【重大事项】 HASHKEY HLDGS(03887)香港公开发售获393.71倍认购 每股发售价6.68港元 【回购增减持】 腾讯控股(00700)12月16日耗资约6.36亿港元回购106.7万股 小米集团-W(01810)12月16日斥资2.94亿港元回购720万股 快手-W(01024)12月16日斥资1.16亿港元回购182.31万股 吉利汽车(00175)12月16日斥资5054.44万港元回购29.99万股 碧桂园服务(06098)12月16日耗资约3127.38万港元回购500万股 中远海控(01919)12月16日斥资4031.69万港元回购300万股 歌礼制药-B(01672)将股份购回资金由最多3亿港元增至最多5亿港元 红星美凯龙(01528)股东淘宝控股及新零售基金合计减持公司4164.66万股H股 金风科技(02208)股东和谐健康累计减持约3594.99万股股份 世纪联合控股(01959)控股权易主 获折让约66.78%提全购要约 12月17日复牌 【财报数据】 中国太保(02601)：太平洋人寿保险前11个月原保险保费收入为2503.22亿元 同比增长9.4% 中煤能源(0189 ...

Core Viewpoint - The "Precision Radiotherapy for Depression" project aims to advance clinical research and application breakthroughs in treating depression using new generation precision radiotherapy technology, specifically the ZAP-X system, which is currently in the clinical research phase focusing on safety and efficacy [1] Group 1: Market Overview - Depression is one of the most common mental disorders globally, with approximately 332 million people affected, including over 90 million in China, of which 10 to 12 million require treatment during depressive episodes [1] - The antidepressant market in China is highly competitive, with SSRIs and SNRIs accounting for about 60% of the market share. The sales revenue for antidepressants in sample hospitals is expected to exceed 8 billion yuan in 2024, with SSRIs contributing 3.58 billion yuan (43.44%) and SNRIs 1.42 billion yuan (17.18%) [3][4] - The global antidepressant market was valued at approximately $14.5 billion in 2022 and is projected to reach $17.6 billion by 2030, with China's market expected to grow to 23.8 billion yuan by 2030, reflecting a compound annual growth rate (CAGR) of 4.2% from 2022 to 2030 [3][4] Group 2: Innovation and Development - There is a significant unmet clinical need as about 30% of patients do not respond to existing antidepressants, highlighting the potential of neuromodulation technologies as a complementary treatment, especially for treatment-resistant depression (TRD) [6] - Non-invasive neuromodulation techniques, such as transcranial magnetic stimulation (TMS), are gaining traction in clinical settings. TMS has been FDA-approved for depression treatment since 2008, and several certified TMS systems are available globally [7] - The "Precision Radiotherapy for Depression" project focuses on exploring the clinical efficacy and safety of low-dose radiotherapy for treatment-resistant depression, aiming to establish a new neuromodulation method with high precision targeting [9][10] Group 3: Research and Clinical Trials - The project is part of a broader trend in the development of innovative antidepressant therapies, with numerous new drugs in clinical trials targeting various mechanisms [4][5] - The project aims to investigate the potential of radiotherapy as a neuromodulation method, traditionally used for brain tumors, to treat depression, with initial studies showing promising results [10] - Collaboration among various professionals and addressing regulatory, funding, and resource challenges are crucial for the project's success and eventual commercialization [11]

来源：视频滚动新闻 翰森制药(03692.HK)在港交所公告，于二零二五年十二月十六日，本公司全资附属公司江苏豪森药业集 团有限公司与Glenmark Specialty S.A.就阿美替尼订立独家许可、合作及分销协议。阿美替尼是一款用于 治疗非小细胞肺癌的三代表皮生长因子受体-酪氨酸激酶抑制剂。根据许可协议，许可人将授予被许可 人独占许可，允许其在授权区域开发并商业化阿美替尼。 ...

中国能源建设(03996.HK)：投资建设的中能建松原氢能产业园(绿色氢氨醇一体化)项目一期工程正式投产运行。 中煤能源(01898.HK)：前11月商品煤销量为约2.34亿吨，同比减少8.7%。11月煤销量为2174万吨，同比减少15.7%。 中国太保(02601.HK)：前11月，太平洋人寿累计原保险保费收入为人民币2503.22亿元，同比增长9.4%，太平洋财险累计原保险保费收入为人民币1876.82亿 元，同比增长0.3%。 中国铁建(01186.HK)：拟发行不超过40亿元可续期公司债券。 智通财经12月16日讯（编辑 冯轶）智通财经为您带来今日港股重要公告 2）回购动态 1）公司要闻 翰森制药(03692.HK)：与GLENMARK就阿美替尼订立许可协议。 公告称，根据协议将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净销售额的分级特许权使用费。 越秀地产(00123.HK)：获授5亿港元的定期贷款融资。 腾讯控股(00700.HK)：斥资约6.36亿港元回购106.7万股，回购价592.5-602.5港元。 小米集团-W(01810.HK)：斥资2.94亿港元回购7 ...

翰森制药(03692)发布公告，于2025年12月16日，公司全资附属公司江苏豪森药业集团有限公司(许可人) 与Glenmark Specialty S.A.(被许可人)就阿美替尼订立独家许可、合作及分销协议(许可协议)。阿美替尼 是一款用于治疗非小细胞肺癌(NSCLC)的三代表皮生长因子受体-酪氨酸激酶抑制剂(EGFR-TKI)。 根据许可协议，许可人将授予被许可人独占许可，允许其在授权区域(中东与非洲、东南亚与南亚、澳 大利亚、新西兰、俄罗斯与其他独联体国家，以及协议覆盖的部分特定加勒比国家)开发并商业化阿美 替尼。许可人将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净 销售额的分级特许权使用费。 ...

根据许可协议，许可人将授予被许可人独占许可，允许其在授权区域(中东与非洲、东南亚与南亚、澳 大利亚、新西兰、俄罗斯与其他独联体国家，以及协议覆盖的部分特定加勒比国家)开发并商业化阿美 替尼。许可人将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净 销售额的分级特许权使用费。 格隆汇12月16日丨翰森制药(03692.HK)宣布，于2025年12月16日，公司全资附属公司江苏豪森药业集团 有限公司(「许可人」)与Glenmark SpecialtyS.A.(「被许可人」)就阿美替尼订立独家许可、合作及分销 协议(「许可协议」)。阿美替尼是一款用于治疗非小细胞肺癌(「NSCLC」)的三代表皮生长因子受体－ 酪氨酸激酶抑制剂(「EGFR-TKI」)。 ...

根据许可协议，许可人将授予被许可人独占许可，允许其在授权区域(中东与非洲、东南亚与南亚、澳 大利亚、新西兰、俄罗斯与其他独联体国家，以及协议覆盖的部分特定加勒比国家)开发并商业化阿美 替尼。许可人将获得首付款和后续可能累计超过十亿美元的监管和商业里程碑付款，以及授权区域内净 销售额的分级特许权使用费。 智通财经APP讯，翰森制药(03692)发布公告，于2025年12月16日，公司全资附属公司江苏豪森药业集团 有限公司(许可人)与Glenmark Specialty S.A.(被许可人)就阿美替尼订立独家许可、合作及分销协议(许可 协议)。阿美替尼是一款用于治疗非小细胞肺癌(NSCLC)的三代表皮生长因子受体-酪氨酸激酶抑制剂 (EGFR-TKI)。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 Hansoh Pharmaceutical Group Company Limited 翰森製藥集團有限公司 （於開曼群島註冊成立的有限公司） （股份代號：3692） 自願公告 與GLENMARK訂立許可協議 翰森製藥集團有限公司（「本公司」）董事會（「董事會」）欣然宣佈，於二零二五年十 二月十六日（交易時段後），本公司全資附屬公司江蘇豪森藥業集團有限公司（「許 可人」）與Glenmark Specialty S.A.（「被許可人」）就阿美替尼訂立獨家許可、合作 及分銷協議（「許可協議」）。阿美替尼是一款用於治療非小細胞肺癌（「NSCLC」） 的三代表皮生長因子受體－酪氨酸激酶抑制劑（「EGFR-TKI」）。 根據許可協議，許可人將授予被許可人獨佔許可，允許其在授權區域（中東與非 洲、東南亞與南亞、澳大利亞、新西蘭、俄羅斯與其他獨聯體國家，以及協議覆 蓋的部分特定加勒比國家）開發並商業化阿美替尼。許可人 ...

Core Insights - The Hong Kong Innovative Drug ETF (159567) closed down 1.91% on December 16, with a trading volume of 1.078 billion yuan [1] - The fund was established on January 3, 2024, with an annual management fee of 0.50% and a custody fee of 0.10% [1] - As of December 15, 2024, the fund's total shares reached 10.425 billion, with a total size of 8.174 billion yuan, reflecting a significant increase in shares and size compared to the previous year [1] Fund Performance - The fund manager, Ma Jun, has achieved a return of 64.28% since taking over management on January 3, 2024 [2] - The fund's performance benchmark is the National Index of Hong Kong Innovative Drugs, adjusted for valuation exchange rates [1] Holdings Overview - Major holdings in the fund include: - BeiGene (10.62% holding, market value 817 million yuan) - CanSino Biologics (10.55% holding, market value 812 million yuan) - Innovent Biologics (10.21% holding, market value 786 million yuan) - China National Pharmaceutical Group (9.62% holding, market value 741 million yuan) - CSPC Pharmaceutical Group (7.56% holding, market value 583 million yuan) [2]

Core Insights - The article highlights the launch of the Super CEO series by Zhito Finance for the ninth consecutive year, featuring various sub-lists that reflect the diverse driving forces behind China's economic growth, particularly in the healthcare sector [1] Industry Overview - The Chinese pharmaceutical manufacturing industry is experiencing a decline, with revenue of 1,227.52 billion yuan in the first half of 2025, down 1.2% year-on-year, and total profit of 176.69 billion yuan, down 2.8% year-on-year, indicating ongoing industry pressure and deepening segmentation [1] - Since 2025, numerous policies have been introduced to support high-quality development in innovative pharmaceuticals, including measures to enhance the clinical trial approval process and the introduction of a commercial insurance directory for innovative drugs [2] - The medical device export sector continues to grow, with a total import and export value of 41.09 billion USD in the first half of 2025, a 1.1% increase year-on-year, while imports decreased by 3.9%, indicating a shift towards domestic alternatives in high-end equipment [3] Investment Trends - The overseas business development (BD) orders for innovative pharmaceuticals have reached a record high, surpassing 60 billion USD, with significant transactions indicating a shift in China's role from a follower to a contributor in the global pharmaceutical landscape [4] - Capital preferences are improving, with the healthcare industry in China seeing a recovery in financing activities, particularly in medical devices and innovative pharmaceuticals, with significant investments in areas like cancer screening and AI healthcare [5] Future Outlook - The 15th Five-Year Plan emphasizes the importance of health in economic development, aiming to enhance public health and support the growth of innovative drugs and medical devices, which will shape the future of the healthcare industry in China [6] - The aging population, active policy support, and the internationalization of medical devices are driving demand and supply upgrades in the healthcare sector, presenting both opportunities and challenges for industry leaders [6] CEO Insights - The Super CEO list features 25 leaders whose companies have shown median revenue growth of 6.11% and net profit growth of 16.08%, with an average market capitalization of 86.1 billion yuan [9] - The list includes a notable representation of women leaders, with three female CEOs demonstrating strong strategic vision in high-barrier industries [10] - The majority of CEOs on the list have advanced degrees, reflecting the industry's demand for leaders with deep scientific understanding and business acumen [10] Company Highlights - Li Ge, CEO of WuXi AppTec, leads the list, showcasing strong performance with a revenue of 32.857 billion yuan in the first three quarters of 2025, a year-on-year increase of 18.61% [17] - Zhu Yi, CEO of BaiLi TianHeng, achieved significant revenue growth through strategic partnerships, emphasizing the importance of building a robust product pipeline [18] - Wu Hao, CEO of Mindray, reported a revenue of 36.726 billion yuan in 2024, with a focus on R&D and international expansion [19] - Zhong Huijuan, CEO of Hansoh Pharmaceutical, became the richest woman in China with a revenue of 12.261 billion yuan in 2024, driven by innovative drug sales [19] - Shi Yifeng, CEO of Aimeike, led the company to a revenue of 3.026 billion yuan in 2024, emphasizing shareholder value through high dividend payouts [20]