中国新闻周刊作者：刘孜妍 发于2025.8.25总第1201期《中国新闻周刊》杂志 近日，歌手陈奕迅公开承认自己压力太大陷入焦虑症，引发关注。 8月14日，陈奕迅再次回应：一直没有把这件事告诉妈妈。陈奕迅强调："其实我真的不是很严重， 还没严重到出不了房门的地步，大家不用太担心。" 焦虑症又称焦虑障碍。2019年，《柳叶刀-精神病学》发布的中国精神卫生调查研究显示，中国各 类主要精神障碍中，焦虑障碍是最常见的精神障碍。中国成年人中，焦虑症的年患病率(即一年内患病 人群的比例)为5.0%，终生患病率为7.6%。国内成年人焦虑症的患病率甚至超过抑郁症。今年1月，发表 于《英国精神病学杂志》的一项研究指出，1990年到2021年，中国焦虑症患者数量从4050万上升至5310 万，增长了31.2%。 社交媒体上，对于升学焦虑、面试焦虑、就业焦虑、婚恋焦虑等话题的讨论层出不穷。当各种焦虑 情绪持续发酵、难以缓解，甚至发展为符合临床诊断标准的病症时，它的具体表现有哪些？又应如何进 行规范诊断与治疗？ 濒死感袭来 早在高三确诊焦虑症之前，夏晴就已时常感到胸闷气促。每天早晨的干呕，都会让她觉得呼吸困 难、浑身发麻，"像是触电 ...

Core Viewpoint - The article discusses the significant impact of high fructose consumption, particularly during early life, on neurodevelopment and the potential increase in anxiety disorders in adolescents. It highlights the mechanisms by which fructose affects microglial function and brain development, emphasizing the role of the GLUT5 protein in this process [1][3][11]. Group 1: Fructose Consumption and Health Implications - Fructose is a common sugar that has been widely used in food and beverages, often perceived as a "healthy sugar" due to its low glycemic index and high sweetness [1]. - Over the past 50 years, fructose consumption has surged, primarily due to the use of high fructose corn syrup in processed foods and drinks, which is linked to metabolic diseases such as obesity, diabetes, and fatty liver [1][6]. - Excessive fructose intake has also been associated with an increased risk of colorectal cancer and anxiety disorders, particularly among adolescents [1][6]. Group 2: Research Findings on Fructose and Neurodevelopment - A study published in Nature indicates that high fructose intake during early life impairs microglial phagocytosis and neurodevelopment, potentially leading to increased anxiety risk later in life [2][3][11]. - The research found that high fructose consumption significantly reduces the phagocytic activity of microglial cells in the brains of young mice, which is crucial for clearing dead neurons and ensuring proper brain development [5][7]. - The negative effects of high fructose on brain function are mediated by the GLUT5 protein, which is responsible for fructose transport into cells. The absence of GLUT5 can reverse the adverse effects of high fructose on microglial function [7][9]. Group 3: Implications for Dietary Habits - The findings suggest that early life exposure to high fructose may lead to cognitive deficits and anxiety-like behaviors during adolescence, highlighting the importance of dietary choices during pregnancy and early childhood [9][16]. - The research team is exploring fructose analogs as potential substitutes to mitigate the negative impacts of fructose in modern diets, acknowledging the challenges in changing dietary habits [12][13].