2月27日，记者从国家税务总局获悉，天津、黑龙江、贵州、重庆等地多部门联合依法查处并曝光4起骗 取出口退税违法案件。 2025年3月，税务部门依据《中华人民共和国税收征收管理法》等相关法律法规规定，对上述3户企业追 缴骗取出口退税款2.01亿元，三年内停止为其办理出口退税。目前，杨荣栋等6人因涉嫌骗取出口退税 罪等由天津市滨海新区人民检察院向天津市第三中级人民法院、天津市滨海新区人民法院提起公诉。 国家税务总局驻沈阳稽查局联合黑龙江省税务公安等部门依法查处以刘敬伟为实际控制人的7户企业骗 取出口退税案件。 经查，2020年至2023年，以刘敬伟为实际控制人的牡丹江浩玮智能家具有限公司等7户企业，通过虚开 农产品发票，采取买单配票等违法手段骗取出口退税。 2024年2月，税务部门依据《中华人民共和国税收征收管理法》等相关法律法规规定，对牡丹江浩玮智 能家具有限公司等7户企业追缴骗取出口退税款6697.45万元，三年内停止为其办理出口退税。2025年10 月，齐齐哈尔市铁锋区人民法院对该案作出判决，主犯刘敬伟因犯骗取出口退税罪，被判处有期徒刑十 五年并处罚金；其余12名从犯分别被判处有期徒刑二年零十个月至十二年并 ...

天眼查App显示，近日，江苏洋河生物工程科技有限公司成立，法定代表人为陈翔，注册资本1亿人民 币，经营范围含工程和技术研究和试验发展，发酵过程优化技术研发，技术服务、技术开发、技术咨 询、技术交流、技术转让、技术推广，科技推广和应用服务，工业酶制剂研发，污水处理及其再生利用 等，由洋河股份全资持股。 ...

Core Viewpoint - The article discusses the development of next-generation biomanufacturing technologies based on extreme microorganisms, particularly Halomonas bluephagenes, emphasizing their potential to achieve sustainable industrial production while addressing the challenges of traditional microbial platforms [2][3]. Group 1: Need for Biomanufacturing Transition - The biomanufacturing technology using microorganisms is increasingly recognized as an environmentally friendly alternative for producing diverse chemicals, driven by advancements in synthetic biology [8]. - Current industrial biotechnology faces limitations due to high energy-consuming sterilization processes and inefficiencies in continuous production, necessitating the shift to next-generation biomanufacturing (NGIB) using extreme microorganisms [9][10]. Group 2: Industrial Value of Extreme Microorganisms - Extreme microorganisms, such as thermophiles, acidophiles, and halophiles, exhibit remarkable growth capabilities in harsh environments, making them suitable for industrial applications [11]. - These microorganisms can significantly reduce sterilization needs and enhance production efficiency, positioning them as valuable assets in sustainable biomanufacturing [14][15]. Group 3: Development of Next-Generation Industrial Biotechnology - Halomonas bluephagenes, a halophilic bacterium, shows promise in producing biopolymers like PHB, with advantages in genetic engineering and metabolic pathway optimization [13][16]. - The development of genetic tools and adaptive evolution strategies has led to significant improvements in product yields and metabolic efficiency [17][20]. Group 4: Metabolic Engineering and Product Synthesis - Metabolic engineering is crucial for enhancing the production of target metabolites in extreme microorganisms, with strategies focusing on cell morphology optimization and dynamic control of protein degradation rates [20][21]. - Halomonas bluephagenes has been engineered to utilize various low-cost substrates, including starch and food waste, for the production of biopolymers and high-value chemicals [27][33]. Group 5: Industrial Applications and Future Directions - The NGIB technology has been successfully applied in the production of biodegradable materials like PHA and various fine chemicals, with industrial-scale implementations already underway [39]. - Future advancements will require integrating cutting-edge technologies and optimizing metabolic pathways to enhance the efficiency and sustainability of biomanufacturing processes [41][43].

Group 1 - The board of directors of Zhengzhou Antu Bioengineering Co., Ltd. held its tenth meeting of the fifth session on January 20, 2026, with all 12 directors present and no dissenting votes [2][3][5] - The board unanimously approved the proposal to conduct foreign exchange hedging business to mitigate foreign exchange risks due to increasing overseas sales and currency fluctuations [4][12][17] - The company plans to apply for loans up to RMB 1.5 billion from financial institutions to support its operations and development, with the loan amount depending on actual funding needs [6][17] Group 2 - The foreign exchange hedging business aims to stabilize foreign exchange exposure, reduce financial costs, and enhance financial stability, with a maximum transaction amount of USD 89 million or equivalent [12][13][22] - The funding for the hedging business will come from the company's own funds, and the transactions will be conducted with qualified financial institutions approved by relevant authorities [14][15] - The board has authorized the chairman or designated representatives to implement the hedging business within a 12-month period following the board's approval [16][22]

Group 1 - The core viewpoint of the article is that Aibio (Hangzhou) Biotechnology Co., Ltd. has completed a Pre-A round financing, raising several tens of millions of RMB, with participation from investment institutions including Pudong Venture Capital Group, Yuanjing Capital, and Xihu Science and Technology Investment [1] - Aibio's AIxBio is an intelligent fermentation technology platform that utilizes mathematical models and artificial intelligence to combine biological and fluid information, enabling rapid and cost-effective transition from laboratory to mass production in biological manufacturing [1] - The intelligent platform is designed to save significant time and resources while optimizing production efficiency [1]

Core Viewpoint - Anqiu is focusing on industrial strength and aims to create a trillion-level industrial cluster by 2026, marking a key year for its development strategy [1]. Group 1: Industrial Development - Anqiu is committed to the strategy of "industrial city, industrial strength," advancing its industrial economy as a top priority and fostering large enterprises to build a modern industrial system with local characteristics [1]. - The industrial transformation is evident, with companies like Boyang Machinery achieving domestic leadership in intelligent loading systems, significantly improving efficiency [4]. - In 2025, Anqiu's industrial electricity consumption reached 19 billion kWh, a year-on-year increase of 3.9%, while the total industrial output value grew by 8.4%, leading the region [5]. Group 2: Green Transformation - Shandong Lanxiang Environmental Technology Co., Ltd. was recognized as a provincial "green factory," enhancing its industry leadership through innovative low-carbon water equipment projects [8]. - The company aims to produce 2,000 units annually, generating sales revenue of 3 billion yuan, showcasing Anqiu's commitment to green manufacturing [8]. - Anqiu is promoting green technology upgrades across enterprises, enhancing economic value through increased "green content" [8]. Group 3: Innovation and Support - Anqiu is implementing a "seedling cultivation" project for high-tech enterprises, establishing a nurturing system for startups and small to medium-sized tech firms [9]. - The government is enhancing service efficiency by assigning over 460 officials to support key enterprises, ensuring targeted assistance [9]. - Various initiatives, including market expansion activities, have been organized to help businesses grow and stabilize [9].

Core Viewpoint - The research project led by Wang Cuicui focuses on the mechanism of ubiquitination in regulating tomato fruit ripening, aiming to provide a theoretical basis for improving preservation techniques in the agricultural sector [3][5][7]. Group 1: Research Background and Significance - Wang Cuicui's project, titled "Research on the Mechanism of SlPUB13 Mediated SlSPL-CNR Ubiquitination Degradation Inhibiting Tomato Fruit Ripening," has been approved by the Beijing Natural Science Foundation, filling a research gap in the field of fruit ripening regulation [3][4]. - The project is significant as it explores the upstream regulatory mechanisms of ubiquitination degradation, which has been less studied compared to transcription factors and other regulatory methods [5][6]. Group 2: Research Process and Challenges - The project has entered its initial phase, with successful in vivo ubiquitination experiments, although in vitro results have not yet met expectations [7]. - The application process for the project was rigorous, requiring a well-crafted proposal that highlighted both innovative aspects and feasibility, demonstrating the collaborative effort among researchers [6][7]. Group 3: Future Applications and Impact - The research aims to clarify the regulatory mechanisms of fruit ripening, which could lead to the development of more efficient and environmentally friendly preservation methods, ultimately contributing to food safety and preservation technology in China [7][8]. - The findings from this research could potentially be applied to other fruits and vegetables, enhancing the overall understanding of fruit ripening processes [5][6]. Group 4: Educational Integration - The integration of research and teaching is emphasized, with the research findings being used to enrich the educational experience of students in the biological engineering program [8]. - The upcoming shift in the focus of the biological engineering discipline towards pharmaceutical engineering and synthetic biology presents new opportunities for applying plant molecular research [8].

Core Insights - The research team led by Zhang Yiheng from the Tianjin Institute of Industrial Biotechnology has achieved a significant breakthrough by enhancing the real conversion rate of cellulose to starch to 93.3% [1] Group 1: Technological Innovations - The team developed a new energy recycling pathway, innovatively designing a glucose recovery and activation mechanism that addresses carbon loss issues, increasing theoretical starch yield from 50% to 100% [1] - A more stable and efficient "enzyme factory" was created, identifying a series of novel enzyme components with high thermal stability, allowing the reaction temperature to be raised to 50°C, which accelerates the reaction speed and reduces enzyme usage [1] - Through precise collaborative regulation of the reaction system, the theoretical advantages were transformed into practical productivity, achieving a high conversion efficiency of 93.3% [1] Group 2: Application Potential - The technology not only produces regular starch but also generates high-value starch with precise structural control, showcasing application potential in high-end food, pharmaceuticals, and materials sectors [1]

Group 1 - The 2025 Xianshang Conference was held in Fengxian District, gathering nearly 450 entrepreneurs and representatives from various industries to celebrate achievements in the private economy [1] - Fengxian is one of the most active areas for private enterprises in Shanghai, with nearly 90% of the total number of enterprises being private, contributing over 60% of industrial output value, more than half of tax revenue, and over 60% of employment [1] - The conference highlighted both established companies and new entrants, showcasing their stories as examples of the resilience and vitality of Fengxian's private economy [1] Group 2 - Yaoshu Technology, focusing on organ-on-a-chip technology, has established its R&D center in Fengxian and has gained attention from major industry players, including multinational pharmaceutical companies and leading domestic firms [2] - The organ-on-a-chip technology simulates real organ structures and functions, providing a platform for drug development, especially in light of recent changes in regulations regarding animal testing [2] - The company was attracted to Fengxian due to its clear industrial planning and supportive policies, which align with the company's development direction [3] Group 3 - Established companies like Shanghai McLean Biochemical Technology Co., Ltd. have thrived in Fengxian, successfully localizing over 2,000 high-end reagents and significantly reducing research costs for domestic institutions [4] - The company received a low-interest loan of 10 million yuan from Fengxian during a challenging period, which helped it expand its product line and achieve sales exceeding 600 million yuan last year [4] - Shanghai Pudong Electric Wire and Cable Group is investing in a new high-end intelligent manufacturing plant in Fengxian, reflecting confidence in the region's industrial environment [4] Group 4 - The company aims to implement digital production management systems and AI detection to enhance its manufacturing capabilities, addressing traditional industry pain points [5] - The "Shanghang Xiancheng" project was launched to connect new and established businesses, providing customized services to facilitate collaboration [5] - Fengxian plans to deepen industrial collaboration, focusing on innovation in AI and biomedicine, and support the establishment of R&D centers in partnership with universities and research institutions [5]

Group 1 - The establishment of Shandong Yuanlang Biotechnology Co., Ltd. has been recently registered with a legal representative named Wu Chengyan and a registered capital of 3 million RMB [1] - The company's business scope includes research and development of bio-organic fertilizers, sales of chemical fertilizers, sales of fertilizers, sales of agricultural products, sales of feed raw materials, and research and development of compound microbial fertilizers [1] - Additional activities include import and export of goods, operation of agricultural crop seeds (limited to packaged seeds that are not repackaged), and various technical services such as consulting, development, and promotion [1]