【瞧！我们的前沿科技】 光明日报上海2月25日电 记者颜维琦从上海交通大学获悉，针对罕见病"确诊难、漏诊率高"的全球性难 题，该校人工智能学院与医学院附属新华医院联合团队推出全球首个智能体式罕见病循证推理诊断系统 DeepRare。日前，国际学术期刊《自然》在线发表了这一成果。 团队介绍，该系统实现了对传统医学AI的代际超越：首先，它超越了单纯的信息检索，实时链接并整 合海量医学文献知识库与真实临床病例数据，实现对医学知识的深度理解与内化，相当于为每一次诊断 调动全球最顶尖的医学知识储备。其次，不同于传统AI的"快思考（模式匹配）"，该系统具备了类似人 类医生的"慢思考"能力。它能主动提问以补充缺失信息，通过"假设—验证—自我反思"的迭代循环，对 诊断线索进行反复推敲，从而修正潜在的逻辑漏洞。此外，针对AI医疗最大的"信任危机"，该系统实现 了全流程的循证推理。系统生成的每一个诊断结论，都可溯源——附带一条清晰、完整的证据链条，让 医生不仅知道"是什么"，更清楚"为什么"。 论文数据显示，在仅提供患者临床表型信息而不包含基因数据的情况下，系统展现出惊人的"表型解 码"能力。其表型诊断的首位准确率达57.18% ...

论文数据显示，DeepRare的诊断效能实现颠覆性突破。仅依靠患者临床表型、不借助基因数据时，其首 位诊断准确率达57.18%，较该领域国际最佳模型提升23.79个百分点，彻底改变"不测基因难确诊"的困 境。在回顾性人机对比中，其诊断召回率超越拥有十年临床经验的罕见病专科医生，成为首个在该指标 上优于人类医生的罕见病诊断方法。引入基因数据后，其复杂病例综合首位准确率突破70.6%，显著优 于国际通用工具Exomiser(53.2%)，系统推理报告更获得95.4%的临床专家认可。 图 中新网上海新闻2月19日电（记者 许婧）北京时间2月19日凌晨，国际顶级学术期刊《自然》(Nature)在 线发表上海交通大学人工智能学院与医学院附属新华医院联合团队的重磅成果，同期《自然》 News&views版块配发专文评论，评价该成果在AI罕见病诊断领域的突破性意义。 该研究由上海交大张娅教授、谢伟迪副教授与新华医院孙锟教授、余永国教授领衔，针对罕见病"确诊 难、漏诊率高"的全球性难题，研发出全球首个智能体式罕见病循证推理诊断系统DeepRare。该系统采 用创新"中枢-分身"架构，在三大维度实现对传统医学AI的代际超越。 ...

机器之心发布 罕见病，是医学界公认的 "拼图游戏"。全球 7000 多种病种、3 亿患者，面临的是平均 4.7 年的确诊周期和 50% 的误诊率。当人类医生的 "脑力" 达到 极限，谁来接棒？ 今天， 上海交通 大学 人工智能学院与医学院附属新华医院 联合团队，在国际顶级期刊《 Nature 》发表题为 "An Agentic System for Rare Disease Diagnosis" 的研究成果。他们提出的 DeepRare 系统，模拟了人类专家的 "System 2 慢思考" 逻辑，在诊断精度上全面超越了资深专科医生。 但这不仅仅是一篇论文的胜利。从实验室的代码，到医院的系统，再到一家名为 "观壹智能" 的创业公司，这个团队展示了 "医工交叉" 最理想的模样。 机器之心独家专访了团队核心成员： 张娅、谢伟迪、孙锟、余永国、王延峰 ，深度复盘这场跨越学科的 "破冰之旅"。 第一篇章：临床的呼唤 —— 为什么我们需要 AI？ 受访人：孙锟（上海交通大学医学院附属新华医院 原院长） 机器之心： 孙院长，作为一家顶尖三甲医院的掌门人，您为何如此坚定地支持 AI 介入罕见病诊疗？ 孙锟： 因为这是 "临床 ...

Core Insights - The development of the East Lake High-tech Zone in Wuhan has transformed it into a significant hub for innovation and technology, contributing to China's strategic technological advancements [1][4] - The East Lake Laboratory has achieved world records in high-speed rail technology, indicating a strong focus on cutting-edge transportation solutions [2] - The establishment of various national and regional laboratories and innovation platforms has strengthened the research and development ecosystem in the region [4][12] Group 1: Technological Innovations - The East Lake Laboratory has successfully accelerated a high-speed train model to 800 km/h in just 5.3 seconds, breaking previous records and advancing research in high-speed transportation [2] - The Nine Peaks Mountain Laboratory focuses on compound semiconductor technology, aiming to provide foundational hardware support for future industries [3] - The integration of medical and engineering technologies has led to the development of innovative medical devices, such as a minimally invasive heart surgery tool inspired by fruit cutting techniques [6][7] Group 2: Research and Development Ecosystem - The East Lake High-tech Zone has established a comprehensive innovation ecosystem with over 5,800 high-tech enterprises and 196 national-level specialized "little giant" companies [12] - The Wuhan Innovation Development Research Institute has facilitated the growth of nearly 1,000 projects, enhancing the local innovation landscape [7][8] - The region's R&D investment intensity reached 9.4%, ranking third among national high-tech zones, showcasing a strong commitment to technological advancement [4][12] Group 3: Talent Development - The East Lake High-tech Zone has attracted over 40,000 master's and 8,000 doctoral graduates, emphasizing the importance of talent in driving innovation [12] - Collaborative initiatives with local universities have been established to cultivate industry-ready talent, addressing the demand for skilled professionals in emerging sectors [12] - The "Doctor 500 Plan" at Huagong Technology aims to enhance the company's R&D capabilities by increasing the proportion of PhD talent [10]

Core Viewpoint - The development of the East Lake High-tech Zone in Wuhan, known as "China's Optics Valley," has become a significant hub for technological innovation and industry integration, emphasizing the need for high-level technological self-reliance and the fusion of technological and industrial innovation [1][4]. Group 1: Technological Innovation and Achievements - The East Lake Laboratory has achieved a world record by accelerating a high-speed train model to 800 km/h in just 5.3 seconds, showcasing advancements in transportation technology [2]. - The laboratory is also developing a comprehensive electric power system for ships, addressing traditional inefficiencies in testing and ensuring reliability and safety [2]. - The Nine Peaks Mountain Laboratory focuses on compound semiconductor technology, aiming to provide foundational hardware support for future industries [3]. Group 2: Research and Development Ecosystem - The East Lake High-tech Zone has established a comprehensive innovation ecosystem with 1 national laboratory, 13 national key laboratories, and numerous innovation platforms, achieving a research and development intensity of 9.4%, ranking third among national high-tech zones [4]. - The integration of various stakeholders, including enterprises, talent, and market resources, is crucial for achieving breakthroughs and effective technology transfer [4]. Group 3: Unique Innovations in Biotechnology and Medical Devices - Wuhan Heyuan Biotechnology Co., Ltd. has developed a groundbreaking "rice blood production" technology, allowing for the production of human serum albumin from rice, marking a significant advancement in biotechnology [5]. - The innovative micro-invasive myocardial resection system, inspired by a pineapple cutting tool, has been successfully implemented in clinical settings, demonstrating the potential of cross-disciplinary collaboration in medical technology [6][7]. Group 4: Talent Development and Investment - The East Lake High-tech Zone has established a government-led investment fund of 89 billion yuan, with over 70 billion yuan allocated annually for scientific innovation, significantly exceeding the national average [12]. - The region has attracted over 40,000 master's and 8,000 doctoral graduates, emphasizing the importance of talent in driving technological and industrial innovation [12]. Group 5: Future Industry Development - The East Lake High-tech Zone is focusing on emerging industries such as artificial intelligence, humanoid robots, brain-machine interfaces, and biomanufacturing, aiming to create a trillion-yuan scale "World Optics Valley" [12]. - The integration of innovative elements and a supportive ecosystem is essential for fostering a competitive environment that encourages risk-taking and innovation [12].

本报讯（记者 孙奇茹）近日，奇点创智·人才系列交流活动之医工交叉专场活动在京举行，全球首创 CT/MRI孔径内实时可视化微创机器人系统、全球首款无创全脑多通道脑氧监护仪、全球最细超微型磁 控内窥镜系统……一批来自北京知名高校、医院和科技企业的医工交叉前沿科技成果在活动上路演亮 相。 胃镜筛查是一项不可或缺的医学检查手段，但现有筛查手段存在明显局限：胃镜侵入式且需麻醉，无线 磁控胶囊内镜图像差、盲区多，还存在滞留风险。北京大学第一医院内镜中心主任戎龙带来的超微型磁 控内窥镜系统，采用全球首创"有线传输+磁控"双模驱动技术，可实现上消化道无痛、高清、实时、可 控的全流程筛查，为上消化道疾病早筛早治大规模普及提供了创新解决方案。 北京医院肿瘤微创治疗中心主任李晓光带来的全球首创CT/MRI孔径内实时可视化微创机器人系统，中 科搏锐公司的全球首款无创全脑多通道脑氧监护仪，北京积水潭医院主任医师周一新团队的"膝关节重 建个性化假体外形调制与植入关键技术"……涵盖仿生神经导管、无创脑机接口等多个前沿赛道的医工 交叉领域创新成果接连亮相，每一项成果都紧扣临床需求、突破行业瓶颈，极具成果转化潜力。 活动以"人才搭桥、成果落地 ...

胃镜筛查是一项对不少人来说不可或缺的医学检查手段，但现有筛查手段存在明显局限：胃镜侵入式且 需麻醉，无线磁控胶囊内镜图像差、盲区多，还存在滞留风险。北京大学第一医院内镜中心主任戎龙带 来的超微型磁控内窥镜系统，采用全球首创"有线传输+磁控"双模驱动技术，可实现上消化道无痛、高 清、实时、可控的全流程筛查，为上消化道疾病早筛早治大规模普及提供了创新解决方案。 2月7日，奇点创智·人才系列交流活动之医工交叉专场活动在集智未来人工智能产业创新基地举行，全 球首创CT/MRI 孔径内实时可视化微创机器人系统、全球首款无创全脑多通道脑氧监护仪、全球最细超 微型磁控内窥镜系统……一批来自北京知名高校、医院和科技企业的医工交叉前沿科技成果在活动上路 演亮相。 来源：北京日报客户端 北京医院肿瘤微创治疗中心主任李晓光带来的全球首创CT/MRI 孔径内实时可视化微创机器人系统，中 科搏锐公司的全球首款无创全脑多通道脑氧监护仪，北京积水潭医院主任医师周一新团队的"膝关节重 建个性化假体外形调制与植入关键技术"……涵盖仿生神经导管、无创脑机接口、无创全脑多通道脑氧 监护仪等多个前沿赛道的医工交叉领域创新成果接连亮相，每一项成果都紧 ...

南方财经记者伍素文广州报道 长时间独处后，明明没发生什么事，却莫名心慌、坐立不安甚至对社交产生恐惧？世界卫生组织已将"社会孤立"列 为全球健康重大威胁，科学家们也一直困惑，"孤独"引发焦虑背后的生物学开关到底是什么？ 其实，不仅是"心情不好"——社交隔离也在悄悄改变你的大脑。 南方财经记者从华南理工大学获悉，近日该校医学院王卓副教授团队联合浙江大学、南方医科大学等单位，在国际 顶级期刊Cell Metabolism（《细胞·代谢》）发表原创性研究成果。该研究首次揭示了社交隔离会触发大脑特定区域 的"铁堆积"，进而激活一条全新的神经可塑性通路——研究团队将其命名为"铁可塑性"（Ferroplasticity）。 过去，人们认为铁只是维持神经健康的"营养元素"，但本研究证明，在心理压力下，"铁"会成为一把"双刃剑"—— 它能直接驱动神经突触的结构与功能重塑。这项发现，不仅解开了"孤独伤脑"的长久谜题，更开辟了一条无需传统 抗焦虑药物无创可逆的全新干预路径。 首次提出"铁可塑性" 据悉，研究团队通过模拟人类长期独居的小鼠模型，发现了被单独饲养的小鼠，其大脑中一个叫 "腹侧海马" 的区 域（更偏好调控情绪的海马亚区） ...

Group 1 - The Shandong Provincial Government is focusing on the development of key industries, including new generation information technology and artificial intelligence, as well as emerging sectors like life health and green energy, as part of its "10+1" industrial development strategy [2] - Qingdao University is aligning its academic programs with the regional industrial layout by establishing interdisciplinary doctoral programs in areas such as low-altitude technology and artificial intelligence [2][3] - The university has formed seven academic clusters from 39 disciplines, emphasizing peak disciplines in systems, textiles, and medicine, while also developing advantageous clusters in new energy and cultural creativity [3] Group 2 - Qingdao University has established its own medical technology company to leverage its clinical advantages, focusing on smart medical devices and innovative healthcare solutions [4] - The university is actively promoting the construction of research centers in extreme environment medicine and artificial intelligence, with several projects already approved or in progress [3] - The integration of AI into various research initiatives is a priority for Qingdao University, aiming to enhance its contributions to the local economy and healthcare innovation [2][4]

Group 1 - The Shandong Provincial People's Congress emphasized the importance of a first-class university named after a city as a hallmark of a modern international metropolis, with a focus on high-quality development of local universities and application-oriented institutions [1] - Qingdao University aims to leverage its strengths in medicine, healthcare, and engineering to contribute to the development of the Qingdao Science and Technology Innovation Corridor and the "China Health Bay" initiative, presenting both challenges and opportunities for the institution [1] Group 2 - Qingdao City has outlined a "10+1" industrial development strategy focusing on emerging industries such as new generation information technology, artificial intelligence, and health, while also enhancing existing industries like smart home appliances and high-end chemicals [2] - Qingdao University has established eight interdisciplinary doctoral programs in areas such as low-altitude technology and artificial intelligence, fostering a collaborative ecosystem through the integration of education and industry [2] Group 3 - Qingdao University has organized 39 first-level disciplines into seven discipline clusters, with a focus on developing peak discipline clusters in "system+", "textile+", and "medicine+" [3] - The university is actively promoting projects related to extreme environment special medicine and artificial intelligence, with plans for future energy and intelligent connected vehicle centers [3] Group 4 - Qingdao University has established its own wholly-owned medical technology company to incubate innovations in smart diagnostics, medical devices, and pharmaceuticals, aiming to create a strong brand in medical technology [4]