Group 1 - The company plans to globally offer 33.44 million shares, with 3.34 million shares available in Hong Kong and 30.10 million shares for international sale [1] - The subscription period is from July 31 to August 5, with a maximum offer price of HKD 15.50 per share and an entry fee of approximately HKD 3,131.26 for 200 shares [1] - The total expected fundraising amount is HKD 475 million, with a net amount of HKD 421 million allocated for core product development, vaccine research, production capacity enhancement, working capital, and technology platform upgrades [1] Group 2 - The company is a China-based vaccine firm focused on innovative vaccines and the commercialization of traditional vaccines using new technologies [2] - The product pipeline includes two core products: a quadrivalent influenza virus subunit vaccine and a developing freeze-dried human rabies vaccine, along with 11 other vaccines in development [2] - The net profits for the fiscal years 2023, 2024, and the first quarter of 2025 are projected to be -425 million, -259 million, and -87.31 million respectively [2]

Core Viewpoint - Zhonghui Biotech-B (02627) is set to launch an initial public offering (IPO) from July 31 to August 5, 2025, aiming to issue 33.44 million H-shares globally, with 10% allocated for Hong Kong and 90% for international investors, at a price range of HKD 12.9 to HKD 15.5 per share [1] Group 1 - The company is a China-based vaccine manufacturer focused on the research, development, and commercialization of innovative vaccines and traditional vaccines using new technologies [1] - The product pipeline includes two core products: a quadrivalent influenza virus subunit vaccine and an investigational freeze-dried human rabies vaccine, along with 11 other vaccines in development [1] Group 2 - The cornerstone investors, including Jiaxing Xinyang and Huatai Capital Investment, have agreed to subscribe for shares worth USD 13 million, with an estimated total of 7.1136 million H-shares to be purchased at a midpoint price of HKD 14.20 per share [2] - This subscription represents approximately 21.3% of the total shares offered in the global sale, assuming no exercise of the over-allotment option [2] Group 3 - The net proceeds from the global offering are estimated to be around HKD 421 million after deducting underwriting fees and expenses, with approximately 63.6% allocated to the development and registration of core products [3] - Specific allocations include about 32.4% for the continued R&D and overseas registration of the quadrivalent influenza virus subunit vaccine, and about 31.2% for the Phase III clinical trials and registration of the investigational freeze-dried human rabies vaccine [3] - Additional funds will be used for the development of other investigational vaccines, enhancement of production and commercialization capabilities, and the development of various technological platforms [3]

Group 1 - The company, Zhonghui Biotech-B (02627), plans to conduct an initial public offering (IPO) from July 31 to August 5, 2025, with a global offering of 33.44 million H-shares, where 10% will be offered in Hong Kong and 90% internationally [1] - The offering price per share is set between HKD 12.9 and HKD 15.5, with trading expected to commence on August 8, 2025 [1] - The company focuses on the research, development, manufacturing, and commercialization of innovative vaccines and traditional vaccines using new technologies, aiming to replace traditional and imported vaccines in China and expand its competitive advantage internationally [1] Group 2 - The cornerstone investors, including Jiaxing Xinyang and Huatai Capital Investment, have agreed to subscribe for shares worth approximately USD 13 million, with an estimated subscription of 7.1136 million H-shares at a midpoint offering price of HKD 14.20 per share [2] - This subscription represents about 21.3% of the total shares offered in the global offering, assuming no exercise of the over-allotment option [2] - The estimated net proceeds from the global offering, after deducting underwriting fees and expenses, is approximately HKD 421 million [2] Group 3 - The company plans to allocate approximately 63.6% of the net proceeds from the global offering to the development and registration of its core products, with specific allocations for ongoing research and overseas registration of the quadrivalent influenza virus subunit vaccine and the Phase III clinical trial of the freeze-dried rabies vaccine [3] - About 18.1% will be used for the development and registration of other pipeline vaccines, while 8.4% will enhance production and commercialization capabilities [3] - Additionally, 4.9% will be allocated for the development and operation of various technological platforms, and 5.0% will be used for working capital and general corporate purposes [3]

公司、联席保荐人及整体协调人已与基石投资者(即嘉兴鑫扬及华泰资本投资(与华泰背对背总回报掉期 及华泰客户总回报掉期有关))订立基石投资协议，基石投资者同意认购可按发售价购买有关数目的发售 股份，认购总金额为1300万美元(约为1.02亿港元)。假设发售价为每股发售股份14.20港元(即本招股章程 所载指示性发售价范围的中位数)，基石投资者将予认购的发售股份总数将为711.36万股H股。 假设发售价为每股发售股份14.20港元(即本招股章程所载指示性发售价范围的中位数)及假设发售量调整 权未获行使，公司估计将获得所得款项净额约4.205亿港元。公司计划将全球发售所得款项净额用于以 下用途：(i)约63.6%将分配至公司的核心产品的开发及国内外注册，其中：(a)约32.4%将用于公司的四 价流感病毒亚单位疫苗的持续研发及海外市场注册；(b)约31.2%将用于公司的在研冻乾人用狂犬病疫苗 的III期临床试验及注册，公司预计于2025年第三季度启动该试验；(ii)约18.1%将用于公司的其他在研疫 苗的开发和注册；(iii)约8.4%将分配至提升公司的生产及商业化能力；(iv)约4.9%将分配至公司的技术 平台(包括 ...

江蘇中慧元通生物科技股份有限公司 Ab&B Bio-Tech CO., LTD. JS 全球發售 聯席保薦人、整體協調人、聯席全球協調人、聯席賬簿管理人及聯席牽頭經辦人 聯席賬簿管理人兼聯席牽頭經辦人 Ab&B Bio-Tech CO., LTD. JS 江蘇中慧元通生物科技股份有限公司 重要提示 （於中華人民共和國成立的股份有限公司） 股份代號 : 2 6 2 7 重要提示：閣下如對本招股章程的任何內容有任何疑問，應尋求獨立專業意見。 Ab&B Bio-Tech CO., LTD. JS 江蘇中慧元通生物科技股份有限公司 （於中華人民共和國成立的股份有限公司） 全球發售 全球發售項下的發售股份數目 33,442,600股H股（視發售量調整權 行使與否而定） 香港發售股份數目 3,344,400股H股（可予重新分配） 國際發售股份數目 30,098,200股H股（可予重新分配及 視發售量調整權行使與否而定） 最高發售價 每股H股15.50港元，另加1.0%經紀 佣金、0.0027%證監會交易徵費、 0.00565%聯交所交易費及 0.00015%會財局交易徵費（須於申請 時以港元繳足，多繳股款可予退還） 面值 ...

Group 1 - The overall investment in the pharmaceutical industry has not recovered despite positive news regarding innovative drugs, with 61 companies forecasting profits and 46 forecasting losses as of July 30, 2025 [1] - Pharmaceutical outsourcing service companies (CROs) have reported better-than-expected performance, with WuXi AppTec's revenue for the first half of 2025 reaching 20.64% growth year-on-year, and net profit increasing by 101.92% [3] - The CRO sector has seen a significant recovery in orders and performance, with over 50 global cooperation agreements in innovative drugs totaling over $48.4 billion in the first half of 2025 [4] Group 2 - 20 companies have reported their first net profit losses, with major contributors including Liao Ning Cheng Da and Wan Tai Bio, primarily due to policy impacts and market strategy failures [6] - Wan Tai Bio reported a projected net loss of between 130 million to 160 million yuan for the first half of 2025, marking its first loss since going public in 2020 [6][7] - Jiangsu Lianhuan Pharmaceutical expects a net loss of 38 million to 45 million yuan for the first half of 2025, attributed to a significant fine related to a monopoly agreement [7][8] Group 3 - The trend of business development (BD) in innovative drugs is expected to continue, with the total transaction amount approaching last year's levels, although the quality of these transactions may decline [10] - The vaccine and CXO sectors are anticipated to see a turnaround in the second half of 2025, with domestic vaccines expected to gain market share [10] - New opportunities may arise in technology platforms, with ADC and bispecific antibodies being key transaction categories, while multi-antibody platforms and TCE platforms are expected to gain traction [10]

Group 1 - The core viewpoint is that the pharmaceutical and biotechnology industry is expected to benefit from the recent outbreak of Chikungunya fever, with a gradual recovery in vaccine sector performance and potential valuation adjustments due to innovation attributes [1] - The pharmacy sector is exploring new business models in the context of medical insurance reforms, with non-pharmaceutical products emerging as a potential breakthrough direction [1] - The diagnostics sector is anticipated to improve due to the digestion of pandemic-related baselines and new demand arising from the current health landscape [1] Group 2 - The medium to long-term focus is on "innovation + AI healthcare + recovery," with innovative drugs and medical devices receiving clear support from the National Healthcare Security Administration, emphasizing differentiated innovation [1] - AI healthcare is gaining attention due to the World Artificial Intelligence Conference, with focus areas including diagnostic paradigms and drug development [1] - Recovery lines include a rebound in medical equipment procurement, as well as a restoration of demand in CXO and upstream life sciences [1] Group 3 - The Guotai Innovation Drug ETF (517110) tracks the SHS Innovation Drug Index (931409), which selects listed companies involved in new drug research, production, and sales from the Shanghai, Shenzhen, and Hong Kong markets to reflect the overall performance of innovative pharmaceutical companies [1] - Investors without stock accounts can consider the Guotai CSI Hong Kong-Shenzhen Innovation Drug Industry ETF Initiation Link C (014118) and Link A (014117) [1]

疫苗股继续活跃，其中，康希诺AH股午后拉升，A股一度涨超16%报82.48元，股价创2023年12月以来新高；H股拉升一度涨近14%报48.55港元，股价创 2023年3月以来新高。 随着确诊病例数量的增加，以及世界卫生组织专家发出的警报，市场对相关疫苗的需求预期显著增强，刺激疫苗股获资金追捧。 消息面上，基孔肯雅热在广东佛山市的爆发继续成为市场关注的焦点。据广东省疾控局消息，2025年7月20日0时至7月26日24时，广东省新增报告2940例 基孔肯雅热本地病例，未报告重症和死亡病例。病例分布在佛山2882例，广州22例，中山18例，东莞、珠海、河源各3例，江门、阳江、肇庆各2例，清 远、深圳、湛江各1例。 ...

Core Viewpoint - The company Zhonghui Biotech is preparing for its third IPO in Hong Kong, marking a significant step in its growth after achieving core technological breakthroughs and initial commercial success in the innovative vaccine sector [1][4]. Group 1: Company Overview - Zhonghui Biotech, established in 2015, focuses on subunit vaccines, which enhance safety and efficacy by extracting viral surface antigens with over 95% purity [4]. - The company's flagship product, "Hui Er Kang Xin," has shown a serum protection rate exceeding 89% against four flu virus strains, with a notably high rate of 97.98% for H3N2 [4]. - The company holds the only approved quadrivalent influenza subunit vaccine in China, which is expected to generate significant revenue growth, with projected income of 2.6 billion RMB in 2024, a 397.65% increase year-on-year [7][8]. Group 2: Product Pipeline and R&D - Zhonghui Biotech has developed a diverse pipeline of 13 differentiated research projects, including rabies vaccines and a 24-valent pneumonia conjugate vaccine targeting infants and the elderly [6]. - The company is advancing multiple vaccine candidates, with plans for clinical trials and regulatory submissions in 2025, including a rabies vaccine and an RSV vaccine [5][6]. - The company has invested heavily in R&D, with expenditures of 2.83 billion RMB in 2023 and 2.06 billion RMB in 2024, representing 79% of its revenue [14]. Group 3: Financial Performance - The company reported a cumulative loss of 684 million RMB from 2023 to 2024, with a further loss of 87.3 million RMB in Q1 2025 [14]. - As of March 2025, the company had cash reserves of only 115 million RMB against short-term liabilities of 2.54 billion RMB, indicating a significant liquidity challenge [10][14]. - The company’s revenue for 2023 was 52.168 million RMB, which increased to 259.612 million RMB in 2024, reflecting strong sales growth [9]. Group 4: Market Position and Strategy - Zhonghui Biotech's "Hui Er Kang Xin" was launched at a price of 319 RMB per dose, significantly higher than the average price of traditional vaccines, allowing it to quickly penetrate the market [8]. - The company is facing intense competition, with 19 flu vaccines already on the market and more in development, including from international giants like Sanofi [10][14]. - The upcoming IPO aims to raise funds primarily for core product development and international market expansion, particularly in Southeast Asia, to mitigate domestic price competition [16].

Core Viewpoint - The Hong Kong stock market has become a popular choice for healthcare companies to go public, with 11 out of the top 50 IPOs in 2023 being from the healthcare sector, raising approximately HKD 18.12 billion, indicating a strong interest despite cautious investor sentiment in the secondary market [1][4]. Group 1: Market Dynamics - The healthcare sector's IPO activity has been robust, but the average subscription multiple for companies, excluding a major player, is only 3.78 times, reflecting a more rational investment attitude in the secondary market [1][4]. - The domestic vaccine market is experiencing intense competition, with 19 flu vaccines already on the market and 16 more in clinical development, leading to price wars and compressed industry profits [4][7]. Group 2: Company Overview - Zhonghui Biotech, established in 2015, focuses on the research, development, and commercialization of innovative vaccines, with a pipeline of 13 products, including one commercialized vaccine [1][2]. - The company's only commercialized product, the four-valent influenza virus subunit vaccine (Hui Er Kang Xin®), has shown high efficacy rates, exceeding EU standards [5][6]. Group 3: Financial Performance - Zhonghui Biotech reported a significant revenue increase of 397.65% in 2024, with Q1 2025 revenue growing by 34.97%, indicating strong growth despite industry challenges [4][10]. - The company faces financial challenges, with a projected net loss of CNY 2.59 billion in 2024 despite achieving CNY 2.6 billion in revenue, highlighting the impact of high sales and R&D expenses [10][12]. Group 4: Competitive Position - The company's pricing strategy for its high-end vaccine remains at CNY 319 per dose, while competitors have significantly reduced their prices, indicating a potential disadvantage in a price-sensitive market [7][9]. - Zhonghui Biotech's late entry into the market with its commercial product may hinder its ability to compete effectively during peak demand seasons [9][10]. Group 5: Valuation Concerns - The company's estimated PS ratio of 16.1x is significantly higher than the industry average of 7.55x, suggesting that it may be overvalued relative to its peers [12].