2025年9月，创新药研发平台型企业百奥赛图在过去一个月连续发布多项重要合作进展。无论是与跨国 巨头默克在抗体偶联脂质纳米颗粒（LNP）递送方案上的探索，还是与德国Tubulis的抗体许可协议，亦 或是合作伙伴IDEAYA在双抗ADC联合治疗的推进，都进一步印证了公司"双业务线"战略布局的前瞻性 与国际竞争力。 双业务线逻辑：模式动物+抗体平台 百奥赛图的发展战略核心在于"双业务线"： 与默克再度携手：探索抗体偶联LNP递送 9月初，百奥赛图宣布与默克（Merck）签署抗体选择权评估协议，围绕抗体偶联LNP递送展开合作。百 奥赛图将基于其RenMice®平台提供全人抗体，由默克评估其在LNP系统中的可行性。若默克选择行 权，百奥赛图将获得相应首付款、里程碑及分成收益。 这一合作不仅拓展了全人抗体在传统抗体药物之外的应用场景，也展示了抗体在核酸药物递送系统中潜 在的关键作用。业内人士认为，随着mRNA、siRNA等核酸疗法快速发展，精准递送已成为瓶颈，而抗 体偶联LNP有望提供更高效和更靶向的解决方案。 Tubulis行权：全人抗体进入ADC研发 紧随其后，9月中旬，百奥赛图宣布与德国新锐ADC企业Tubuli ...

Core Viewpoint - WuXi Biologics reported a strong performance for the first half of 2025, with revenue reaching 9.95 billion RMB, a year-on-year increase of 16.1%, and a net profit growth of 54.8% to 2.76 billion RMB, indicating robust business growth and a positive outlook for the future [1][2]. Financial Performance - The company achieved a gross margin of 42.7%, up 3.6 percentage points year-on-year [1]. - Adjusted net profit increased by 11.6% to 2.84 billion RMB, while profit attributable to shareholders rose by 56.0% to 2.34 billion RMB [1]. - WuXi Biologics raised its full-year revenue guidance for 2025 to a growth range of 14%-16% [1]. Business Development - The company signed 86 new comprehensive projects in the first half of 2025, setting a historical record and bringing the total number of projects to 864 [1]. - Over 70% of new projects focus on ADC (Antibody-Drug Conjugates) and bispecific/multispecific antibodies, highlighting the high demand in these areas [1]. - The conversion rate from R&D to development and manufacturing exceeds 90%, showcasing strong client relationships and business integration [4]. Market Position and Strategy - WuXi Biologics has a significant order backlog of 20.34 billion USD, with over 4.21 billion USD in unfulfilled orders expected in the next three years, reinforcing the stability and growth potential of its core business [2]. - The company has evolved from a traditional service provider to a platform company that empowers global innovative biopharmaceutical development [4]. - The firm’s unique CRDMO business model creates substantial competitive barriers that are difficult to replicate [4]. Technological Innovation - WuXi Biologics launched several advanced platforms in 2023, including EffiXTM and WuXiaHigh2.0, enhancing its production capabilities [6]. - The company’s automated production line has achieved a breakthrough in continuous production, significantly increasing output [6]. External Environment and Market Trends - The capital market for innovative drugs is recovering, with significant increases in financing activities in the healthcare sector [2]. - Policy updates in China are expected to stimulate domestic innovative drug development, benefiting WuXi Biologics as a leading CXO enterprise [7]. Valuation and Investment Potential - As of August 18, the company's PE ratio reached 35.35, indicating a recovery in valuation, yet it remains below the historical average, suggesting potential for further appreciation [8]. - The company’s stock buyback program has increased its net asset value per share to 11.28 HKD, enhancing its investment appeal [7].

Group 1 - The Hang Seng Biotechnology ETF (159615) has seen a 2.27% increase, marking a three-day rising streak with an active trading volume of 35.71% and a transaction value of 131 million yuan [1] - The Hang Seng Biotechnology Index, which the ETF tracks, rose by 1.67%, with notable increases in constituent stocks such as JD Health (up 12.22%) and Sihuan Pharmaceutical (up 8.49%) [1] - The ETF has accumulated a 2.72% increase over the past week, ranking first among comparable funds, and its latest scale reached 352 million yuan, a three-month high [1] Group 2 - According to Guojin Securities, China's innovative drugs are on the rise, entering the initial phase of innovation results realization, with significant opportunities for independent development and large-scale transactions in the future [2] - In the oncology field, two main directions are highlighted: the multidimensional iteration of ADCs (antibody-drug conjugates) and innovations in the combination of immune therapy molecular components [2] - The Hang Seng Biotechnology Index reflects the overall performance of the largest 50 biotechnology companies listed in Hong Kong, with top-weighted stocks including BeiGene, Innovent Biologics, and WuXi Biologics [2]

Core Insights - Global pharmaceutical giants are increasingly turning Chinese laboratories into new drug "arsenals" as evidenced by significant licensing deals and collaborations with Chinese biotech firms [2][3][4] Group 1: Licensing Deals and Collaborations - Rongchang Biopharma licensed its self-developed product Taitasip to Vor Biopharma for $45 million upfront and potential total payments of up to $4.23 billion [2] - CSPC Pharmaceutical Group announced a strategic R&D collaboration with AstraZeneca, receiving $110 million upfront with potential total revenue reaching $5.33 billion [2] - In May alone, at least six Chinese pharmaceutical companies announced major business development (BD) deals, indicating a surge in interest from global players [3] Group 2: Market Growth and Trends - The total value of BD transactions in China's pharmaceutical sector reached $63.5 billion in 2024, a 22.59% increase from 2023, with 24 major deals accounting for $43 billion [3][4] - China's share of global BD transactions with upfront payments over $50 million surged from 5% in 2021 to 42% in the first five months of 2025 [4] - The trend indicates that Chinese innovative drug assets are becoming increasingly attractive to multinational corporations due to their high cost-effectiveness [8] Group 3: Competitive Advantages - Chinese drug development costs are significantly lower, with recruitment costs for clinical trials being one-third of those in Western countries, leading to faster drug development timelines [9] - The increasing number of original innovative drugs entering clinical trials in China, which reached 704 in 2024, positions China as a global leader in new drug development [10] Group 4: Future Outlook - The growth of BD transactions in China is expected to continue, driven by the need for innovative drugs amid the looming "patent cliff" faced by many global pharmaceutical companies [9][10] - Structural changes in the BD landscape are evident, with ADCs and bispecific/multispecific antibodies emerging as leading technologies in international markets [7][11]