第三代生物炼制技术旨在利用一碳分子和可再生能源，实现燃料与化学品的"负碳"生产，以应对日益严峻的气候变化和粮 食短缺问题。由合成气发酵制得的乙酸，作为一种可行的非粮碳源，近来在大宗化学品的生物合成中地位日益凸显。 3-羟基丙酸（3-HP）是一种可再生的大宗化学品，可通过氧化还原反应衍生出丙烯腈、1,3-丙二醇、丙烯酰胺、丙二酸和 丙烯酸等多种高值产品。据预测，其市场规模将突破360万吨/年，产值超过100亿美元/年。 SynBio团队 | 吴辉 【SynBioCon】 获 悉 ， 华东理工大学生物工程学院上海生物制造技术协同创新中心生物反应器工程国家重点实验室 的吴辉老 师团队 通过丙二酰 -CoA 途径，在大肠杆菌中成功构建了以乙酸为原料合成 3- 羟基丙酸（ 3-HP ）的工程菌 株。最终，工程菌株 ZWR18(M DA) 的 3-HP 产量达到 5.53 g/L ，得率为 0.732 g/g ，占理论得率的 97.60% 。在全 细胞催化条件下，该菌株可产 23.89 g/L 3-HP ，得率为 0.734 g/g ，达到理论得率的 97.87% 。以合成气来源的乙酸 为底物进行全细胞催化时， ZWR1 ...

Group 1: Industrial Development - Shanghai Jinshan District is focusing on strengthening its leading industries such as high-end chemicals, new materials, new energy vehicles, and low-altitude economy, while also accelerating the growth of emerging industries like biomanufacturing, electronic information, and green energy [1][2] - The district is promoting AI transformation in traditional manufacturing sectors and deep integration of emerging industries with AI [1] - The Lexus new energy project, which started construction in June, aims to build a complete ecosystem for intelligent connected new energy vehicles, leveraging the district's advantages in high-end chemicals, new materials, and hydrogen energy [1][2] Group 2: Innovation and Technology - Jinshan District is actively promoting the integration of technological innovation and industrial transformation by building platforms that optimize the combination of innovation and industrial resources [2] - The Shanghai Bay Area Software and Information Service Industry Base is a key project for digital empowerment, with the Shanghai Bay Area Building set to complete its main structure by the end of this year and begin operations mid-next year [2] - The project aims to attract technology innovation companies in the digital economy and other key sectors, providing a comprehensive multifunctional service platform [2] Group 3: Cultural and Tourism Development - Jinshan District plans to enhance consumer spending by integrating cultural tourism with commerce and agriculture, focusing on transforming visitor traffic into consumption growth [3] - The district aims to deepen the "ticket economy" and streamline various aspects of travel, including dining, accommodation, transportation, and entertainment, to create a large-scale consumption pattern [3]

Core Insights - The Chinese biomanufacturing industry is projected to reach a scale of 1.01 trillion yuan in 2024, with a year-on-year growth of 15.4%. By 2030, the industry is expected to exceed 2.5 trillion yuan, with a compound annual growth rate of 16.8% [1]. Group 1: Industry Development - The DT New Materials Research Institute has been actively monitoring and supporting the progress and innovation in the synthetic biology industry since the release of the "China Synthetic Biology Industry Map (2023)" which includes over 300 listed companies [1]. - The upcoming "4th Synthetic Biology and Green Biomanufacturing Conference (SynbioCon 2025)" will take place from August 20-22 in Ningbo, Zhejiang, where the "China Synthetic Biology Industry Distribution Map (2025 Edition)" will be announced, featuring over 500 representative biomanufacturing companies and their product information [1][9]. Group 2: Conference Details - The conference will focus on five key areas: AI + Biomanufacturing, Green Chemistry and New Materials, Future Food, Future Agriculture, and Beauty Raw Materials, inviting industry leaders, experts, and various stakeholders to explore the development trends of the biomanufacturing industry during the 14th Five-Year Plan [9]. - Participants at the conference can receive a free copy of the industry map valued at 499 yuan, and eligible biomanufacturing companies can apply to be listed on the map [6][10].

Group 1 - The industrial economy in China is experiencing growth driven by over a hundred AI-enabled devices such as AI smartphones, computers, and glasses [2] - The number of 5G mobile phone users has reached 1.118 billion, with intelligent computing power scaling up to 748 EFLOPS [3] - More than 140,000 specialized and innovative small and medium-sized enterprises have been cultivated, including 14,600 "little giant" enterprises [4] Group 2 - New work plans for stabilizing growth in key industries such as steel, non-ferrous metals, petrochemicals, and building materials will be released soon [5] - Implementation plans for digital transformation in the automotive and machinery sectors are set to be issued [6] - The "Artificial Intelligence +" initiative will accelerate the deployment of large models in key manufacturing sectors [6] Group 3 - The establishment of national-level manufacturing pilot platforms is underway, focusing on critical areas such as raw materials and emerging industries [6] - A series of actions will be taken to address overdue payments to small and medium-sized enterprises [7] - The establishment of the second phase of the National SME Development Fund aims to attract more social capital for investment in hard technology [7] Group 4 - The first public REITs for data centers have been established, raising a total of 69 billion yuan, indicating strong investor interest [11][12] - China's unicorn companies have a total valuation exceeding 1.2 trillion USD, reflecting the vitality of new productive forces [12] - The digital asset exchange Bullish has filed for an IPO, marking the first public listing attempt following the enactment of the stablecoin legislation [12]

Core Viewpoint - Isomaltulose is a new type of natural sweetener with low calories (4 kcal/g), high stability, and no adverse health effects, widely used in pharmaceuticals and food industries [1]. Market Overview - The global isomaltulose market reached $16.2 million in 2023 and is expected to grow to $48.9 million by 2030, with a compound annual growth rate (CAGR) of 17.19% from 2024 to 2030 [2]. Production Technology - The enzymatic preparation of isomaltulose has high conversion rates and meets green environmental requirements. Sucrose isomerase (SI) is an effective enzyme for catalyzing isomaltulose production. Immobilizing SI can improve its stability, reduce inactivation, and enhance recyclability in industrial applications [3]. Research and Development - Professor Liu Fufeng's team at Tianjin University of Science and Technology developed a directed immobilized enzyme that significantly improves heat resistance and reusability while maintaining high activity after multiple cycles. This work lays a solid foundation for the green manufacturing of isomaltulose and provides innovative ideas for the development of new directed immobilized enzyme technologies [4]. Conference Information - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, as well as four application areas: green chemicals and new materials, future food, future agriculture, and beauty raw materials. The "Youth Forum on Biological Manufacturing" will highlight scientific issues, solutions, results, scalability, and future directions in the research field [8][11].

Core Insights - Wuhan Ruijia Kang has been selected as one of the first 100 "Gazelle Selected" enterprises in the China Optics Valley 2025 initiative, standing out among over 5,800 high-tech companies in the region [1][3] - The "Gazelle Selected" enterprises exhibit characteristics such as over 50% of their workforce in R&D, an average of over 60 million yuan in equity financing over the past three years, and a strong presence in cutting-edge fields like integrated circuits, intelligent robotics, and biomanufacturing [1] Company Overview - Wuhan Ruijia Kang specializes in producing cellulose ethanol and high-purity lactic acid from non-grain raw materials, achieving significant breakthroughs in industrial strain gene editing technology and core strain construction [3] - The company has over 70% of its workforce in R&D, with 80% holding master's or doctoral degrees, and has secured 75 million yuan in investments from industry, government, and venture capital [3] - It has received multiple recognitions, including being designated as a national high-tech enterprise and a 2024 seed unicorn enterprise in Wuhan [3] Industry Events - The SynBioCon 2025 conference will be held from August 20-22 in Ningbo, Zhejiang, focusing on the intersection of AI and biomanufacturing, as well as advancements in green chemistry, new materials, future food, future agriculture, and beauty raw materials [5][9] - The conference will feature various forums, including a macro forum on biomanufacturing and specialized sessions on green chemistry and new materials [6][8]

Group 1 - In the first half of the year, China's industrial added value above designated size grew by 6.4% year-on-year, with the manufacturing added value accounting for 25.7% of GDP [1] - The number of industrial enterprises above designated size reached 520,000, and profits in the manufacturing sector increased by 5.4% year-on-year [1] - The digital industry, driven by rapid advancements in digital technologies such as 5G and AI, achieved a business revenue growth of 9.3%, an increase of 3.4 percentage points compared to the same period last year [1] Group 2 - In the automotive industry, production and sales reached 15.621 million and 15.653 million units respectively, marking year-on-year growth of 12.5% and 11.4% [2] - New energy vehicles saw production and sales of 6.968 million and 6.937 million units, with year-on-year growth of 41.4% and 40.3%, making up 44.3% of total new car sales [2] - The Ministry of Industry and Information Technology plans to introduce stability growth plans for key industries such as steel, non-ferrous metals, petrochemicals, and building materials [2]

Core Insights - The industrial added value of large-scale industries in China grew by 6.4% year-on-year in the first half of the year, demonstrating strong resilience following a good start in the first quarter [1] - The manufacturing added value accounted for 25.7% of GDP, remaining stable [1] - Key industries such as electrical machinery, automobiles, electronics, general equipment, chemicals, and non-ferrous metals showed rapid growth, contributing significantly to the overall industrial growth [1] Group 1: Industrial Performance - In the first quarter and second quarter, the industrial added value grew by 6.5% and 6.3% year-on-year, respectively, building on a high base from the previous year [1] - The contribution rates of equipment manufacturing and high-tech manufacturing increased, with their added values reaching 35.5% and 16.4% of large-scale industries, respectively [1] - Profits in industries such as electronics, electrical machinery, and general equipment grew by over 10% [1] Group 2: Regional Contributions - All 31 provinces reported growth in industrial added value, with provinces like Fujian, Anhui, Henan, and Hunan achieving over 8% growth [1] - Eight industrial provinces saw profit growth rates exceeding the national average, with Henan, Hunan, Hubei, and Jiangsu achieving double-digit growth [1] Group 3: Future Initiatives - The Ministry of Industry and Information Technology plans to implement a new round of growth stabilization work for ten key industries, including steel, non-ferrous metals, petrochemicals, and building materials [1] - Support will be provided to key industrial provinces to enhance their roles, including policy implementation, new growth point cultivation, and industrial transformation [1] - The ministry aims to accelerate the "Artificial Intelligence +" initiative, promoting the deployment of large models in key manufacturing sectors to enhance intelligence levels [1]

Core Insights - The industrial sector in China showed a robust performance in the first half of 2023, with a year-on-year growth of 6.4% in industrial added value, surpassing GDP growth by 1.1 percentage points [1] - Manufacturing investment increased by 7.5% year-on-year, supported by major engineering projects and technological upgrades [1] - Key industries such as electrical machinery, automotive, electronics, and chemicals contributed significantly to industrial growth, with high-tech manufacturing accounting for 16.4% of the total industrial added value [1][4] Group 1: Industrial Growth and Performance - All 31 provinces in China reported growth in industrial added value, with notable increases in Fujian, Anhui, Henan, and Hunan exceeding 8% [2] - Eight major industrial provinces achieved profit growth rates above the national average, with Henan, Hunan, Hubei, and Jiangsu recording double-digit growth [2] - The equipment manufacturing sector played a stabilizing role, representing 35.5% of total industrial added value, with profits increasing by 7.2% from January to May [4] Group 2: Policy and Future Directions - The government plans to implement a new round of growth stabilization measures across ten key industries, focusing on structural adjustments and eliminating outdated production capacity [2][5] - Emphasis will be placed on enhancing development quality through technological innovation and promoting high-end manufacturing [3] - Initiatives will be taken to support small and medium enterprises, reduce their burdens, and improve the overall business environment [3]

Group 1 - The Ministry of Industry and Information Technology (MIIT) is set to release a work plan aimed at stabilizing growth in ten key industries, including steel, non-ferrous metals, petrochemicals, and building materials [1] - The MIIT will focus on structural adjustments, optimizing supply, and eliminating outdated production capacity in these industries [1] - Efforts will be made to enhance the quality of development by integrating technological and industrial innovation, promoting high-end manufacturing, and implementing the "Artificial Intelligence+" initiative [2] Group 2 - The MIIT plans to implement digital transformation schemes for industries such as textiles, light industry, food, and pharmaceuticals, identifying 82 typical scenarios for smart transformation [2] - There will be a focus on green and low-carbon standards, particularly in the comprehensive utilization of resources like power batteries [2] - The MIIT aims to cultivate new industries and develop new growth drivers, including biomanufacturing and low-altitude industries, while promoting innovation in future industries such as humanoid robots and brain-computer interfaces [1]