showing a reduction in total material costs from $60,000 to $2,000 and production costs from $95,780 to $4,460 [5] - The company has developed innovative technologies to address the immune rejection of non-autologous cells, with patents granted in multiple regions, aiming for the first universal CAR-T product to be launched within five years [5] Group 4: Market Dynamics and Payment Solutions - The large patient base in China, especially as CAR-T therapies expand to solid tumors, presents a theoretical market space that is vast [7] - Since the approval of the first hematological CAR-T therapy, the company has received 154 valid orders across 23 provinces in 2024, indicating a growing commercial presence [7] - The introduction of the first version of the "Commercial Health Insurance Innovative Drug Directory" in 2025, which includes multiple CAR-T therapies, marks a breakthrough in addressing payment challenges and is expected to facilitate the commercial development of CAR-T therapies in China [7][8] Group 5: Policy Support and Industry Growth - The company has achieved a significant reduction in losses, with an adjusted net loss of approximately 75 million yuan in the first half of 2025, down 78.1% from the same period last year [10] - Policy support, particularly in expediting drug review and approval processes, is crucial for the successful development of the CAR-T industry in China [10] - Recent policies aimed at enhancing the review process for advanced therapies are expected to significantly shorten the R&D and commercialization cycles, improving cash flow for innovative drug companies [10][11]

翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) FF305 表格類別： 股票 狀態： 重新提交 公司名稱： 科濟藥業控股有限公司 呈交日期： 2026年1月23日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 02171 | 說明 | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | 事件 | | 已發行股份（不包括庫存股份）變動 | 庫存股份變動 | | 已發行股份總數 | | | | 已發行股份（不包括庫存股份）數 目 | 佔有關事件前的現有已發 ...

FF305 呈交日期： 2026年1月23日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 02171 | 說明 | | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | | 庫存股份變動 | | | | | 事件 | 已發行股份（不包括庫存股份）數 目 | | 佔有關事件前的現有已發 行股份（不包括庫存股 份）數目百分比 (註3) | 庫存股份數目 | 每股發行/出售價 (註4) | 已發行股份總數 | | 於下列日期開始時的結 ...

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) 表格類別： 股票 狀態： 重新提交 公司名稱： 科濟藥業控股有限公司 呈交日期： 2026年1月23日 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 不適用 | | 於香港聯交所上市 | 是 | | | 證券代號 (如上市) | 02171 | 說明 | | | | | | A. 已發行股份或庫存股份變動 | | | | | | | | | | 已發行股份（不包括庫存股份）變動 | | 庫存股份變動 | | | | | 事件 | 已發行股份（不包括庫存股份）數 目 | 佔有關事件前的現有已發 行股份（不包括庫 ...

Core Viewpoint - The sales of CAR-T cell therapy Carvykti (西达基奥仑赛) have significantly increased, but the stock price of Legend Biotech (传奇生物) has declined following the earnings report from Johnson & Johnson (强生) [1] Group 1: Financial Performance - Johnson & Johnson reported a total revenue of $94.193 billion for 2025, a year-on-year increase of 6% [1] - Carvykti generated $1.887 billion in revenue for 2025, representing a 95.95% increase compared to $963 million in 2024 [1] - In Q4 2025, Carvykti's sales reached $555 million, a 65.8% year-on-year increase, but only a 5.9% quarter-on-quarter growth [1] Group 2: Market Position and Product Development - Carvykti is positioned as a one-time therapy for relapsed or refractory multiple myeloma and has been approved in the U.S., EU, and Japan [3] - The product was priced at $465,000 per dose in the U.S., which is approximately three times the price of other domestic CAR-T products [3] - Legend Biotech aims to achieve profitability in 2026 by expanding Carvykti's application globally and increasing its use in community healthcare settings [4] Group 3: Production and Clinical Trials - Legend Biotech has completed the expansion of its production facility in Raritan, which is the largest CAR-T production base in the U.S., capable of supporting the treatment of up to 10,000 patients annually [4] - The company has initiated a Phase 3 clinical trial (CARTITUDE-6) for new indications targeting newly diagnosed multiple myeloma patients [4] Group 4: Market Challenges and Pricing - The commercialization of Carvykti in China lagged behind the U.S. market by two years, with approval granted in August 2024 [7] - The pricing strategy for the Chinese market has not yet been disclosed, and the product has not participated in national health insurance negotiations [7] - The high costs associated with CAR-T therapies pose challenges for accessibility, despite ongoing efforts to explore diverse payment models [8][9]

Group 1 - Oil stocks generally rose, with CNOOC (02883) up 4.32%, PetroChina (00857) up 3.33%, CNOOC (00883) up 2.98%, and Sinopec (00386) up 3.01%. International oil prices saw a slight increase, with WTI crude oil futures for February closing at $60.62 per barrel, up 0.43%, and Brent crude oil futures for March at $65.24 per barrel, up 0.49% [1] - CATL (03750) fell over 4%, down 4.4% as of the report. A report from Citi raised concerns about CATL's growth prospects due to slowing EV sales in China, rising lithium prices, and reduced export VAT rebates [1] - Kintor Pharmaceutical (02171) rose nearly 4% after announcing a clinical collaboration with Dispatch Bio to initiate a Phase I clinical trial in China by 2026 for a treatment method targeting solid tumors [1] Group 2 - Guoxia Technology (02655) surged over 7% following a strategic cooperation agreement with Shuneng Electric to enhance collaboration in the energy storage sector [2] - Kingsoft Biotech (01548) dropped over 6% after its affiliate Legend Biotech's stock fell more than 11%. Kingsoft reported that Legend's CARVYKTI had a net sales of approximately $555 million for Q4 [2] - Hong Kong real estate stocks saw a general rise, with Hysan Development (00014) up 5.17%, Sun Hung Kai Properties (00016) up 3.36%, and Wharf Real Estate (01997) up 4.02%. A report from Citi indicated a recovery in Hong Kong property prices, predicting a continued upward trend, albeit at a moderate pace due to tempered interest rate cut expectations [2] Group 3 - Baidu Group (09888) rose nearly 5%, with a cumulative increase of over 40% in the past two months. The company launched the official version of its Wenxin large model 5.0, featuring 2.4 trillion parameters [3] - Pacific Basin Shipping (02343) increased over 9%, reaching a new high of HKD 2.96, benefiting from a rise in the Baltic Dry Index, which increased by 74 points or 4.3% to 1803 points [3] - GDS Holdings (09698) rose nearly 3% after announcing the sale of shares in DayOne for $385 million, recovering approximately 95% of its investment principal with a return rate close to 6.5 times [4] Group 4 - The US stock market saw an expansion in gains, with the Nasdaq up 1%. Notable tech stocks like Intel (INTC.US) rose 11.72%, reaching a market cap of over $250 billion, the highest in four years [5] - The storage sector continued to strengthen, with Micron Technology (MU.US) up 6.61% and Western Digital (WDC.US) up 8.49%. Counterpoint Research indicated that the storage market has entered a "super bull market" phase, surpassing previous highs due to increased demand from AI and server capacity [5] - The Nasdaq Golden Dragon China Index surged 2%, with popular Chinese stocks like Bilibili (BILI.US) up 5.65% and Baidu (BIDU.US) up 8.17% [6]