Group 1 - The 2025 American Society of Clinical Oncology (ASCO) annual meeting will take place in Chicago from May 30 to June 3, with a record number of presentations from Chinese experts, further fueling investment enthusiasm in innovative drugs [1] - In the medium to long term, innovative drugs will remain the main focus of pharmaceutical investments in China, transitioning from quantity and speed to quality and innovation, supported by increasing policy backing [1] - Recent significant transactions in the innovative drug sector include a deal exceeding $6 billion by 3SBio and a forecasted $5 billion deal by CSPC Pharmaceutical Group, alongside a $9 billion collaboration between BMS and BioNTech [1] Group 2 - The domestic innovative payment system has enabled some innovative products to achieve a positive cycle of R&D investment returns, with sales reaching new highs and an increase in overseas clinical data and licensing agreements [2] - The Guotai Innovative Drug ETF (517110) tracks the SHS Innovative Drug Index (931409), which reflects the overall performance of listed companies involved in innovative drug R&D, production, and sales in the A-share market [2] - The index consists of stocks with significant R&D investment characteristics and growth potential, representing the performance of the innovative drug industry chain [2]

Group 1 - The innovative drug sector showed strong performance today, with notable gains from companies such as Innovent Biologics rising over 13%, and Tigermed, Ascentage Pharma-B, and Kelun Pharmaceutical increasing over 3% [1] - The Tianhong Innovative Drug ETF (517380) rose by 1.88% in early trading, reaching a 250-day high in net value, influenced by the overall market trend [1] - The upcoming 2025 American Society of Clinical Oncology (ASCO) annual meeting in Chicago is expected to further boost investment enthusiasm in innovative drugs, with a record number of presentations from Chinese experts [1] Group 2 - The Tianhong Innovative Drug ETF (517380) has a core holding that includes leading innovative drug companies such as Hengrui Medicine, BeiGene, Innovent Biologics, Kelun Pharmaceutical, China National Pharmaceutical Group, Hansoh Pharmaceutical, and CXO companies like WuXi AppTec and Kelun [2] - Historically, the Tianhong Innovative Drug ETF has shown strong excess returns, with a cumulative increase of over 25% this year, outperforming the second-best industry ETF by more than 10 percentage points [2] Group 3 - Investors optimistic about the pharmaceutical sector may consider focusing on linked funds, specifically Class A (014564) and Class C (014565) [3]

Group 1 - The Chinese innovative pharmaceutical industry is experiencing an unprecedented revaluation, with the innovative drug index rising over 20% and the Hong Kong innovative drug index increasing by more than 45% this year [1][2] - Institutions have shown heightened interest in the innovative drug sector, with numerous companies such as BeiGene and I-Mab being heavily researched by various institutions [1][3] - The focus of institutional research has shifted from generic drugs and raw materials to cutting-edge areas like ADCs, bispecific antibodies, and cell therapies, indicating a growing interest in clinical data and international progress [4][5] Group 2 - The recent surge in the innovative drug sector is attributed to the culmination of years of investment and development, with many projects now reaching commercialization [5][6] - The improvement in liquidity and the influx of foreign capital have significantly boosted the performance of Hong Kong innovative drug stocks, with net purchases exceeding 600 billion yuan this year [6][7] - The next three years are expected to be critical for the Chinese innovative drug industry, with 2025 marking a pivotal year for revenue growth, profitability, and valuation increases [8][9] Group 3 - The innovative drug sector is anticipated to remain a key focus within the pharmaceutical industry, with particular attention on companies that are successfully entering overseas markets and those that are experiencing significant domestic sales growth [9]

2025ASCO 揭幕，持续关注创新药 [Table_Industry] 医药 ——国泰海通医药 2025 年 6 月月报 [Table_Invest] 评级： 增持 [Table_subIndustry] 细分行业评级 医药制造业 增持 医药服务业 增持 本报告导读： 2025ASCO 揭幕，中国创新药资产继续在国际舞台上发光发热，持续关注景气度向上 的创新药。 投资要点： 行 业 月 报 证 券 研 究 报 告 请务必阅读正文之后的免责条款部分 股 票 研 究 股票研究 /[Table_Date] 2025.06.02 [table_Authors] 余文心(分析师) 郑琴(分析师) 谈嘉程(分析师) 021-38676666 021-38676666 021-38676666 登记编号 S0880525040111 S0880525040108 S0880523070004 2025-06-03 [Table_Summary] 持续关注景气度向上的创新药：国泰海通医药 2025 年 6 月月度 A 股组合：恒瑞医药、华东医药、科伦药业、贝达药业、信立泰、百 利天恒、泽璟制药、益方生物、艾力斯、药明康德。 ...

Investment Rating - The report assigns an "Overweight" rating to the pharmaceutical industry, specifically for pharmaceutical manufacturing and pharmaceutical services [1][2]. Core Insights - Continuous attention is recommended for innovative drugs with rising prosperity, as evidenced by the record number of 73 oral reports on Chinese innovative drug assets at the 2025 ASCO annual meeting [2][36]. - The Chinese innovative drug sector is experiencing a significant demand from multinational corporations (MNCs), which is reflected in the increasing number of overseas business development (BD) transactions [36]. - The pharmaceutical sector outperformed the market in May 2025, with the SW Pharmaceutical and Biological sector rising by 6.4%, ranking first among Shenwan's primary industries [15][37]. Summary by Sections Investment Highlights - The report highlights a portfolio of A-Shares including Jiangsu Heng Rui Medicine, Huadong Medicine, Sichuan Kelun Pharmaceutical, and others, indicating a focus on companies with strong growth potential [2][5]. - The report notes that the pharmaceutical sector's premium level relative to all A-Shares is currently at a normal level, with a relative premium rate of 87.88% as of the end of May 2025 [28][37]. Performance Analysis - In May 2025, the pharmaceutical sector's performance was ranked first, with individual stock gains led by Staidson Beijing BioPharmaceuticals (+145.4%) and Sunshine Guojian Pharmaceutical (+99.4%) [15][37]. - The report also details the performance of the Hong Kong and U.S. pharmaceutical sectors, noting that the Hong Kong stock pharmaceutical sector outperformed the market while the U.S. sector underperformed [38]. Market Trends - The report emphasizes the upward trend in the innovative drug market, with traditional pharmaceutical companies emerging from centralized procurement challenges and entering a phase of profitability [36]. - The report indicates that the biopharmaceutical sector's sub-sectors, such as chemical raw materials and biological products, have shown strong performance, with increases of 10.5% and 7.3% respectively [20][37].

Group 1 - The A-share and Hong Kong stock markets saw a strong performance in the innovative drug sector, with the Tianhong Innovative Drug ETF (517380) closing up 2.24%, ranking first among innovative drug ETFs and twelfth in the overall ETF market, with a trading volume exceeding 11 million yuan [1] - The Tianhong Innovative Drug ETF was launched in 2021 and tracks the "Hang Seng Shanghai-Shenzhen Hong Kong Innovative Drug Selected 50" index, providing comprehensive coverage of the innovative drug industry across A-shares and Hong Kong stocks [1] - Key stocks in the ETF included Ruizhi Pharmaceutical, which rose over 13%, along with other notable gainers such as Tigermed, Hutchison China MediTech, Federal Pharmaceutical, and Huahai Pharmaceutical [1] Group 2 - Hansoh Pharmaceutical announced a licensing agreement with Regeneron Pharmaceuticals for the global exclusive rights to develop, produce, and commercialize HS-20094, excluding mainland China, Hong Kong, and Macau, with an upfront payment of $80 million and potential milestone payments of up to $1.93 billion [2] - The innovative drug sector is expected to continue being a primary focus for pharmaceutical investments, driven by increasing policy support and a shift from quantity and speed to quality and innovation in Chinese innovative drugs [4] - The number of original research drugs entering clinical stages in China has reached 704, surpassing the United States and positioning China as the global leader in this area [3]

本文摘自：2025年6月2日发布的 2025ASCO揭幕，持续推荐创新药 余文心 ，资格证书编号： S0880525040111 郑 琴 ，资格证书编号： S0880525040108 谈嘉程 ，资格证书编号： S0880523070004 更多国泰海通研究和服务 亦可联系对口销售获取 报告导读： 2025ASCO 揭幕，中国创新药资产继续在国际舞台上发光发热，持续推荐景 气度向上的创新药。 2025ASCO 揭幕，中国创新药资产继续在国际舞台上发光发热。 2025 年美国临床肿瘤学会（ ASCO ） 年会当地时间 5/30-6/3 在美国芝加哥举行。本次 ASCO 中国创新药资产的口头报告（ oral+rapid oral+LBA ）数量达 73 项，创历史新高 。经过十余年来的发展，中国创新药已走到国际舞台中央，一个 又一个交易额突破新高的海外 BD 反映了 MNC 对中国创新药资产的需求已远大于对地缘风险的担忧。随 着头部创新药企已经开始批量进入扭亏为盈的新发展阶段，中生代 Biotech 旗下优质资产迎来 BD 浪潮 开始密集出海，传统药企走出集采阴影、创新药业务进入兑现期迎来估值重估，中国创新药产业 ...

Group 1 - Public funds are adopting an "angel investor" strategy in the innovative drug sector, despite the high volatility and risks associated with drug development and approval processes [1][4] - The significant returns in the innovative drug sector are driven by overseas licensing and collaboration events, rather than traditional metrics like revenue and profit growth [2][5] - The top-performing funds in the market, such as the Huatai-PineBridge Hong Kong Advantage Fund, have achieved substantial returns, with a 71% increase this year, primarily through heavy investments in innovative drugs [2][7] Group 2 - Many innovative drug companies show poor financial indicators, with substantial net profit losses, yet public funds continue to invest heavily based on future potential rather than current performance [3][4] - Event-driven strategies, such as licensing agreements with multinational pharmaceutical companies, have significantly boosted stock prices in the innovative drug sector [5][6] - The expectation of financial recovery in the innovative drug sector is growing, with fund managers predicting a collective improvement in revenue and profitability starting from mid-2025 [7][8] Group 3 - The period from 2025 to 2028 is anticipated to be crucial for Chinese innovative drug companies, with many expected to enter a profitability phase, marking a potential turning point for the sector [8]

Core Viewpoint - The Hong Kong innovative pharmaceutical sector has gained significant traction in the capital market this year, with a notable performance of related ETFs, indicating strong investor interest and potential growth in the industry [3][5]. Group 1: Performance of ETFs - As of May 30, 2023, the top 17 cross-border ETFs in terms of returns are all related to Hong Kong pharmaceuticals, with annual returns exceeding 40% [3][5]. - Specific ETFs such as the Huatai-PB Hang Seng Innovative Drug ETF and the GF CSI Hong Kong Innovative Drug ETF have reported returns of 43.36% and 42.09% respectively [5]. - The total net inflow of funds into these ETFs has been substantial, with the Huatai-PB ETF seeing an increase of 19.78 million shares [5]. Group 2: Private Equity Interest - Private equity firms have shown a strong preference for newly listed ETFs, particularly in the sci-tech sector, with 104 private equity products appearing in the top ten holdings of 97 newly listed ETFs, holding a total of 1.783 billion shares [3][8]. - The sci-tech ETFs have attracted 32.02% of the total shares held by private equity, indicating a robust interest in high-growth potential sectors [8]. Group 3: Future Outlook for Innovative Pharmaceuticals - Industry experts express optimism regarding the investment potential in innovative pharmaceuticals, citing favorable policies and market conditions as catalysts for growth [4][6]. - The ongoing development of innovative drugs is supported by government initiatives, which aim to streamline approval processes and enhance market access [7][8]. - The increasing demand for innovative drugs is driven by an aging population and heightened health awareness, suggesting a sustainable growth trajectory for the sector [7][8]. Group 4: Free Cash Flow ETFs - Newly listed free cash flow ETFs have emerged as a popular choice among private equity investors, with 16 such ETFs collectively holding 350 million shares [10][12]. - These ETFs focus on companies with strong cash flow, reflecting their true profitability and financial health, which is increasingly appealing in the current market environment [11][12]. - The demand for stable, high-quality investment options has led to a growing interest in free cash flow ETFs, which offer both cash returns and growth potential [12].

"拿了快五年的医药主题基金终于开始赚钱了。"近日医药行情持续回暖，让很多投资者眼前一亮。随着 相关板块特别是创新药这一细分领域逐渐受到市场关注，多家公募基金公司纷纷开始宣推医药主题基 金，多位医药基金经理频频亮相发声。 在公募机构人士看来，医药行情回暖并不是短期市场情绪推动那么简单。经历近五年的调整后，原先制 约医药板块表现的多个负面因素正逐渐消退。医药板块，特别是创新药领域涌现出许多新变化。多位基 金经理表示，看好后续医药板块尤其是创新药细分领域的投资机会。 ● 本报记者 张韵 医药主题基金水涨船高 近期，医药板块行情持续回暖，多只医药主题基金也收获了不同程度的涨幅。 以被动产品为例，主投医药尤其是港股医药品种的ETF近期表现突出。5月20日，多只港股创新药ETF 跳空高开，截至当日收盘，全市场涨幅前十的ETF中有8只为港股创新药产品，涨幅全部超过4%。5月 23日，创新药ETF再度领涨，一只创新药产品位居全市场ETF涨幅榜首位。5月27日，医药主题ETF再度 领涨，港股创新药ETF占据全市场ETF涨幅前六位置。 Wind数据显示，截至5月28日，今年以来全市场涨幅前十的ETF均为主投港股医药的产品，涨幅均 ...