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AI+生信,在CNS顶刊论文的应用
生物世界· 2025-09-25 04:35
Core Viewpoint - The article emphasizes the integration of AI tools, particularly DeepSeek, in enhancing research methodologies in bioinformatics, specifically in the analysis of multi-omics data and the design of research projects [1][3][29]. Course Structure - The course includes practical sessions on AI-assisted design of research topics, focusing on multi-omics data analysis, including metabolomics, proteomics, and genomics [3][30]. - It covers the use of AI for efficient reading and summarizing of CNS literature, as well as the evaluation of innovative ideas and data analysis feasibility in bioinformatics [3][29]. AI Applications in Bioinformatics - AI is utilized for sample grouping, data filtering from public databases, and visualizing bioinformatics analysis results [4][19]. - The course includes modules on machine learning applications in metabolomics, proteomics, and transcriptomics, highlighting various algorithms and their implementations [33][40]. Research Methodologies - The curriculum emphasizes the importance of understanding and applying various statistical and machine learning methods for data analysis, including regression models and clustering techniques [44][40]. - It also includes practical coding sessions to replicate high-level research from CNS articles, enhancing hands-on experience [50][51]. Continuous Support and Learning - The program offers ongoing support and one-on-one guidance even after course completion, ensuring that participants can effectively apply their learning in real-world scenarios [22][24][50]. - The course is designed to be flexible, allowing participants to revisit materials and receive assistance as needed [22][26].
2026年北京医药健康产业总体规模预计达1.25万亿元
Xin Jing Bao· 2025-09-14 11:52
Group 1 - The core viewpoint of the article highlights the significance of the 2025 China International Fair for Trade in Services and the investment forum on medical technology innovation and achievement transformation held in Beijing [1] - The overall scale of Beijing's medical and health industry surpassed 1 trillion yuan last year, with expectations to reach 1.25 trillion yuan by 2026, indicating substantial growth in the sector [1] - Medical devices and AI-related medical devices account for one-third of the national total, showcasing Beijing's leading position in these areas [1] Group 2 - The integration of bioinformatics with medical health is emphasized as a crucial factor for the advancement of medicine and precision medicine [1] - The Beijing Medical and Health Technology Promotion Center aims to establish a platform through this forum to encourage collaboration among professionals from various fields [1] - The center calls for leveraging China's advantages in bioinformatics to promote innovation and transformation in the medical sector [1]
复旦大学宋振举教授课题组招聘博士后
生物世界· 2025-07-02 08:03
Group 1 - The article introduces Professor Song Zhenju, who holds multiple prestigious positions in emergency medicine and clinical research, including Director of the Emergency Department at Fudan University Zhongshan Hospital and Vice President of the same hospital [1] - Professor Song has led numerous national and provincial research projects, published extensively in high-impact journals, and holds multiple patents, indicating a strong research background and contributions to the field [1] Group 2 - The research directions focus on Acute Respiratory Distress Syndrome (ARDS) mechanisms and interventions, organ damage from sepsis, and mechanisms and interventions for acute poisoning [6] Group 3 - Recruitment is open for postdoctoral positions in fields such as Clinical Medicine, Life Sciences, Biology, Biomedical Engineering, and Pharmacy [3] - Candidates must be under 35 years old, have a strong academic background, and have published at least one SCI paper [5] Group 4 - Compensation will follow national and Fudan University standards, with additional rewards for outstanding performance during the contract period [7] Group 5 - Applicants are required to submit a detailed CV, proof of doctoral degree, and 1-3 representative papers [8] - Contact information for applications is provided, with specific instructions for email subject lines [9][10]
新工具发现230种海洋巨型病毒
Ke Ji Ri Bao· 2025-06-13 01:56
Core Insights - Scientists at the University of Miami developed an innovative bioinformatics tool named BEREN, which identified 230 new giant viruses from ocean metagenomic datasets and characterized their functions [1][3] Group 1: Research Findings - The tool BEREN efficiently identifies giant virus genomes from large public DNA sequencing datasets, addressing previous limitations in bioinformatics processes [3] - The research revealed that these giant virus genomes contain 530 new functional proteins, with 9 involved in photosynthesis, indicating potential manipulation of host photosynthesis during infection [3] Group 2: Ecological Impact - Giant viruses play a crucial role in the survival of single-celled marine organisms, which are foundational to the ocean food web, including algae, amoebas, and flagellates [3] - The study highlights the potential for giant DNA viruses to trigger harmful algal blooms, impacting human health due to their role in the food chain [3] Group 3: Technological Advancements - The research utilized the "Pegasus" supercomputer at the University of Miami to process and assemble extensive metagenomic data, reconstructing hundreds of microbial community datasets [3] - This study establishes a new framework for detecting novel viruses, which may aid in identifying pollutants and pathogens in waterways in the future [3]
全球人群基因组填上“最后一块拼图”,能解答人类起源了吗?
Guan Cha Zhe Wang· 2025-05-30 03:53
Core Insights - The Southeast Asia Genome Project has created the most comprehensive dataset of genomic variations in Southeast Asian populations, filling a critical gap in global genomic research [1][14] - The project utilizes advanced sequencing technologies and bioinformatics tools to analyze and compare human genes, addressing previous criticisms regarding the limited number of loci in molecular biology methods [3][4] - The findings from the project indicate significant genetic contributions from Denisovans to modern human populations in Southeast Asia, highlighting the complex evolutionary history of human beings [5][12] Group 1: Technological Advancements - The project employs second and third-generation sequencing technologies for comprehensive genome coverage, effectively dispelling concerns about insufficient loci [3] - A suite of bioinformatics tools is used to identify and analyze genetic variations, allowing for statistical analysis of frequency and genetic similarity among populations [3][4] Group 2: Evolutionary Insights - The Southeast Asia Genome Project has revealed evidence of multiple gene flow events from Denisovans into indigenous Southeast Asian populations, suggesting a close relationship between Denisovans and modern humans [5][12] - The project challenges previous assumptions about molecular clock hypotheses, indicating that genetic variation rates can differ and that some genetic lineages may disappear due to genetic drift [4][12] Group 3: Historical Context - The research highlights the historical neglect of Asian populations in genomic studies, emphasizing the importance of Southeast Asia as a key region in the migration routes of early modern humans [14] - The genetic diversity found in Southeast Asian populations provides critical insights into potential disease-related genetic markers relevant to East Asian populations [14]