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复旦大学宋振举教授课题组招聘博士后
生物世界· 2025-07-02 08:03
Group 1 - The article introduces Professor Song Zhenju, who holds multiple prestigious positions in emergency medicine and clinical research, including Director of the Emergency Department at Fudan University Zhongshan Hospital and Vice President of the same hospital [1] - Professor Song has led numerous national and provincial research projects, published extensively in high-impact journals, and holds multiple patents, indicating a strong research background and contributions to the field [1] Group 2 - The research directions focus on Acute Respiratory Distress Syndrome (ARDS) mechanisms and interventions, organ damage from sepsis, and mechanisms and interventions for acute poisoning [6] Group 3 - Recruitment is open for postdoctoral positions in fields such as Clinical Medicine, Life Sciences, Biology, Biomedical Engineering, and Pharmacy [3] - Candidates must be under 35 years old, have a strong academic background, and have published at least one SCI paper [5] Group 4 - Compensation will follow national and Fudan University standards, with additional rewards for outstanding performance during the contract period [7] Group 5 - Applicants are required to submit a detailed CV, proof of doctoral degree, and 1-3 representative papers [8] - Contact information for applications is provided, with specific instructions for email subject lines [9][10]
新工具发现230种海洋巨型病毒
Ke Ji Ri Bao· 2025-06-13 01:56
Core Insights - Scientists at the University of Miami developed an innovative bioinformatics tool named BEREN, which identified 230 new giant viruses from ocean metagenomic datasets and characterized their functions [1][3] Group 1: Research Findings - The tool BEREN efficiently identifies giant virus genomes from large public DNA sequencing datasets, addressing previous limitations in bioinformatics processes [3] - The research revealed that these giant virus genomes contain 530 new functional proteins, with 9 involved in photosynthesis, indicating potential manipulation of host photosynthesis during infection [3] Group 2: Ecological Impact - Giant viruses play a crucial role in the survival of single-celled marine organisms, which are foundational to the ocean food web, including algae, amoebas, and flagellates [3] - The study highlights the potential for giant DNA viruses to trigger harmful algal blooms, impacting human health due to their role in the food chain [3] Group 3: Technological Advancements - The research utilized the "Pegasus" supercomputer at the University of Miami to process and assemble extensive metagenomic data, reconstructing hundreds of microbial community datasets [3] - This study establishes a new framework for detecting novel viruses, which may aid in identifying pollutants and pathogens in waterways in the future [3]
全球人群基因组填上“最后一块拼图”,能解答人类起源了吗?
Guan Cha Zhe Wang· 2025-05-30 03:53
Core Insights - The Southeast Asia Genome Project has created the most comprehensive dataset of genomic variations in Southeast Asian populations, filling a critical gap in global genomic research [1][14] - The project utilizes advanced sequencing technologies and bioinformatics tools to analyze and compare human genes, addressing previous criticisms regarding the limited number of loci in molecular biology methods [3][4] - The findings from the project indicate significant genetic contributions from Denisovans to modern human populations in Southeast Asia, highlighting the complex evolutionary history of human beings [5][12] Group 1: Technological Advancements - The project employs second and third-generation sequencing technologies for comprehensive genome coverage, effectively dispelling concerns about insufficient loci [3] - A suite of bioinformatics tools is used to identify and analyze genetic variations, allowing for statistical analysis of frequency and genetic similarity among populations [3][4] Group 2: Evolutionary Insights - The Southeast Asia Genome Project has revealed evidence of multiple gene flow events from Denisovans into indigenous Southeast Asian populations, suggesting a close relationship between Denisovans and modern humans [5][12] - The project challenges previous assumptions about molecular clock hypotheses, indicating that genetic variation rates can differ and that some genetic lineages may disappear due to genetic drift [4][12] Group 3: Historical Context - The research highlights the historical neglect of Asian populations in genomic studies, emphasizing the importance of Southeast Asia as a key region in the migration routes of early modern humans [14] - The genetic diversity found in Southeast Asian populations provides critical insights into potential disease-related genetic markers relevant to East Asian populations [14]